Gene: HYAL3

8372
HYAL-3|LUCA-3|LUCA3
hyaluronoglucosaminidase 3
protein-coding
3p21.31
Ensembl:ENSG00000186792 MIM:604038 Vega:OTTHUMG00000156936 UniprotKB:O43820
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
3.950e-1 (AD)  9.480e-1 (ND)   (Frontal_Cortex)
5.029e-1 (AD)  7.503e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM57B0.881
RTN20.88
FAM171A20.879
ANKRD34A0.878
GFOD20.877
PRRT30.875
MON1A0.875
SYT30.873
B4GALNT10.873
THY10.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.611
YES1-0.577
WWTR1-0.56
WEE1-0.557
RAI14-0.546
LATS2-0.544
MBNL3-0.539
COPZ2-0.534
EBF1-0.533
HEY2-0.525

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HYAL3 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HYAL3 mRNA22484513
C547126AZM551248AZM551248 results in increased expression of HYAL3 mRNA22323515
C028559bathocuproine sulfonate[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HYAL3 mRNA15477007
C006780bisphenol Abisphenol A results in decreased methylation of HYAL3 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of HYAL3 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of HYAL3 mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of HYAL3 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HYAL3 mRNA25993096
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HYAL3 mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of HYAL3 mRNA19549813
D002945CisplatinCisplatin results in increased expression of HYAL3 mRNA27392435
D004237DiuronDiuron results in increased expression of HYAL3 mRNA21551480
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of HYAL3 promoter27415467
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HYAL3 mRNA20938992
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HYAL3 mRNA20044591
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HYAL3 mRNA20938992
C051752nefazodonenefazodone results in decreased expression of HYAL3 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of HYAL3 mRNA24136188
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of HYAL3 mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HYAL3 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of HYAL3 mRNA23557933
C020972pyrrolidine dithiocarbamic acid[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HYAL3 mRNA15477007
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of HYAL3 mRNA27914987
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HYAL3 mRNA"26179874
C406224valdecoxibvaldecoxib results in decreased expression of HYAL3 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of HYAL3 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of HYAL3 mRNA19165385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activityNOTIDA11296287  
GO:0004415hyalurononglucosaminidase activity-IDA11944887  17170110  18390475  
GO:0005515protein binding-IPI25416956  
GO:0033906hyaluronoglucuronidase activity-IDA21699545  
GO ID GO Term Qualifier Evidence PubMed
GO:0001552ovarian follicle atresia-ISS-  
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006954inflammatory response-IDA18390475  
GO:0007341penetration of zona pellucida-ISS-  
GO:0009615response to virus-IDA11296287  
GO:0030214hyaluronan catabolic process-IDA21699545  
GO:0046677response to antibiotic-IEP11944887  
GO:0051216cartilage development-IEP11944887  
GO:0071347cellular response to interleukin-1-IDA18390475  
GO:0071356cellular response to tumor necrosis factor-IEP18390475  
GO:0071493cellular response to UV-B-IDA21699545  
GO:2000355negative regulation of ovarian follicle development-ISS-  
GO:2000368positive regulation of acrosomal vesicle exocytosis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-ISS-  
GO:0002080acrosomal membrane-ISS-  
GO:0005576extracellular region-IEA-  
GO:0005764lysosome-IDA16600643  
GO:0005769early endosome-ISS-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005886plasma membrane-IEA-  
GO:0031410cytoplasmic vesicle-IDA18390475  
GO:0031410cytoplasmic vesicle-ISS-  
GO:0097225sperm midpiece-ISS-  
KEGG ID KEGG Term
hsa00531Glycosaminoglycan degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-2024101CS/DS degradationTAS
R-HSA-2142845Hyaluronan metabolismTAS
R-HSA-2160916Hyaluronan uptake and degradationTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23549009Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients. (2013 Jan-Feb)Zhang RXTumori