Gene: STK40

83931
SHIK|SgK495
serine/threonine kinase 40
protein-coding
1p34.3
Ensembl:ENSG00000196182 MIM:609437 Vega:OTTHUMG00000008238 UniprotKB:Q8N2I9
NC_000001.11
PubMed|SNP Mapped
2   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.043e-2 (AD)  4.720e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4451521chr1:36365663 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11583322chr1:36356711 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP2K30.851
SHMT20.814
NKIRAS20.811
VPS37C0.803
XBP10.803
SESN20.795
LMNB20.782
DNAJB110.779
AEN0.778
ZDHHC180.777

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.52
OR4F29-0.472
OMD-0.304
PDE11A-0.289
CDNF-0.271
CCT6B-0.263
SNX22-0.232
ALDH1L1-AS2-0.22
DIAPH3-0.198
SFTA2-0.198

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of STK40 mRNA28329830
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STK40 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of STK40 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of STK40 mRNA17562736
D001151ArsenicArsenic affects the methylation of STK40 gene25304211
C547126AZM551248AZM551248 results in decreased expression of STK40 mRNA22323515
D001554BenzeneBenzene results in increased expression of STK40 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to STK40 promoter]19654925
C044887beta-methylcholinebeta-methylcholine affects the expression of STK40 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of STK40 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of STK40 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of STK40 mRNA25979313
C018021cobaltous chloridecobaltous chloride results in increased expression of STK40 mRNA24386269
D003042CocaineCocaine affects the expression of STK40 mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of STK40 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of STK40 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of STK40 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of STK40 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of STK40 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of STK40 mRNA18042831
C118739entinostatentinostat results in decreased expression of STK40 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STK40 mRNA22079256
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of STK40 mRNA28329830
C039281furanfuran results in increased methylation of STK40 gene22079235
D005839GentamicinsGentamicins results in decreased expression of STK40 mRNA22061828
D007213IndomethacinIndomethacin results in increased expression of STK40 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of STK40 mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of STK40 mRNA28001369
C570897NSC668394NSC668394 results in increased expression of STK40 mRNA27137931
D000073878Palm OilPalm Oil results in decreased expression of STK40 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of STK40 mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of STK40 mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of STK40 mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STK40 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of STK40 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of STK40 mRNA22714537
D012999SomanSoman results in increased expression of STK40 mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of STK40 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STK40 mRNA18762178
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STK40 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STK40 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of STK40 mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of STK40 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of STK40 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of STK40 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of STK40 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of STK40 mRNA20546886
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of STK40 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of STK40 mRNA18593933
C088658zoledronic acidzoledronic acid results in decreased expression of STK40 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005515protein binding-IPI21784977  25852190  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003016respiratory system process-IEA-  
GO:0005977glycogen metabolic process-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0010468regulation of gene expression-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043408regulation of MAPK cascade-IEA-  
GO:0048286lung alveolus development-IEA-  
GO:0060425lung morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26173551A New Genomewide Association Meta-Analysis of Alcohol Dependence. (2015 Aug)Zuo LAlcohol Clin Exp Res