Gene: CALN1

83698
CABP8
calneuron 1
protein-coding
7q11.22
Ensembl:ENSG00000183166 MIM:607176 Vega:OTTHUMG00000023787 UniprotKB:Q9BXU9
NC_000007.14
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.017e-1 (AD)  5.768e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7809631chr7:72443666 (GRCh38.p7)G>A / G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FRRS1L0.899
GPR1760.898
MMP240.896
PTPRO0.895
DGKB0.892
TTC90.889
MYT1L0.887
GRIN2B0.887
LHFPL40.887
ZNF804A0.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGIF1-0.536
CSAG1-0.534
HEY2-0.518
CNN2-0.517
MYL3-0.511
ROM1-0.51
FLT3LG-0.51
RNF135-0.504
SNHG18-0.503
AGTRAP-0.501

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CALN1 mRNA"22698814
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALN1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CALN1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CALN1 protein20106945
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CALN1 mRNA28522335
C015001arsenitearsenite results in increased methylation of CALN1 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CALN1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CALN1 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of CALN1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CALN1 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of CALN1 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CALN1 mRNA22079614
D002220CarbamazepineCarbamazepine affects the expression of CALN1 mRNA25979313
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CALN1 mRNA24763279
D007631ChlordeconeCALN1 gene SNP affects the susceptibility to Chlordecone25622337
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALN1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of CALN1 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CALN1 gene20938992
D003300Copper[Copper co-treated with Dietary Sucrose] results in decreased expression of CALN1 mRNA26033743
D016572CyclosporineCyclosporine results in decreased methylation of CALN1 promoter27989131
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in decreased expression of CALN1 mRNA26033743
D004317DoxorubicinDoxorubicin affects the methylation of CALN1 gene28962528
C118739entinostatentinostat results in increased expression of CALN1 mRNA27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CALN1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CALN1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CALN1 gene20938992
D004397FonofosFonofos results in increased methylation of CALN1 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of CALN1 mRNA23649840
C039281furanfuran results in decreased expression of CALN1 mRNA25539665
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CALN1 mRNA24763279
D007213IndomethacinIndomethacin results in increased expression of CALN1 mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CALN1 mRNA24796395
D007854LeadLead affects the expression of CALN1 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CALN1 gene20938992
D008727MethotrexateMethotrexate results in increased expression of CALN1 mRNA24449571
D008727MethotrexateMethotrexate affects the expression of CALN1 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CALN1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CALN1 mRNA"25620056
D010278ParathionParathion results in increased methylation of CALN1 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CALN1 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALN1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CALN1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of CALN1 mRNA18301758|2381119
D011374ProgesteroneProgesterone results in decreased expression of CALN1 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of CALN1 mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of CALN1 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of CALN1 mRNA21457566
C012568terbufosterbufos results in increased methylation of CALN1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CALN1 mRNA19684285
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CALN1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CALN1 mRNA19684285
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CALN1 gene27618143
D014635Valproic AcidValproic Acid affects the expression of CALN1 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of CALN1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CALN1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0032588trans-Golgi network membrane-IDA19338761  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal