Gene: SESN2

83667
HI95|SES2|SEST2
sestrin 2
protein-coding
1p35.3
Ensembl:ENSG00000130766 MIM:607767 Vega:OTTHUMG00000003532 UniprotKB:P58004
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.719e-1 (AD)  4.788e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SHMT20.845
FKBP40.84
MED260.838
CEBPG0.836
KLHL250.835
CHAC10.829
STIP10.823
ZDHHC180.819
XBP10.819
MRPL180.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX22-0.409
OR4F5-0.389
PDE11A-0.359
OR4F29-0.345
CHP2-0.334
SLCO1A2-0.33
CTNNA3-0.327
ECM2-0.32
MYLK2-0.307
C5orf64-0.305

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of SESN2 protein"26035713
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of SESN2 protein]"26035713
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SESN2 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SESN2 mRNA28329830
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SESN2 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SESN2 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of SESN2 mRNA"19095052
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of SESN2 protein]25637945
C0261142-xylene2-xylene results in increased expression of SESN2 mRNA20359517
C0473683-methylquercetin[3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA24211276
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SESN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SESN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SESN2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of SESN2 mRNA"19561079
C0343434-aminobenzhydrazide4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in increased expression of SESN2 mRNA]24530881
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SESN2 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SESN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SESN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SESN2 mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of SESN2 mRNA"19936915
C120508A 192621A 192621 results in increased expression of SESN2 mRNA19040731
D000082AcetaminophenAcetaminophen affects the expression of SESN2 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of SESN2 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of SESN2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of SESN2 protein28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in decreased expression of GPT protein]28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in increased cleavage of CASP3 protein]28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in increased secretion of IL1B protein]28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in increased secretion of IL6 protein]28209544
D000082AcetaminophenSESN2 protein inhibits the reaction [Acetaminophen results in increased secretion of TNF protein]28209544
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Quercetin results in increased expression of SESN2 protein]24535669
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SESN2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SESN2 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SESN2 mRNA19770486
C005197alternariolalternariol results in increased expression of SESN2 protein25456271
C103505AM 251AM 251 results in increased expression of SESN2 mRNA16500647
D000638AmiodaroneAmiodarone affects the expression of SESN2 mRNA25064622
D000638AmiodaroneAmiodarone results in increased expression of SESN2 mRNA19774075
C006632arsenic trioxidearsenic trioxide results in increased expression of SESN2 mRNA24356939
D001205Ascorbic Acid[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA20530418
D001205Ascorbic Acidnutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]20530418
D001280AtrazineAtrazine results in increased expression of SESN2 mRNA25929836
D001379AzathioprineAzathioprine results in increased expression of SESN2 mRNA22623647
C547126AZM551248AZM551248 results in decreased expression of SESN2 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of SESN2 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SESN2 mRNA27858113
D001554BenzeneBenzene results in increased expression of SESN2 mRNA20359517|2184381
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SESN2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SESN2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of SESN2 mRNA21873647
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of SESN2 mRNA24356939
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SESN2 mRNA20064835|2010694
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SESN2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SESN2 mRNA19770486|2156981
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased expression of SESN2 protein]25637945
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SESN2 protein25637945
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of SESN2 protein25637945
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeLipopolysaccharides inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of SESN2 protein]25637945
D004958EstradiolEstradiol results in decreased expression of SESN2 mRNA19167446
D004958EstradiolEstradiol results in increased expression of SESN2 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of SESN2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SESN2 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of SESN2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of SESN2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of SESN2 mRNA26079696
D002104CadmiumCadmium results in increased expression of SESN2 mRNA24284285
D002220CarbamazepineCarbamazepine affects the expression of SESN2 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SESN2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SESN2 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of SESN2 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of SESN2 mRNA25064622
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SESN2 mRNA27858113
C031180chrysenechrysene results in decreased expression of SESN2 mRNA26377693
D002994ClofibrateClofibrate results in decreased expression of SESN2 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in increased expression of SESN2 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in increased expression of SESN2 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SESN2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of SESN2 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of SESN2 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of SESN2 mRNA26577399|2752363
D003513Cycloheximidebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased expression of SESN2 protein]25637945
D003513CycloheximideCycloheximide inhibits the reaction [Lipopolysaccharides results in increased expression of SESN2 protein]25637945
D003513CycloheximideCycloheximide results in decreased expression of SESN2 protein25637945
D003520CyclophosphamideCyclophosphamide metabolite results in decreased expression of SESN2 mRNA24356939
D016572CyclosporineCyclosporine affects the expression of SESN2 mRNA25064622
D016572CyclosporineCyclosporine affects the expression of SESN2 mRNA25224403
D016572CyclosporineCyclosporine results in increased expression of SESN2 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of SESN2 mRNA25224403
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SESN2 mRNA23640034
D003703DemecolcineDemecolcine results in increased expression of SESN2 mRNA23649840
C016366dibenzothiophenedibenzothiophene results in increased expression of SESN2 mRNA23656968
D002945CisplatinCisplatin results in increased expression of SESN2 mRNA21532991|2759478
D004041Dietary FatsDietary Fats results in decreased expression of SESN2 mRNA23651738
D004041Dietary FatsDietary Fats results in decreased expression of SESN2 protein23651738
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SESN2 mRNA21607683
D004237DiuronDiuron results in decreased expression of SESN2 mRNA21551480
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SESN2 mRNA"23811387
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SESN2 mRNA25064622
C004912ethylbenzeneethylbenzene results in increased expression of SESN2 mRNA20359517
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SESN2 mRNA23649840
C540355fenamidonefenamidone results in increased expression of SESN2 mRNA27029645
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SESN2 mRNA28329830
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of SESN2 mRNA21607683
D005472FluorouracilFluorouracil results in increased expression of SESN2 mRNA22525470
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of SESN2 mRNA]15016801
D005485FlutamideFlutamide results in decreased expression of SESN2 mRNA24136188
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of SESN2 mRNA24657277
D005557FormaldehydeFormaldehyde results in increased expression of SESN2 mRNA17938736|2364984
C039281furanfuran results in increased expression of SESN2 mRNA24183702
C039281furanfuran results in decreased expression of SESN2 mRNA22079235
D005688Galactosamine[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of SESN2 mRNA25637945
D005688Galactosamine[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of SESN2 protein25637945
D019833GenisteinGenistein results in increased expression of SESN2 mRNA26865667
D005978Glutathione"Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of SESN2 protein]"26035713
D005978GlutathioneGlutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein]26035713
D005978Glutathione"Glutathione inhibits the reaction [p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased expression of SESN2 protein]"26035713
D005978GlutathioneGlutathione deficiency results in increased expression of SESN2 mRNA20621112
D017313FenretinideFenretinide results in increased expression of SESN2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SESN2 mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SESN2 mRNA29274434
D006861Hydrogen PeroxideSaponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of SESN2 mRNA]29274434
C031927hydroquinonehydroquinone results in increased expression of SESN2 mRNA23416264
C013038hydroxyhydroquinone4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in increased expression of SESN2 mRNA]24530881
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of SESN2 mRNA24530881
C492448ICG 001ICG 001 results in increased expression of SESN2 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of SESN2 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SESN2 mRNA25613284
C051890irinotecanirinotecan metabolite results in increased expression of SESN2 mRNA15956246
C051890irinotecanirinotecan results in increased expression of SESN2 mRNA15956246
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of SESN2 mRNA25307878
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SESN2 mRNA24796395
C410337K 7174K 7174 results in increased expression of SESN2 mRNA24086573
C045463leflunomideleflunomide results in increased expression of SESN2 mRNA28988120
D064704LevofloxacinLevofloxacin results in increased expression of SESN2 mRNA24136188
D001556LindaneLindane results in increased expression of SESN2 mRNA24356939
D008070LipopolysaccharidesJUN protein promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of SESN2 protein]25637945
D008070LipopolysaccharidesNFE2L2 protein promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of SESN2 protein]25637945
D008070LipopolysaccharidesRELA protein inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of SESN2 protein]25637945
D008070LipopolysaccharidesCycloheximide inhibits the reaction [Lipopolysaccharides results in increased expression of SESN2 protein]25637945
D008070Lipopolysaccharides[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of SESN2 mRNA25637945
D008070Lipopolysaccharides[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of SESN2 protein25637945
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of SESN2 protein]25637945
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased activity of SESN2 protein25637945
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SESN2 mRNA25637945
D008070Lipopolysaccharides2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of SESN2 protein]25637945
D008070Lipopolysaccharideswortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of SESN2 protein]25637945
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SESN2 mRNA"27188386
D008687Metformin[Metformin co-treated with Rotenone] results in increased expression of SESN2 protein26031332
D008694MethamphetamineMethamphetamine results in increased expression of SESN2 mRNA28619521
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of SESN2 mRNA24657277
D008727MethotrexateMethotrexate results in increased expression of SESN2 mRNA24657277
D008752Methylene ChlorideMethylene Chloride results in increased expression of SESN2 mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SESN2 mRNA23179753|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SESN2 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SESN2 mRNA24810058
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of SESN2 protein24625837
C437683motexafin gadolinium[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA20530418
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of SESN2 mRNA16357179
C437683motexafin gadoliniumnutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]20530418
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA16357179
D009285NaphthoquinonesNaphthoquinones results in increased expression of SESN2 mRNA23811387
C051752nefazodonenefazodone results in decreased expression of SESN2 mRNA24136188
C022838nickel chloridenickel chloride results in increased expression of SESN2 mRNA24612858
C028007nickel monoxidenickel monoxide results in increased expression of SESN2 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of SESN2 mRNA24136188
C570897NSC668394NSC668394 results in increased expression of SESN2 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SESN2 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of SESN2 mRNA20971185
C482205nutlin 3nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]20530418
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of SESN2 mRNA24356939
C016340o,p'-DDT"o,p'-DDT results in increased expression of SESN2 mRNA"18204070
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SESN2 mRNA25729387
D010269ParaquatParaquat affects the expression of SESN2 mRNA25064622
C000610380p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane"Glutathione inhibits the reaction [p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased expression of SESN2 protein]"26035713
C000610380p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased expression of SESN2 protein"26035713
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SESN2 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of SESN2 mRNA19095052
D010457PeptidoglycanPeptidoglycan results in increased expression of SESN2 mRNA25637945
D010634PhenobarbitalPhenobarbital affects the expression of SESN2 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SESN2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SESN2 mRNA26272509
C121565pifithrin[pifithrin co-treated with Quercetin] results in increased expression of SESN2 protein24535669
C121565pifithrinpifithrin inhibits the reaction [Rotenone results in increased expression of SESN2 protein]26031332
C006253pirinixic acidpirinixic acid results in increased expression of SESN2 mRNA23811191
D011070Poly I-CPoly I-C results in increased expression of SESN2 mRNA25637945
D011137PolystyrenesPolystyrenes results in increased expression of SESN2 mRNA25102311
D011374ProgesteroneProgesterone results in increased expression of SESN2 mRNA18037150
C066229prolinedithiocarbamateprolinedithiocarbamate results in increased expression of SESN2 mRNA18951928
C066229prolinedithiocarbamateZinc Sulfate inhibits the reaction [prolinedithiocarbamate results in increased expression of SESN2 mRNA]18951928
C005556propionaldehydepropionaldehyde results in increased expression of SESN2 mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SESN2 mRNA27029645
D011794QuercetinAcetylcysteine inhibits the reaction [Quercetin results in increased expression of SESN2 protein]24535669
D011794Quercetin[pifithrin co-treated with Quercetin] results in increased expression of SESN2 protein24535669
D011794QuercetinQuercetin results in increased expression of SESN2 mRNA21632981
D011794QuercetinQuercetin results in increased expression of SESN2 protein24535669
D011794Quercetin[SB 203580 co-treated with Quercetin] results in increased expression of SESN2 protein24535669
C059514resveratrolPARP1 protein affects the reaction [resveratrol results in increased expression of SESN2 protein]25533949
C059514resveratrolresveratrol results in decreased expression of SESN2 mRNA19167446
C059514resveratrolresveratrol results in increased expression of SESN2 mRNA23651738
C059514resveratrolresveratrol results in increased expression of SESN2 protein23651738|2553394
C059514resveratrolSTF-118804 inhibits the reaction [resveratrol results in increased expression of SESN2 protein]25533949
D012402Rotenone[Metformin co-treated with Rotenone] results in increased expression of SESN2 protein26031332
D012402Rotenonepifithrin inhibits the reaction [Rotenone results in increased expression of SESN2 protein]26031332
D012402RotenoneRotenone results in increased expression of SESN2 mRNA26031332
D012402RotenoneRotenone results in increased expression of SESN2 protein26031332
D012402RotenoneSESN2 protein inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]26031332
D012402RotenoneSESN2 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein]26031332
D012402RotenoneSESN2 protein inhibits the reaction [Rotenone results in increased expression of SQSTM1 protein]26031332
D012402RotenoneTRP53 protein promotes the reaction [Rotenone results in increased expression of SESN2 protein]26031332
D012402RotenoneRotenone results in increased expression of SESN2 protein26031332
D012503SaponinsSaponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of SESN2 mRNA]29274434
C093642SB 203580[SB 203580 co-treated with Quercetin] results in increased expression of SESN2 protein24535669
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SESN2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of SESN2 mRNA19073995
D012834SilverSilver results in increased expression of SESN2 mRNA26014281|2895954
D019821SimvastatinSimvastatin results in increased expression of SESN2 mRNA19262002
D020123Sirolimus[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of SESN2 mRNA25307878
D018038Sodium SeleniteSodium Selenite results in increased expression of SESN2 mRNA24383545
C000593977STF-118804STF-118804 inhibits the reaction [resveratrol results in increased expression of SESN2 protein]25533949
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SESN2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SESN2 promoter]19654925
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of SESN2 mRNA28973375
D013752TetracyclineTetracycline affects the expression of SESN2 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SESN2 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of SESN2 mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of SESN2 mRNA25064622
C423915TO-901317SESN2 protein inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein]23651738
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SESN2 mRNA28065790
D014050TolueneToluene results in increased expression of SESN2 mRNA20359517
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SESN2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SESN2 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of SESN2 mRNA20359517
C012589trichostatin Atrichostatin A affects the expression of SESN2 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of SESN2 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SESN2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SESN2 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of SESN2 mRNA19140230
D014415TunicamycinTunicamycin results in increased expression of SESN2 mRNA22378314
D014520UrethaneUrethane results in increased expression of SESN2 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of SESN2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of SESN2 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of SESN2 mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in increased expression of SESN2 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SESN2 gene25560391
D014750VincristineVincristine results in increased expression of SESN2 mRNA23649840
C009687wortmanninwortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of SESN2 protein]25637945
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SESN2 mRNA18593933
D019345Zinc Acetate[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA20530418
D019345Zinc Acetatenutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]20530418
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of SESN2 mRNA16357179
D019287Zinc SulfateZinc Sulfate inhibits the reaction [prolinedithiocarbamate results in increased expression of SESN2 mRNA]18951928

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005092GDP-dissociation inhibitor activity-IEA-  
GO:0005515protein binding-IPI15105503  18692468  23274085  25040165  25263562  26449471  
26586190  26972053  
GO:0016684oxidoreductase activity, acting on peroxide as acceptor-IBA21873635  
GO:0016684oxidoreductase activity, acting on peroxide as acceptor-IDA26612684  
GO:0032542sulfiredoxin activity-IDA15105503  
GO:0032542sulfiredoxin activityNOTIDA19113821  
GO:0070728leucine binding-IBA21873635  
GO:0070728leucine binding-IDA26449471  26586190  
GO ID GO Term Qualifier Evidence PubMed
GO:0001932regulation of protein phosphorylation-IDA25040165  
GO:0006111regulation of gluconeogenesis-IEA-  
GO:0006635fatty acid beta-oxidation-IEA-  
GO:0009749response to glucose-IEA-  
GO:0016239positive regulation of macroautophagy-IBA21873635  
GO:0016239positive regulation of macroautophagy-IMP23274085  
GO:0030308negative regulation of cell growth-ISS-  
GO:0030330DNA damage response, signal transduction by p53 class mediator-IMP18692468  
GO:0032042mitochondrial DNA metabolic process-IEA-  
GO:0032868response to insulin-IEA-  
GO:0034198cellular response to amino acid starvation-IMP25263562  
GO:0034599cellular response to oxidative stress-ISS-  
GO:0036091positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress-IMP23274085  
GO:0042149cellular response to glucose starvation-IMP25263562  
GO:0042593glucose homeostasis-IEA-  
GO:0043491protein kinase B signaling-IEA-  
GO:0046323glucose import-IEA-  
GO:0070328triglyceride homeostasis-IEA-  
GO:0071230cellular response to amino acid stimulus-IBA21873635  
GO:0071230cellular response to amino acid stimulus-IMP25457612  
GO:0071233cellular response to leucine-IBA21873635  
GO:0071233cellular response to leucine-IMP26586190  
GO:0072593reactive oxygen species metabolic process-IMP15105503  
GO:0098869cellular oxidant detoxification-IDA26612684  
GO:0098869cellular oxidant detoxificationNOTIDA19113821  
GO:0098869cellular oxidant detoxification-IMP15105503  
GO:1900182positive regulation of protein localization to nucleus-IMP23274085  
GO:1901031regulation of response to reactive oxygen species-IEA-  
GO:1902010negative regulation of translation in response to endoplasmic reticulum stress-IMP24947615  
GO:1904262negative regulation of TORC1 signaling-IBA21873635  
GO:1904262negative regulation of TORC1 signaling-IMP18692468  24947615  25263562  25457612  26449471  26586190  26612684  
GO:1904504positive regulation of lipophagy-IEA-  
GO:1990253cellular response to leucine starvation-IBA21873635  
GO:1990253cellular response to leucine starvation-IMP26449471  
GO:2000479regulation of cAMP-dependent protein kinase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasmCOLOCALIZES_WITHIBA21873635  
GO:0005737cytoplasm-IDA15105503  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-TAS-  
GO:0031588nucleotide-activated protein kinase complexcolocalizes_withISS-  
GO:0031932TORC2 complexCOLOCALIZES_WITHIBA21873635  
GO:0031932TORC2 complexcolocalizes_withISS-  
GO:0061700GATOR2 complexCOLOCALIZES_WITHIBA21873635  
GO:0061700GATOR2 complexcolocalizes_withIDA25263562  25457612  26449471  26586190  26612684  
GO:1990316Atg1/ULK1 kinase complexcolocalizes_withIDA25040165  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20106877Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD. (2010 Mar-Apr)Wempe FDis Model Mech