Gene: BCO2

83875
B-DIOX-II|BCDO2
beta-carotene oxygenase 2
protein-coding
11q23.1
Ensembl:ENSG00000197580 MIM:611740 Vega:OTTHUMG00000167155 UniprotKB:Q9BYV7
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
5.366e-1 (AD)  5.884e-1 (ND)   (Frontal_Cortex)
5.286e-1 (AD)  5.050e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM480.793
PCID20.785
NAALAD20.775
DNAJC90.775
HINFP0.775
SPAG50.774
RAD520.773
STK11IP0.772
HERC40.772
FASTKD10.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRB1-0.411
OR4F5-0.361
IL2RB-0.34
KLRF1-0.339
GPR171-0.332
TBX21-0.33
OR4F29-0.32
CD2-0.318
HES1-0.316
IL18RAP-0.315

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of BCO2 mRNA"21354444
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of BCO2 mRNA16014739
C5323083'-dehydrolutein[BCO2 protein affects the metabolism of Lutein] which results in increased abundance of 3'-dehydrolutein21106934
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of BCO2 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of BCO2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BCO2 mRNA22100608
C004984apocarotenal[BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal21106934
C004984apocarotenal[BCO2 protein results in increased metabolism of Cryptoxanthins] which results in increased chemical synthesis of apocarotenal21106934
C004984apocarotenal[BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite21106934
C004984apocarotenal[BCO2 protein results in increased metabolism of Zeaxanthins] which results in increased chemical synthesis of apocarotenal metabolite21106934
D001151ArsenicArsenic affects the methylation of BCO2 gene25304211
D001280AtrazineAtrazine results in increased expression of BCO2 mRNA22378314
D019207beta CaroteneBCO2 protein results in increased metabolism of beta Carotene21106934
D019207beta Carotene[BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal21106934
D019207beta CaroteneBCO2 protein results in increased metabolism of beta Carotene25344780
D019207beta Carotene[BCO2 protein results in increased metabolism of beta Carotene] which results in increased abundance of Vitamin A25344780
C006780bisphenol Abisphenol A results in decreased expression of BCO2 mRNA25181051
D002104CadmiumCadmium results in increased expression of BCO2 mRNA23256528
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of BCO2 mRNA27339419
D002338CarotenoidsBCO2 gene mutant form results in decreased metabolism of Carotenoids21106934
D002338Carotenoids[BCO2 gene mutant form results in decreased metabolism of Carotenoids] which results in increased abundance of Carotenoids21106934
D002338Carotenoids[[BCO2 gene mutant form results in decreased metabolism of Carotenoids] which results in increased abundance of Carotenoids] which results in increased expression of SOD2 protein21106934
D002338CarotenoidsBCO2 protein results in increased oxidation of and results in increased cleavage of Carotenoids21106934
D019327Copper SulfateCopper Sulfate results in increased expression of BCO2 mRNA19549813
D065366CryptoxanthinsBCO2 protein results in increased metabolism of Cryptoxanthins21106934
D065366Cryptoxanthins[BCO2 protein results in increased metabolism of Cryptoxanthins] which results in increased chemical synthesis of apocarotenal21106934
D003471CuprizoneCuprizone results in decreased expression of BCO2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of BCO2 mRNA20106945|2798913
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of BCO2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of BCO2 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of BCO2 mRNA24535843
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BCO2 mRNA"22485181
D017313FenretinideFenretinide results in decreased expression of BCO2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCO2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of BCO2 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of BCO2 mRNA22609695
D014975LuteinBCO2 protein affects the metabolism of Lutein21106934
D014975Lutein[BCO2 protein affects the metabolism of Lutein] which results in increased abundance of 3'-dehydrolutein21106934
D014975LuteinBCO2 protein results in increased metabolism of Lutein21106934
D014975Lutein[BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite21106934
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BCO2 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BCO2 mRNA23179753
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BCO2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BCO2 mRNA"25620056
C007350nitrofennitrofen results in increased expression of BCO2 protein25344780
D009966OrphenadrineOrphenadrine affects the expression of BCO2 mRNA23665939
D052638Particulate Matter[BCO2 gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of BCO2 mRNA21222557|2122255
C031181phenanthrenephenanthrene results in increased expression of BCO2 mRNA19457238
D010634PhenobarbitalPhenobarbital results in increased expression of BCO2 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BCO2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of BCO2 mRNA17426115
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of BCO2 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of BCO2 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of BCO2 mRNA26079696
D012834SilverSilver results in increased expression of BCO2 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of BCO2 mRNA16014739
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BCO2 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BCO2 mRNA20106945
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCO2 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of BCO2 mRNA23411599
D014212TretinoinTretinoin results in increased expression of BCO2 mRNA23724009
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of BCO2 mRNA29024780
D014635Valproic AcidValproic Acid results in decreased methylation of BCO2 gene29154799
D001335Vehicle Emissions[BCO2 gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of BCO2 mRNA21222557|2122255
C025643vinclozolinvinclozolin results in increased expression of BCO2 mRNA22570695
D014801Vitamin A[BCO2 protein results in increased metabolism of beta Carotene] which results in increased abundance of Vitamin A25344780
D065146Zeaxanthins[BCO2 gene mutant form results in decreased metabolism of Zeaxanthins] which results in increased expression of HIF1A protein21106934
D065146Zeaxanthins[BCO2 gene mutant form results in decreased metabolism of Zeaxanthins] which results in increased expression of MAPK1 protein modified form21106934
D065146Zeaxanthins[BCO2 gene mutant form results in decreased metabolism of Zeaxanthins] which results in increased expression of MAPK3 protein modified form21106934
D065146ZeaxanthinsBCO2 protein affects the metabolism of Zeaxanthins21106934
D065146Zeaxanthins[BCO2 protein affects the metabolism of Zeaxanthins] which results in increased abundance of Zeaxanthins metabolite21106934
D065146ZeaxanthinsBCO2 protein results in increased metabolism of Zeaxanthins21106934
D065146Zeaxanthins[BCO2 protein results in increased metabolism of Zeaxanthins] which results in increased chemical synthesis of apocarotenal metabolite21106934
D065146ZeaxanthinsZeaxanthins results in increased expression of BCO2 mRNA21106934

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003834beta-carotene 15,15'-monooxygenase activity-IBA21873635  
GO:0004744retinal isomerase activity-IBA21873635  
GO:0010436carotenoid dioxygenase activity-IBA21873635  
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen-IDA11278918  21302131  
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen-TAS-  
GO:0046872metal ion binding-IEA-  
GO:0102076beta,beta-carotene-9',10'-cleaving oxygenase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0016116carotenoid metabolic process-ISS21106934  
GO:0016119carotene metabolic process-IDA11278918  
GO:0016121carotene catabolic process-IBA21873635  
GO:0016121carotene catabolic process-IDA21302131  
GO:0016122xanthophyll metabolic process-IEA-  
GO:0042573retinoic acid metabolic process-NAS11278918  
GO:0042574retinal metabolic process-IBA21873635  
GO:0042574retinal metabolic process-NAS11278918  
GO:0051881regulation of mitochondrial membrane potential-ISS21106934  
GO:0055114oxidation-reduction process-IDA21302131  
GO:2000377regulation of reactive oxygen species metabolic process-ISS21106934  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IC11278918  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-ISS21106934  
GO:0005739mitochondrion-TAS21106934  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24346170Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). (2014 Jan 29)Meyers KJInvest Ophthalmol Vis Sci