Gene: SPARCL1

8404
MAST 9|MAST9|PIG33|SC1
SPARC like 1
protein-coding
4q22.1
Ensembl:ENSG00000152583 MIM:606041 Vega:OTTHUMG00000130605 UniprotKB:Q14515
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.958e-2 (AD)  7.481e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM213A0.929
TSPAN70.922
TSPAN30.914
PSAP0.911
ATPAF10.91
GPM6A0.91
CPE0.906
ADD10.905
LDHB0.904
SCG30.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.846
OR4F29-0.816
GZMK-0.227
HAS2-0.225
SLAMF6-0.215
EOMES-0.21
GZMA-0.21
KLF17-0.208
CD8B-0.208
C17orf112-0.207

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SPARCL1 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SPARCL1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SPARCL1 mRNA"20959002
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SPARCL1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SPARCL1 mRNA22100608|2715375
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SPARCL1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SPARCL1 mRNA16483693
D001151ArsenicArsenic affects the methylation of SPARCL1 gene25304211
D001205Ascorbic AcidAscorbic Acid results in increased expression of SPARCL1 mRNA15305145
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SPARCL1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SPARCL1 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPARCL1 mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SPARCL1 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of SPARCL1 mRNA20106945
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of SPARCL1 mRNA17404688
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SPARCL1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SPARCL1 mRNA25181051|2757113
D001761BleomycinBleomycin results in decreased expression of SPARCL1 protein25933445
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SPARCL1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SPARCL1 mRNA17484886
C054133casticincasticin results in increased expression of SPARCL1 mRNA28444820
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPARCL1 mRNA20938992
C031180chrysenechrysene results in increased expression of SPARCL1 mRNA26377693
D003042CocaineCocaine affects the expression of SPARCL1 mRNA20187946
D016572CyclosporineCyclosporine results in decreased expression of SPARCL1 mRNA20106945
D013759DronabinolDronabinol results in increased expression of SPARCL1 mRNA11015613
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SPARCL1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SPARCL1 mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SPARCL1 mRNA28962523
D004041Dietary FatsDietary Fats affects the expression of SPARCL1 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of SPARCL1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SPARCL1 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of SPARCL1 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SPARCL1 mRNA"19480007
D004237DiuronDiuron results in increased expression of SPARCL1 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SPARCL1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPARCL1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SPARCL1 mRNA15576828|1735126
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SPARCL1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPARCL1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of SPARCL1 mRNA23649840
D019833GenisteinGenistein results in decreased methylation of SPARCL1 gene28505145
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of SPARCL1 mRNA22634610
C010176halofuginonehalofuginone results in increased expression of SPARCL1 mRNA17180598
D017313FenretinideFenretinide results in increased expression of SPARCL1 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of SPARCL1 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SPARCL1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SPARCL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SPARCL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SPARCL1 mRNA28628672
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of SPARCL1 protein17337753
D007854LeadLead affects the expression of SPARCL1 mRNA28903495
C045463leflunomideleflunomide results in increased expression of SPARCL1 mRNA24136188
D008094LithiumLithium affects the localization of SPARCL1 protein18488994
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPARCL1 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of SPARCL1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SPARCL1 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SPARCL1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SPARCL1 mRNA"25620056
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SPARCL1 mRNA27935865
D000073878Palm OilPalm Oil affects the expression of SPARCL1 mRNA19680557
D000073878Palm OilPalm Oil results in increased expression of SPARCL1 mRNA18042831
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of SPARCL1 mRNA26705709
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SPARCL1 mRNA24535843
D010862PilocarpinePilocarpine affects the localization of SPARCL1 protein18488994
D010862PilocarpinePilocarpine results in decreased expression of SPARCL1 protein18808451
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SPARCL1 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SPARCL1 mRNA19710929
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SPARCL1 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SPARCL1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of SPARCL1 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of SPARCL1 mRNA17404688|2086464
D011441PropylthiouracilPropylthiouracil results in decreased expression of SPARCL1 mRNA18077114
C010313pseudocumenepseudocumene results in increased expression of SPARCL1 protein17337753
C089730rosiglitazonerosiglitazone results in decreased expression of SPARCL1 mRNA25572481
C009277sodium arsenatesodium arsenate results in increased expression of SPARCL1 mRNA21795629
C013698tallowtallow affects the expression of SPARCL1 mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPARCL1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPARCL1 mRNA20106945
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPARCL1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SPARCL1 mRNA20959002
C009495titanium dioxidetitanium dioxide affects the expression of SPARCL1 mRNA17656681
D014212TretinoinTretinoin results in decreased expression of SPARCL1 mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SPARCL1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of SPARCL1 mRNA25572481
C057693troglitazonetroglitazone results in decreased expression of SPARCL1 mRNA28973697
C022884undecaneundecane results in increased expression of SPARCL1 protein17337753
D014635Valproic AcidValproic Acid affects the expression of SPARCL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SPARCL1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of SPARCL1 mRNA24383497
D014640VancomycinVancomycin results in decreased expression of SPARCL1 mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of SPARCL1 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005515protein binding-IPI20926826  
GO:0005518collagen binding-IBA21873635  
GO:0050840extracellular matrix binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0048856anatomical structure development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24921089Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease. (2014 Jul 15)Sato TInt J Cancer