Gene: REG4

83998
GISP|REG-IV|RELP
regenerating family member 4
protein-coding
1p12
Ensembl:ENSG00000134193 MIM:609846 Vega:OTTHUMG00000012175 UniprotKB:Q9BYZ8
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.438e-1 (AD)  8.530e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UGT2A30.651
OR4S20.647
SPATA31D10.645
OR10K20.638
OR4L10.635
OR6Y10.635
TSSK1B0.633
OR10G30.631
TAAR20.629
OR10H30.628

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNG1-0.342
ATP2C2-0.335
PLD6-0.332
PNMA5-0.332
FUT9-0.326
CCNF-0.325
GRM1-0.325
LRRN2-0.322
ANO3-0.321
BTBD9-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the methylation of REG4 gene25304211
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of REG4 mRNA18164116
C006780bisphenol Abisphenol A results in decreased expression of REG4 mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of REG4 mRNA28472532
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of REG4 mRNA20971185
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of REG4 mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of REG4 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of REG4 mRNA18457598
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of REG4 mRNA18164116
C118739entinostatentinostat results in increased expression of REG4 mRNA27188386
D005472FluorouracilREG4 protein results in decreased susceptibility to Fluorouracil17237819
D004397FonofosFonofos results in increased methylation of REG4 promoter22847954
C039281furanfuran results in increased expression of REG4 mRNA27387713
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of REG4 mRNA20044591
C016517indole-3-carbinolindole-3-carbinol affects the expression of REG4 mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of REG4 mRNA26752646
D008727MethotrexateMethotrexate affects the expression of REG4 mRNA18502557
C517284monomethyl phthalatemonomethyl phthalate affects the expression of REG4 mRNA26924002
C500085muraglitazarmuraglitazar results in decreased expression of REG4 mRNA21515302
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of REG4 mRNA20971185
D010278ParathionParathion results in increased methylation of REG4 promoter22847954
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of REG4 mRNA23602845
C005556propionaldehydepropionaldehyde results in decreased expression of REG4 mRNA26079696
C089730rosiglitazonerosiglitazone results in decreased expression of REG4 mRNA21515302
C016104sodium bichromatesodium bichromate results in increased expression of REG4 mRNA22561333
C012568terbufosterbufos results in increased methylation of REG4 promoter22847954
C501413tesaglitazartesaglitazar results in decreased expression of REG4 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of REG4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of REG4 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of REG4 mRNA21724226
C057693troglitazonetroglitazone results in decreased expression of REG4 mRNA21515302
D001335Vehicle EmissionsVehicle Emissions affects the methylation of REG4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005509calcium ion bindingNOTIDA20692269  
GO:0008201heparin binding-IDA20692269  
GO:2001065mannan binding-IBA21873635  
GO:2001065mannan binding-IDA20692269  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005737cytoplasm-IDA12819006  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19434873[Pancreatic tumors]. (2008 Oct)Iglesias-Garcia JGastroenterol Hepatol