Gene: CDCA7

83879
ICF3|JPO1
cell division cycle associated 7
protein-coding
2q31.1
Ensembl:ENSG00000144354 MIM:609937 Vega:OTTHUMG00000132296 UniprotKB:Q9BWT1
NG_047202.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.086e-1 (AD)  6.245e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TOX30.685
NXPH10.673
KIAA10240.663
DLX10.662
GRIK10.661
VWC20.637
BTBD110.635
VAX10.634
ERBB40.634
HAPLN10.632

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC4E-0.423
CDA-0.402
TNFRSF10D-0.362
PPBP-0.36
GPR4-0.36
TUBAL3-0.358
S100A12-0.355
SLC52A3-0.353
FUT7-0.347
ANGPT2-0.346

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDCA7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDCA7 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of CDCA7 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDCA7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDCA7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CDCA7 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of CDCA7 mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of CDCA7 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CDCA7 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CDCA7 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDCA7 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDCA7 mRNA23630614
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CDCA7 mRNA24449571
D001379AzathioprineAzathioprine results in decreased expression of CDCA7 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDCA7 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDCA7 mRNA22610609
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDCA7 mRNA"20382639
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CDCA7 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CDCA7 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CDCA7 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDCA7 mRNA28628672
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CDCA7 mRNA27339419
D002994ClofibrateClofibrate results in increased expression of CDCA7 mRNA23811191
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CDCA7 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of CDCA7 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of CDCA7 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of CDCA7 mRNA20106945|2556210
D003703DemecolcineDemecolcine results in decreased expression of CDCA7 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CDCA7 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDCA7 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of CDCA7 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CDCA7 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDCA7 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDCA7 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CDCA7 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CDCA7 mRNA27392435
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of CDCA7 mRNA21852083
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDCA7 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDCA7 mRNA]17854601
D002117CalcitriolCalcitriol results in decreased expression of CDCA7 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CDCA7 mRNA21592394
D004237DiuronDiuron results in increased expression of CDCA7 mRNA21551480
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDCA7 mRNA26159488
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of CDCA7 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of CDCA7 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CDCA7 mRNA17555576
D005472FluorouracilFluorouracil affects the expression of CDCA7 mRNA20421339
D005557FormaldehydeFormaldehyde results in decreased expression of CDCA7 mRNA23649840
C039281furanfuran results in increased expression of CDCA7 mRNA25539665
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CDCA7 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDCA7 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDCA7 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CDCA7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDCA7 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CDCA7 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDCA7 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDCA7 mRNA25982114
C410337K 7174K 7174 results in decreased expression of CDCA7 mRNA24086573
D007649KetamineKetamine results in decreased expression of CDCA7 mRNA20080153
D007854LeadLead affects the expression of CDCA7 mRNA28903495
D008694MethamphetamineMethamphetamine results in decreased expression of CDCA7 mRNA26307267
C013598methoxyacetic acidmethoxyacetic acid affects the expression of CDCA7 mRNA20421339
C028577monobutyl phthalatemonobutyl phthalate affects the expression of CDCA7 mRNA20421339
C047806monomethylpropionmonomethylpropion results in increased expression of CDCA7 mRNA22303338
D009151Mustard GasMustard Gas results in decreased expression of CDCA7 mRNA25102026
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CDCA7 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CDCA7 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of CDCA7 mRNA26516004
D017239PaclitaxelPaclitaxel results in decreased expression of CDCA7 mRNA18058816
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of CDCA7 mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of CDCA7 mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in decreased expression of CDCA7 mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of CDCA7 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDCA7 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDCA7 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CDCA7 mRNA18301758|2381119
D011374ProgesteroneProgesterone results in decreased expression of CDCA7 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of CDCA7 mRNA23018184
D011374ProgesteroneProgesterone results in decreased expression of CDCA7 mRNA21795739
D011441PropylthiouracilPropylthiouracil results in increased expression of CDCA7 mRNA24780913
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of CDCA7 mRNA21852083
D012402RotenoneRotenone results in decreased expression of CDCA7 mRNA19013527
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of CDCA7 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CDCA7 mRNA23806026
C016104sodium bichromatesodium bichromate results in increased expression of CDCA7 mRNA22155349
C016104sodium bichromatesodium bichromate affects the expression of CDCA7 mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of CDCA7 mRNA25993096
D013605T-2 ToxinT-2 Toxin results in increased expression of CDCA7 mRNA26141394
D013629TamoxifenTamoxifen affects the expression of CDCA7 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CDCA7 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CDCA7 mRNA21592394
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CDCA7 mRNA]20032058
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDCA7 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDCA7 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDCA7 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDCA7 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDCA7 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of CDCA7 mRNA22378314
D013853ThioacetamideThioacetamide results in increased expression of CDCA7 mRNA22659510|2341159
C009495titanium dioxidetitanium dioxide results in increased expression of CDCA7 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CDCA7 mRNA22363418|2806579
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CDCA7 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CDCA7 mRNA23830798
D014212TretinoinTretinoin affects the expression of CDCA7 mRNA20421339
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDCA7 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CDCA7 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of CDCA7 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CDCA7 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDCA7 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CDCA7 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of CDCA7 mRNA22378314
D014415TunicamycinTunicamycin results in decreased expression of CDCA7 mRNA17127020
D014520UrethaneUrethane results in decreased expression of CDCA7 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDCA7 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CDCA7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CDCA7 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of CDCA7 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of CDCA7 mRNA20421339
D014635Valproic AcidValproic Acid results in decreased expression of CDCA7 mRNA20546886|2142705
D014635Valproic AcidValproic Acid results in decreased expression of CDCA7 mRNA15901671
D014750VincristineVincristine results in decreased expression of CDCA7 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of CDCA7 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of CDCA7 mRNA20044591
C088658zoledronic acidzoledronic acid results in decreased expression of CDCA7 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0042127regulation of cell proliferation-IDA11598121  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11598121  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28355295Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population. (2017)Hong EPPLoS One