Gene: ULK1

8408
ATG1|ATG1A|UNC51|Unc51.1|hATG1
unc-51 like autophagy activating kinase 1
protein-coding
12q24.33
Ensembl:ENSG00000177169 MIM:603168 Vega:OTTHUMG00000168052 UniprotKB:O75385
NC_000012.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.448e-1 (AD)  1.814e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21649013chr12:132381683ULK1Gene body5.323e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCDN0.95
NISCH0.932
PHYHIP0.928
ARHGEF170.923
MARK40.917
LZTS30.917
CPNE50.914
LMTK30.914
PPP2R5D0.914
TEF0.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.585
OR4F29-0.54
TFPI2-0.432
RAI14-0.405
KLRB1-0.397
C9orf135-0.391
FZD10-0.39
MYL3-0.382
SGMS2-0.379
COPZ2-0.378

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of ULK1 protein"27629431
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ULK1 mRNA"28903501
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ULK1 mRNA16788091
C0259463-methyladenine"3-methyladenine affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ULK1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Oligomycins results in increased expression of ULK1 mRNA]"27629431
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Oligomycins results in increased expression of ULK1 protein]"27629431
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of ULK1 protein"27629431
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Ethanol results in decreased phosphorylation of ULK1 protein]"23448468
D000082AcetaminophenAcetaminophen results in decreased expression of ULK1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of ULK1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ULK1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein]27106530
D000841AnisomycinAnisomycin results in decreased expression of ULK1 protein27629431
D000924Anticholesteremic AgentsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ULK1 mRNA]28275691
D000968Antimycin AAntimycin A inhibits the reaction [Cycloheximide results in decreased expression of ULK1 protein]27629431
D000968Antimycin AAntimycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]27629431
D000968Antimycin AAntimycin A promotes the reaction [ATG13 protein results in increased expression of ULK1 protein]27629431
D000968Antimycin AAntimycin A results in increased expression of ULK1 mRNA27629431
D000968Antimycin AAntimycin A results in increased expression of ULK1 protein27629431
D000968Antimycin AATG13 protein promotes the reaction [Antimycin A results in increased expression of ULK1 protein]27629431
D000968Antimycin ACycloheximide inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]27629431
D000968Antimycin ANitrogen deficiency inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]27629431
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ULK1 mRNA24449571
D001151ArsenicArsenic affects the expression of ULK1 mRNA25304211
D001151ArsenicArsenic affects the methylation of ULK1 gene25304211
D001280AtrazineAtrazine results in increased expression of ULK1 mRNA25929836
C057620bafilomycin AATG13 protein promotes the reaction [bafilomycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]]27629431
C057620bafilomycin AATG7 protein promotes the reaction [bafilomycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]]27629431
C057620bafilomycin Abafilomycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]27629431
C040929bafilomycin A1"bafilomycin A1 affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ULK1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ULK1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ULK1 mRNA22300585
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]27629431
D004958EstradiolEstradiol results in increased expression of ULK1 mRNA15757668
C044887beta-methylcholinebeta-methylcholine affects the expression of ULK1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased phosphorylation of ULK1 protein26139607
C006780bisphenol Abisphenol A results in increased expression of ULK1 mRNA25181051
D002065BuspironeBuspirone results in increased expression of ULK1 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of ULK1 mRNA26079696
D002104CadmiumCadmium results in increased expression of ULK1 mRNA27492225
D002246Carbon DisulfideCarbon Disulfide results in increased expression of ULK1 protein24887698
D002246Carbon DisulfideCarbon Disulfide results in increased phosphorylation of ULK1 protein27530093
D002922CiguatoxinsCiguatoxins affects the expression of ULK1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of ULK1 mRNA17585979|2381119
C018021cobaltous chloridecobaltous chloride results in increased expression of ULK1 mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in increased expression of ULK1 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of ULK1 mRNA19549813
C102326cucurbitacin EAcetylcysteine inhibits the reaction [cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein]27106530
C102326cucurbitacin Ecucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein27106530
D003513CycloheximideAntimycin A inhibits the reaction [Cycloheximide results in decreased expression of ULK1 protein]27629431
D003513CycloheximideCycloheximide inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]27629431
D003513CycloheximideCycloheximide results in decreased expression of ULK1 protein27629431
D016572CyclosporineCyclosporine results in increased expression of ULK1 mRNA25562108
C017160cypermethrincypermethrin results in increased expression of ULK1 mRNA27704156
D013759DronabinolDronabinol results in decreased expression of ULK1 mRNA16616335
D003907DexamethasoneDexamethasone results in decreased expression of ULK1 mRNA25047013
D004041Dietary FatsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ULK1 mRNA]28275691
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ULK1 mRNA28275691
D004041Dietary FatsDietary Fats results in decreased expression of ULK1 mRNA18042831
D019422Dietary SucroseAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ULK1 mRNA]28275691
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ULK1 mRNA28275691
D002117CalcitriolCalcitriol results in increased expression of ULK1 mRNA16002434
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of ULK1 mRNA24690739
C007590emulphogene BC 720emulphogene BC 720 results in increased expression of ULK1 mRNA25398874
D000431EthanolEthanol results in decreased expression of ULK1 mRNA29018328
D000431EthanolEthanol results in increased expression of and results in decreased phosphorylation of ULK1 protein23448468
D000431EthanolEthanol results in increased expression of ULK1 mRNA24095927
D000431EthanolFOXO3 gene mutant form inhibits the reaction [Ethanol results in increased expression of ULK1 mRNA]24095927
D000431EthanolPRKAA2 protein affects the reaction [Ethanol results in increased expression of ULK1 protein]23448468
D000431Ethanol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Ethanol results in decreased phosphorylation of ULK1 protein]"23448468
D000431EthanolEthanol results in decreased phosphorylation of ULK1 protein23448468
C069837fullerene C60fullerene C60 results in increased expression of ULK1 mRNA19167457
C056933fumonisin B1fumonisin B1 results in decreased expression of ULK1 mRNA16221962
D005839GentamicinsGentamicins results in decreased expression of ULK1 mRNA22061828
D005947Glucose"3-methyladenine affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
D005947Glucose"bafilomycin A1 affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
D005947GlucoseGlucose affects the phosphorylation of ULK1 protein29128638
D005947Glucose"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]"29128638
D005947Glucose"Sirolimus affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
D005947GlucoseULK1 protein affects the reaction [Glucose affects the phosphorylation of ULK1 protein]29128638
D005947GlucoseULK1 protein affects the reaction [Glucose results in decreased expression of ATG5 protein]29128638
D005947GlucoseULK1 protein affects the reaction [Glucose results in decreased expression of MAP1LC3B protein]29128638
D005947GlucoseULK1 protein affects the reaction [Glucose results in increased expression of SQSTM1 protein]29128638
D005947Glucose"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
D005947Glucose"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
D005947Glucose"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]]"29128638
D005947Glucose"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]]"29128638
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ULK1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ULK1 mRNA24796395
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ULK1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ULK1 mRNA25613284
C412811maslinic acid[maslinic acid analog co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of ULK1 protein26513295
C030667methylazoxymethanolmethylazoxymethanol results in increased expression of ULK1 mRNA17107856
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ULK1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ULK1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ULK1 mRNA25680463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ULK1 protein25680463
D0156551-Methyl-4-phenylpyridiniumULK1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of RPS6KB1 protein]25680463
D0156551-Methyl-4-phenylpyridinium[ULK1 protein results in decreased phosphorylation of RPS6KB1 protein] which results in increased susceptibility to 1-Methyl-4-phenylpyridinium25680463
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ULK1 mRNA22401849
C030517myxothiazolmyxothiazol results in increased expression of ULK1 protein27629431
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"3-methyladenine affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"bafilomycin A1 affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"Sirolimus affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]]"29128638
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ULK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ULK1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of ULK1 mRNA19167457
D009584NitrogenAntimycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]27629431
D009584NitrogenATG13 protein inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]27629431
D009584NitrogenATG13 protein promotes the reaction [bafilomycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]]27629431
D009584NitrogenATG7 protein inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]27629431
D009584NitrogenATG7 protein promotes the reaction [bafilomycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]]27629431
D009584Nitrogenbafilomycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]27629431
D009584Nitrogenbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]27629431
D009584NitrogenNitrogen deficiency inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]27629431
D009584NitrogenNitrogen deficiency inhibits the reaction [ATG13 protein results in increased expression of ULK1 protein]27629431
D009584NitrogenNitrogen deficiency results in decreased expression of and results in decreased phosphorylation of and results in increased cleavage of and affects the localization of ULK1 protein27629431
D009584NitrogenNitrogen deficiency results in increased expression of ULK1 mRNA27629431
C010615Nonidet P-40Nonidet P-40 results in decreased expression of ULK1 mRNA26552463
C018620oleoresinsoleoresins results in increased expression of ULK1 mRNA20008804
D009840Oligomycins"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Oligomycins results in increased expression of ULK1 mRNA]"27629431
D009840Oligomycins"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Oligomycins results in increased expression of ULK1 protein]"27629431
D009840OligomycinsOligomycins results in increased expression of ULK1 mRNA27629431
D009840OligomycinsOligomycins results in increased expression of ULK1 protein27629431
D010126OzoneOzone results in increased expression of ULK1 mRNA27206323
D000073878Palm OilPalm Oil results in decreased expression of ULK1 mRNA18042831
D010269ParaquatParaquat results in decreased phosphorylation of ULK1 protein25092649|2724669
D010269ParaquatParaquat results in increased phosphorylation of ULK1 protein25092649
D010269ParaquatTLR4 protein affects the reaction [Paraquat results in decreased phosphorylation of ULK1 protein]27246695
D010269ParaquatParaquat affects the phosphorylation of ULK1 protein27324791
D010269ParaquatULK1 protein affects the susceptibility to Paraquat27324791
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ULK1 mRNA26879310
C006253pirinixic acidpirinixic acid results in decreased expression of ULK1 mRNA16221962|2527062
C006253pirinixic acidpirinixic acid results in increased expression of ULK1 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of ULK1 mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of ULK1 mRNA21278054
D012402RotenoneRotenone results in increased expression of ULK1 protein27629431
D020123Sirolimus"Sirolimus affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]"29128638
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ULK1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ULK1 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ULK1 mRNA19770486|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ULK1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ULK1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[maslinic acid analog co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of ULK1 protein26513295
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ULK1 mRNA25613284
C009438tetrandrinetetrandrine results in decreased expression of ULK1 protein25266202
C009438tetrandrinetetrandrine results in increased phosphorylation of ULK1 protein26822499
D013804ThenoyltrifluoroacetoneThenoyltrifluoroacetone results in increased expression of ULK1 protein27629431
C009495titanium dioxidetitanium dioxide results in decreased expression of ULK1 mRNA23409001
D014212TretinoinTretinoin results in increased expression of ULK1 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ULK1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ULK1 mRNA28973697
C080163trovafloxacintrovafloxacin results in increased expression of ULK1 mRNA24136188
D014520UrethaneUrethane results in increased expression of ULK1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ULK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of ULK1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ULK1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ULK1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA18936157  25126726  27103069  
GO:0004674protein serine/threonine kinase activity-NAS9693035  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI11146101  17353931  17389358  18936157  19211835  19597335  
20562859  22354037  22613832  23392225  23524951  24290141  
24603492  25126726  25127057  25438055  25686248  25891078  
26347139  26593251  28195531  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-TAS-  
GO:0017137Rab GTPase binding-IPI22613832  
GO:0042802identical protein binding-IPI20562859  23524951  
GO:0044877protein-containing complex binding-IPI19211835  
GO:0051020GTPase binding-IPI25891078  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0006468protein phosphorylation-NAS9693035  
GO:0006914autophagy-IDA18936157  
GO:0006914autophagy-IMP17595159  
GO:0006914autophagy-ISS-  
GO:0007165signal transduction-IEA-  
GO:0008104protein localization-IMP16940348  
GO:0010506regulation of autophagy-IBA21873635  
GO:0016236macroautophagy-IMP22354037  
GO:0016236macroautophagy-TAS-  
GO:0016241regulation of macroautophagy-TAS-  
GO:0018105peptidyl-serine phosphorylation-IDA25126726  27103069  
GO:0018107peptidyl-threonine phosphorylation-IDA27103069  
GO:0031102neuron projection regeneration-IEA-  
GO:0031175neuron projection development-IMP18007665  
GO:0031333negative regulation of protein complex assembly-IDA25126726  
GO:0031669cellular response to nutrient levels-ISS-  
GO:0042594response to starvation-ISS-  
GO:0046777protein autophosphorylation-IBA21873635  
GO:0046777protein autophosphorylation-IDA18936157  
GO:0048675axon extension-IBA21873635  
GO:0075044autophagy of host cells involved in interaction with symbiont-IGI28389568  
GO:2000786positive regulation of autophagosome assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000407phagophore assembly site-IBA21873635  
GO:0005737cytoplasm-NAS9693035  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005776autophagosome-IDA17595159  22456507  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA11146101  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IBA21873635  
GO:0030424axon-IEA-  
GO:0032045guanyl-nucleotide exchange factor complexcolocalizes_withIDA27103069  
GO:0034045phagophore assembly site membrane-IDA18936157  
GO:0055037recycling endosome-TAS-  
GO:0097629extrinsic component of omegasome membrane-IDA22885598  
GO:0097632extrinsic component of phagophore assembly site membrane-IDA22885598  
GO:0097635extrinsic component of autophagosome membrane-IDA22885598  
GO:1990316Atg1/ULK1 kinase complex-IPI19211835  
KEGG ID KEGG Term
hsa04140Regulation of autophagy
hsa04150mTOR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1632852MacroautophagyTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5205647MitophagyTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8854214TBC/RABGAPsTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-8934903Receptor Mediated MitophagyTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28017600Ulk1 protects against ethanol-induced neuronal stress and cognition-related behavioral deficits. (2017 Apr)Sumitomo ANeurosci Res