Gene: OBSCN

84033
ARHGEF30|UNC89
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
protein-coding
1q42.13
Ensembl:ENSG00000154358 MIM:608616 Vega:OTTHUMG00000039772 UniprotKB:Q5VST9
NG_032122.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.813e-1 (AD)  8.595e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11578798chr1:228355602 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00270521chr1:228503273OBSCNGene body1.296e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM120B0.735
STRIP20.727
CCDC88C0.704
LRRC560.702
TRIM170.7
WNT10.698
ANKRD630.686
ASCL50.68
ATG9B0.679
ACE0.674

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTNNA3-0.343
SGMS2-0.333
MYOT-0.333
FXYD4-0.322
RBP7-0.312
ZFP57-0.311
TGFB3-0.31
TMEM139-0.309
ROM1-0.308
FAM107B-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide affects the expression of OBSCN mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OBSCN mRNA16483693
D001151ArsenicArsenic affects the methylation of OBSCN gene25304211
D001280AtrazineAtrazine results in decreased expression of OBSCN mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OBSCN mRNA26001963
C006780bisphenol Abisphenol A results in decreased expression of OBSCN mRNA25181051|2717856
D000069286BortezomibBortezomib results in decreased expression of OBSCN mRNA20977926
D003042CocaineCocaine affects the expression of OBSCN mRNA20187946
D003471CuprizoneCuprizone results in increased expression of OBSCN mRNA26577399
D016572CyclosporineCyclosporine results in decreased methylation of OBSCN promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of OBSCN mRNA23914054
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of OBSCN mRNA28085963
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of OBSCN mRNA20360939
D002117CalcitriolCalcitriol results in increased expression of OBSCN mRNA26485663
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of OBSCN mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OBSCN mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of OBSCN mRNA27776689
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of OBSCN mRNA17183730
D008694MethamphetamineMethamphetamine results in increased expression of OBSCN mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of OBSCN mRNA23103053
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of OBSCN mRNA"29244179
C028007nickel monoxidenickel monoxide results in increased expression of OBSCN mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of OBSCN mRNA27935865
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of OBSCN mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of OBSCN mRNA19482888
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of OBSCN mRNA27935865
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of OBSCN mRNA25895662
D018038Sodium SeleniteSodium Selenite results in increased expression of OBSCN mRNA18175754
D053260SootSoot results in increased expression of OBSCN mRNA26551751
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OBSCN mRNA17942748
C009495titanium dioxidetitanium dioxide results in decreased expression of OBSCN mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of OBSCN mRNA20133372
D014241TrichloroethyleneTrichloroethylene results in decreased expression of OBSCN mRNA28973375
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of OBSCN mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of OBSCN mRNA17183730
D014635Valproic AcidValproic Acid results in increased methylation of OBSCN gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of OBSCN gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI11448995  12527750  16962094  20133654  20489725  23414517  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0008307structural constituent of muscle-NAS11717165  
GO:0030506ankyrin binding-IPI18782775  
GO:0031432titin binding-IPI11717165  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007275multicellular organism development-IEA-  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0036309protein localization to M-band-ISS18782775  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0045214sarcomere organization-TAS18782775  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016604nuclear body-IDA-  
GO:0030016myofibril-NAS11717165  
GO:0030018Z disc-ISS11717165  
GO:0031430M band-ISS11717165  18782775  
GO:0042383sarcolemma-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal