Gene info: ID 8314

Gene: BAP1

GENE ID: 8314

Synonyms: HUCEP-13|UCHL2|hucep-6

Description: BRCA1 associated protein 1

Gene type: protein-coding

Location: 3p21.1

dbXrefs: Ensembl:ENSG00000163930 MIM:603089 Vega:OTTHUMG00000158392 UniprotKB:Q92560

RefSeq: NG_031859.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.723e-1 (AD) 3.594e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PDZD4	0.97
PPP1R9B	0.967
NCS1	0.966
FBXL16	0.964
GIT1	0.96
CBX6	0.954
TNPO2	0.954
SLC25A23	0.954
SEPT5	0.952
MAP3K10	0.95

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.79
OR4F29	-0.742
TFPI2	-0.36
C9orf135	-0.347
SGMS2	-0.326
KCNJ15	-0.319
ANXA13	-0.319
IGF2BP2	-0.315
C1orf87	-0.309
IL18RAP	-0.307

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BAP1 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of BAP1 mRNA"	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of BAP1 mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of BAP1 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of BAP1 mRNA	19770486
C006632	arsenic trioxide	arsenic trioxide affects the expression of BAP1 mRNA	17530438
D001194	Asbestos	Asbestos results in increased mutagenesis of BAP1 gene	26463840
D001194	Asbestos	BAP1 gene mutant form results in increased susceptibility to Asbestos	24928783
D017638	Asbestos, Crocidolite	"BAP1 gene mutant form results in increased susceptibility to Asbestos, Crocidolite"	26119930
D001241	Aspirin	Aspirin results in decreased expression of BAP1 mRNA	15928584
C547126	AZM551248	AZM551248 results in increased expression of BAP1 mRNA	22323515
D001554	Benzene	Benzene results in increased expression of BAP1 mRNA	19162166
C006780	bisphenol A	bisphenol A affects the expression of BAP1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of BAP1 mRNA	28196854
C006780	bisphenol A	bisphenol A affects the expression of BAP1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of BAP1 gene	28505145
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BAP1 gene	20938992
D016572	Cyclosporine	Cyclosporine results in increased methylation of BAP1 promoter	27989131
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of BAP1 mRNA	21318169
D005485	Flutamide	Flutamide results in increased expression of BAP1 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BAP1 gene	20938992
C015329	lycopene	lycopene results in increased expression of BAP1 mRNA	16886892
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BAP1 gene	20938992
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAP1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BAP1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAP1 mRNA]"	20230807
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of BAP1 protein	24625837
C028007	nickel monoxide	nickel monoxide results in increased expression of BAP1 mRNA	19167457
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BAP1 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAP1 mRNA]"	20230807
C531550	olaparib	BAP1 gene mutant form results in increased susceptibility to olaparib	22683710
C006253	pirinixic acid	pirinixic acid results in increased expression of BAP1 mRNA	21318169
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of BAP1 mRNA]	21318169
C059514	resveratrol	resveratrol results in decreased expression of BAP1 mRNA	12569576
D012643	Selenium	Selenium results in increased expression of BAP1 mRNA	19244175
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BAP1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BAP1 promoter]	19654925
D014050	Toluene	Toluene results in decreased expression of BAP1 mRNA	28245982
D014635	Valproic Acid	Valproic Acid results in increased methylation of BAP1 gene	29154799
D014810	Vitamin E	Vitamin E results in increased expression of BAP1 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003682	chromatin binding	-	IDA	19815555
GO:0004843	thiol-dependent ubiquitin-specific protease activity	-	IBA	21873635
GO:0004843	thiol-dependent ubiquitin-specific protease activity	-	IDA	18757409 19188440 19815555 20436459 24703950
GO:0005515	protein binding	-	IPI	9528852 19117993 19188440 19615732 19815555 20436459 22897849 24211834 27705803
GO:0008233	peptidase activity	-	NAS	9528852
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	IDA	24703950
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	IMP	18757409 19188440 19815555
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001558	regulation of cell growth	-	IMP	19815555
GO:0006464	cellular protein modification process	-	NAS	9528852
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	TAS	9528852
GO:0010035	response to inorganic substance	-	IEA	-
GO:0016579	protein deubiquitination	-	IBA	21873635
GO:0016579	protein deubiquitination	-	IDA	18757409 19815555
GO:0016579	protein deubiquitination	-	TAS	-
GO:0035520	monoubiquitinated protein deubiquitination	-	IDA	24703950
GO:0035522	monoubiquitinated histone H2A deubiquitination	-	IDA	20436459
GO:0051726	regulation of cell cycle	-	IMP	19188440
GO:0061519	macrophage homeostasis	-	IEA	-
GO:0071108	protein K48-linked deubiquitination	-	IMP	19188440
GO:1900015	regulation of cytokine production involved in inflammatory response	-	IEA	-
GO:1903955	positive regulation of protein targeting to mitochondrion	-	HMP	24270810

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	18757409 19188440 19815555 24703950
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	18757409 19188440 24703950
GO:0005829	cytosol	-	IDA	-
GO:0035517	PR-DUB complex	-	IDA	20436459

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689603	UCH proteinases	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	TAS
R-HSA-5693606	DNA Double Strand Break Response	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73894	DNA Repair	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26384258	III Italian Consensus Conference on Malignant Mesothelioma of the Pleura. Epidemiology, Public Health and Occupational Medicine related issues. (2015 Sep 9)	Magnani C	Med Lav
24128712	Clinical characteristics of patients with malignant pleural mesothelioma harboring somatic BAP1 mutations. (2013 Nov)	Zauderer MG	J Thorac Oncol
27748099	BAP1 Tumor Predisposition Syndrome (1993)	Pilarski R	-
29187476	A Case of the Resected Lymphohistiocytoid Mesothelioma: BAP1 Is a Key of Accurate Diagnosis. (2017 Dec)	Matsubara T	Anticancer Res
27352265	Bladder Cancer and Genetic Mutations. (2015 Sep)	Zhang X	Cell Biochem Biophys
25839328	Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. (2015 Apr 2)	Zhang L	Am J Hum Genet