Gene: FZD4

8322
CD344|EVR1|FEVR|FZD4S|Fz-4|Fz4|FzE4|GPCR|hFz4
frizzled class receptor 4
protein-coding
11q14.2
Ensembl:ENSG00000174804 MIM:604579 Vega:OTTHUMG00000167231 UniprotKB:Q9ULV1
NG_011752.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.248e-1 (AD)  6.752e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTDSP20.755
MACF10.751
ACO10.743
SP10.736
MTA20.728
SEMA4B0.72
MOCS10.72
SNX330.719
AFF10.714
SEC14L10.714

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.42
OR4F29-0.42
CRH-0.309
PPP1R17-0.309
SMIM18-0.291
MYCNOS-0.272
CRHBP-0.258
GPD1-0.257
SERF1B-0.254
CCDC129-0.251

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FZD4 mRNA"28903501
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FZD4 mRNA19933214
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of FZD4 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FZD4 mRNA"23196670
D000079AcetaldehydeAcetaldehyde affects the expression of FZD4 mRNA22634333
D000082AcetaminophenAcetaminophen results in decreased expression of FZD4 mRNA21420995|2906747
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of FZD4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FZD4 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FZD4 mRNA22100608|2715375
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FZD4 mRNA16483693
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of FZD4 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of FZD4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FZD4 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FZD4 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FZD4 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FZD4 mRNA27195522
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of FZD4 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of FZD4 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of FZD4 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of FZD4 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FZD4 mRNA20147733|2207961
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FZD4 mRNA20478370
D002220CarbamazepineCarbamazepine affects the expression of FZD4 mRNA24752500|2597931
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FZD4 mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of FZD4 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of FZD4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FZD4 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of FZD4 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of FZD4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of FZD4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of FZD4 mRNA20106945|2163298
C014347decitabinedecitabine results in increased expression of FZD4 mRNA27915011
C107676deguelindeguelin results in increased expression of FZD4 mRNA19861542
D003907DexamethasoneDexamethasone results in increased expression of FZD4 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FZD4 mRNA28628672
D003976DiazinonDiazinon affects the expression of FZD4 mRNA19130878
D004008DiclofenacDiclofenac affects the expression of FZD4 mRNA24752500
C061365flusilazoleflusilazole affects the expression of FZD4 mRNA22634333
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of FZD4 mRNA19695318
D017313FenretinideFenretinide results in decreased expression of FZD4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FZD4 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FZD4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FZD4 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FZD4 mRNA26830473
C410337K 7174K 7174 results in decreased expression of FZD4 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of FZD4 mRNA28988120
D018021Lithium ChlorideLithium Chloride results in increased expression of FZD4 mRNA20069066
D008727MethotrexateMethotrexate affects the expression of FZD4 mRNA18502557
D015735MifepristoneMifepristone results in increased expression of FZD4 mRNA17584828
C523799MRK 003FZD4 results in decreased susceptibility to MRK 00319903844
D009532NickelNickel affects the expression of FZD4 mRNA14575637
D009532NickelNickel results in decreased expression of FZD4 mRNA24768652|2558310
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of FZD4 mRNA]14575637
D009532NickelNickel affects the expression of FZD4 mRNA19130878
D009532NickelNickel results in decreased expression of FZD4 mRNA19130878
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of FZD4 mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of FZD4 mRNA24236059
D010126OzoneOzone results in decreased expression of FZD4 mRNA12763052
D010269ParaquatParaquat results in decreased expression of FZD4 mRNA28619522
D052638Particulate MatterParticulate Matter results in decreased expression of FZD4 mRNA17450221
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of FZD4 mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of FZD4 mRNA19159669
D010936Plant ExtractsPlant Extracts results in decreased expression of FZD4 mRNA23557933
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of FZD4 mRNA19695318
C012526quercitrinquercitrin results in increased expression of FZD4 mRNA25193878
D053260SootSoot results in increased expression of FZD4 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FZD4 mRNA15667827|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FZD4 mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of FZD4 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FZD4 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of FZD4 mRNA23830798
D014212TretinoinTretinoin results in increased expression of FZD4 mRNA21934132
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of FZD4 mRNA]14575637
C012589trichostatin Atrichostatin A results in increased expression of FZD4 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FZD4 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FZD4 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of FZD4 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of FZD4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FZD4 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of FZD4 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FZD4 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of FZD4 mRNA20044591
D014873Water PollutantsWater Pollutants results in increased expression of FZD4 mRNA23591932

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IPI18234671  
GO:0005515protein binding-IPI17955262  19277043  19837033  20802536  
GO:0017147Wnt-protein binding-IBA21873635  
GO:0017147Wnt-protein binding-TAS18234671  25424568  
GO:0019955cytokine binding-IPI17955262  
GO:0030165PDZ domain binding-IDA20802536  
GO:0030165PDZ domain binding-IPI19388021  
GO:0031625ubiquitin protein ligase binding-IPI22575959  
GO:0038023signaling receptor activity-ISS-  
GO:0042803protein homodimerization activity-IPI14688793  
GO:0042813Wnt-activated receptor activity-IBA21873635  
GO:0042813Wnt-activated receptor activity-IDA17955262  28733458  
GO:0044877protein-containing complex binding-IPI18234671  
GO:0046982protein heterodimerization activity-IPI14688793  
GO ID GO Term Qualifier Evidence PubMed
GO:0001570vasculogenesis-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0007223Wnt signaling pathway, calcium modulating pathway-IDA12172548  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0007605sensory perception of sound-IEA-  
GO:0010812negative regulation of cell-substrate adhesion-IMP18156211  
GO:0016055Wnt signaling pathway-IDA14688793  17955262  
GO:0016055Wnt signaling pathway-ISS-  
GO:0030182neuron differentiation-ISS-  
GO:0030947regulation of vascular endothelial growth factor receptor signaling pathway-IEA-  
GO:0031987locomotion involved in locomotory behavior-IEA-  
GO:0034446substrate adhesion-dependent cell spreading-IEA-  
GO:0035426extracellular matrix-cell signaling-IEA-  
GO:0035567non-canonical Wnt signaling pathway-IBA21873635  
GO:0035567non-canonical Wnt signaling pathway-TAS25424568  
GO:0042701progesterone secretion-IEA-  
GO:0043507positive regulation of JUN kinase activity-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA15035989  17955262  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA14688793  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-IDA15035989  20802536  28733458  
GO:0060070canonical Wnt signaling pathway-TAS25424568  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-TAS-  
GO:0061024membrane organization-TAS-  
GO:0061299retina vasculature morphogenesis in camera-type eye-IBA21873635  
GO:0061299retina vasculature morphogenesis in camera-type eye-IMP12172548  15024691  
GO:0061301cerebellum vasculature morphogenesis-IEA-  
GO:0061304retinal blood vessel morphogenesis-IEA-  
GO:0071300cellular response to retinoic acid-ISS-  
GO:0150012positive regulation of neuron projection arborization-ISS-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA12172548  14688793  15035989  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IC17955262  
GO:0005911cell-cell junction-IEA-  
GO:0009986cell surface-IDA19643732  
GO:0016021integral component of membrane-IBA21873635  
GO:0030425dendrite-ISS-  
GO:0030665clathrin-coated vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-373080Class B/2 (Secretin family receptors)IEA
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-4086398Ca2+ pathwayIEA
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-4608870Asymmetric localization of PCP proteinsTAS
R-HSA-4641263Regulation of FZD by ubiquitinationTAS
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-500792GPCR ligand bindingIEA
R-HSA-5099900WNT5A-dependent internalization of FZD4TAS
R-HSA-5340588RNF mutants show enhanced WNT signaling and proliferationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28245136Reduced Frizzled Receptor 4 Expression Prevents WNT/beta-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease. (2017 Jul 15)Skronska-Wasek WAm J Respir Crit Care Med