Gene: CCM2

83605
C7orf22|OSM|PP10187
CCM2 scaffold protein
protein-coding
7p13
Ensembl:ENSG00000136280 MIM:607929 Vega:OTTHUMG00000129246 UniprotKB:Q9BSQ5
NG_016295.1
PubMed
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.832e-1 (AD)  5.476e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXW50.936
UBXN60.934
CCDC1060.931
CNIH20.929
HSPBP10.927
ARHGDIG0.926
AES0.924
MAP2K20.923
MYL6B0.923
WDR130.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.762
OR4F29-0.722
KCNJ15-0.416
IL18RAP-0.395
FCGR3B-0.39
VNN2-0.385
CXCR1-0.377
STEAP4-0.377
CXCR2-0.375
TFPI2-0.364

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of CCM2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CCM2 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of CCM2 mRNA"23195993
C006780bisphenol Abisphenol A affects the expression of CCM2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CCM2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CCM2 gene28505145
D019327Copper SulfateCopper Sulfate results in decreased expression of CCM2 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CCM2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CCM2 mRNA21266533
C069837fullerene C60fullerene C60 results in increased expression of CCM2 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of CCM2 mRNA22061828
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CCM2 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCM2 mRNA25613284
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of CCM2 mRNA19812364
D009532NickelNickel results in decreased expression of CCM2 mRNA23195993
C028007nickel monoxidenickel monoxide results in increased expression of CCM2 mRNA19167457
C006253pirinixic acidpirinixic acid results in increased expression of CCM2 mRNA18301758|2381119
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCM2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCM2 mRNA25613284
D014212TretinoinTretinoin results in increased expression of CCM2 mRNA23724009
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CCM2 mRNA17183730
C025643vinclozolinvinclozolin results in decreased expression of CCM2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16037064  17657516  20489202  23007647  23266514  25814554  
25910212  
GO ID GO Term Qualifier Evidence PubMed
GO:0001570vasculogenesis-IMP14740320  
GO:0001701in utero embryonic development-IEA-  
GO:0001885endothelial cell development-IEA-  
GO:0007229integrin-mediated signaling pathway-TAS16037064  
GO:0035264multicellular organism growth-IEA-  
GO:0045216cell-cell junction organization-IEA-  
GO:0048839inner ear development-IEA-  
GO:0048845venous blood vessel morphogenesis-IEA-  
GO:0051403stress-activated MAPK cascade-TAS16037064  
GO:0060039pericardium development-IEA-  
GO:0060837blood vessel endothelial cell differentiation-IEA-  
GO:0061154endothelial tube morphogenesis-IMP19151727  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA16037064  
GO:0005739mitochondrion-IDA-  
GO:0032991protein-containing complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal