Gene: ARHGAP24

83478
FILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAP
Rho GTPase activating protein 24
protein-coding
4q21.23-q21.3
Ensembl:ENSG00000138639 MIM:610586 Vega:OTTHUMG00000130427 UniprotKB:Q8N264
NG_051627.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.516e-2 (AD)  1.657e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1994074chr4:85542405 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CADPS20.869
ANO50.862
TTBK20.861
VAMP10.858
FAM217B0.854
LSM110.852
SLC25A120.851
NIPAL20.848
ARHGAP260.846
LIN7A0.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH2D1A-0.44
MDFI-0.436
EVA1A-0.436
BCL7C-0.432
OR4F5-0.415
RAI14-0.41
ACAP1-0.408
TIGIT-0.395
KLRB1-0.389
TMSB15A-0.388

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ARHGAP24 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ARHGAP24 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP24 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP24 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ARHGAP24 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ARHGAP24 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ARHGAP24 mRNA24449571
C487081belinostatbelinostat results in increased expression of ARHGAP24 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARHGAP24 mRNA19770486
C006780bisphenol Abisphenol A affects the expression of ARHGAP24 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ARHGAP24 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ARHGAP24 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ARHGAP24 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ARHGAP24 gene28505145
D002065BuspironeBuspirone results in decreased expression of ARHGAP24 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of ARHGAP24 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of ARHGAP24 mRNA19320972
D003471CuprizoneCuprizone results in increased expression of ARHGAP24 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA]18200517
D016572CyclosporineCyclosporine results in decreased expression of ARHGAP24 mRNA27989131
D016572CyclosporineCyclosporine results in increased methylation of ARHGAP24 promoter27989131
D016572CyclosporineCyclosporine results in decreased expression of ARHGAP24 mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ARHGAP24 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ARHGAP24 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of ARHGAP24 mRNA20705681
D002945CisplatinCisplatin results in decreased expression of ARHGAP24 mRNA21603599|2739243
D004041Dietary FatsDietary Fats results in increased expression of ARHGAP24 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ARHGAP24 mRNA19638242
D004237DiuronDiuron results in increased expression of ARHGAP24 mRNA21551480
C118739entinostatentinostat results in increased expression of ARHGAP24 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGAP24 mRNA22079256
C000499ferric oxideferric oxide analog results in increased expression of ARHGAP24 mRNA25086211
D005557FormaldehydeFormaldehyde results in decreased expression of ARHGAP24 mRNA23416264
C546771gardiquimodgardiquimod results in increased expression of ARHGAP24 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ARHGAP24 mRNA]28003376
D005897GlafenineGlafenine results in decreased expression of ARHGAP24 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of ARHGAP24 mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of ARHGAP24 mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGAP24 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of ARHGAP24 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ARHGAP24 mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ARHGAP24 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARHGAP24 mRNA25119042
C008261lead acetatelead acetate results in increased expression of ARHGAP24 mRNA20542052
D008558MelphalanMelphalan results in decreased expression of ARHGAP24 mRNA22363485
D008727MethotrexateMethotrexate affects the expression of ARHGAP24 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ARHGAP24 mRNA28001369
C031721naphthalenenaphthalene results in increased expression of ARHGAP24 mRNA18978301
D009532NickelNickel results in decreased expression of ARHGAP24 mRNA25583101
C012655nimesulidenimesulide results in decreased expression of ARHGAP24 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ARHGAP24 mRNA25729387
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of ARHGAP24 mRNA20705681
D000073878Palm OilPalm Oil results in increased expression of ARHGAP24 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ARHGAP24 mRNA25119042
D010416PentachlorophenolPentachlorophenol results in increased expression of ARHGAP24 mRNA23892564
C046012pentanalpentanal results in decreased expression of ARHGAP24 mRNA26079696
D010634PhenobarbitalPhenobarbital results in increased expression of ARHGAP24 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ARHGAP24 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARHGAP24 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARHGAP24 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGAP24 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARHGAP24 mRNA22079256|2271453
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ARHGAP24 mRNA]28003376
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ARHGAP24 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ARHGAP24 mRNA23221170
C017947sodium arsenitesodium arsenite affects the methylation of ARHGAP24 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of ARHGAP24 mRNA22714537
C016104sodium bichromatesodium bichromate results in decreased expression of ARHGAP24 mRNA25993096
D012999SomanSoman results in increased expression of ARHGAP24 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of ARHGAP24 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARHGAP24 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARHGAP24 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARHGAP24 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARHGAP24 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARHGAP24 mRNA21215274|2172422
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGAP24 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ARHGAP24 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ARHGAP24 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ARHGAP24 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of ARHGAP24 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of ARHGAP24 mRNA24935251
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA18200517
C057693troglitazonetroglitazone results in decreased expression of ARHGAP24 mRNA28973697
C080163trovafloxacintrovafloxacin results in decreased expression of ARHGAP24 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP24 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ARHGAP24 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ARHGAP24 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of ARHGAP24 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ARHGAP24 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ARHGAP24 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP24 mRNA"27188386
C088658zoledronic acidzoledronic acid results in decreased expression of ARHGAP24 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-TAS-  
GO:0005515protein binding-IPI16862148  17500595  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0007165signal transduction-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005925focal adhesion-IEA-  
GO:0042995cell projection-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal