Gene info: ID 8398

Gene: PLA2G6

GENE ID: 8398

Description: phospholipase A2 group VI

Gene type: protein-coding

Location: 22q13.1

dbXrefs: Ensembl:ENSG00000184381 MIM:603604 Vega:OTTHUMG00000151246 UniprotKB:O60733

RefSeq: NG_007094.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.653e-1 (AD) 1.039e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABCB8	0.89
TECPR2	0.884
FAM171A1	0.875
NACAD	0.873
PPP1R3E	0.873
SMPD1	0.872
SH2B1	0.872
TOM1L2	0.871
GNAO1	0.868
TBC1D17	0.867

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.541
TFPI2	-0.51
OR4F29	-0.5
GSDMA	-0.468
SUCNR1	-0.467
PABPC4L	-0.456
ARHGEF35	-0.455
SIX1	-0.453
C9orf135	-0.449
DPPA4	-0.441

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01103	Quinacrine	Small Molecule	83-89-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PLA2G6 mRNA"	19850644
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PLA2G6 mRNA]"	19850644
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PLA2G6 mRNA"	27291303
C447028	2,2',4,6-tetrachlorobiphenyl	"PLA2G6 protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid]"	16120751
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PLA2G6 mRNA"	21851831
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PLA2G6 mRNA]"	21851831
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PLA2G6 mRNA"	21346803
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to PLA2G6 protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PLA2G6 protein]	26598702
C029370	4-toluidine	4-toluidine results in increased expression of PLA2G6 mRNA	27638505
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of PLA2G6 mRNA	20829426
C068314	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium]	21178110
C068314	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one results in decreased activity of PLA2G6 protein	16436530\|2117811
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PLA2G6 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PLA2G6 mRNA	16483693
D016718	Arachidonic Acid	"PLA2G6 protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid]"	16120751
D001151	Arsenic	Arsenic affects the methylation of PLA2G6 gene	25304211
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PLA2G6 protein]	26598702
D001241	Aspirin	Aspirin results in increased expression of PLA2G6 mRNA	11906190
C547126	AZM551248	AZM551248 results in decreased expression of PLA2G6 mRNA	22323515
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of PLA2G6 mRNA	26377693
D001554	Benzene	Benzene results in decreased expression of PLA2G6 mRNA	17905399
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PLA2G6 mRNA	21715664
C006780	bisphenol A	bisphenol A affects the expression of PLA2G6 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of PLA2G6 mRNA	25181051
D002104	Cadmium	Cadmium results in increased expression of PLA2G6 mRNA	25808797
D002118	Calcium	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium]	21178110
D002118	Calcium	Calcium deficiency results in increased activity of PLA2G6 protein	17885217
D002118	Calcium	[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium	21178110
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of PLA2G6 mRNA	28472532
D002994	Clofibrate	Clofibrate results in increased expression of PLA2G6 mRNA	23811191
D003042	Cocaine	Cocaine affects the expression of PLA2G6 mRNA	20187946
D003300	Copper	Copper results in decreased expression of PLA2G6 mRNA	22465980
C093628	cyproconazole	cyproconazole results in increased expression of PLA2G6 mRNA	22334560
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of PLA2G6 mRNA	23640034
D003976	Diazinon	Diazinon results in decreased expression of PLA2G6 mRNA	21968025
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of PLA2G6 mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in decreased expression of PLA2G6 mRNA	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of PLA2G6 mRNA	19850644
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of PLA2G6 mRNA	27638505
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of PLA2G6 mRNA	26924002
C109476	epoxiconazole	epoxiconazole results in increased expression of PLA2G6 mRNA	22334560
D005485	Flutamide	Flutamide results in increased expression of PLA2G6 mRNA	24136188
C069837	fullerene C60	fullerene C60 results in increased expression of PLA2G6 mRNA	19167457
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in increased expression of PLA2G6 mRNA	19695318
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PLA2G6 mRNA	20044591
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of PLA2G6 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of PLA2G6 mRNA	27392435
C057416	KT 5720	KT 5720 inhibits the reaction [UCN protein results in decreased expression of PLA2G6 protein]	17885217
D008070	Lipopolysaccharides	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium]	21178110
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein	21178110
D008070	Lipopolysaccharides	[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium	21178110
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PLA2G6 mRNA"	20188158
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PLA2G6 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PLA2G6 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PLA2G6 mRNA"	25620056
C028007	nickel monoxide	nickel monoxide results in increased expression of PLA2G6 mRNA	19167457
D000073878	Palm Oil	Palm Oil results in decreased expression of PLA2G6 mRNA	18042831
C016030	pantogab	pantogab results in increased expression of PLA2G6 mRNA	17379144
C046012	pentanal	pentanal results in decreased expression of PLA2G6 mRNA	26079696
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PLA2G6 mRNA	17681415
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PLA2G6 mRNA]	19482888
D010634	Phenobarbital	NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of PLA2G6 mRNA]	19850644
D010634	Phenobarbital	Phenobarbital affects the expression of PLA2G6 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of PLA2G6 mRNA	19482888\|1985064
D010656	Phenylephrine	PLA2G6 protein affects the susceptibility to Phenylephrine	17885217
C006253	pirinixic acid	pirinixic acid results in increased expression of PLA2G6 mRNA	17426115\|1830175
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of PLA2G6 mRNA]	19850644
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of PLA2G6 mRNA]	20059764
C006253	pirinixic acid	pirinixic acid results in increased expression of PLA2G6 mRNA	19162173
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in increased expression of PLA2G6 mRNA	19695318
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of PLA2G6 mRNA	28903501
C045950	propiconazole	propiconazole results in increased expression of PLA2G6 mRNA	22334560
C059514	resveratrol	resveratrol results in increased expression of PLA2G6 mRNA	15767336
D012524	Sarin	Sarin results in increased expression of PLA2G6 mRNA	19522546
D014284	Triiodothyronine	Triiodothyronine results in increased expression of PLA2G6 mRNA	15953391
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PLA2G6 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	"Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PLA2G6 mRNA]"	21851831
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PLA2G6 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PLA2G6 mRNA	19465110\|2629044
D019284	Thapsigargin	PLA2G6 mutant form inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]	25762722
D019284	Thapsigargin	PLA2G6 protein affects the susceptibility to Thapsigargin	17885217
D019284	Thapsigargin	Thapsigargin results in increased activity of PLA2G6 protein	17885217
D019284	Thapsigargin	Thapsigargin results in increased expression of PLA2G6 protein	25762722
D019284	Thapsigargin	UCN protein inhibits the reaction [Thapsigargin results in increased activity of PLA2G6 protein]	17885217
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of PLA2G6 mRNA	19969065
C057693	troglitazone	troglitazone results in decreased expression of PLA2G6 mRNA	12732648
C057693	troglitazone	[troglitazone co-treated with TNF protein] results in decreased expression of PLA2G6 mRNA	12732648
D014635	Valproic Acid	Valproic Acid results in increased methylation of PLA2G6 gene	29154799
C025643	vinclozolin	vinclozolin results in decreased expression of PLA2G6 mRNA	23555832
D014873	Water Pollutants	Water Pollutants results in increased expression of PLA2G6 mRNA	23591932

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004623	phospholipase A2 activity	-	TAS	-
GO:0005516	calmodulin binding	-	IEA	-
GO:0016787	hydrolase activity	-	TAS	-
GO:0017171	serine hydrolase activity	-	IEA	-
GO:0019901	protein kinase binding	-	IEA	-
GO:0043008	ATP-dependent protein binding	-	IEA	-
GO:0047499	calcium-independent phospholipase A2 activity	-	IEA	-
GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)	-	IEA	-
GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	IEA	-
GO:0006935	chemotaxis	-	IEA	-
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IEA	-
GO:0007613	memory	-	IEA	-
GO:0014832	urinary bladder smooth muscle contraction	-	IEA	-
GO:0016042	lipid catabolic process	-	IEA	-
GO:0019731	antibacterial humoral response	-	IDA	18714013
GO:0032049	cardiolipin biosynthetic process	-	IMP	19164547
GO:0034976	response to endoplasmic reticulum stress	-	IEA	-
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	-	IEA	-
GO:0036151	phosphatidylcholine acyl-chain remodeling	-	TAS	-
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	-	TAS	-
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0045921	positive regulation of exocytosis	-	IEA	-
GO:0051967	negative regulation of synaptic transmission, glutamatergic	-	IEA	-
GO:0060135	maternal process involved in female pregnancy	-	IEA	-
GO:0090037	positive regulation of protein kinase C signaling	-	IEA	-
GO:0090200	positive regulation of release of cytochrome c from mitochondria	-	IEA	-
GO:0090238	positive regulation of arachidonic acid secretion	-	IEA	-
GO:0097755	positive regulation of blood vessel diameter	-	IEA	-
GO:1901339	regulation of store-operated calcium channel activity	-	IEA	-
GO:2000304	positive regulation of ceramide biosynthetic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IDA	18714013
GO:0005739	mitochondrion	-	IEA	-
GO:0005815	microtubule organizing center	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0016020	membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00564	Glycerophospholipid metabolism
hsa00565	Ether lipid metabolism
hsa00590	Arachidonic acid metabolism
hsa00591	Linoleic acid metabolism
hsa00592	alpha-Linolenic acid metabolism
hsa01100	Metabolic pathways
hsa04010	MAPK signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04370	VEGF signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04730	Long-term depression
hsa04912	GnRH signaling pathway
hsa04972	Pancreatic secretion
hsa04975	Fat digestion and absorption
hsa05145	Toxoplasmosis

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-1482788	Acyl chain remodelling of PC	TAS
R-HSA-1482798	Acyl chain remodeling of CL	IEA
R-HSA-1482839	Acyl chain remodelling of PE	TAS
R-HSA-1483206	Glycerophospholipid biosynthesis	IEA
R-HSA-1483206	Glycerophospholipid biosynthesis	TAS
R-HSA-1483257	Phospholipid metabolism	IEA
R-HSA-1483257	Phospholipid metabolism	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029485	Role of phospholipids in phagocytosis	TAS
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS
R-HSA-8856688	Golgi-to-ER retrograde transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27602958	Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms. (2016 Oct 25)	Freeman JR	Oncotarget