Gene: SOX7

83595
-
SRY-box 7
protein-coding
8p23.1
Ensembl:ENSG00000171056 MIM:612202 Vega:OTTHUMG00000090585 UniprotKB:Q9BT81
NG_053010.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.340e-1 (AD)  7.440e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC320.814
SCARF10.804
IER30.803
F11R0.801
CDH50.797
PXN0.779
TNFRSF10A0.77
BCL30.77
TNFRSF10B0.766
ITPR30.766

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPLX3-0.329
CRH-0.308
NKX2-8-0.302
C1orf53-0.299
ASPDH-0.295
KIT-0.288
HES5-0.286
FBLL1-0.274
GSG1-0.268
DLX1-0.264

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of SOX7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SOX7 mRNA21641981
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SOX7 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOX7 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOX7 mRNA23735875
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SOX7 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of SOX7 mRNA19484750
C006780bisphenol Abisphenol A affects the methylation of SOX7 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of SOX7 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of SOX7 mRNA19549813
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SOX7 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SOX7 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of SOX7 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of SOX7 mRNA18042831
D004147DioxinsDioxins affects the expression of SOX7 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SOX7 mRNA23550701
D005557FormaldehydeFormaldehyde results in decreased expression of SOX7 mRNA20655997
C039281furanfuran results in increased expression of SOX7 mRNA27387713
D007213IndomethacinIndomethacin results in decreased expression of SOX7 mRNA16984733
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SOX7 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SOX7 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SOX7 mRNA"20188158|2625132
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of SOX7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SOX7 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SOX7 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SOX7 mRNA"25554681
D000073878Palm OilPalm Oil results in increased expression of SOX7 mRNA18042831
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SOX7 protein23718831
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SOX7 mRNA20660070
D011374ProgesteroneNCOA2 protein affects the reaction [Progesterone results in decreased expression of SOX7 mRNA]17556502
D011374ProgesteroneProgesterone results in decreased expression of SOX7 mRNA17556502
D011441PropylthiouracilPropylthiouracil results in increased expression of SOX7 mRNA24780913
C017947sodium arsenitesodium arsenite results in increased expression of SOX7 mRNA20308225
D053260SootSoot results in decreased expression of SOX7 mRNA22461453|2655175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOX7 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SOX7 mRNA25270620
D013849ThimerosalThimerosal results in decreased expression of SOX7 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of SOX7 mRNA23557971|2776080
D014050TolueneToluene results in increased expression of SOX7 mRNA22967744
D014212TretinoinTretinoin results in increased expression of SOX7 mRNA17138961|2193413
D014212TretinoinTretinoin results in increased expression of SOX7 mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of SOX7 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of SOX7 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of SOX7 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SOX7 mRNA24935251
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SOX7 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SOX7 mRNA20566332
D002762CholecalciferolCholecalciferol results in increased expression of SOX7 mRNA17170073
D002762CholecalciferolCholecalciferol results in increased expression of SOX7 protein17170073

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003700DNA-binding transcription factor activity-IDA19108950  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0043565sequence-specific DNA binding-IEA-  
GO:0044212transcription regulatory region DNA binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0001706endoderm formation-IDA18682240  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0008285negative regulation of cell proliferation-IDA19108950  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0030154cell differentiation-IBA21873635  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA19108950  
GO:0045892negative regulation of transcription, DNA-templated-IDA19108950  
GO:0045893positive regulation of transcription, DNA-templated-IEA-  
GO:0060828regulation of canonical Wnt signaling pathway-IDA19108950  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18682240  19108950  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA18819930  
GO:0044798nuclear transcription factor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23557216SOX7 is down-regulated in lung cancer. (2013 Apr 4)Hayano TJ Exp Clin Cancer Res