Gene: FZD8

8325
FZ-8|hFZ8
frizzled class receptor 8
protein-coding
10p11.21
Ensembl:ENSG00000177283 MIM:606146 Vega:OTTHUMG00000017956 UniprotKB:Q9H461
NG_029968.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.243e-1 (AD)  8.697e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SALL30.807
OTX10.779
EMID10.779
BMP70.773
PYGM0.772
MSI10.77
OAF0.767
NR2E10.767
PSD20.765
SOX210.765

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
THEMIS-0.36
NRG1-0.346
NOX4-0.339
SMYD1-0.337
EMB-0.334
FOXP2-0.329
CCDC68-0.322
AK7-0.316
PSMA8-0.315
ENPP6-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FZD8 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of FZD8 mRNA22634333
D000082AcetaminophenAcetaminophen results in increased expression of FZD8 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of FZD8 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FZD8 mRNA24449571
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of FZD8 mRNA18585445
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of FZD8 mRNA18585445
D001280AtrazineAtrazine results in increased expression of FZD8 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FZD8 mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FZD8 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of FZD8 mRNA21185374
C006780bisphenol Abisphenol A results in decreased expression of FZD8 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of FZD8 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FZD8 mRNA20478370
D002220CarbamazepineCarbamazepine affects the expression of FZD8 mRNA25979313
D002220CarbamazepineCarbamazepine affects the expression of FZD8 mRNA22634333
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FZD8 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FZD8 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of FZD8 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of FZD8 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of FZD8 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of FZD8 mRNA26577399
C014347decitabinedecitabine results in increased expression of FZD8 mRNA27915011
C107676deguelindeguelin results in increased expression of FZD8 mRNA19861542
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FZD8 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of FZD8 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FZD8 mRNA27392435
D004026DieldrinDieldrin results in decreased expression of FZD8 mRNA23041725
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of FZD8 mRNA27638505
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of FZD8 mRNA25380136
C118739entinostatentinostat results in decreased expression of FZD8 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C024565ethylene dichlorideethylene dichloride results in decreased expression of FZD8 mRNA28189721
D005411Flame RetardantsFlame Retardants results in increased expression of FZD8 mRNA27219277
C061365flusilazoleflusilazole affects the expression of FZD8 mRNA22634333
D005485FlutamideFlutamide results in decreased expression of FZD8 mRNA24136188
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in decreased methylation of FZD8 mRNA22959928
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FZD8 gene20938992
C039281furanfuran results in decreased expression of FZD8 mRNA24183702
D005897GlafenineGlafenine results in decreased expression of FZD8 mRNA24136188
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in increased expression of FZD8 mRNA27219277
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FZD8 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FZD8 mRNA27392435
C119620kenpaullonekenpaullone results in decreased expression of FZD8 mRNA17993264
C011890kojic acidkojic acid results in increased expression of FZD8 mRNA16595896
C045463leflunomideleflunomide results in increased expression of FZD8 mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of FZD8 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FZD8 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FZD8 mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of FZD8 mRNA"19285098
C523799MRK 003MRK 003 results in decreased expression of FZD8 mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FZD8 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FZD8 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of FZD8 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of FZD8 mRNA24136188
D009532NickelNickel results in decreased expression of FZD8 mRNA25583101
C012655nimesulidenimesulide results in decreased expression of FZD8 mRNA24136188
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
D052638Particulate MatterParticulate Matter results in increased expression of FZD8 mRNA24769257
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FZD8 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of FZD8 mRNA18445702
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FZD8 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FZD8 mRNA23221170
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in decreased methylation of FZD8 mRNA22959928
C016104sodium bichromatesodium bichromate affects the expression of FZD8 mRNA22110744
D013629TamoxifenTamoxifen results in decreased expression of FZD8 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FZD8 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FZD8 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FZD8 mRNA26290441|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FZD8 mRNA15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FZD8 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FZD8 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of FZD8 mRNA24154490
D013853ThioacetamideThioacetamide results in decreased expression of FZD8 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in decreased expression of FZD8 mRNA25549359
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FZD8 mRNA26272509
C057693troglitazonetroglitazone results in decreased expression of FZD8 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FZD8 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FZD8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FZD8 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of FZD8 gene29154799
D014635Valproic AcidValproic Acid affects the expression of FZD8 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO:0005515protein binding-IPI22682250  
GO:0017147Wnt-protein binding-IBA21873635  
GO:0030165PDZ domain binding-IPI18256285  
GO:0031625ubiquitin protein ligase binding-IPI22575959  
GO:0042813Wnt-activated receptor activity-IBA21873635  
GO:0042813Wnt-activated receptor activity-IDA28733458  
GO:0042813Wnt-activated receptor activity-TAS11295046  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001525angiogenesis-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0030182neuron differentiation-ISS-  
GO:0033077T cell differentiation in thymus-IEA-  
GO:0035567non-canonical Wnt signaling pathway-IBA21873635  
GO:0043507positive regulation of JUN kinase activity-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-IDA28733458  
GO:0060070canonical Wnt signaling pathway-IMP22138402  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-TAS11295046  
GO:1990851Wnt-Frizzled-LRP5/6 complex-IEA-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-373080Class B/2 (Secretin family receptors)IEA
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-4608870Asymmetric localization of PCP proteinsTAS
R-HSA-4641263Regulation of FZD by ubiquitinationTAS
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-500792GPCR ligand bindingIEA
R-HSA-5340588RNF mutants show enhanced WNT signaling and proliferationTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26797711A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis. (2016 Apr)Spanjer AIThorax