Gene: IMMP2L

83943
IMMP2L-IT1|IMP2|IMP2-LIKE
inner mitochondrial membrane peptidase subunit 2
protein-coding
7q31.1
Ensembl:ENSG00000184903 MIM:605977 Vega:OTTHUMG00000155023 UniprotKB:Q96T52
NG_030016.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.380e-1 (AD)  5.625e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6962665chr7:111309510 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11534045chr7:111295923 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COA10.805
RPA30.792
TIMM90.79
POLB0.79
MRPL220.79
IAH10.783
PGRMC20.78
NIPSNAP3B0.778
RSL24D10.778
SVIP0.777

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.455
OR4F29-0.405
PTGDR2-0.338
MTRNR2L6-0.321
P2RY14-0.306
TTLL10-0.306
MTRNR2L10-0.286
MTRNR2L9-0.285
HIGD1B-0.265
SYPL2-0.253

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of IMMP2L mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of IMMP2L mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IMMP2L protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IMMP2L mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IMMP2L mRNA19770486
C103505AM 251AM 251 results in increased expression of IMMP2L mRNA16500647
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of IMMP2L mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IMMP2L mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IMMP2L mRNA19770486|2071347
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IMMP2L mRNA"26238291
D004958Estradiol[Dieldrin co-treated with Estradiol] results in increased expression of IMMP2L mRNA23041725
D004958EstradiolEstradiol results in decreased expression of IMMP2L mRNA19484750
C006780bisphenol Abisphenol A affects the expression of IMMP2L mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of IMMP2L mRNA26063408
D002220CarbamazepineCarbamazepine affects the expression of IMMP2L mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of IMMP2L mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of IMMP2L mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of IMMP2L mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of IMMP2L mRNA]27941970
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of IMMP2L mRNA26873546
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of IMMP2L mRNA27392435
D002945CisplatinCisplatin results in decreased expression of IMMP2L mRNA27392435|2759478
D002945CisplatinCisplatin results in decreased expression of IMMP2L mRNA25270620
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in increased expression of IMMP2L mRNA23041725
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of IMMP2L mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of IMMP2L mRNA26873546
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of IMMP2L mRNA23649840
D005485FlutamideFlutamide results in decreased expression of IMMP2L mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of IMMP2L mRNA23649840
D017313FenretinideFenretinide results in decreased expression of IMMP2L mRNA28973697
C492448ICG 001ICG 001 results in increased expression of IMMP2L mRNA26191083
C051890irinotecanirinotecan analog results in decreased expression of IMMP2L mRNA18927307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of IMMP2L mRNA27392435
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of IMMP2L mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of IMMP2L mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IMMP2L mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IMMP2L mRNA"20188158
D009151Mustard GasMustard Gas results in decreased expression of IMMP2L mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IMMP2L mRNA"25554681
C006253pirinixic acidpirinixic acid results in increased expression of IMMP2L mRNA23811191
C016104sodium bichromatesodium bichromate results in decreased expression of IMMP2L mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IMMP2L mRNA21570461
C009495titanium dioxidetitanium dioxide affects the expression of IMMP2L mRNA23557971
D014520UrethaneUrethane results in increased expression of IMMP2L mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IMMP2L gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008233peptidase activity-ISS15814844  
GO:0008236serine-type peptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001541ovarian follicle development-IEA-  
GO:0006627protein processing involved in protein targeting to mitochondrion-IBA21873635  
GO:0006627protein processing involved in protein targeting to mitochondrion-ISS15814844  
GO:0006801superoxide metabolic process-IEA-  
GO:0006974cellular response to DNA damage stimulus-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0007420brain development-IEA-  
GO:0008015blood circulation-IEA-  
GO:0022904respiratory electron transport chain-IEA-  
GO:0030728ovulation-IEA-  
GO:0033108mitochondrial respiratory chain complex assembly-IBA21873635  
GO:0061300cerebellum vasculature development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0042720mitochondrial inner membrane peptidase complex-IBA21873635  
GO:0042720mitochondrial inner membrane peptidase complex-ISS15814844  
KEGG ID KEGG Term
hsa03060Protein export
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal