Gene: MAD1L1

8379
MAD1|PIG9|TP53I9|TXBP181
mitotic arrest deficient 1 like 1
protein-coding
7p22.3
Ensembl:ENSG00000002822 MIM:602686 Vega:OTTHUMG00000151493 UniprotKB:Q9Y6D9
NG_011518.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.377e-2 (AD)  3.279e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17132242chr7:2139827 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4332037chr7:1911173 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01302853chr7:2236170MAD1L1Gene body7.057e-4Alcohol use disorders26763658
cg01119831chr7:2119608MAD1L11.890e-9Maternal smoking in pregnancy27040690
cg07065756chr7:2119340MAD1L14.810e-8Maternal smoking in pregnancy27040690
cg09367467chr7:1894209MAD1L12.180e-8Maternal smoking in pregnancy27040690
cg08712631chr7:1960676MAD1L11.700e-11Smoking27651444
cg06857018chr7:1908314MAD1L14.100e-10Smoking27651444
cg17551891chr7:1960795MAD1L12.500e-9Smoking27651444
cg07556911chr7:2044787MAD1L12.100e-8Alcohol consumption der day27843151
cg17551891chr7:1960795MAD1L14.250e-14Smoking28686328
cg01436487chr7:1890148MAD1L15.100e-8Smoking28686328
cg21422361chr7:1884392MAD1L15.740e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SARS20.909
TOM10.904
THOP10.887
PIGQ0.885
GPS10.883
MRPL20.882
IDH3G0.879
PEX140.879
C6orf1360.878
XRCC10.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.555
OR4F29-0.515
MTRNR2L9-0.461
MTRNR2L6-0.455
KCNJ15-0.431
MTRNR2L10-0.421
PABPC4L-0.398
FHL5-0.387
KIAA0040-0.386
EBF1-0.383

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MAD1L1 mRNA"21354444|2269881
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of MAD1L1 mRNA"20005886
D020106AcrylamideAcrylamide results in increased expression of MAD1L1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MAD1L1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MAD1L1 mRNA22100608|2715375
D001151ArsenicArsenic affects the methylation of MAD1L1 gene25304211
D001374AzacitidineAzacitidine results in decreased expression of MAD1L1 mRNA19194470
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAD1L1 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAD1L1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAD1L1 mRNA"19150397|2038263
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of MAD1L1 mRNA20404318
D004958EstradiolEstradiol results in increased expression of MAD1L1 mRNA16474171
C006780bisphenol Abisphenol A affects the expression of MAD1L1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MAD1L1 mRNA29027980
C006780bisphenol Abisphenol A results in increased expression of MAD1L1 mRNA16474171
C006780bisphenol Abisphenol A affects the expression of MAD1L1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MAD1L1 mRNA25181051
D002330CarmustineCarmustine results in decreased expression of MAD1L1 mRNA15980968
D019327Copper SulfateCopper Sulfate results in decreased expression of MAD1L1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of MAD1L1 mRNA26577399
D016572CyclosporineCyclosporine results in increased methylation of MAD1L1 promoter27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MAD1L1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MAD1L1 mRNA21532991|2739243
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAD1L1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MAD1L1 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of MAD1L1 mRNA23649840
D019833GenisteinGenistein results in increased expression of MAD1L1 mRNA16474171
D017313FenretinideFenretinide results in increased expression of MAD1L1 mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of MAD1L1 mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MAD1L1 mRNA23086925
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MAD1L1 mRNA"24972896
D008748MethylcholanthreneMethylcholanthrene results in increased expression of MAD1L1 mRNA20713471
C005223methyleugenolmethyleugenol results in decreased expression of MAD1L1 mRNA26011634
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MAD1L1 mRNA23649840
D015741MetriboloneMetribolone results in decreased expression of MAD1L1 protein17152098
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MAD1L1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MAD1L1 mRNA25729387
C005290oxybenzoneoxybenzone results in increased expression of MAD1L1 mRNA22721600
D010416PentachlorophenolPentachlorophenol results in increased expression of MAD1L1 mRNA24642059
D010634PhenobarbitalPhenobarbital affects the expression of MAD1L1 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAD1L1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of MAD1L1 mRNA23811191
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of MAD1L1 mRNA16474171
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MAD1L1 mRNA28903501
D011398PromethazinePromethazine results in decreased expression of MAD1L1 mRNA26011634
D011794QuercetinQuercetin results in decreased expression of MAD1L1 mRNA21632981
D011794QuercetinQuercetin results in increased expression of MAD1L1 protein14750173
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAD1L1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAD1L1 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of MAD1L1 mRNA25975270
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of MAD1L1 mRNA19031421
D013853ThioacetamideThioacetamide results in decreased expression of MAD1L1 mRNA26011634
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MAD1L1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of MAD1L1 mRNA16140955
D014635Valproic AcidValproic Acid results in increased methylation of MAD1L1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12006501  14978040  16189514  18318601  18692475  18981471  
19273613  21041666  21516116  21772247  21988832  22351768  
22493223  24581499  25036637  25416956  25910212  26258632  
26496610  26871637  27107014  
GO:0042802identical protein binding-IPI16189514  22493223  27107012  
GO:0043515kinetochore binding-IDA22351768  
GO ID GO Term Qualifier Evidence PubMed
GO:0007093mitotic cell cycle checkpoint-NAS9546394  
GO:0007094mitotic spindle assembly checkpoint-IBA21873635  
GO:0042130negative regulation of T cell proliferation-IEA-  
GO:0048538thymus development-IEA-  
GO:0051301cell division-IEA-  
GO:0051315attachment of mitotic spindle microtubules to kinetochore-IBA21873635  
GO:0090235regulation of metaphase plate congression-IDA20133940  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IBA21873635  
GO:0000776kinetochore-IDA20133940  
GO:0000776kinetochorecolocalizes_withIDA17363900  18981471  22351768  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005635nuclear envelope-IBA21873635  
GO:0005635nuclear envelopecolocalizes_withIDA22351768  
GO:0005643nuclear porecolocalizes_withIDA18981471  
GO:0005813centrosome-NAS9546394  
GO:0005819spindle-NAS9546394  
GO:0005829cytosol-TAS-  
GO:0072686mitotic spindle-IBA21873635  
GO:0072686mitotic spindle-IDA20133940  
GO:0097431mitotic spindle polecolocalizes_withIDA22351768  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26183163MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer. (2015 Jul 17)Zhong RSci Rep
28346444Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. (2017 May)Wright DJNat Genet