Gene: HDAC10

83933
HD10
histone deacetylase 10
protein-coding
22q13.33
Ensembl:ENSG00000100429 MIM:608544 Vega:OTTHUMG00000044647 UniprotKB:Q969S8
NG_029758.1
PubMed
0   ANCO-SNPs
ND
1   
5.894e-1 (AD)  8.724e-1 (ND)   (Frontal_Cortex)
7.788e-2 (AD)  7.630e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFRSF250.686
RGS110.661
KLHL170.659
ZNF6920.652
FGF170.651
ZNF4440.645
CDK100.645
CROCC0.639
ADCK50.638
OSBPL70.637

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.348
AGTR1-0.335
OR4F29-0.327
CRNDE-0.319
ZNF84-0.318
ODAM-0.292
ZC3H11B-0.287
NTS-0.286
NMS-0.283
CALCR-0.282

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05015BelinostatSmall Molecule866323-14-0Approved|InvestigationalTarget
DB06603PanobinostatSmall Molecule404950-80-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of HDAC10 mRNA"20702594
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of HDAC10 mRNA"25710175
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HDAC10 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HDAC10 mRNA"21346803
C0163923,3'-diindolylmethane"3,3'-diindolylmethane promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC10 mRNA]"24200994
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HDAC10 mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of HDAC10 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of HDAC10 mRNA17562736
D001280AtrazineAtrazine results in increased expression of HDAC10 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of HDAC10 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HDAC10 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HDAC10 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HDAC10 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of HDAC10 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HDAC10 gene28505145
D000069286BortezomibBortezomib results in decreased expression of HDAC10 mRNA20977926
C018475butyraldehydebutyraldehyde results in decreased expression of HDAC10 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HDAC10 mRNA27396813
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HDAC10 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of HDAC10 mRNA24386269
D003042CocaineCocaine affects the expression of HDAC10 mRNA20187946
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of HDAC10 mRNA23914054
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HDAC10 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HDAC10 mRNA28628672
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HDAC10 mRNA17602206
C031818enterotoxin B, staphylococcal"3,3'-diindolylmethane promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC10 mRNA]"24200994
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in decreased expression of HDAC10 mRNA"24200994
C026098etiracetametiracetam results in decreased expression of HDAC10 mRNA20345932
C029424hydrazinehydrazine results in decreased expression of HDAC10 mRNA15282401
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of HDAC10 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HDAC10 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HDAC10 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HDAC10 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HDAC10 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HDAC10 mRNA23086925
D007854LeadLead results in decreased expression of HDAC10 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HDAC10 mRNA"24972896
D008694MethamphetamineMethamphetamine results in decreased expression of HDAC10 mRNA25452209
D008713MethimazoleMethimazole results in increased expression of HDAC10 mRNA22504374
D008727MethotrexateMethotrexate results in decreased expression of HDAC10 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HDAC10 mRNA23458150
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of HDAC10 mRNA21334430
D011441PropylthiouracilPropylthiouracil results in increased expression of HDAC10 mRNA22504374|2478091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HDAC10 mRNA20702594|2157046
C012589trichostatin Atrichostatin A results in decreased activity of HDAC10 protein25699604
C000602704UF010 compoundUF010 compound results in decreased activity of HDAC10 protein25699604
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HDAC10 gene25560391
C111237vorinostatvorinostat results in decreased activity of HDAC10 protein25699604

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004407histone deacetylase activity-IDA11861901  
GO:0004407histone deacetylase activity-TAS-  
GO:0005515protein binding-IPI17172643  
GO:0019899enzyme binding-IPI11861901  
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)-IEA-  
GO:0033558protein deacetylase activity-IDA17172643  
GO:0042826histone deacetylase binding-IDA11861901  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA11726666  
GO:0006325chromatin organization-NAS11861901  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IDA11861901  
GO:0006476protein deacetylation-IDA17172643  
GO:0014003oligodendrocyte development-IEA-  
GO:0016575histone deacetylation-IDA11861901  
GO:0045892negative regulation of transcription, DNA-templated-IDA11726666  11861901  
GO:0070932histone H3 deacetylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-IDA11861901  
GO:0005634nucleus-IDA11861901  
GO:0005654nucleoplasm-IDA11726666  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA11726666  11861901  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-3214815HDACs deacetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20471694Association of histone deacetylase genes with schizophrenia in Korean population. (2010 Jul 30)Kim TPsychiatry Res