Gene: ITCH

83737
ADMFD|AIF4|AIP4|NAPP1
itchy E3 ubiquitin protein ligase
protein-coding
20q11.22
Ensembl:ENSG00000078747 MIM:606409 Vega:OTTHUMG00000032300 UniprotKB:Q96J02
NG_023206.1
PubMed
0   ANCO-SNPs
CD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.209e-1 (AD)  7.861e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USO10.922
MTDH0.921
AGPS0.921
PBRM10.919
NEMF0.918
MPP50.918
TRIP120.917
SEL1L0.915
RPS6KB10.914
UBA60.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.569
OR4F29-0.558
PLA2G5-0.296
HES5-0.268
MTRNR2L10-0.257
MTRNR2L6-0.25
PTGDR2-0.236
EYA2-0.236
PPP1R3G-0.231
OR4F16-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of ITCH mRNA"20406850
D000082AcetaminophenAcetaminophen results in decreased expression of ITCH mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of ITCH mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ITCH mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITCH mRNA21632981|2623829
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ITCH mRNA"19150397|2001819
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ITCH mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of ITCH mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ITCH mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of ITCH mRNA26079696
D019327Copper SulfateCopper Sulfate results in increased expression of ITCH mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ITCH mRNA20106945|2556210
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ITCH mRNA22079256
D011345FenofibrateFenofibrate results in decreased expression of ITCH mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in decreased expression of ITCH mRNA]21318169
D005839GentamicinsGentamicins results in increased expression of ITCH mRNA22061828
C544151jinfukangjinfukang results in decreased expression of ITCH mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ITCH mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ITCH mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITCH mRNA"20188158
C025256nonylphenolnonylphenol results in decreased expression of ITCH mRNA22982499
C025589ochratoxin Aochratoxin A results in decreased expression of ITCH mRNA18417182
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ITCH mRNA18593933
C046012pentanalpentanal results in decreased expression of ITCH mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of ITCH mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of ITCH mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of ITCH mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of ITCH mRNA]21318169
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ITCH mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ITCH mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of ITCH mRNA19690047
C009277sodium arsenatesodium arsenate results in increased expression of ITCH mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of ITCH mRNA27862939
D018038Sodium SeleniteSodium Selenite results in decreased expression of ITCH mRNA18175754
C483909torcetrapibtorcetrapib results in increased expression of ITCH mRNA23228038
D014635Valproic AcidValproic Acid affects the expression of ITCH mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ITCH mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ITCH gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ITCH mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-IDA17592138  
GO:0004842ubiquitin-protein transferase activity-IMP24790097  
GO:0004842ubiquitin-protein transferase activity-NAS10940313  
GO:0005515protein binding-IPI9647693  12226085  14684745  15051726  15678106  16888620  
16908849  17028573  17174309  17592138  19580544  20068034  
20392206  20491914  20676133  20818436  20858735  22057290  
22810586  23146885  24790097  25436413  
GO:0016874ligase activity-IEA-  
GO:0019787ubiquitin-like protein transferase activity-TAS-  
GO:0043021ribonucleoprotein complex binding-IPI19881509  
GO:0044389ubiquitin-like protein ligase binding-IPI24790097  
GO:0045236CXCR chemokine receptor binding-IPI19116316  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-IDA15678106  
GO:0061630ubiquitin protein ligase activity-TAS-  
GO:1990763arrestin family protein binding-IPI23886940  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0001558regulation of cell growth-NAS9462742  
GO:0002669positive regulation of T cell anergy-IEA-  
GO:0006511ubiquitin-dependent protein catabolic process-IDA15678106  
GO:0006511ubiquitin-dependent protein catabolic process-NAS9462742  
GO:0006915apoptotic process-IEA-  
GO:0006954inflammatory response-NAS9462742  
GO:0007219Notch signaling pathway-TAS-  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IDA17592138  25631046  
GO:0016567protein ubiquitination-IMP24790097  
GO:0032088negative regulation of NF-kappaB transcription factor activity-ISS-  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0035519protein K29-linked ubiquitination-IBA21873635  
GO:0035519protein K29-linked ubiquitination-IDA17028573  18628966  
GO:0043066negative regulation of apoptotic process-IMP20068034  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0045087innate immune response-IEA-  
GO:0045732positive regulation of protein catabolic process-IBA21873635  
GO:0045732positive regulation of protein catabolic process-IEA-  
GO:0046329negative regulation of JNK cascade-ISS-  
GO:0046642negative regulation of alpha-beta T cell proliferation-IEA-  
GO:0046718viral entry into host cell-TAS12450395  
GO:0050687negative regulation of defense response to virus-IMP19881509  
GO:0051607defense response to virus-IEA-  
GO:0051865protein autoubiquitination-IMP24790097  
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway-TAS-  
GO:0070534protein K63-linked ubiquitination-IBA21873635  
GO:0070534protein K63-linked ubiquitination-IDA18718448  19592251  
GO:0070936protein K48-linked ubiquitination-IBA21873635  
GO:0070936protein K48-linked ubiquitination-IDA19881509  
GO:0090085regulation of protein deubiquitination-ISS-  
GO:1902036regulation of hematopoietic stem cell differentiation-TAS-  
GO:2000646positive regulation of receptor catabolic process-IMP24790097  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005769early endosomecolocalizes_withIDA24790097  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA14602072  
GO:0005938cell cortex-IEA-  
GO:0016020membrane-HDA19946888  
GO:0031901early endosome membrane-IEA-  
GO:0032991protein-containing complex-IDA24790097  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1253288Downregulation of ERBB4 signalingTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-157118Signaling by NOTCHTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168638NOD1/2 Signaling PathwayTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusTAS
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610780Degradation of GLI1 by the proteasomeTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19538185Itch and scratching as predictors of time to clearance of psoriasis with narrow-band ultraviolet B therapy. (2009 Sep)Evers AWBr J Dermatol
27162327Collybolide is a novel biased agonist of kappa-opioid receptors with potent antipruritic activity. (2016 May 24)Gupta AProc Natl Acad Sci U S A
22294496Prevalence and determinants of allergic diseases in a Congolese population. (2012 Jul-Aug)Nyembue TDInt Forum Allergy Rhinol
24830002Clinical Aspects of Itch: Psoriasis (2014)Reich A-
10768819Pathophysiology and treatment of psoriasis. (2000 Apr 1)Peters BPAm J Health Syst Pharm
23868626[The possible uses of balneotherapy in treating chronic venous insufficiency of lower limbs]. (2013 May-Jun)Petraccia LClin Ter