Gene: KLF16

83855
BTEB4|DRRF|NSLP2
Kruppel like factor 16
protein-coding
19p13.3
Ensembl:ENSG00000129911 MIM:606139 Vega:OTTHUMG00000179994 UniprotKB:Q9BXK1
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.722e-1 (AD)  3.110e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4807154chr19:1858874 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23290456chr19:1859341KLF161.600e-9Smoking27651444
cg08525314chr19:1854819KLF162.500e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSD0.896
DLGAP30.894
SEMA6B0.893
LRP30.883
NACC10.882
RPS6KA40.879
DLG40.873
SYNPO0.872
CTXN10.872
MAP3K100.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.614
OR4F29-0.554
MYOT-0.44
CTNNA3-0.434
SEPT10-0.404
ZFP57-0.397
VRK2-0.394
SGMS2-0.391
CLEC4E-0.383
DTHD1-0.369

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of KLF16 mRNA19933214
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of KLF16 mRNA"28073004
D000082AcetaminophenAcetaminophen results in increased expression of KLF16 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of KLF16 mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of KLF16 mRNA19774075
D001151ArsenicArsenic results in increased methylation of KLF16 promoter21291286
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLF16 mRNA22228805
D004958EstradiolEstradiol results in increased expression of KLF16 mRNA23019147
C006780bisphenol Abisphenol A affects the methylation of KLF16 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of KLF16 mRNA25181051
D016572CyclosporineCyclosporine results in increased expression of KLF16 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of KLF16 mRNA23640034
D003976DiazinonDiazinon results in increased methylation of KLF16 gene22964155
D002945CisplatinCisplatin results in decreased expression of KLF16 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of KLF16 mRNA28302478
C544151jinfukangjinfukang results in increased expression of KLF16 mRNA27392435
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of KLF16 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of KLF16 mRNA24810058
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of KLF16 mRNA"29244179
D010936Plant ExtractsPlant Extracts results in decreased expression of KLF16 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of KLF16 mRNA24780913
D019821SimvastatinSimvastatin results in increased expression of KLF16 mRNA19262002
D053260SootSoot results in increased expression of KLF16 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLF16 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLF16 mRNA19933214
D014635Valproic AcidValproic Acid results in increased methylation of KLF16 gene29154799
D055549Volatile Organic CompoundsVolatile Organic Compounds affects the expression of KLF16 mRNA20823639

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0007212dopamine receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal