Gene: CARS

833
CARS1|CYSRS|MGC:11246
cysteinyl-tRNA synthetase
protein-coding
11p15.4
Ensembl:ENSG00000110619 MIM:123859 Vega:OTTHUMG00000010927 UniprotKB:P49589
NC_000011.10
PubMed|SNP Mapped
8   ANCO-SNPs
CD|ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.523e-1 (AD)  1.208e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs406598chr11:3055055 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs369461chr11:3040762 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs451041chr11:3039495 (GRCh38.p7)A>C / A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs434114chr11:3028980 (GRCh38.p7)A>C / A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs377765chr11:3025068 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs428726chr11:3024971 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7481584chr11:3007859 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs729662chr11:3006910 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YARS0.902
SMIM120.894
NANS0.892
GARS0.888
YRDC0.884
SLC35B10.883
MED80.883
SARS0.882
ZNF2630.881
PSMC10.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.553
OR4F29-0.538
P2RY14-0.405
ASB4-0.403
PON3-0.396
PARD3B-0.377
EYA1-0.357
DIAPH3-0.357
KCNJ16-0.355
FREM2-0.352

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CARS mRNA28329830
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of CARS mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CARS mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CARS mRNA"19095052
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of CARS mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARS mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of CARS mRNA"19561079
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to CARS protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CARS protein]26598702
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of CARS mRNA14583596
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of CARS mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARS mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CARS mRNA17562736
C103505AM 251AM 251 results in increased expression of CARS mRNA16500647
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CARS protein]26598702
C006632arsenic trioxidearsenic trioxide results in decreased expression of CARS mRNA12852829
C006632arsenic trioxidearsenic trioxide results in increased expression of CARS mRNA24356939
C547126AZM551248AZM551248 results in increased expression of CARS mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of CARS mRNA24356939
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CARS mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CARS mRNA"19150397|2001819
C006780bisphenol Abisphenol A affects the expression of CARS mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CARS mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of CARS mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of CARS mRNA19371625|2927551
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CARS mRNA28628672
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CARS mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CARS mRNA22079614
C584509C646 compoundC646 compound results in increased expression of CARS mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CARS mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CARS mRNA23741332
D002185CannabidiolCannabidiol results in increased expression of CARS mRNA21542829
D002220CarbamazepineCarbamazepine affects the expression of CARS mRNA25979313
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of CARS mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARS mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of CARS mRNA26272509
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CARS mRNA28472532
C059262cidofovircidofovir results in decreased expression of CARS mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of CARS mRNA25596134
D002994ClofibrateClofibrate results in decreased expression of CARS mRNA23811191
D019327Copper SulfateCopper Sulfate results in increased expression of CARS mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of CARS mRNA15755911
D003520CyclophosphamideCyclophosphamide metabolite results in decreased expression of CARS mRNA24356939
D016572CyclosporineCyclosporine affects the expression of CARS mRNA25224403
D016572CyclosporineCyclosporine results in increased expression of CARS mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of CARS mRNA25224403
C093628cyproconazolecyproconazole results in decreased expression of CARS mRNA22334560
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CARS mRNA23914054
D013759DronabinolDronabinol results in increased expression of CARS mRNA21542829
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CARS mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CARS mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CARS mRNA21266533
D002945CisplatinCisplatin results in decreased expression of CARS mRNA25596134
D002945CisplatinCisplatin results in increased expression of CARS mRNA27594783
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of CARS mRNA15784690
D004041Dietary FatsDietary Fats results in decreased expression of CARS mRNA25016146
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of CARS gene23968726
D004147DioxinsDioxins affects the expression of CARS mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of CARS mRNA20530235
C118739entinostatentinostat results in decreased expression of CARS mRNA27188386
C118739entinostatentinostat results in increased expression of CARS mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARS mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CARS protein23301498
C109476epoxiconazoleepoxiconazole results in decreased expression of CARS mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CARS mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CARS mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CARS mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CARS mRNA20170705|2686566
D015025ZearalenoneZearalenone results in increased expression of CARS mRNA19371625
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CARS mRNA28329830
D005485FlutamideFlutamide results in decreased expression of CARS mRNA21126777
D005485FlutamideFlutamide results in increased expression of CARS mRNA24136188
D019833GenisteinGenistein affects the expression of CARS mRNA26865667
D019833GenisteinGenistein results in increased expression of CARS mRNA19371625
D005897GlafenineGlafenine results in increased expression of CARS mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CARS mRNA21179406
C492448ICG 001ICG 001 results in increased expression of CARS mRNA26191083
D007069IfosfamideIfosfamide results in decreased expression of CARS mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CARS mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CARS mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CARS mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CARS mRNA28628672
C410337K 7174K 7174 results in increased expression of CARS mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of CARS mRNA16807920
C008261lead acetatelead acetate results in increased expression of CARS mRNA11578147
D001556LindaneLindane results in increased expression of CARS mRNA24356939
C042720mercuric bromidemercuric bromide results in increased expression of CARS mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARS mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CARS mRNA16507785
D008687MetforminMetformin results in increased expression of CARS mRNA25596134
D008713MethimazoleMethimazole results in increased expression of CARS mRNA22504374
D008727MethotrexateMethotrexate results in decreased expression of CARS mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CARS mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CARS mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CARS mRNA24810058
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CARS mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CARS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CARS mRNA"25554681
C022838nickel chloridenickel chloride results in increased expression of CARS mRNA17312168
C016340o,p'-DDT"o,p'-DDT results in increased expression of CARS mRNA"19371625
D010100OxygenOxygen deficiency results in decreased expression of CARS mRNA25596134
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CARS mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CARS protein26178269
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of CARS gene23968726
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CARS mRNA22714537
C045950propiconazolepropiconazole results in decreased expression of CARS mRNA22334560
D011441PropylthiouracilPropylthiouracil results in increased expression of CARS mRNA22504374
D012834SilverSilver results in increased expression of CARS mRNA26014281
C009277sodium arsenatesodium arsenate results in increased expression of CARS mRNA23922661
D012969Sodium FluorideSodium Fluoride results in decreased expression of CARS protein28918527
D012999SomanSoman results in increased expression of CARS mRNA19281266
D013605T-2 ToxinT-2 Toxin results in decreased expression of CARS mRNA26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CARS mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CARS mRNA17942748
D013893ThiramThiram results in decreased expression of CARS mRNA20530235
C012589trichostatin Atrichostatin A results in decreased expression of CARS mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CARS mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of CARS mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of CARS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CARS mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of CARS mRNA28001369
C025643vinclozolinvinclozolin results in decreased expression of CARS mRNA23034163
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of CARS mRNA15784690
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CARS mRNA18593933
C088658zoledronic acidzoledronic acid results in increased expression of CARS mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-IMP17303165  
GO:0000049tRNA binding-NAS7987009  
GO:0004817cysteine-tRNA ligase activity-IBA21873635  
GO:0004817cysteine-tRNA ligase activity-IDA10908348  17303165  
GO:0004817cysteine-tRNA ligase activity-TAS-  
GO:0005515protein binding-IPI10908348  
GO:0005524ATP binding-IBA21873635  
GO:0005524ATP binding-IDA17303165  
GO:0042803protein homodimerization activity-IMP17303165  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006423cysteinyl-tRNA aminoacylation-IBA21873635  
GO:0006423cysteinyl-tRNA aminoacylation-IDA10908348  17303165  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA11347887  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-379716Cytosolic tRNA aminoacylationTAS
R-HSA-379724tRNA AminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19357146Second-hand smoke exposure in cars and respiratory health effects in children. (2009 Sep)Kabir ZEur Respir J
25398951Intake of toxic and carcinogenic volatile organic compounds from secondhand smoke in motor vehicles. (2014 Dec)St Helen GCancer Epidemiol Biomarkers Prev
25194244Prevalence and risk factors for tobacco smoking among pre-adolescent Pacific children in New Zealand. (2014 Sep 1)Nosa VJ Prim Health Care
17692720Efficacy and tolerability of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, in a 12-week, randomized, placebo-controlled, dose-response study with 40-week follow-up for smoking cessation in Japanese smokers. (2007 Jun)Nakamura MClin Ther
19393386[Treatment of a serious autistic disorder in a child with Naltrexone in an oral suspension form]. (2009 Apr)Desjardins SEncephale
21477347Policy guidance on threats to legislative interventions in public health: a realist synthesis. (2011 Apr 10)Wong GBMC Public Health
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res
20873049[Pathogenesis, trigger and risk factors in asthma]. (2009)Martinez Aguilar NERev Alerg Mex
21571691Socioeconomic patterning in changes in child exposure to secondhand smoke after implementation of smoke-free legislation in Wales. (2011 Oct)Moore GFNicotine Tob Res
21536968Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. (2011 Sep)Brody ALArch Gen Psychiatry
17692719A randomized, placebo-controlled trial of varenicline, a selective alpha4beta2 nicotinic acetylcholine receptor partial agonist, as a new therapy for smoking cessation in Asian smokers. (2007 Jun)Tsai STClin Ther
21733632Driving kids to smoke? Children's reported exposure to smoke in cars and early smoking initiation. (2011 Nov)Glover MAddict Behav