Gene: SH3BGRL2

83699
-
SH3 domain binding glutamate rich protein like 2
protein-coding
6q14.1
Ensembl:ENSG00000198478 MIM:615678 Vega:OTTHUMG00000015081 UniprotKB:Q9UJC5
NC_000006.12
SNP Mapped
0   ANCO-SNPs
AD
0   
2.984e-1 (AD)  3.445e-1 (ND)   (Frontal_Cortex)
7.193e-1 (AD)  5.985e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAB390.955
RAB3GAP10.954
BCAP290.954
COL4A3BP0.949
NAPG0.947
UBE2K0.946
SLU70.945
GPD1L0.944
SRPK20.944
ARMC80.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.52
OR4F29-0.514
AQP5-0.413
HEY2-0.404
CSAG1-0.399
MTRNR2L10-0.384
MDFI-0.38
MYL3-0.375
MTRNR2L6-0.371
EYA2-0.368

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of SH3BGRL2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SH3BGRL2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SH3BGRL2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of SH3BGRL2 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of SH3BGRL2 mRNA"23195993
C547126AZM551248AZM551248 results in decreased expression of SH3BGRL2 mRNA22323515
D001554BenzeneBenzene results in decreased expression of SH3BGRL2 mRNA19162166
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of SH3BGRL2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SH3BGRL2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SH3BGRL2 mRNA21839799
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of SH3BGRL2 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of SH3BGRL2 mRNA21179406
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of SH3BGRL2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SH3BGRL2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SH3BGRL2 gene28505145
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SH3BGRL2 mRNA28472532
D019327Copper SulfateCopper Sulfate results in increased expression of SH3BGRL2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SH3BGRL2 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of SH3BGRL2 mRNA25562108
C016366dibenzothiophenedibenzothiophene results in decreased expression of SH3BGRL2 mRNA23656968
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of SH3BGRL2 mRNA21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SH3BGRL2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of SH3BGRL2 mRNA]19850644
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SH3BGRL2 mRNA22129741
D004237DiuronDiuron results in decreased expression of SH3BGRL2 mRNA21551480
D011345FenofibrateFenofibrate results in increased expression of SH3BGRL2 mRNA25572481
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of SH3BGRL2 mRNA22634610
D017313FenretinideFenretinide results in increased expression of SH3BGRL2 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SH3BGRL2 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SH3BGRL2 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of SH3BGRL2 mRNA27392435
C045463leflunomideleflunomide results in increased expression of SH3BGRL2 mRNA28988120
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of SH3BGRL2 protein24625837
D009532NickelNickel results in decreased expression of SH3BGRL2 mRNA24768652|2558310
D009532NickelNickel results in increased expression of SH3BGRL2 mRNA23195993
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SH3BGRL2 mRNA25729387
C006253pirinixic acidpirinixic acid results in decreased expression of SH3BGRL2 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of SH3BGRL2 mRNA18301758|2381119
D011441PropylthiouracilPropylthiouracil results in decreased expression of SH3BGRL2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SH3BGRL2 mRNA21632981
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of SH3BGRL2 mRNA21852083
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SH3BGRL2 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of SH3BGRL2 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of SH3BGRL2 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SH3BGRL2 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SH3BGRL2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SH3BGRL2 mRNA19684285
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SH3BGRL2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of SH3BGRL2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SH3BGRL2 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SH3BGRL2 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of SH3BGRL2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SH3BGRL2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SH3BGRL2 mRNA23179753|2915479
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SH3BGRL2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SH3BGRL2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017124SH3 domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal