Gene info: ID 83439

Gene: TCF7L1

GENE ID: 83439

Synonyms: TCF-3|TCF3

Description: transcription factor 7 like 1

Gene type: protein-coding

Location: 2p11.2

dbXrefs: Ensembl:ENSG00000152284 MIM:604652 Vega:OTTHUMG00000130026 UniprotKB:Q9HCS4

RefSeq: NC_000002.12

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.983e-1 (AD) 6.433e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6709476	chr2:85216801 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SYDE1	0.82
SCAMP2	0.815
HDAC1	0.81
ITGB5	0.807
SORBS3	0.805
PTBP1	0.798
FCGRT	0.798
CSF1	0.795
MAPKAPK2	0.795
EMP3	0.793

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PPEF1	-0.579
CDH8	-0.564
KCNS2	-0.556
STYK1	-0.546
EPHA5	-0.543
STXBP5L	-0.54
GPR61	-0.539
SOWAHB	-0.538
SLC7A4	-0.537
PTPRR	-0.533

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TCF7L1 mRNA"	19167446
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCF7L1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCF7L1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of TCF7L1 mRNA	22230336\|2669055
D020106	Acrylamide	Acrylamide results in decreased expression of TCF7L1 mRNA	28959563
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of TCF7L1 mRNA	24449571
D001280	Atrazine	Atrazine results in increased expression of TCF7L1 mRNA	25929836
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TCF7L1 mRNA"	20382639
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TCF7L1 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the methylation of TCF7L1 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of TCF7L1 mRNA	25270620
C006780	bisphenol A	bisphenol A results in decreased expression of TCF7L1 mRNA	25181051
D002104	Cadmium	Cadmium results in decreased expression of TCF7L1 mRNA	24067728
D002220	Carbamazepine	Carbamazepine affects the expression of TCF7L1 mRNA	25979313
D002994	Clofibrate	Clofibrate results in decreased expression of TCF7L1 mRNA	17585979
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TCF7L1 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of TCF7L1 mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of TCF7L1 mRNA	27989131
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TCF7L1 mRNA	28628672
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of TCF7L1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of TCF7L1 mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of TCF7L1 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of TCF7L1 mRNA	25016146
D002117	Calcitriol	Calcitriol results in decreased expression of TCF7L1 mRNA	16002434
D019813	1,2-Dimethylhydrazine	"1,2-Dimethylhydrazine results in decreased expression of TCF7L1 mRNA"	27840820
C118739	entinostat	entinostat results in increased expression of TCF7L1 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCF7L1 mRNA"	27188386
D005557	Formaldehyde	Formaldehyde results in decreased expression of TCF7L1 mRNA	20655997
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TCF7L1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TCF7L1 mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of TCF7L1 mRNA	27392435
C008261	lead acetate	lead acetate results in increased expression of TCF7L1 mRNA	22609695
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TCF7L1 mRNA	28001369
C523799	MRK 003	MRK 003 results in decreased expression of TCF7L1 mRNA	21169257
D009532	Nickel	Nickel results in decreased expression of TCF7L1 mRNA	24768652\|2558310
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of TCF7L1 mRNA	24952340
C029938	nickel sulfate	nickel sulfate results in increased expression of TCF7L1 mRNA	22714537
C087058	penconazole	penconazole results in increased expression of TCF7L1 mRNA	23811263
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of TCF7L1 mRNA	27029645
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of TCF7L1 mRNA	19167446
C079198	S 1 (combination)	TCF7L1 protein results in decreased susceptibility to S 1 (combination)	16734730
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of TCF7L1 mRNA	25895662
D012834	Silver	Silver results in increased expression of TCF7L1 mRNA	27131904
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of TCF7L1 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TCF7L1 mRNA	24058054
D013849	Thimerosal	Thimerosal results in decreased expression of TCF7L1 mRNA	27188386
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased expression of TCF7L1 mRNA"	17951470
C057693	troglitazone	troglitazone results in decreased expression of TCF7L1 mRNA	28973697
D014520	Urethane	Urethane results in decreased expression of TCF7L1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of TCF7L1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of TCF7L1 mRNA	19101580
C025643	vinclozolin	vinclozolin results in decreased expression of TCF7L1 mRNA	23034163
D014810	Vitamin E	Vitamin E results in increased expression of TCF7L1 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0003677	DNA binding	-	NAS	1741298 11085512
GO:0003682	chromatin binding	-	IBA	21873635
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0003700	DNA-binding transcription factor activity	-	NAS	1741298 11085512
GO:0008013	beta-catenin binding	-	IBA	21873635
GO:0043565	sequence-specific DNA binding	-	IBA	21873635
GO:0044212	transcription regulatory region DNA binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006325	chromatin organization	-	NAS	1741298 11085512
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IBA	21873635
GO:0006355	regulation of transcription, DNA-templated	-	NAS	1741298 11085512
GO:0006357	regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0016055	Wnt signaling pathway	-	IBA	21873635
GO:0022008	neurogenesis	-	IBA	21873635
GO:0030111	regulation of Wnt signaling pathway	-	NAS	1741298 11085512
GO:0048699	generation of neurons	-	IBA	21873635
GO:0060070	canonical Wnt signaling pathway	-	IBA	21873635
GO:1904837	beta-catenin-TCF complex assembly	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	NAS	1741298 11085512
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IBA	21873635
GO:0005829	cytosol	-	IDA	-

KEGG ID	KEGG Term
hsa04310	Wnt signaling pathway
hsa04520	Adherens junction
hsa04916	Melanogenesis
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05213	Endometrial cancer
hsa05215	Prostate cancer
hsa05216	Thyroid cancer
hsa05217	Basal cell carcinoma
hsa05221	Acute myeloid leukemia
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	IEA
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	IEA
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	TAS
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-4086398	Ca2+ pathway	TAS
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	TAS
R-HSA-4641265	Repression of WNT target genes	TAS
R-HSA-4641265	Repression of WNT target genes	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8951430	RUNX3 regulates WNT signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal