Gene: EMILIN2

84034
EMILIN-2|FOAP-10
elastin microfibril interfacer 2
protein-coding
18p11.32-p11.31
Ensembl:ENSG00000132205 MIM:608928 Vega:OTTHUMG00000128525 UniprotKB:Q9BXX0
NC_000018.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.153e-1 (AD)  2.197e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LILRB20.831
TRPV40.818
TFPI0.816
PLEKHG20.799
TFPI20.798
PARP150.791
ALPK10.785
MAP3K80.782
SLC26A20.779
SPTLC30.778

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.513
NEUROD6-0.504
KCNA2-0.496
FUT9-0.487
ST6GALNAC5-0.473
CDS1-0.473
LRTM2-0.472
KCNB2-0.472
EXTL1-0.463
SVOP-0.462

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of EMILIN2 mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EMILIN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EMILIN2 mRNA"27188386
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EMILIN2 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EMILIN2 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of EMILIN2 mRNA24449571
D001151ArsenicArsenic affects the methylation of EMILIN2 gene25304211
C015001arsenitearsenite results in increased methylation of EMILIN2 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EMILIN2 mRNA21569818|2222880
D004958EstradiolEstradiol results in increased expression of EMILIN2 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of EMILIN2 mRNA26063408
C018475butyraldehydebutyraldehyde results in increased expression of EMILIN2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of EMILIN2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EMILIN2 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EMILIN2 mRNA24982889
D002737ChloropreneChloroprene results in decreased expression of EMILIN2 mRNA23125180
D004390Chlorpyrifos[nickel chloride co-treated with Chlorpyrifos] affects the expression of EMILIN2 mRNA21496282
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EMILIN2 mRNA20938992
D003033Coal TarCoal Tar results in increased expression of EMILIN2 mRNA27858113
D019327Copper SulfateCopper Sulfate results in decreased expression of EMILIN2 mRNA19549813
D003907DexamethasoneDexamethasone results in increased expression of EMILIN2 mRNA25047013
D002945CisplatinCisplatin results in increased expression of EMILIN2 mRNA27594783
D002945CisplatinCisplatin results in increased expression of EMILIN2 mRNA21151649
D004041Dietary FatsDietary Fats results in decreased expression of EMILIN2 mRNA18042831
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EMILIN2 mRNA22129741
D004237DiuronDiuron results in decreased expression of EMILIN2 mRNA25152437
C118739entinostatentinostat results in increased expression of EMILIN2 mRNA27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EMILIN2 mRNA20938992
D005839GentamicinsGentamicins results in decreased expression of EMILIN2 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of EMILIN2 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of EMILIN2 mRNA26191083
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EMILIN2 mRNA22129741
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EMILIN2 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EMILIN2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EMILIN2 mRNA"20188158
C523799MRK 003EMILIN2 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of EMILIN2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EMILIN2 mRNA"25554681
D009532NickelNickel results in increased expression of EMILIN2 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of EMILIN2 mRNA21496282
C022838nickel chloride[nickel chloride co-treated with Chlorpyrifos] affects the expression of EMILIN2 mRNA21496282
C028007nickel monoxidenickel monoxide results in increased expression of EMILIN2 mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of EMILIN2 mRNA18042831
C046012pentanalpentanal results in increased expression of EMILIN2 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of EMILIN2 mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EMILIN2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EMILIN2 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of EMILIN2 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of EMILIN2 mRNA22698814
D012822Silicon DioxideSilicon Dioxide results in increased expression of EMILIN2 mRNA23221170
D053260SootSoot results in increased expression of EMILIN2 mRNA22461453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EMILIN2 mRNA21570461
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of EMILIN2 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of EMILIN2 mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of EMILIN2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of EMILIN2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of EMILIN2 mRNA24896083
C029297vinylidene chloridevinylidene chloride results in increased expression of EMILIN2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11278945  
GO:0030023extracellular matrix constituent conferring elasticity-NAS11278945  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0008150biological_process-ND-  
GO:0010811positive regulation of cell-substrate adhesion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA11278945  
GO:0005581collagen trimer-IEA-  
GO:0031012extracellular matrix-HDA23658023  
GO:0031012extracellular matrix-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-1566948Elastic fibre formationIEA
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-2129379Molecules associated with elastic fibresIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24398667Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers. (2014 Jun)Tessema MCarcinogenesis