Gene: CDC45

8318
CDC45L|CDC45L2|MGORS7|PORC-PI-1
cell division cycle 45
protein-coding
22q11.21
Ensembl:ENSG00000093009 MIM:603465 Vega:OTTHUMG00000150386 UniprotKB:O75419
NG_052958.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.842e-1 (AD)  7.701e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACSM30.635
RHAG0.633
TOP2A0.631
SSX10.623
IGF2BP10.622
PRAME0.621
KIF20A0.616
CTCFL0.609
AURKB0.6
MKI670.599

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENDOU-0.305
HES6-0.296
DIO2-0.288
ARSF-0.277
PYGM-0.272
ACBD7-0.262
SLC13A5-0.261
ZNF98-0.254
REN-0.249
WNT7B-0.243

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of CDC45 mRNA"20713471
D000082AcetaminophenAcetaminophen affects the expression of CDC45 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CDC45 mRNA28959563
C006632arsenic trioxidearsenic trioxide results in decreased expression of CDC45 mRNA19128835
D018053Arsenites[AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of CDC45 mRNA19411561
D001280AtrazineAtrazine results in decreased expression of CDC45 mRNA22378314
C105832auraptenaurapten affects the expression of CDC45 mRNA23320178
D001379AzathioprineAzathioprine results in decreased expression of CDC45 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDC45 mRNA20064835
D004958EstradiolEstradiol results in increased expression of CDC45 mRNA16474171
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of CDC45 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of CDC45 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of CDC45 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CDC45 mRNA16474171
C006780bisphenol Abisphenol A affects the expression of CDC45 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CDC45 mRNA25979313
D002509CephaloridineCephaloridine results in increased expression of CDC45 mRNA18500788
C018021cobaltous chloridecobaltous chloride results in increased expression of CDC45 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CDC45 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of CDC45 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CDC45 mRNA23640034
D003703DemecolcineDemecolcine results in decreased expression of CDC45 mRNA23649840
D002945CisplatinCisplatin results in increased expression of CDC45 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of CDC45 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDC45 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC45 mRNA]17854601
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CDC45 mRNA23550701
D005472FluorouracilFluorouracil affects the expression of CDC45 mRNA16557594
D005472Fluorouracil[Leucovorin co-treated with Fluorouracil] results in increased expression of CDC45 mRNA15342418
D005472FluorouracilFluorouracil results in decreased expression of CDC45 mRNA19272435
D002955Leucovorin[Leucovorin co-treated with Fluorouracil] results in increased expression of CDC45 mRNA15342418
C039281furanfuran results in increased expression of CDC45 mRNA25539665
D019833GenisteinGenistein results in increased expression of CDC45 mRNA16474171
C492448ICG 001ICG 001 results in increased expression of CDC45 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of CDC45 mRNA28201806
C544151jinfukangjinfukang results in increased expression of CDC45 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDC45 mRNA24796395
D007840LatexLatex analog results in increased expression of CDC45 mRNA24768652
C008261lead acetatelead acetate results in increased expression of CDC45 mRNA21829687
D008694MethamphetamineMethamphetamine results in decreased expression of CDC45 mRNA25290377
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CDC45 mRNA20713471
C002950methylformamidemethylformamide analog results in increased expression of CDC45 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of CDC45 mRNA17040096
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CDC45 mRNA"25554681
D009532NickelNickel results in increased expression of CDC45 mRNA25583101
C025256nonylphenolnonylphenol results in increased expression of CDC45 mRNA22982499
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CDC45 mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of CDC45 mRNA26516004
D010126OzoneOzone results in decreased expression of CDC45 mRNA24336422
C500026palbociclibpalbociclib results in decreased expression of CDC45 mRNA22869556
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of CDC45 mRNA26678675
C006253pirinixic acidpirinixic acid results in increased expression of CDC45 mRNA18445702
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of CDC45 mRNA16474171
D011441PropylthiouracilPropylthiouracil results in increased expression of CDC45 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of CDC45 mRNA23727915
D012835Silver NitrateSilver Nitrate analog results in increased expression of CDC45 mRNA22831968
D012835Silver NitrateSilver Nitrate results in increased expression of CDC45 mRNA22831968
D019821SimvastatinSimvastatin results in decreased expression of CDC45 mRNA17428261
D012999SomanSoman results in increased expression of CDC45 mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CDC45 mRNA"26680231
D014284Triiodothyronine[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDC45 mRNA14761676
D013749Tetrachlorodibenzodioxin[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDC45 mRNA14761676
D019284ThapsigarginThapsigargin results in decreased expression of CDC45 mRNA22378314
D013853ThioacetamideThioacetamide results in increased expression of CDC45 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of CDC45 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of CDC45 mRNA16054129
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDC45 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of CDC45 mRNA17127020
D014520UrethaneUrethane results in decreased expression of CDC45 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CDC45 gene25560391
C094299ZD 9331ZD 9331 results in increased expression of CDC45 mRNA15342418
D015032ZincZinc deficiency results in increased expression of CDC45 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IBA21873635  
GO:0003688DNA replication origin binding-IBA21873635  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0005515protein binding-IPI10518787  15232106  17887956  19805216  23910567  25241761  
25416956  26167883  
GO:00431383'-5' DNA helicase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000076DNA replication checkpoint-TAS9660782  
GO:0000082G1/S transition of mitotic cell cycle-TAS-  
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TAS-  
GO:0000727double-strand break repair via break-induced replication-IBA21873635  
GO:0006260DNA replication-TAS-  
GO:0006267pre-replicative complex assembly involved in nuclear cell cycle DNA replication-IBA21873635  
GO:0006270DNA replication initiation-IBA21873635  
GO:0031938regulation of chromatin silencing at telomere-IBA21873635  
GO:0032508DNA duplex unwinding-IEA-  
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IBA21873635  
GO:1902977mitotic DNA replication preinitiation complex assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA21383955  
GO:0005654nucleoplasm-TAS-  
GO:0005656nuclear pre-replicative complex-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005813centrosome-IDA-  
GO:0031261DNA replication preinitiation complex-IBA21873635  
GO:0031298replication fork protection complex-IBA21873635  
KEGG ID KEGG Term
hsa04110Cell cycle
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-176974Unwinding of DNAIEA
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-539107Activation of E2F1 target genes at G1/STAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68962Activation of the pre-replicative complexTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69190DNA strand elongationIEA
R-HSA-69205G1/S-Specific TranscriptionTAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69239Synthesis of DNAIEA
R-HSA-69242S PhaseIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69306DNA ReplicationTAS
R-HSA-69306DNA ReplicationIEA
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29328493Meta-analysis of mRNA expression profiles to identify differentially expressed genes in lung adenocarcinoma tissue from smokers and non-smokers. (2018 Mar)He XOncol Rep