Gene: BRAP

8315
BRAP2|IMP|RNF52
BRCA1 associated protein
protein-coding
12q24.12
Ensembl:ENSG00000089234 MIM:604986 Vega:OTTHUMG00000169600 UniprotKB:Q7Z569
NC_000012.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.258e-1 (AD)  7.807e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3782886chr12:111672685 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPRS0.944
SRP680.942
ARCN10.941
ADNP0.938
USP100.938
FAF20.936
SEC31A0.936
CSNK2A10.936
POLR2C0.935
TAF70.933

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.71
OR4F29-0.656
KLRB1-0.311
FCRL1-0.251
IFNG-0.249
KLF17-0.249
MS4A1-0.248
KLRF1-0.248
VNN3-0.243
MTRNR2L9-0.242

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of BRAP mRNA22230336|2669055
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BRAP mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of BRAP mRNA21932408
C006780bisphenol Abisphenol A results in increased methylation of BRAP promoter27312807
D002922CiguatoxinsCiguatoxins affects the expression of BRAP mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of BRAP mRNA17585979
D002994ClofibrateClofibrate results in increased expression of BRAP mRNA23811191
D016572CyclosporineCyclosporine results in increased expression of BRAP mRNA20106945|2556210
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of BRAP mRNA21318169
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of BRAP mRNA"23811387
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BRAP mRNA17555576
C024565ethylene dichlorideethylene dichloride results in decreased expression of BRAP mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of BRAP mRNA23649840
D011345FenofibrateFenofibrate affects the expression of BRAP mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate affects the expression of BRAP mRNA]21318169
C410337K 7174K 7174 results in increased expression of BRAP mRNA24086573
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BRAP mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BRAP mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BRAP mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BRAP mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of BRAP mRNA23811387
C016030pantogabpantogab results in increased expression of BRAP mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of BRAP mRNA18593933
D010634PhenobarbitalPhenobarbital results in increased expression of BRAP mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BRAP mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of BRAP mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of BRAP mRNA]21318169
D010936Plant ExtractsPlant Extracts results in increased expression of BRAP mRNA23557933
D011794QuercetinQuercetin results in decreased expression of BRAP mRNA17103110
D012969Sodium FluorideSodium Fluoride results in increased expression of BRAP protein28918527
D013629TamoxifenTamoxifen affects the expression of BRAP mRNA20937368
D013893ThiramThiram results in decreased expression of BRAP mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of BRAP mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BRAP mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BRAP mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of BRAP mRNA28973697
D014520UrethaneUrethane results in increased expression of BRAP mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of BRAP mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BRAP gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of BRAP mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0004842ubiquitin-protein transferase activity-IDA14724641  
GO:0005515protein binding-IPI9497340  14724641  25820252  
GO:0008139nuclear localization sequence binding-IDA9497340  
GO:0008270zinc ion binding-IEA-  
GO:0042802identical protein binding-IPI14724641  25820252  
GO:0061630ubiquitin protein ligase activity-IDA14724641  
GO:0061630ubiquitin protein ligase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IDA14724641  
GO:0000165MAPK cascade-TAS-  
GO:0007265Ras protein signal transduction-IDA14724641  
GO:0009968negative regulation of signal transduction-IDA14724641  
GO:0016567protein ubiquitination-IDA14724641  
GO:0016567protein ubiquitination-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IDA14724641  
GO:0005737cytoplasm-IDA9497340  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673000RAF activationTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27827461Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population. (2016 Nov 9)Lin ESci Rep