Gene: CASP8

841
ALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5
caspase 8
protein-coding
2q33.1
Ensembl:ENSG00000064012 MIM:601763 Vega:OTTHUMG00000132821 UniprotKB:Q14790
NG_007497.1
PubMed
0   ANCO-SNPs
ND
15   
2.976e-1 (AD)  6.410e-1 (ND)   (Frontal_Cortex)
1.527e-1 (AD)  2.641e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARP150.816
MAP3K80.809
LILRB20.798
SPTLC30.786
ALPK10.785
LY750.781
SP140L0.781
TNFAIP80.779
PLEKHG20.779
TRIM60.778

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf53-0.443
ASPDH-0.432
HHATL-0.395
MAGIX-0.389
C9orf24-0.388
CPLX3-0.382
KCNIP3-0.373
C19orf73-0.37
TM7SF2-0.368
HES6-0.36

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12651BardoxoloneSmall Molecule218600-44-3InvestigationalTarget
ID Drug Name Action PubMed
C53442210-(2-pyrazolylethoxy)camptothecin10-(2-pyrazolylethoxy)camptothecin results in increased activity of CASP8 protein18708040
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one inhibits the reaction [FADD protein binds to CASP8 protein]"20833157
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one results in increased activity of and results in increased cleavage of CASP8 protein"20833157
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"CASP8 protein affects the susceptibility to 10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"20833157
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"CASP8 protein affects the susceptibility to [10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one affects the localization of BID protein alternative form]"20833157
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"CASP8 protein affects the susceptibility to [10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one results in decreased expression of BCL2L1 protein]"20833157
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"CASP8 protein affects the susceptibility to [10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one results in decreased expression of BCL2 protein]"20833157
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"CASP8 protein affects the susceptibility to [10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one results in increased activity of CASP3 protein]"20833157
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"CASP8 protein affects the susceptibility to [10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one results in increased activity of CASP9 protein]"20833157
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in increased cleavage of CASP8 protein23001822
C4496731,1,4-tris(acetyloxy)-2-nonene"[GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene] which results in increased activity of CASP8 protein"24353929
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP8 protein"24515801|2603571
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP8 protein]"24515801
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"NR4A1 protein inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP8 protein]"24515801
C44794311-keto-boswellic acid11-keto-boswellic acid analog results in increased activity of CASP8 protein21056033
C4127911,2,3,4,6,7-hexachlorinated naphthalene"1,2,3,4,6,7-hexachlorinated naphthalene results in increased activity of CASP8 protein"27501765
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased expression of CASP8 mRNA19435785
C5395511,2,4,5-benzenetetraamine"1,2,4,5-benzenetetraamine results in increased cleavage of CASP8 protein"22276220
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"[1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]"29111403
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]"29111403
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]"15799720
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]"15799720
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased activity of CASP8 protein"21903591|2382612
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased cleavage of CASP8 protein"21903591
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"CCAR1 protein affects the reaction [1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased activity of CASP8 protein]"21903591
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"[Bortezomib co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased activity of CASP8 protein"15070698
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of CASP8 mRNA"23958786
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of CASP8 mRNA"24375616
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [N,N-dimethylphytosphingosine results in increased activity of CASP8 protein]"19481559
C5822861-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased cleavage of CASP8 protein26208482
C5822861-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased cleavage of CASP8 protein]26208482
C5822861-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea"4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased cleavage of CASP8 protein]"26208482
C5524201-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane"1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased activity of and results in increased cleavage of CASP8 protein"20674558
C5524201-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane"Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased activity of and results in increased cleavage of CASP8 protein]"20674558
C5524201-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane"[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to 1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane"20674558
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [lead acetate results in increased activity of CASP8 protein]"22033380
C0374131,3-dinitropyrene"1,3-dinitropyrene results in increased cleavage of and results in increased activity of CASP8 protein"17240030
C4164421,4-anthraquinone"1,4-anthraquinone analog results in increased activity of CASP8 protein"17912452
C4164421,4-anthraquinone"1,4-anthraquinone analog results in increased activity of CASP8 protein"17912452
C0353421,4-naphthoquinone"1,4-naphthoquinone results in increased activity of CASP8 protein"20138029
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP8 protein"15498850
C5484331-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate"1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate results in increased activity of CASP8 protein"25452174
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"[1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one co-treated with Dithiothreitol] inhibits the reaction [[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein results in increased activity of CASP8 protein]]"10792026
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein results in increased activity of CASP8 protein]]"10792026
C0326681-nitropyrene1-nitropyrene results in increased cleavage of and results in increased activity of CASP8 protein17240030
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the activity of CASP8 protein"27589474
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of CASP8 mRNA"27589474
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP8 mRNA"26808241
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP8 mRNA"25462306
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP8 mRNA"16488489
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP8 protein]21964635
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased cleavage of CASP8 protein]21165570
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tobacco Smoke Pollution results in increased phosphorylation of and results in increased activity of MAPK1 protein] promotes the reaction [FAS protein binds to CASP8 protein]]20118622
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tobacco Smoke Pollution results in increased phosphorylation of and results in increased activity of MAPK3 protein] promotes the reaction [FAS protein binds to CASP8 protein]]20118622
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [methyl 5-chloro-4,5-didehydrojasmonate results in increased activity of CASP8 protein]"20696234
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate co-treated with BCL2 protein co-treated with esculetin] results in increased activity of CASP8 protein]19786087
C4465202-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone"2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone results in increased activity of CASP8 protein"16096431
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CASP8 mRNA"19114083
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased cleavage of CASP8 protein"26451628
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]"25432964
C4166532-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased cleavage of and results in increased activity of CASP8 protein23523585
C4166532-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased expression of CASP8 mRNA23523585
C4166532-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased cleavage of CASP8 protein]23523585
C4408502,4,3',5'-tetramethoxystilbene"2,4,3',5'-tetramethoxystilbene results in increased activity of CASP8 protein"20490654
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of CASP8 mRNA"20638727
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CASP8 protein"20638727
C0140242,4,5,2',4',5'-hexachlorobiphenyl"wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP8 protein]"24726520
C5622542'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione"2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in increased cleavage of and results in increased activity of CASP8 protein"21741372
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CASP8 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP8 protein15850772
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]20856197
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]27032576
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein15942663
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein]"15942663
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneBCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]20856197
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneTP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]20856197
C450643(2)-5,6,7,8,4'-pentamethoxyflavanone"(2)-5,6,7,8,4'-pentamethoxyflavanone results in increased cleavage of CASP8 protein"19450678
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of CASP8 protein"18444175
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid results in increased cleavage of CASP8 protein"18444175
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased cleavage of CASP8 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased cleavage of CASP8 protein"21214929
C00799725-hydroxycholesterol25-hydroxycholesterol results in increased activity of CASP8 protein25845326
C00799725-hydroxycholesterol"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]"25845326
C00799725-hydroxycholesterolAcetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]25845326
C00799725-hydroxycholesterolBAY 11-7085 inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]25845326
C00799725-hydroxycholesterolquercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]25845326
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of CASP8 mRNA"20406850
C06289728-deoxonimbolide28-deoxonimbolide results in increased activity of CASP8 protein21381696
C00059917928-O-acetylbetulin-3-ylglucopyranoside28-O-acetylbetulin-3-ylglucopyranoside results in increased activity of CASP8 protein26772157
C00059917928-O-acetylbetulin-3-ylglucopyranoside28-O-acetylbetulin-3-ylglucopyranoside results in increased activity of CASP8 protein26772157
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CASP8 mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CASP8 mRNA"20816883
C0005991782-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate2-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate analog results in increased activity of CASP8 protein26772157
C0005991782-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate2-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate results in increased activity of CASP8 protein26772157
C0005991782-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate2-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate analog results in increased activity of CASP8 protein26772157
C0005991782-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate2-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate results in increased activity of CASP8 protein26772157
C0059262-amino-4-hydroxy-6-formylpteridine2-amino-4-hydroxy-6-formylpteridine results in increased activity of CASP8 protein16019850
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased activity of CASP8 protein12717745|1281561
C0312782-chloroethyl ethyl sulfideAcetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of CASP8 protein]12815614
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of CASP8 mRNA12208782
C0228302-methoxyestradiol2-methoxyestradiol results in increased expression of CASP8 protein modified form23967052
C4337712-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein11226294
C4337712-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid esterDithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein]11226294
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased cleavage of CASP8 protein]26208482
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in increased activity of CASP8 protein"16158945
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in increased cleavage of CASP8 protein"21167276
C4175203-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein]"15942663
C4175203-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]"15475000
C4175203-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein]"15475000
C5546663,4-methylenedioxypyrovalerone"3,4-methylenedioxypyrovalerone results in increased activity of CASP8 protein"27255387
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in increased cleavage of and results in increased activity of CASP8 protein16173963
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]"23452621
C0259463-methyladenine3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]20104024
C0259463-methyladenine3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]20104024
C0259463-methyladenine3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]20104024
C0259463-methyladenine3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]20104024
C0259463-methyladeninebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]20104024
C0259463-methyladeninebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]]20104024
C0259463-methyladenine3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein]28803810
C0336433-nitrofluoranthene3-nitrofluoranthene results in increased activity of CASP8 protein19041363
C0153923-nitropropionic acid3-nitropropionic acid results in increased activity of CASP8 protein15571979
C0006020014-(3,5-dimethoxystyryl)phenyl acetate"4-(3,5-dimethoxystyryl)phenyl acetate results in increased cleavage of CASP8 protein"26138072
C525246(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)"(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II) results in decreased activity of CASP8 protein"22540380
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in increased cleavage of and results in increased activity of CASP8 protein12203115
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamideTNFSF10 protein promotes the reaction [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in increased cleavage of and results in increased activity of CASP8 protein]12203115
C4053544,5,6,7-tetrabromobenzotriazole"[4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased activity of CASP8 protein"16489027
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of CASP8 protein"24161432
C0325384-cresol4-cresol results in increased cleavage of CASP8 protein25668154
C0325384-cresolSQSTM1 mutant form inhibits the reaction [4-cresol results in increased cleavage of CASP8 protein]25668154
C4756224-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine"4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased cleavage of CASP8 protein]"26208482
C5080854'-demethyldesoxypodophyllotoxin4'-demethyldesoxypodophyllotoxin analog results in increased cleavage of CASP8 protein25446499
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CASP8 mRNA12419474
C0159524-iodo-2,5-dimethoxyphenylisopropylamine"4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of CASP8 protein"22983118
C5852024-methylethcathinone4-methylethcathinone results in increased activity of CASP8 protein27255387
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of CASP8 mRNA]"26546572
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CASP8 mRNA21167638
C0415944-nonylphenol4-nonylphenol results in increased cleavage of CASP8 protein22056370
C0415944-nonylphenol4-nonylphenol results in decreased expression of CASP8 mRNA27087316
C0297284-phenylenediamine4-phenylenediamine results in increased activity of CASP8 protein20156547
C0297284-phenylenediaminebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP8 protein]20156547
C5031195-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased cleavage of CASP8 protein15831436
C1109625,6-dichlorobenzimidazole"5,6-dichlorobenzimidazole promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]"15688023
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased cleavage of CASP8 protein"19135124
C5582885-methylselenylmethyl-2'-deoxyuridine5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of and results in increased activity of CASP8 protein22002103
C5582885-methylselenylmethyl-2'-deoxyuridineCASP8 protein affects the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased activity of CASP3 protein]22002103
C5805985-OH-BDE-475-OH-BDE-47 results in decreased activity of CASP8 protein27589474
C5805985-OH-BDE-475-OH-BDE-47 results in decreased expression of CASP8 mRNA27589474
C5582895-phenylselenylmethyl-2'-deoxyuridine5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of and results in increased activity of CASP8 protein22002103
C5582895-phenylselenylmethyl-2'-deoxyuridineCASP8 protein affects the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased activity of CASP3 protein]22002103
C5762686-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide"6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog results in increased activity of CASP8 protein"27720946
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C4833216-bromoindirubin-3'-oxime6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of CASP8 protein modified form]28414160
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]"23711929
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]"25845326
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]"25845326
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased activity of CASP8 protein]"19477266
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CASP8 mRNA]"19477266
C5306306(hydroxymethyl)-1,4-anthracenedione"6(hydroxymethyl)-1,4-anthracenedione results in increased activity of CASP8 protein"17912452
C5838836-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone"6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP8 protein"23212307
C5838836-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone"pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP8 protein]"23212307
C5319376-O-angeloylenolin6-O-angeloylenolin results in increased cleavage of CASP8 protein21192922
C5805996-OH-BDE-476-OH-BDE-47 results in decreased activity of CASP8 protein27589474
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of CASP8 mRNA27589474
C0413987,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester"7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester results in decreased activity of CASP8 protein"21467741
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of CASP8 protein modified form"19936915
C0548527-hydroxystaurosporine[7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP8 protein15767555
C0548527-hydroxystaurosporine[alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein16012789
C0548527-hydroxystaurosporinepyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein]15767555
C0030017-ketocholesterol"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]"25845326
C0030017-ketocholesterol7-ketocholesterol results in increased activity of CASP8 protein25845326
C0030017-ketocholesterolAcetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]25845326
C0030017-ketocholesterolBAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]25845326
C0030017-ketocholesterolquercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]25845326
C5742749-hydroxycanthin-6-one9-hydroxycanthin-6-one results in increased cleavage of CASP8 protein29225138
C0257249-methoxycamptothecin9-methoxycamptothecin results in increased activity of CASP8 protein23369935
C512352abexinostatabexinostat results in increased cleavage of CASP8 protein19417023
C512352abexinostatBortezomib promotes the reaction [abexinostat results in increased cleavage of CASP8 protein]19417023
C496492abrineabrine results in increased cleavage of and results in increased activity of CASP8 protein23788630
C496492abrineabrine results in increased cleavage of and results in increased activity of CASP8 protein23788630
C501332ABT-7373-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]20104024
C501332ABT-7373-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]20104024
C501332ABT-7373-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]20104024
C501332ABT-737[ABT-737 co-treated with Celecoxib] results in increased activity of CASP8 protein20104024
C501332ABT-737ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]20104024
C501332ABT-737ABT-737 promotes the reaction [wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]20104024
C501332ABT-737ABT-737 results in increased cleavage of CASP8 protein20104024
C501332ABT-737benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]20104024
C501332ABT-737benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]]20104024
C501332ABT-737benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]20104024
C501332ABT-737benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]20104024
C501332ABT-737Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]20104024
C501332ABT-737MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]20104024
C501332ABT-737PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]20104024
D000082AcetaminophenAcetaminophen results in decreased expression of CASP8 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased activity of CASP812005112
D000082AcetaminophenAcetaminophen affects the expression of CASP8 mRNA17562736
D000082Acetaminophen[Acetaminophen co-treated with TNF protein] results in increased activity of CASP8 protein12085349
D000082AcetaminophenAcetaminophen results in increased expression of CASP8 protein12540782
D000082Acetaminophen"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of CASP8 protein]"12540782
C464485acetamipridacetamiprid results in increased expression of CASP8 mRNA29091792
C464485acetamiprid[iprodione co-treated with acetamiprid] results in decreased expression of CASP8 mRNA29091792
C464485acetamiprid[iprodione co-treated with pyrachlostrobin co-treated with acetamiprid co-treated with iprodione] results in increased expression of CASP8 mRNA29091792
C464485acetamiprid[iprodione co-treated with pyrachlostrobin co-treated with acetamiprid] results in increased expression of CASP8 mRNA29091792
C464485acetamiprid[iprodione co-treated with pyrimethanil co-treated with acetamiprid] results in increased expression of CASP8 mRNA29091792
C099158acetyl-aspartyl-glutamyl-valyl-aspartalacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Okadaic Acid results in increased cleavage of and results in increased activity of CASP8 protein]19084044
C487680acetylbritannilatoneacetylbritannilatone analog results in increased activity of CASP8 protein27262408
C487680acetylbritannilatonebenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [acetylbritannilatone analog results in increased activity of CASP8 protein]27262408
C487680acetylbritannilatoneTP53 protein affects the reaction [acetylbritannilatone analog results in increased activity of CASP8 protein]27262408
D000111AcetylcysteineAcetylcysteine inhibits the reaction [epigallocatechin gallate promotes the reaction [arsenite results in increased activity of CASP8 protein]]26375285
D000111AcetylcysteineAcetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of CASP8 protein]12815614
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Biological Products results in increased cleavage of CASP8 protein]28219700
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cadmium acetate results in increased activity of CASP8 protein]16169029
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP8 protein]"28087840
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]17574045
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein]21310227
D000111AcetylcysteineAcetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP8 protein]22578287
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]27313093
D000111AcetylcysteineAcetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]23867903
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein]19014919
D000111AcetylcysteineAcetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein]28918123
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sinularin results in increased cleavage of CASP8 protein]28548367
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]27313093
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]25034532
D000111AcetylcysteineAcetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]23711929
D000111Acetylcysteine"Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased activity of and results in increased cleavage of CASP8 protein]"20674558
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cannabidiol hydroxyquinone results in increased activity of CASP8 protein]20184945
D000111AcetylcysteineAcetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein]20576514
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP8 protein]20883752
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein]24614525
D000111Acetylcysteine[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein]20946910
D000111Acetylcysteine[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased expression of CASP8 protein]20946910
D000111AcetylcysteineAcetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]25845326
D000111AcetylcysteineAcetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]25845326
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cholesterol analog results in increased activity of CASP8 protein]19477266
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP8 mRNA]19477266
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Glucose results in increased activity of CASP8]18791325
D000111AcetylcysteineAcetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of CASP8 protein]27484784
D000111AcetylcysteineAcetylcysteine inhibits the reaction [resveratrol results in increased cleavage of CASP8 protein]26849945
C081895acetyldinalineacetyldinaline promotes the reaction [decitabine results in increased expression of CASP8 protein]21771726
C401206acetyl-isoleucyl-glutamyl-threonyl-aspartyl-aldehydeacetyl-isoleucyl-glutamyl-threonyl-aspartyl-aldehyde inhibits the reaction [hispanolone analog results in increased activity of CASP8 protein]25930665
C401206acetyl-isoleucyl-glutamyl-threonyl-aspartyl-aldehydeacetyl-isoleucyl-glutamyl-threonyl-aspartyl-aldehyde inhibits the reaction [TNFSF10 protein promotes the reaction [hispanolone analog results in increased activity of CASP8 protein]]25930665
C420218acetyl-leucyl-glutamyl-histidyl-aspartalacetyl-leucyl-glutamyl-histidyl-aspartal affects the reaction [Cisplatin results in increased activity of CASP8 protein]21801448
C420218acetyl-leucyl-glutamyl-histidyl-aspartalacetyl-leucyl-glutamyl-histidyl-aspartal inhibits the reaction [Etoposide results in increased activity of CASP8 protein]21801448
C063261acetylleucyl-leucyl-norleucinalacetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
D017255AcitretinAcitretin results in increased activity of CASP8 protein18624760
D015250AclarubicinAclarubicin results in increased activity of CASP8 protein20399885
D000171AcroleinAcrolein results in increased activity of CASP8 protein17196791|1732076
D000171AcroleinAcrolein results in increased cleavage of CASP8 protein17320762
D000171AcroleinAcrolein affects the activity of CASP8 protein17222828
D000171AcroleinAcrolein affects the alkylation of CASP8 protein17222828
D000171AcroleinAcrolein affects the cleavage of CASP8 protein17222828
D000171AcroleinAcrolein inhibits the reaction [FAS protein results in increased activity of CASP8 protein]17222828
D000171AcroleinAcrolein inhibits the reaction [FAS protein results in increased cleavage of CASP8 protein]17222828
D000171AcroleinAcrolein promotes the reaction [Zidovudine results in increased cleavage of CASP8 protein]27238871
D000171AcroleinAcrolein results in increased cleavage of CASP8 protein27238871
D000171AcroleinZidovudine promotes the reaction [Acrolein results in increased cleavage of CASP8 protein]27238871
D000171AcroleinAcrolein results in decreased activity of CASP8 protein11803030
D000171AcroleinAcrolein results in increased expression of CASP8 protein24376112
D000171Acroleincapsazepine inhibits the reaction [Acrolein results in increased expression of CASP8 protein]24376112
D000171AcroleinGlutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein]24376112
D020106AcrylamideAcrylamide results in increased expression of CASP8 mRNA28959563
D000241AdenosineAdenosine results in increased activity of CASP8 protein17303086
D000241AdenosineDipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein]17303086
D000241AdenosineAdenosine results in increased activity of CASP8 protein16469385
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased activity of CASP8 protein17997382
D000255Adenosine Triphosphatetetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased activity of CASP8 protein]17997382
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CASP8 mRNA27017951|2894338
D016604Aflatoxin B1[gluconic acid co-treated with Zinc Sulfate] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA]27017951
D016604Aflatoxin B1Zinc Sulfate inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA]27017951
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CASP8 mRNA28789997
C004363alantolactonealantolactone results in increased cleavage of CASP8 protein22721982
C054122alanylglutamine"alanylglutamine inhibits the reaction [tcdA protein, Clostridium difficile results in increased activity of CASP8 protein]"16368960
C012708alborixinalborixin results in increased activity of CASP8 protein27378626
C103303alitretinoinalitretinoin results in increased activity of CASP8 protein16449964
C518327aloe emodinaloe emodin results in increased activity of CASP8 protein19928967
C518327aloe emodinaloe emodin results in increased expression of CASP8 protein modified form19928967
C518327aloe emodin[Fluorouracil co-treated with aloe emodin] affects the expression of CASP819928967
C518327aloe emodinFluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]19928967
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CASP8 mRNA27732882
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased activity of CASP8 protein28070108
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of and results in increased cleavage of and results in increased activity of CASP8 protein27732882
D000517alpha-Chlorohydrinquinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP8 protein]27732882
C011512alpha-naphthoflavonealpha-naphthoflavone results in increased activity of CASP8 protein18334599
D024502alpha-Tocopherolalpha-Tocopherol analog results in increased cleavage of CASP8 protein20686688
C064176alpha-viniferinalpha-viniferin analog results in increased activity of CASP8 protein16158945
C064176alpha-viniferinalpha-viniferin results in increased activity of CASP8 protein16158945
C010845aluminum chloridealuminum chloride results in increased expression of CASP8 protein28623112
C010845aluminum chlorideChlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of CASP8 protein]28623112
C077990alvocidib[alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein16012789
C077990alvocidib[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP8 protein15634644
C077990alvocidib[alvocidib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein16951203
C077990alvocidibalvocidib results in increased cleavage of CASP8 protein10896673|1258903
C077990alvocidib[Imatinib Mesylate co-treated with alvocidib] results in increased activity of CASP8 protein12231544
D000584AmilorideAmiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]15607733
D000584AmilorideAmiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]16059913
D000622Aminolevulinic AcidAminolevulinic Acid analog results in increased activity of CASP8 protein21138480
D000622Aminolevulinic Acidpyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP8 protein]21138480
D000638Amiodarone[TNFSF10 co-treated with Amiodarone] results in increased cleavage of CASP8 protein21292685
D000638AmiodaroneAmiodarone results in increased expression of CASP8 protein modified form21224497
D017311Amlodipine[Amlodipine co-treated with Topotecan] results in increased activity of CASP8 protein16516327
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CASP8 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased activity of CASP8 protein18722528
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of CASP8 protein16483693
C054105ammonium trichloro(dioxoethylene-O,O'-)tellurate"ammonium trichloro(dioxoethylene-O,O'-)tellurate results in decreased activity of CASP8 protein"18571097
C088115anacardic acid[anacardic acid co-treated with TNF protein] results in increased cleavage of CASP8 protein18349320
C030419andrographolide[andrographolide co-treated with Cisplatin] results in increased expression of CASP8 mRNA24563380
C030419andrographolideandrographolide results in increased activity of CASP8 protein19097688
C030419andrographolideandrographolide results in increased expression of CASP8 mRNA24563380
C030419andrographolideCASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]19097688
C030419andrographolideCASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]19097688
C030419andrographolideCASP8 results in increased susceptibility to [andrographolide co-treated with Fluorouracil]19097688
C030419andrographolideFluorouracil promotes the reaction [andrographolide results in increased activity of CASP8 protein]19097688
C030419andrographolideandrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein]20946909
D000841AnisomycinAnisomycin results in increased activity of CASP8 protein18241849
C540917anthraceno(1,2-c)(1,2,5)selenadiazolo-6,11-dione"anthraceno(1,2-c)(1,2,5)selenadiazolo-6,11-dione results in increased cleavage of CASP8 protein"19146838
D000970Antineoplastic AgentsAntineoplastic Agents results in increased expression of and results in increased cleavage of CASP8 protein22010212
D000970Antineoplastic AgentsCASP8 protein results in increased susceptibility to Antineoplastic Agents22010212
D000970Antineoplastic Agents[Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Antineoplastic Agents22010212
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CASP8 mRNA24449571
C102351apicidinapicidin results in increased activity of CASP8 protein19070610
D047310ApigeninApigenin results in increased cleavage of CASP8 protein15486995
D047310Apigenin[TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein29247770
D047310ApigeninApigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP8 protein]24144774
D047310ApigeninApigenin results in increased activity of CASP8 protein24144774
D047310Apigeninhydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP8 protein]24144774
D016718Arachidonic AcidArachidonic Acid results in increased activity of CASP8 protein19720122
D016718Arachidonic AcidFADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP8 protein]19720122
D001104ArbutinArbutin results in decreased expression of CASP8 mRNA17103032
C061640arjunolic acidarjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]21420465
D001151ArsenicArsenic affects the methylation of CASP8 gene25304211
D001151ArsenicArsenic results in increased expression of CASP8 mRNA27838757
C006632arsenic trioxidearsenic trioxide affects the expression of CASP8 mRNA28454103
C006632arsenic trioxidearsenic trioxide affects the activity of CASP8 protein16010437
C006632arsenic trioxide[arsenic trioxide co-treated with Bortezomib] results in decreased expression of CASP8 mRNA20471514
C006632arsenic trioxide[arsenic trioxide co-treated with Curcumin] results in increased expression of CASP8 protein27430728
C006632arsenic trioxide[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP8 protein23082001
C006632arsenic trioxide[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein21889928
C006632arsenic trioxide[arsenic trioxide co-treated with Quercetin] results in increased cleavage of and results in increased activity of CASP8 protein18359480
C006632arsenic trioxide[arsenic trioxide co-treated with TNF protein] results in increased cleavage of and results in increased activity of CASP8 protein17673311
C006632arsenic trioxide[arsenic trioxide co-treated with TNFSF10 protein] results in increased activity of CASP8 protein24345465
C006632arsenic trioxidearsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP8 protein]21418039
C006632arsenic trioxidearsenic trioxide promotes the reaction [puerarin results in increased expression of CASP8 protein]20416161
C006632arsenic trioxidearsenic trioxide promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]16434995
C006632arsenic trioxidearsenic trioxide results in increased activity of CASP8 protein10721769|1214889
C006632arsenic trioxidearsenic trioxide results in increased cleavage of and results in increased activity of CASP8 protein18546268|1940830
C006632arsenic trioxidearsenic trioxide results in increased cleavage of CASP8 protein18491231|2308200
C006632arsenic trioxidearsenic trioxide results in increased expression of CASP8 protein27430728
C006632arsenic trioxidearsenic trioxide results in increased expression of CASP8 protein modified form20953137
C006632arsenic trioxideBCL2 inhibits the reaction [[arsenic trioxide co-treated with TNF protein] results in increased activity of CASP8 protein]17673311
C006632arsenic trioxideBCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein]21889928
C006632arsenic trioxideBCL2 protein inhibits the reaction [[arsenic trioxide co-treated with Quercetin] results in increased cleavage of and results in increased activity of CASP8 protein]18359480
C006632arsenic trioxidebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [[arsenic trioxide co-treated with TNF protein] results in increased cleavage of and results in increased activity of CASP8 protein]17673311
C006632arsenic trioxide[Bortezomib co-treated with arsenic trioxide] results in increased expression of CASP8 protein24377552
C006632arsenic trioxideBortezomib promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein]20471514
C006632arsenic trioxide[Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein17145888
C006632arsenic trioxide[CSF2 protein co-treated with arsenic trioxide] results in decreased expression of and affects the activity of CASP8 protein16174796
C006632arsenic trioxideGenistein promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP8 protein]18546268
C006632arsenic trioxideisoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [arsenic trioxide promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]]16434995
C006632arsenic trioxideMAPK8 protein affects the reaction [arsenic trioxide results in increased activity of CASP8 protein]20534739
C006632arsenic trioxidePoly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein]21418039
C006632arsenic trioxidepyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein]17145888
C006632arsenic trioxidepyrazolanthrone promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein]16972261
C006632arsenic trioxide[sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein24345465
C006632arsenic trioxide[sanguinarine co-treated with arsenic trioxide] results in increased activity of CASP8 protein24345465
C006632arsenic trioxideU 0126 promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein]16972261
C006632arsenic trioxide[Valproic Acid co-treated with arsenic trioxide] results in increased expression of CASP8 mRNA25815518
C006632arsenic trioxide[Valproic Acid co-treated with arsenic trioxide] results in increased expression of CASP8 protein25815518
C006632arsenic trioxide"arsenic trioxide promotes the reaction [Drugs, Chinese Herbal results in increased cleavage of CASP8 protein]"28587418
C006632arsenic trioxidearsenic trioxide results in increased activity of CASP8 protein21565247|2541015
C006632arsenic trioxidearsenic trioxide results in increased activity of CASP8 protein14726646
C015001arseniteAcetylcysteine inhibits the reaction [epigallocatechin gallate promotes the reaction [arsenite results in increased activity of CASP8 protein]]26375285
C015001arsenitearsenite results in increased activity of CASP8 protein26375285
C015001arseniteepigallocatechin gallate promotes the reaction [arsenite results in increased activity of CASP8 protein]26375285
C519899AS602868AS602868 results in increased cleavage of and results in increased activity of CASP8 protein18182997
C519899AS602868irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP8 protein]18182997
C012195asaroneasarone results in increased activity of CASP8 protein29174417
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of CASP8 protein"20855422
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [Asbestos, Crocidolite results in increased activity of CASP8 protein]"22608188
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased activity of CASP8 protein"22608188
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CASP8 mRNA"23634900
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CASP8 protein"23634900
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]23711929
D001205Ascorbic Acid[Ascorbic Acid co-treated with INS1 protein] results in increased expression of CASP8 mRNA20400526
D001205Ascorbic Acid[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA18544905
C108637aspartyl-glutamyl-valyl-aspartalaspartyl-glutamyl-valyl-aspartal results in decreased activity of CASP8 protein10896673
D001241Aspirin[Aspirin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein21171083
D001241Aspirin[Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein18483385
D001241AspirinAspirin results in increased activity of CASP8 protein11034327
D001241AspirinAspirin results in increased cleavage of and results in increased activity of CASP8 protein15481331
D001241AspirinAspirin results in increased expression of CASP8 mRNA20457246
D001241AspirinCASP8 affects the reaction [Aspirin results in increased cleavage of BID protein]15976387
D001241AspirinCASP8 affects the reaction [Aspirin results in increased localization of BAX protein]15976387
D001241Aspirin[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of CASP8 protein16199534
D000069059Atorvastatin Calcium[Atorvastatin Calcium co-treated with Celecoxib] results in increased cleavage of CASP8 protein18172863
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased activity of CASP8 protein15705602
D000069059Atorvastatin Calcium[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein]20946910
D000069059Atorvastatin Calcium[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased expression of CASP8 protein]20946910
D001310AuranofinAuranofin results in decreased expression of and results in increased cleavage of CASP8 protein20542334
C426023austenitic steel[Nickel co-treated with austenitic steel analog] results in increased expression of CASP8 mRNA23638002
D001374AzacitidineAzacitidine results in increased expression of CASP8 mRNA18082045
D001374AzacitidineAzacitidine results in increased expression of CASP8 mRNA23395740
C010329azadirachtinazadirachtin results in increased expression of CASP8 protein20429769
C479321azadiradioneazadiradione results in increased activity of CASP8 protein21381696
C099015azaspiraneazaspirane results in increased cleavage of and results in increased activity of CASP8 protein15705788
C517975AZD 6244AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP8 protein]]27222248
C040929bafilomycin A1bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
C040929bafilomycin A1bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]28378122
C006680baicaleinbaicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]20850421
C012765bakuchiol[TNFSF10 protein co-treated with bakuchiol] results in increased cleavage of CASP8 protein27033605
C060988baohuoside Ibaohuoside I results in increased activity of CASP8 protein19289254
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]15477007
C028559bathocuproine sulfonatebathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]]15477007
C416282BAY 11-7085BAY 11-7085 inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]25845326
C416282BAY 11-7085BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]25845326
C580697BDMC-ABDMC-A results in increased cleavage of CASP8 protein24365254
C004456beauvericinbeauvericin results in increased expression of CASP8 mRNA29203277
C487081belinostatbelinostat results in increased expression of CASP8 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
D000069461Bendamustine HydrochlorideBendamustine Hydrochloride results in increased activity of CASP8 protein12948851
D000069461Bendamustine HydrochlorideCladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP8 protein]12948851
D001554BenzeneBenzene results in increased expression of CASP8 protein17171516
C026487benzo(e)pyrenebenzo(e)pyrene results in increased activity of CASP8 protein18586875
C026487benzo(e)pyrenebenzo(e)pyrene results in increased activity of CASP8 protein19899995
D053119BenzophenanthridinesBenzophenanthridines analog results in increased activity of CASP8 protein23117580
D001564Benzo(a)pyreneAHR mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein]22951985
D001564Benzo(a)pyreneAHR mutant form inhibits the reaction [Benzo(a)pyrene promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]22951985
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein22951985
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]22951985
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased cleavage of CASP8 protein16041517
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CASP8 mRNA24239969
D001564Benzo(a)pyreneNitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP8 protein]16041517
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CASP8 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CASP8 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CASP8 mRNA28651000
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CASP8 mRNA21774909
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased activity of CASP8 protein22051199
D001564Benzo(a)pyreneGlycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP8 protein]22051199
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP8 protein"21983885
C110772benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketonebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]15516989
C110772benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketonebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [fludarabine results in increased cleavage of CASP8 protein]15516989
C110772benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketonebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Mustard Gas results in increased activity of CASP8 protein]20226831
C110772benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketonebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [GW 7845 results in increased activity of and results in increased cleavage of CASP8 protein]17400580
C427308benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketonebenzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP8 protein]16777994
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP8 protein]20156547
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased cleavage of CASP8 protein]23523585
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]20104024
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]]20104024
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]20104024
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [[arsenic trioxide co-treated with TNF protein] results in increased cleavage of and results in increased activity of CASP8 protein]17673311
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]20104024
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ciglitazone promotes the reaction [Niflumic Acid results in increased activity of CASP8 protein]]21067863
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein]21126053
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Nickel results in increased cleavage of CASP8 protein]24840272
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Niflumic Acid promotes the reaction [ciglitazone results in increased activity of CASP8 protein]]21067863
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [nimesulide results in increased cleavage of and results in increased activity of CASP8 protein]19360361
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone"benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [N,N-dimethylphytosphingosine results in increased cleavage of and results in increased activity of CASP8 protein]"19481559
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Okadaic Acid results in increased cleavage of and results in increased activity of CASP8 protein]19084044
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [[resveratrol results in increased activity of CASP8 protein] which results in increased activity of CASP3 protein]19423619
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [[resveratrol results in increased activity of CASP8 protein] which results in increased activity of CASP9 protein]19423619
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Staurosporine results in increased cleavage of CASP8 protein]24658017
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein12902349|1456316
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [resveratrol results in increased localization of BAK1 protein]12902349
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [resveratrol results in increased localization of BAX protein]12902349
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone"[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to 1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane"20674558
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to flavanone22056764
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to Hydrazones22056764
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to Plant Extracts20229524
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to PRODH protein16619034
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to resveratrol19561642
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to TNFSF10 protein23711929
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]12831782
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein20671745
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]20671745
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]20671745
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]]20671745
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonelactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]]20671745
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [CASP8 protein results in increased susceptibility to Cacodylic Acid]15276415
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]16263807
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein15276415
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein11212279|1218174
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [methyl jasmonate metabolite results in increased susceptibility to TNFSF10 protein]22079975
C403754benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]17574045
C403754benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]27313093
C403754benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]19716835
C403754benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]27313093
C403754benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]12831782
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of and results in increased activity of CASP8 protein15498850
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]]20671745
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]15914627
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CASP8 protein20100472|2044972
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeQuercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]]15914627
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [acetylbritannilatone analog results in increased activity of CASP8 protein]27262408
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cycloheximide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein]18222423
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein]26544897
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP8 protein]19054763
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[resveratrol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein]18222423
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] affects the localization of CASP8 protein]19643600
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] results in increased activity of CASP8 protein]19643600
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]27544635
C103712benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethanebenzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]12831782
D001599BerberineBerberine results in increased activity of CASP8 protein20656010
D004958EstradiolEstradiol results in decreased expression of CASP8 mRNA24349563
D004958EstradiolEstradiol results in increased activity of CASP8 protein19095654
D004958EstradiolABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP8 protein]19095654
D004958Estradiol[Caspase Inhibitors results in decreased activity of CASP8 protein] inhibits the reaction [Estradiol results in increased activity of CASP3 protein]15545282
D004958Estradiol[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP8 protein22465879
D004958EstradiolEstradiol results in increased cleavage of CASP8 protein15545282
D004958Estradiol[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP8 mRNA20732338
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased cleavage of CASP8 protein19760616
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of CASP8 mRNA19175174
C023888beta-hexachlorocyclohexane[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of CASP8 mRNA19175174
C026609beta-solamarinebeta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP8 protein]17619073
C026609beta-solamarinebeta-solamarine results in increased activity of CASP8 protein17619073
C002070betulinic acidbetulinic acid results in increased activity of CASP8 protein26772157
C002070betulinic acidbetulinic acid results in increased activity of CASP8 protein26772157
C518477BI 2536BI 2536 results in increased activity of CASP8 protein24403256
C099952bifenthrinbifenthrin results in decreased expression of CASP8 mRNA26071804
C099952bifenthrinbifenthrin results in increased activity of CASP8 protein26071804
D001688Biological ProductsAcetylcysteine inhibits the reaction [Biological Products results in increased cleavage of CASP8 protein]28219700
D001688Biological ProductsBiological Products results in increased cleavage of CASP8 protein28219700
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased activity of CASP8 protein23458715
C482801bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]21037225
C482801bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)TNFRSF10B protein promotes the reaction [bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]]21037225
D017438Bisphenol A-Glycidyl MethacrylateBisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein26756871
D017438Bisphenol A-Glycidyl Methacrylatewogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein]26756871
C006780bisphenol Abisphenol A affects the expression of CASP8 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CASP8 protein21277958
C006780bisphenol Abisphenol A results in increased expression of CASP8 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of CASP8 mRNA26049153|2674610
C006780bisphenol Abisphenol A results in increased expression of CASP8 protein23900028
C006780bisphenol Abisphenol A results in decreased expression of CASP8 mRNA25181051
C006780bisphenol Abisphenol A results in increased activity of CASP8 protein25454643
C006780bisphenol Abisphenol A results in increased expression of CASP8 mRNA27539358
C006780bisphenol AMelatonin inhibits the reaction [bisphenol A results in increased activity of CASP8 protein]25454643
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of CASP8 mRNA24247028
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of CASP8 mRNA25270620
D001761Bleomycin[Polyphenols co-treated with Bleomycin] results in increased expression of CASP8 mRNA26800624
D001761Bleomycin[Tea co-treated with Bleomycin] results in increased expression of CASP8 mRNA26800624
D001786Blood GlucoseSOD1 protein inhibits the reaction [Blood Glucose results in increased cleavage of CASP8 protein]22425406
D001786Blood GlucoseBlood Glucose results in increased cleavage of CASP8 protein22425406
C476029Boc-D-FMKBoc-D-FMK inhibits the reaction [sorafenib results in increased cleavage of and results in increased activity of CASP8 protein]16007148
C005066borrelidinborrelidin results in increased activity of CASP8 protein14563161
D000069286BortezomibAKT1 protein inhibits the reaction [[Bortezomib co-treated with TNFSF10 protein] results in increased activity of CASP8 protein]19261616
D000069286Bortezomib[arsenic trioxide co-treated with Bortezomib] results in decreased expression of CASP8 mRNA20471514
D000069286Bortezomib"[Bortezomib co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased activity of CASP8 protein"15070698
D000069286Bortezomib[Bortezomib co-treated with arsenic trioxide] results in increased expression of CASP8 protein24377552
D000069286Bortezomib[Bortezomib co-treated with Butyrates] results in increased cleavage of and results in increased activity of CASP8 protein12893773
D000069286Bortezomib[Bortezomib co-treated with TNFSF10 protein] results in increased activity of CASP8 protein19261616|2044229
D000069286Bortezomib[Bortezomib co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein17510429|1762043
D000069286Bortezomib[Bortezomib co-treated with trichostatin A] results in increased cleavage of and results in increased activity of CASP8 protein16904634
D000069286Bortezomib[Bortezomib co-treated with vorinostat] results in increased activity of CASP8 protein18005386|1864136
D000069286Bortezomib[Bortezomib co-treated with vorinostat] results in increased cleavage of and results in increased activity of CASP8 protein12893773
D000069286BortezomibBortezomib promotes the reaction [abexinostat results in increased cleavage of CASP8 protein]19417023
D000069286BortezomibBortezomib promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein]20471514
D000069286BortezomibBortezomib promotes the reaction [Butyrates results in increased activity of CASP8 protein]15173093
D000069286BortezomibBortezomib promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]19100720
D000069286BortezomibBortezomib promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]12902978
D000069286BortezomibBortezomib promotes the reaction [vorinostat results in increased activity of CASP8 protein]15173093
D000069286BortezomibBortezomib results in increased cleavage of and results in increased activity of CASP8 protein16024631|1751042
D000069286BortezomibBortezomib results in increased cleavage of CASP8 protein12393500|1611831
D000069286Bortezomib[Bortezomib results in increased susceptibility to and results in increased activity of TNFSF10 protein] which results in increased cleavage of CASP8 protein17326159
D000069286Bortezomib[CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased cleavage of ATM protein]12393500
D000069286Bortezomib[CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased cleavage of MDM2 protein]12393500
D000069286Bortezomib[CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased cleavage of PRKDC protein]12393500
D000069286Bortezomib[CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased phosphorylation of TP53 protein]12393500
D000069286BortezomibCDKN1A protein affects the reaction [[TNFSF10 protein co-treated with Bortezomib] results in increased cleavage of CASP8 protein]15930312
D000069286Bortezomib[gambogic acid co-treated with Bortezomib] results in increased activity of CASP8 protein24291039
D000069286Bortezomib[IFNA2 protein co-treated with Bortezomib] results in increased activity of CASP8 protein17172406
D000069286Bortezomib[lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP8 protein16118318
D000069286BortezomibSCIO-469 promotes the reaction [Bortezomib results in increased cleavage of CASP8 protein]16617327
D000069286BortezomibTNFRSF10B mutant form inhibits the reaction [[Bortezomib co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein]17510429
D000069286BortezomibTNFRSF10B mutant form inhibits the reaction [Bortezomib results in increased cleavage of CASP8 protein]17510429
D000069286Bortezomib[TNFSF10 protein co-treated with Bortezomib] results in increased cleavage of CASP8 protein15930312
D000069286Bortezomib[trichostatin A co-treated with Bortezomib] results in increased cleavage of CASP8 protein21345073
D000069286Bortezomib[vorinostat co-treated with Bortezomib] results in increased cleavage of CASP8 protein17351739
D000069286BortezomibBortezomib results in increased activity of CASP8 protein20026740
C053342brevetoxinbrevetoxin results in increased activity of CASP8 protein19536525
C546611brevetoxin 2brevetoxin 2 results in increased activity of CASP8 protein19536525
C016274bromoacetatebromoacetate results in decreased expression of CASP8 mRNA19753638
C016274bromoacetatebromoacetate results in increased expression of CASP8 mRNA19753638
D016642BupropionBupropion results in increased activity of CASP8 protein21354251
D002066BusulfanBusulfan results in increased activity of CASP8 protein18339423
D002066Busulfan[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein19732952
D002066Busulfanpifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]19732952
D019328Buthionine Sulfoximine[Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein17145888
D019328Buthionine Sulfoximinepyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein]17145888
D002083Butylated HydroxyanisoleButylated Hydroxyanisole inhibits the reaction [[TNF protein co-treated with Cycloheximide] results in increased activity of CASP8 protein]15950244
C027561butylbenzyl phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CASP8 mRNA28013214
C026105butylidenephthalidebutylidenephthalide results in increased cleavage of CASP8 protein16987298
C026105butylidenephthalidebutylidenephthalide results in increased cleavage of CASP8 protein16987298
D002087Butyrates[Bortezomib co-treated with Butyrates] results in increased cleavage of and results in increased activity of CASP8 protein12893773
D002087ButyratesBortezomib promotes the reaction [Butyrates results in increased activity of CASP8 protein]15173093
D002087ButyratesButyrates results in increased activity of CASP8 protein15173093
D002087ButyratesButyrates results in increased expression of CASP8 mRNA16042588
D002087Butyrates[perifosine co-treated with Butyrates] results in increased activity of CASP8 protein15781658
C400541CA 074 methyl esterCA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]28378122
D002101Cacodylic Acidbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [CASP8 protein results in increased susceptibility to Cacodylic Acid]15276415
D002101Cacodylic AcidCASP8 protein results in increased susceptibility to Cacodylic Acid15276415
D002104CadmiumCadmium results in increased activity of CASP8 protein22768170
D002104CadmiumCadmium results in increased activity of CASP8 protein22692000
D002104Cadmium"[1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]"29111403
D002104Cadmium"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]"29111403
D002104Cadmiumacetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
D002104Cadmiumbafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
D002104CadmiumCadmium results in increased cleavage of CASP8 protein29111403
D002104Cadmiumcalpeptin inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
D002104CadmiumChloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
D002104CadmiumEgtazic Acid inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
D002104CadmiumCadmium inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]16263807
C028031cadmium acetateAcetylcysteine inhibits the reaction [cadmium acetate results in increased activity of CASP8 protein]16169029
C028031cadmium acetatecadmium acetate results in increased activity of CASP8 protein15450950|1616902
C028031cadmium acetateCASP8 affects the reaction [cadmium acetate results in increased cleavage of BID protein]15450950|1616902
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CASP8 protein21136600
D019256Cadmium ChlorideCadmium Chloride affects the reaction [Fluorouracil results in decreased expression of CASP8 mRNA]23941782
D019256Cadmium Chloride[Cadmium Chloride co-treated with Fluorouracil] affects the expression of CASP8 protein23941782
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CASP8 mRNA19426795|2394178
D019256Cadmium ChlorideCadmium Chloride results in increased activity of CASP8 protein21697648|2348565
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CASP8 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CASP8 protein21796402|2429116
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CASP8 promoter25448810
D019256Cadmium ChlorideCASP8 results in decreased susceptibility to Cadmium Chloride25448810
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 mRNA]25448810
D019256Cadmium ChlorideFluorouracil affects the reaction [Cadmium Chloride results in decreased expression of CASP8 mRNA]23941782
D019256Cadmium ChlorideTGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]28342888
D019256Cadmium Chloridearjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]21420465
D019256Cadmium ChlorideCadmium Chloride results in increased activity of CASP8 protein16421179|2125239
D019256Cadmium ChlorideCadmium Chloride results in increased cleavage of CASP8 protein19887573
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CASP8 protein21420465|2834288
D019256Cadmium Chloride[Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased activity of CASP8 protein16421179
D019256Cadmium ChlorideSirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]]28342888
D019256Cadmium ChlorideTGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]28342888
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]16263807
D019256Cadmium ChlorideCadmium Chloride results in decreased cleavage of CASP8 protein22457795
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CASP8 protein22457795
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CASP8 promoter22457795
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in decreased cleavage of CASP8 protein]22457795
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 protein]22457795
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in increased methylation of CASP8 promoter]22457795
C034939cadmium sulfidecadmium sulfide results in decreased expression of CASP8 mRNA27866839
C028337cadmium telluridecadmium telluride analog results in increased activity of CASP8 protein23485651
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein]18436364
C080866cagA protein, Helicobacter pylori"cagA protein, Helicobacter pylori results in decreased cleavage of CASP8 protein"26427350
C080866cagA protein, Helicobacter pylori"ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP8 protein]"26427350
D000001CalcimycinCalcimycin results in increased activity of CASP8 protein25410152
D000001CalcimycinCalcimycin results in increased activity of CASP8 protein25410152
C071482calpeptincalpeptin inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
D002166Camptothecin"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]"15475000
D002166CamptothecinCamptothecin affects the cleavage of CASP8 protein10896673
D002166Camptothecin[Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein15958570
D002166Camptothecin[Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein19633536
D002166CamptothecinCamptothecin results in increased activity of CASP8 protein15475000
D002166CamptothecinLithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]15475000
D002166CamptothecinNaphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]19497415
C073718cannabidiol hydroxyquinoneAcetylcysteine inhibits the reaction [cannabidiol hydroxyquinone results in increased activity of CASP8 protein]20184945
C073718cannabidiol hydroxyquinonecannabidiol hydroxyquinone results in increased activity of CASP8 protein20184945
D002193CantharidinCantharidin results in increased cleavage of and results in increased activity of CASP8 protein27113412
D002211Capsaicin[Capsaicin co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein19939880
D002211CapsaicinCapsaicin promotes the reaction [resveratrol results in decreased expression of CASP8 protein]19846903
D002211CapsaicinCapsaicin promotes the reaction [TNFSF10 results in increased activity of CASP8 protein]22200406
D002211CapsaicinCapsaicin results in decreased expression of CASP8 protein19846903
D002211CapsaicinCapsaicin results in increased activity of CASP8 protein19502594
D002211CapsaicinCapsaicin results in increased expression of CASP8 mRNA19502594
D002211Capsaicinresveratrol promotes the reaction [Capsaicin results in decreased expression of CASP8 protein]19846903
C071423capsazepinecapsazepine inhibits the reaction [Acrolein results in increased expression of CASP8 protein]24376112
C104525caraway oilcaraway oil inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein]25859307
D002220CarbamazepineCarbamazepine affects the expression of CASP8 mRNA24752500
C006698carbendazimcarbendazim affects the expression of CASP8 mRNA25304545
C006698carbendazimcarbendazim results in decreased expression of CASP8 mRNA26055223
D002248Carbon MonoxideCarbon Monoxide results in increased activity of CASP8 protein25562542
D002251Carbon Tetrachloride"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]"25432964
D002251Carbon Tetrachloridecaffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein]18436364
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of CASP8 protein18291569|1843636
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased cleavage of CASP8 protein25432964
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CASP8 protein24530446
D002251Carbon TetrachlorideChangkil inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein]18291569
D002251Carbon TetrachlorideDinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]25432964
D002251Carbon Tetrachlorideneohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP8 protein]24530446
D002251Carbon TetrachloridePTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]25432964
D002251Carbon TetrachlorideSC 560 promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]25432964
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of CASP8 protein12388182
D002251Carbon TetrachlorideTaurocholic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein]12388182
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CASP8 mRNA16039398
C111238carboxycinnamic acid bishydroxamidecarboxycinnamic acid bishydroxamide results in increased cleavage of CASP8 protein15897598
C524865carfilzomib[carfilzomib co-treated with vorinostat] results in increased activity of CASP8 protein20233973
D002336CarnosineCarnosine inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein]29191451
C546626caseargrewiin Fcaseargrewiin F results in increased activity of CASP8 protein25452174
D061945Caspase InhibitorsCaspase Inhibitors inhibits the reaction [Nocodazole analog results in increased expression of CASP8 protein modified form]28412508
D061945Caspase InhibitorsCaspase Inhibitors results in decreased activity of CASP8 protein28412508
D061945Caspase InhibitorsCaspase Inhibitors results in decreased activity of CASP8 protein15545282
D061945Caspase Inhibitors[Caspase Inhibitors results in decreased activity of CASP8 protein] inhibits the reaction [Estradiol results in increased activity of CASP3 protein]15545282
C054133casticincasticin results in increased cleavage of and results in increased activity of CASP8 protein27862857
D002392CatechinCatechin results in increased activity of CASP8 protein20206613
C034221catecholcatechol results in increased activity of CASP8 protein23776099
C099555CD 437CD 437 results in increased activity of CASP8 protein10766194|1602463
C099555CD 437helenalin inhibits the reaction [CD 437 results in increased activity of CASP8 protein]16024638
C099555CD 437NFKBIA protein affects the reaction [CD 437 results in increased activity of CASP8 protein]16024638
D000068579Celecoxib3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]20104024
D000068579Celecoxib3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]20104024
D000068579Celecoxib3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]20104024
D000068579Celecoxib[ABT-737 co-treated with Celecoxib] results in increased activity of CASP8 protein20104024
D000068579CelecoxibABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]20104024
D000068579CelecoxibABT-737 promotes the reaction [wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]20104024
D000068579Celecoxib[Atorvastatin Calcium co-treated with Celecoxib] results in increased cleavage of CASP8 protein18172863
D000068579Celecoxibbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]20104024
D000068579Celecoxibbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]]20104024
D000068579Celecoxibbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]20104024
D000068579Celecoxibbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]20104024
D000068579CelecoxibCelecoxib analog results in increased activity of CASP8 protein15499625
D000068579CelecoxibCelecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]20104024
D000068579CelecoxibCelecoxib results in increased activity of CASP8 protein12824303
D000068579CelecoxibCelecoxib results in increased cleavage of and results in increased activity of CASP8 protein15197583|1557275
D000068579CelecoxibCelecoxib results in increased cleavage of CASP8 protein20104024
D000068579CelecoxibFADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]15572759
D000068579CelecoxibMAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]20104024
D000068579CelecoxibPIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]20104024
D000068579CelecoxibTNFRSF10B mutant form inhibits the reaction [Celecoxib results in increased cleavage of CASP8 protein]15572759
D000068579CelecoxibTNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]15572759
D000068579Celecoxibwortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]20104024
C086276cerivastatincerivastatin results in increased activity of CASP8 protein15705602
D002108CeruletideCeruletide results in increased cleavage of and results in increased activity of CASP8 protein16339139
C119032CFM 1CFM 1 results in increased activity of CASP8 protein23826121
D002599ChalconeChalcone results in increased cleavage of CASP8 protein20620131
D002599ChalconeMYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein]20620131
C440574ChangkilChangkil inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein]18291569
D002699ChlorambucilChlorambucil results in increased activity of CASP8 protein11675354
C004656chloroacetaldehydechloroacetaldehyde results in decreased activity of CASP8 protein17035713
D017338CladribineBCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]15516989
D017338Cladribinebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]15516989
D017338CladribineCladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP8 protein]12948851
D017338CladribineCladribine results in increased activity of CASP8 protein11672427|1294885
D017338CladribineCladribine results in increased cleavage of CASP8 protein15516989
D017338Cladribine[Valproic Acid co-treated with Cladribine] results in increased cleavage of CASP8 protein19006566
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CASP8 mRNA23650126
D002726Chlorogenic AcidChlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of CASP8 protein]28623112
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of CASP8 mRNA26272509
D002738ChloroquineChloroquine results in increased cleavage of CASP8 protein27692344
D002738ChloroquineChloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
C023676chloroquine diphosphatechloroquine diphosphate inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]29133031
C023676chloroquine diphosphatechloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]]29133031
C023676chloroquine diphosphateDoxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]]29133031
D002784Cholesterol"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased activity of CASP8 protein]"19477266
D002784Cholesterol"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CASP8 mRNA]"19477266
D002784CholesterolAcetylcysteine inhibits the reaction [Cholesterol analog results in increased activity of CASP8 protein]19477266
D002784CholesterolAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP8 mRNA]19477266
D002784CholesterolCholesterol analog results in increased activity of CASP8 protein19477266
D002784CholesterolCholesterol analog results in increased expression of CASP8 mRNA19477266
D002784CholesterolCholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]20946910
D002784CholesterolCholesterol results in increased expression of CASP8 protein20946910
D002784CholesterolHydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of CASP8 protein]20946910
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CASP8 gene20938992
C529269cholix toxin, Vibrio cholerae"Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP8 protein]"28087840
C529269cholix toxin, Vibrio cholerae"[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP8 protein"28087840
C022990chromic chloridechromic chloride results in increased expression of and results in increased activity of CASP8 protein14741615
D002857ChromiumChromium results in increased expression of CASP8 mRNA17692352
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of CASP8 mRNA27793765
C043561chrysinchrysin inhibits the reaction [Topotecan results in increased activity of CASP8 protein]20457140
C043561chrysinchrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]21195158
C043561chrysinchrysin results in increased cleavage of CASP8 protein25770930
C043561chrysin[Cisplatin co-treated with chrysin] results in increased cleavage of CASP8 protein25770930
C039671ciglitazonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ciglitazone promotes the reaction [Niflumic Acid results in increased activity of CASP8 protein]]21067863
C039671ciglitazonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Niflumic Acid promotes the reaction [ciglitazone results in increased activity of CASP8 protein]]21067863
C039671ciglitazoneciglitazone promotes the reaction [Niflumic Acid results in increased activity of CASP8 protein]21067863
C039671ciglitazoneciglitazone results in increased activity of CASP8 protein21067863
C039671ciglitazoneDDIT3 mutant form inhibits the reaction [ciglitazone promotes the reaction [Niflumic Acid results in increased activity of CASP8 protein]]21067863
C039671ciglitazoneDDIT3 mutant form inhibits the reaction [Niflumic Acid promotes the reaction [ciglitazone results in increased activity of CASP8 protein]]21067863
C039671ciglitazoneNiflumic Acid promotes the reaction [ciglitazone results in increased activity of CASP8 protein]21067863
D015377CilastatinCilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]20435919
C045645cilostazolcilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP8 protein]18311796
D002927CimetidineCimetidine results in increased activity of CASP8 protein17273750|2012700
C012843cinnamic aldehydecinnamic aldehyde results in increased activity of CASP8 protein15964311
C063451cinobufotalincinobufotalin results in increased cleavage of CASP8 protein22898211
D002939CiprofloxacinCiprofloxacin results in increased activity of CASP8 protein11875713
C057741clavulone IIclavulone II results in increased cleavage of and results in increased activity of CASP8 protein15920677
D002994ClofibrateClofibrate results in increased expression of CASP8 mRNA23811191
D002997ClomipramineClomipramine results in increased activity of CASP8 protein28482088
D003000ClonidineClonidine results in increased activity of CASP8 protein28115640
D003022ClotrimazoleClotrimazole inhibits the reaction [lead acetate results in increased activity of CASP8 protein]22033380
D003022Clotrimazole[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]22033380
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]16051694
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in decreased activity of CASP8 protein16051694
C018021cobaltous chloridecobaltous chloride results in increased activity of CASP8 protein16374551
C018021cobaltous chloridecobaltous chloride affects the activity of CASP8 protein23684559
C060728cobalt oxidecobalt oxide results in increased expression of CASP8 protein25437709
C060728cobalt oxidecobalt oxide results in increased expression of CASP8 protein25437709
D003042CocaineCocaine affects the expression of CASP8 mRNA15681117
D003042CocaineCocaine results in increased activity of CASP8 protein11392460|1897485
C463759codonoposidecodonoposide results in increased activity of CASP8 protein15863893
C024989coenzyme Q10coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein]27087047
D003078ColchicineColchicine results in increased expression of CASP8 mRNA18255150
D003300Copper[Ditiocarb binds to Copper] which results in increased activity of CASP8 protein22951949
D003300Copper[Thiosemicarbazones binds to Copper] which results in decreased activity of CASP8 protein20931265
D003300CopperCopper analog results in increased expression of CASP8 protein22000994
D003300Copper[Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein22276220
D003300Copper[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein22276220
D003300CopperCopper deficiency results in increased expression of CASP8 mRNA17418555
C464760copper-1,10-phenanthroline"copper-1,10-phenanthroline results in increased cleavage of CASP8 protein"24638265
D019327Copper SulfateCopper Sulfate results in decreased expression of CASP8 mRNA19549813
D019327Copper Sulfateandrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein]20946909
D019327Copper SulfateCopper Sulfate results in increased cleavage of and results in increased activity of CASP8 protein20946909
C058120cordycepinAcetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein]21310227
C058120cordycepincordycepin results in increased activity of CASP8 protein21310227
C494620CPS 11CPS 11 results in increased cleavage of CASP8 protein15858615
C494622CPS 49CPS 49 results in increased cleavage of CASP8 protein15858615
C038106cucurbitacin Icucurbitacin I results in increased cleavage of CASP8 protein24858077
C029892cupric chloridecupric chloride results in decreased expression of CASP8 mRNA24650576
C029892cupric chloridecupric chloride results in increased expression of CASP8 protein23313662
D003474Curcumin[arsenic trioxide co-treated with Curcumin] results in increased expression of CASP8 protein27430728
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]23452621
D003474CurcuminCurcumin results in decreased expression of CASP8 protein17148446
D003474CurcuminCurcumin results in increased activity of CASP8 protein17096185
D003474CurcuminCurcumin results in increased cleavage of and results in increased activity of CASP8 protein16173963
D003474CurcuminCurcumin results in increased cleavage of CASP8 protein14555224
D003474CurcuminCurcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]25541178
D003474CurcuminCurcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]23267840
C057862cyanoginosin LRcyanoginosin LR results in increased expression of CASP8 mRNA23891578
C057862cyanoginosin LRcyanoginosin LR results in increased expression of CASP8 protein23454832
D003513Cycloheximidebenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cycloheximide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein]18222423
D003513Cycloheximide[Cycloheximide co-treated with TNF] results in increased cleavage of and results in increased activity of CASP8 protein12925536
D003513Cycloheximide[Cycloheximide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein18222423
D003513CycloheximideCycloheximide promotes the reaction [FAS protein results in increased activity of CASP8 protein]12760867
D003513CycloheximideCycloheximide results in increased activity of CASP8 protein15924153
D003513CycloheximideITPK1 inhibits the reaction [[Cycloheximide co-treated with TNF] results in increased cleavage of and results in increased activity of CASP8 protein]12925536
D003513CycloheximideButylated Hydroxyanisole inhibits the reaction [[TNF protein co-treated with Cycloheximide] results in increased activity of CASP8 protein]15950244
D003513CycloheximideMasoprocol inhibits the reaction [[TNF protein co-treated with Cycloheximide] results in increased activity of CASP8 protein]15950244
D003513Cycloheximide[TNF protein co-treated with Cycloheximide] results in increased activity of CASP8 protein15950244
D003520CyclophosphamideCASP8 protein results in increased susceptibility to Cyclophosphamide metabolite22010212
D003520CyclophosphamideCyclophosphamide metabolite results in increased expression of and results in increased cleavage of CASP8 protein22010212
D003520CyclophosphamideCyclophosphamide results in increased cleavage of and results in increased activity of CASP8 protein17898787
D003520Cyclophosphamide[Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Cyclophosphamide metabolite22010212
D016572CyclosporineCyclosporine inhibits the reaction [FAS protein results in increased activity of CASP8 protein]15548389
D016572CyclosporineCyclosporine inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
C089595cylindrospermopsincylindrospermopsin results in increased expression of CASP8 mRNA23726867
D003561Cytarabine[Cytarabine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein12780785
D003561CytarabineCytarabine promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]18549619
D003561CytarabineCytarabine results in increased expression of and results in increased cleavage of CASP8 protein22010212
D003606DacarbazineDacarbazine results in increased cleavage of and results in increased activity of CASP8 protein17410615
D003606DacarbazineTNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein]17410615
D003609DactinomycinDactinomycin results in decreased expression of CASP8 mRNA16001973
C004315danthronbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein]21126053
C004315danthrondanthron results in increased activity of and results in increased expression of CASP8 protein21126053
C004315danthrondanthron results in increased expression of CASP8 mRNA21126053
C109268darbufelonedarbufelone results in increased activity of CASP8 protein20352217
C515055darinaparsindarinaparsin results in increased cleavage of CASP8 protein25316819
D000069439DasatinibDasatinib results in increased activity of CASP8 protein19398150
D000069439DasatinibDasatinib results in increased cleavage of CASP8 protein18550857
D003630Daunorubicin[Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein12780785
C014347decitabineacetyldinaline promotes the reaction [decitabine results in increased expression of CASP8 protein]21771726
C014347decitabineCASP8 mRNA affects the reaction [[Valproic Acid co-treated with decitabine] results in increased susceptibility to TNFSF10 protein]21771726
C014347decitabine[decitabine affects the methylation of CASP8 gene] which affects the expression of CASP8 protein18649362|1864936
C014347decitabine[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein19732952
C014347decitabine[decitabine co-treated with IFNG protein] results in increased expression of CASP8 protein16607283
C014347decitabine[[[decitabine co-treated with IFNG protein] results in increased expression of CASP8 protein] which co-treated with TNFSF10 protein] results in increased activity of CASP8 protein16607283
C014347decitabine[decitabine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein18636160
C014347decitabine[[decitabine co-treated with trichostatin A] affects the methylation of CASP8 promoter] which affects the expression of CASP8 mRNA18819746|1881974
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 mRNA]25448810
C014347decitabinedecitabine results in decreased methylation of CASP8 promoter19440673
C014347decitabinedecitabine results in increased cleavage of CASP8 protein18636160
C014347decitabinedecitabine results in increased expression of CASP8 mRNA19214542|1944067
C014347decitabinedecitabine results in increased expression of CASP8 protein19214542|2177172
C014347decitabine[Doxorubicin co-treated with decitabine] results in increased cleavage of CASP8 protein17283156
C014347decitabinepifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]19732952
C014347decitabineValproic Acid promotes the reaction [decitabine results in increased expression of CASP8 mRNA]21771726
C014347decitabineValproic Acid promotes the reaction [decitabine results in increased expression of CASP8 protein]21771726
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in decreased cleavage of CASP8 protein]22457795
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 protein]22457795
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in increased methylation of CASP8 promoter]22457795
D003676DeferoxamineDeferoxamine results in increased activity of CASP8 protein16374551
D003676DeferoxamineNitroprusside inhibits the reaction [Deferoxamine results in increased activity of CASP8 protein]16374551
D003676DeferoxamineVanadates inhibits the reaction [Deferoxamine results in increased activity of CASP8 protein]16374551
C107676deguelin[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein25242579
C464444dehydroxymethylepoxyquinomicindehydroxymethylepoxyquinomicin results in increased cleavage of CASP8 protein15501958
C464444dehydroxymethylepoxyquinomicinpyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP8 protein]15501958
D013759DronabinolDronabinol results in decreased expression of CASP8 mRNA16039398
C100698demethoxyfumitremorgin Cdemethoxyfumitremorgin C results in increased activity of CASP8 protein28359723
C007262deoxynivalenoldeoxynivalenol results in increased expression of CASP8 mRNA22846391
C007262deoxynivalenoldeoxynivalenol results in increased activity of and results in increased cleavage of CASP8 protein22491426
C040424destruxin Bdestruxin B results in decreased expression of CASP8 protein23751424
C040424destruxin Bdestruxin B results in increased activity of CASP8 protein23751424
D003907DexamethasoneCASP8 protein results in increased susceptibility to Dexamethasone22010212
D003907DexamethasoneDexamethasone inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]17070682
D003907DexamethasoneDexamethasone results in increased activity of CASP8 protein15576458
D003907Dexamethasone[Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Dexamethasone22010212
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]]17070682
D003907Dexamethasone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]20671745
D003907Dexamethasone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]20671745
D003907Dexamethasonebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]]20671745
D003907DexamethasoneCASP8 protein promotes the reaction [Dexamethasone results in increased expression of TSC22D3 protein]20671745
D003907DexamethasoneDexamethasone results in increased activity of CASP8 protein11399061
D003907Dexamethasonelactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]]20671745
D003907DexamethasoneSpermine inhibits the reaction [Dexamethasone results in increased activity of CASP8 protein]11399061
D003907DexamethasoneDexamethasone inhibits the reaction [TGFB1 protein results in increased activity of CASP8 protein]15388240
D020927DexmedetomidineDexmedetomidine results in increased activity of CASP8 protein18724006
D064730DexrazoxaneDexrazoxane results in increased expression of CASP8 mRNA26873546
C042577diallyl trisulfideAcetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP8 protein]22578287
C042577diallyl trisulfidediallyl trisulfide results in increased activity of CASP8 protein22595511
C042577diallyl trisulfidediallyl trisulfide results in increased cleavage of CASP8 protein22578287
C042577diallyl trisulfide[diallyl trisulfide results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP8 protein28571773
D003976DiazinonDiazinon results in increased expression of CASP8 mRNA27920530
D003976DiazinonMagnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA]27920530
D003976DiazinonSelenium analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA]27920530
D003976DiazinonDiazinon affects the expression of CASP8 mRNA22546817
D003993Dibutyl Phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CASP8 mRNA28013214
C555408dichloridobis(3-imino-2-ethoxyflavanone)ruthenium(II)dichloridobis(3-imino-2-ethoxyflavanone)ruthenium(II) results in increased activity of CASP8 protein21334279
C555407dichloridobis(3-imino-2-methoxyflavanone)ruthenium(II)dichloridobis(3-imino-2-methoxyflavanone)ruthenium(II) results in increased activity of CASP8 protein21334279
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CASP8 mRNA28962523
D002945CisplatinAcetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]17574045
D002945Cisplatinacetyl-leucyl-glutamyl-histidyl-aspartal affects the reaction [Cisplatin results in increased activity of CASP8 protein]21801448
D002945Cisplatin[andrographolide co-treated with Cisplatin] results in increased expression of CASP8 mRNA24563380
D002945CisplatinBCL2 protein inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]17574045
D002945Cisplatinbenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]17574045
D002945Cisplatinbeta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP8 protein]17619073
D002945CisplatinBMI1 inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein]21445297
D002945CisplatinCASP8 inhibits the reaction [CASP8 protein mutant form results in decreased susceptibility to Cisplatin]21801448
D002945CisplatinCASP8 protein mutant form results in decreased susceptibility to Cisplatin21801448
D002945Cisplatin"[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased cleavage of CASP8 protein"21214929
D002945Cisplatin[Cisplatin co-treated with chrysin] results in increased cleavage of CASP8 protein25770930
D002945Cisplatin[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein17574045
D002945Cisplatin[Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP8 protein21216935
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CASP8 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of CASP8 mRNA21791302
D002945CisplatinCisplatin inhibits the reaction [CASP8 protein results in increased cleavage of BID protein]19590723
D002945CisplatinCisplatin promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]21037225
D002945CisplatinCisplatin results in increased activity of CASP8 protein16009487|1680352
D002945CisplatinCisplatin results in increased cleavage of and results in increased activity of CASP8 protein21216935
D002945CisplatinCisplatin results in increased cleavage of CASP8 protein17021654|1805880
D002945CisplatinCisplatin results in increased expression of CASP8 mRNA21487429|2739243
D002945CisplatinCisplatin results in increased expression of CASP8 protein16803524|2148742
D002945Cisplatin[Cisplatin results in increased expression of CASP8 protein] which results in increased susceptibility to TNFSF10 protein21487429
D002945Cisplatin[Cisplatin results in increased expression of SRSF2 protein] which affects the splicing of CASP8 mRNA21157427
D002945Cisplatin[[Cisplatin results in increased expression of SRSF2 protein] which affects the splicing of CASP8 mRNA] which results in increased activity of CASP8 protein21157427|2115742
D002945Cisplatin[Fluorouracil co-treated with Cisplatin] results in increased activity of CASP8 protein16803524
D002945Cisplatin[Fluorouracil co-treated with Cisplatin] results in increased expression of CASP8 protein16803524
D002945CisplatinING4 protein promotes the reaction [Cisplatin results in increased activity of CASP8 protein]21052098
D002945CisplatinProgesterone inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]23482746
D002945CisplatinSirolimus promotes the reaction [Cisplatin results in increased cleavage of CASP8 protein]18058806
D002945Cisplatin[TNFSF10 protein co-treated with Cisplatin] results in increased activity of CASP8 protein21252285
D002945CisplatinYAP1 protein inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein]20947521
D002945Cisplatin"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of CASP8 mRNA]"26546572
D002945CisplatinCarnosine inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein]29191451
D002945CisplatinCisplatin results in increased activity of CASP8 protein21526214
D002945CisplatinCisplatin results in increased cleavage of CASP8 protein29191451
D002945CisplatinCisplatin results in increased expression of CASP8 mRNA26546572
D002945CisplatinCisplatin results in increased expression of CASP8 protein21525749
D002945CisplatinCilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]20435919
D002945CisplatinCisplatin results in increased activity of CASP8 protein20435919
D002945CisplatinCisplatin results in increased expression of CASP812712633
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased activity of CASP8 protein19545618
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of CASP8 protein20025943
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased activity of CASP8 protein24576310
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CASP8 mRNA19644561|2002594
D003633Dichlorodiphenyl Dichloroethylene[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of CASP8 mRNA19175174
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CASP8 mRNA19175174
D004008DiclofenacAcetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]27313093
D004008DiclofenacAcetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]27313093
D004008Diclofenacbenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]27313093
D004008Diclofenacbenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]27313093
D004008DiclofenacDiclofenac affects the expression of CASP8 mRNA24752500
D004008Diclofenac[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein20237495
D004008DiclofenacDiclofenac results in increased activity of CASP8 protein27313093
D004008Diclofenac[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein27313093
D004008DiclofenacDiclofenac results in increased activity of CASP8 protein14609740
D004026DieldrinDieldrin affects the expression of CASP8 mRNA22546817
D004041Dietary FatsDietary Fats results in decreased expression of CASP8 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of CASP8 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased activity of CASP8 protein22155658
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CASP8 mRNA25701202
D004051Diethylhexyl Phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CASP8 mRNA28013214
D004052Diethylnitrosamine[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA23830814
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with thiosalicylic acid] results in increased activity of CASP8 protein19427195
D004052Diethylnitrosamine[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of CASP8 mRNA27048571
D004052Diethylnitrosamine[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein21907755
D004052Diethylnitrosamine[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA21907755
D004052Diethylnitrosaminegeraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]21907755
D004052Diethylnitrosaminegeraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA]21907755
C007379diethyl phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CASP8 mRNA28013214
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CASP8 mRNA15545218
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CASP8 mRNA21658437
D004074DigitoxinDigitoxin analog results in increased cleavage of CASP8 protein22037315
D004074DigitoxinDigitoxin results in increased cleavage of CASP8 protein22037315
D000875AnthralinAnthralin results in decreased activity of CASP8 protein23611293
D002117Calcitriol[Calcitriol co-treated with gemcitabine] results in increased expression of CASP8 protein20699664
D002117CalcitriolCalcitriol affects the expression of CASP8 mRNA15138306
C025605diisobutyl phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CASP8 mRNA28013214
C012125diisononyl phthalate[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CASP8 mRNA28013214
C002302dimethoxondimethoxon results in decreased expression of CASP8 mRNA26688254
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CASP8 protein"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CASP8 protein]"21294050
C010715di-n-octyl phthalatedi-n-octyl phthalate results in decreased expression of CASP8 protein29128616
D004147DioxinsDioxins affects the expression of CASP8 mRNA20463971
C007517diphenyleneiodonium[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
D004176DipyridamoleDipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein]17303086
D004229DithiothreitolDithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein]11226294
D004229Dithiothreitol"[1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one co-treated with Dithiothreitol] inhibits the reaction [[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein results in increased activity of CASP8 protein]]"10792026
D004050Ditiocarb[Ditiocarb binds to Copper] which results in increased activity of CASP8 protein22951949
C521792DMU-212[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of CASP8 mRNA27048571
C067311docetaxeldocetaxel results in increased activity of CASP8 protein16361572
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased activity of CASP8 protein23523905
C076946donepezildonepezil results in increased activity of CASP8 protein20522977
D004317Doxorubicin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]20856197
D004317DoxorubicinBCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]20856197
D004317DoxorubicinBCL2 protein inhibits the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]20856197
D004317DoxorubicinCASP3 protein promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]17013758
D004317Doxorubicin[CASP8 protein co-treated with CASP3 protein] affects the susceptibility to Doxorubicin22609468
D004317DoxorubicinCASP8 protein results in increased susceptibility to Doxorubicin22010212
D004317DoxorubicinDoxorubicin affects the activity of CASP8 protein15870702
D004317DoxorubicinDoxorubicin affects the expression of CASP8 mRNA16705698
D004317DoxorubicinDoxorubicin analog results in increased cleavage of CASP8 protein15981920
D004317Doxorubicin[Doxorubicin binds to TF protein] which results in increased activity of CASP8 protein24998637
D004317Doxorubicin"[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased cleavage of CASP8 protein"21214929
D004317Doxorubicin[Doxorubicin co-treated with decitabine] results in increased cleavage of CASP8 protein17283156
D004317Doxorubicin[Doxorubicin co-treated with FAS protein] results in increased activity of CASP8 protein15958570
D004317Doxorubicin[Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP8 protein16168113
D004317Doxorubicin[Doxorubicin co-treated with Paclitaxel] results in increased activity of CASP8 protein16168113
D004317Doxorubicin[Doxorubicin co-treated with Phellinus linteus extract] results in increased cleavage of and results in increased activity of CASP8 protein16868541
D004317Doxorubicin[Doxorubicin co-treated with Selenium] promotes the reaction [FADD protein binds to CASP8 protein]17970047
D004317Doxorubicin[Doxorubicin co-treated with Selenium] promotes the reaction [FAS protein binds to CASP8 protein]17970047
D004317DoxorubicinDoxorubicin results in increased activity of CASP8 protein15868924|1743784
D004317DoxorubicinDoxorubicin results in increased cleavage of and results in increased activity of CASP8 protein15897917|1602463
D004317DoxorubicinDoxorubicin results in increased cleavage of CASP8 protein18071906|2085619
D004317DoxorubicinDoxorubicin results in increased expression of and results in increased cleavage of CASP8 protein22010212
D004317DoxorubicinDoxorubicin results in increased expression of CASP8 mRNA16001973
D004317DoxorubicinDoxorubicin results in increased expression of CASP8 protein25339540
D004317Doxorubicin[Indomethacin results in increased activity of CASP8 protein] which results in increased susceptibility to Doxorubicin15812552
D004317DoxorubicinLIG4 protein affects the reaction [Doxorubicin results in increased activity of CASP8 protein]18508926
D004317Doxorubicin[Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Doxorubicin22010212
D004317DoxorubicinPI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]20856197
D004317DoxorubicinPRKDC protein affects the reaction [Doxorubicin results in increased activity of CASP8 protein]18508926
D004317DoxorubicinTNFRSF10A protein affects the reaction [Doxorubicin results in increased activity of CASP8 protein]17437844
D004317DoxorubicinTP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]20856197
D004317DoxorubicinTP53 protein promotes the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]20856197
D004317DoxorubicinDoxorubicin results in increased activity of CASP8 protein16018998
D004317DoxorubicinDoxorubicin results in increased expression of CASP8 mRNA26873546
D004317Doxorubicin[zoledronic acid co-treated with Doxorubicin] results in increased activity of CASP8 protein19789217
D004317Doxorubicin"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]"15799720
D004317Doxorubicinbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
D004317Doxorubicinchloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]]29133031
D004317Doxorubicincoenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein]27087047
D004317DoxorubicinCyclosporine inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
D004317Doxorubicin[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
D004317DoxorubicinDoxorubicin inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]29133031
D004317DoxorubicinDoxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]]29133031
D004317DoxorubicinDoxorubicin results in increased activity of CASP8 protein15799720|1668761
D004317DoxorubicinDoxorubicin results in increased cleavage of and results in increased activity of CASP8 protein17651020
D004317DoxorubicinDoxorubicin results in increased cleavage of CASP8 protein12107157|1570396
D004317DoxorubicinDoxorubicin results in increased expression of CASP8 protein27087047
D004317DoxorubicinGPX1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
D004317Doxorubicinpifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]16687611
D004317DoxorubicinSOD2 protein inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
D004317DoxorubicinTNF protein promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP8 protein]17651020
C060327dracorhodindracorhodin analog results in increased activity of CASP8 protein15215653|1568447
C060327dracorhodindracorhodin analog results in increased cleavage of CASP8 protein15813022
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased activity of CASP8 protein"15456542|1580253
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of and results in increased activity of CASP8 protein"23239598|2331583
D004365Drugs, Chinese Herbal"arsenic trioxide promotes the reaction [Drugs, Chinese Herbal results in increased cleavage of CASP8 protein]"28587418
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased cleavage of CASP8 protein"28587418
C509867E804 bisindoleE804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of CASP8 mRNA]23107598
C509867E804 bisindoleE804 bisindole results in increased expression of CASP8 mRNA23107598
C509867E804 bisindoleLipopolysaccharides inhibits the reaction [E804 bisindole results in increased expression of CASP8 mRNA]23107598
C022999echinocystic acidechinocystic acid analog results in increased activity of CASP8 protein15863893
C060311eckol[eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein21514314
D004533Egtazic Acid"[1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]"29111403
D004533Egtazic AcidEgtazic Acid inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]29111403
C034192ellipticineellipticine results in increased cleavage of and results in increased activity of CASP8 protein21843585
D004642Emodin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]27032576
D004642EmodinEmodin results in increased activity of CASP8 protein27032576
D004642EmodinSB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]27032576
D004642EmodinU 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein]27032576
C118739entinostatentinostat results in increased expression of CASP8 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
D015251EpirubicinEpirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]23867903
D015251EpirubicinEpirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA]23867903
C045651epigallocatechin gallateAcetylcysteine inhibits the reaction [epigallocatechin gallate promotes the reaction [arsenite results in increased activity of CASP8 protein]]26375285
C045651epigallocatechin gallateepigallocatechin gallate promotes the reaction [arsenite results in increased activity of CASP8 protein]26375285
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CASP8 mRNA22079256
C472787erucylphospho-N,N,N-trimethylpropylammonium"erucylphospho-N,N,N-trimethylpropylammonium results in increased cleavage of and results in increased activity of CASP8 protein"20177898
C007628esculetin[esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein16051289
C007628esculetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate co-treated with BCL2 protein co-treated with esculetin] results in increased activity of CASP8 protein]19786087
C007628esculetin[ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate co-treated with BCL2 protein co-treated with esculetin] results in increased activity of CASP8 protein19786087
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of and results in increased activity of CASP8 protein24316378
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of CASP8 mRNA24316378
C074283estradiol 3-benzoateQuercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of and results in increased activity of CASP8 protein]24316378
C074283estradiol 3-benzoateQuercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of CASP8 mRNA]24316378
D004976Ethacrynic Acid[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP8 protein23082001
D004976Ethacrynic AcidEthacrynic Acid results in increased cleavage of CASP8 protein23082001
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased expression of CASP8 protein]19429258
D000431EthanolEthanol results in increased expression of CASP8 protein19429258
D000431Ethanolcaraway oil inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein]25859307
D000431EthanolEthanol results in increased activity of CASP8 protein25289771
D000431EthanolEthanol results in increased cleavage of CASP8 protein25859307|2908558
D000431Ethanolnymphayol inhibits the reaction [Ethanol results in increased activity of CASP8 protein]25289771
D000431Ethanolthymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein]29085585
C456800ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP8 protein15634644
C456800ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate co-treated with BCL2 protein co-treated with esculetin] results in increased activity of CASP8 protein]19786087
C456800ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate[ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate co-treated with BCL2 protein co-treated with esculetin] results in increased activity of CASP8 protein19786087
D005047Etoposide"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein]"15475000
D005047Etoposideacetyl-leucyl-glutamyl-histidyl-aspartal inhibits the reaction [Etoposide results in increased activity of CASP8 protein]21801448
D005047Etoposide[CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]21801448
D005047Etoposide[CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]21801448
D005047Etoposide[CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]21801448
D005047Etoposide[CASP8 co-treated with TP53] inhibits the reaction [CASP8 protein mutant form results in decreased susceptibility to Etoposide]21801448
D005047EtoposideCASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]21801448
D005047EtoposideCASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP9 protein]21801448
D005047EtoposideCASP8 protein mutant form results in decreased susceptibility to Etoposide21801448
D005047EtoposideCASP8 protein results in increased susceptibility to Etoposide22010212
D005047EtoposideEtoposide results in increased activity of CASP8 protein15475000
D005047EtoposideEtoposide results in increased cleavage of and results in increased activity of CASP8 protein21745461
D005047EtoposideEtoposide results in increased cleavage of CASP8 protein21801448
D005047EtoposideEtoposide results in increased expression of and results in increased cleavage of CASP8 protein22010212
D005047EtoposideLithium inhibits the reaction [Etoposide results in increased activity of CASP8 protein]15475000
D005047Etoposidenimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP8 protein]21745461
D005047EtoposideTP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP8 protein]21801448
C496966Eudragit RSPOEudragit RSPO results in decreased expression of CASP8 mRNA22119964
C060802fangchinolinefangchinoline results in increased cleavage of CASP8 protein28754437
C020326ferric nitrilotriacetate[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein21907755
C020326ferric nitrilotriacetate[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA21907755
C020326ferric nitrilotriacetategeraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]21907755
C020326ferric nitrilotriacetategeraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA]21907755
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in increased cleavage of CASP8 protein25939952
D000068876Fingolimod HydrochlorideSQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]25939952
C017875fisetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP8 protein]21964635
C017875fisetin[Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP8 protein21216935
C017875fisetinfisetin results in increased activity of CASP8 protein21964635|2818138
C017875fisetinfisetin results in increased cleavage of and results in increased activity of CASP8 protein21216935
C028610flavanone[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to flavanone22056764
C028610flavanoneflavanone results in increased cleavage of and results in increased activity of CASP8 protein22056764
D047309FlavonesFlavones analog results in increased activity of CASP8 protein20674374
D044948FlavonolsFlavonols results in increased activity of and results in increased cleavage of CASP8 protein28235426
C548902FLLL 32FLLL 32 results in increased activity of CASP8 protein20576164
C024352fludarabine[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP8 protein15850772
C024352fludarabineBCL2 inhibits the reaction [fludarabine results in increased cleavage of CASP8 protein]15516989
C024352fludarabinebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [fludarabine results in increased cleavage of CASP8 protein]15516989
C024352fludarabine[fludarabine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein12780785
C024352fludarabinefludarabine results in increased activity of CASP8 protein11675354
C024352fludarabinefludarabine results in increased cleavage of CASP8 protein15516989
C024352fludarabine[LAQ824 co-treated with fludarabine] results in increased activity of CASP8 protein18852132
C024352fludarabine[Valproic Acid co-treated with fludarabine] results in increased cleavage of CASP8 protein19006566
D005472Fluorouracilbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein]26544897
D005472FluorouracilCadmium Chloride affects the reaction [Fluorouracil results in decreased expression of CASP8 mRNA]23941782
D005472Fluorouracil[Cadmium Chloride co-treated with Fluorouracil] affects the expression of CASP8 protein23941782
D005472FluorouracilCASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]19097688
D005472FluorouracilCASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]19097688
D005472FluorouracilCASP8 results in increased susceptibility to [andrographolide co-treated with Fluorouracil]19097688
D005472Fluorouracil[Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP8 protein16168113
D005472FluorouracilFAS protein affects the reaction [Fluorouracil results in increased activity of CASP8 protein]17056233
D005472FluorouracilFluorouracil affects the reaction [Cadmium Chloride results in decreased expression of CASP8 mRNA]23941782
D005472Fluorouracil[Fluorouracil co-treated with aloe emodin] affects the expression of CASP819928967
D005472Fluorouracil[Fluorouracil co-treated with Cisplatin] results in increased activity of CASP8 protein16803524
D005472Fluorouracil[Fluorouracil co-treated with Cisplatin] results in increased expression of CASP8 protein16803524
D005472Fluorouracil[Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein26544897
D005472FluorouracilFluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]19928967
D005472FluorouracilFluorouracil promotes the reaction [andrographolide results in increased activity of CASP8 protein]19097688
D005472FluorouracilFluorouracil promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]20876774
D005472FluorouracilFluorouracil results in decreased expression of CASP8 mRNA23941782
D005472FluorouracilFluorouracil results in increased activity of CASP8 protein10779637|1089139
D005472FluorouracilFluorouracil results in increased cleavage of CASP8 protein19816940|2654489
D005472FluorouracilFluorouracil results in increased expression of CASP8 mRNA17637740
D005472FluorouracilFluorouracil results in increased expression of CASP8 protein15585135|1680352
D005472FluorouracilIFNA1 promotes the reaction [Fluorouracil results in increased expression of CASP8 protein]21474236
D005472FluorouracilIFNA1 protein promotes the reaction [Fluorouracil results in increased activity of CASP8 protein]17016659
D005472Fluorouracilisoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Fluorouracil results in increased activity of CASP8 protein]14607657
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of CASP8 mRNA]17637740
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of CASP8 protein]17637740
D005472FluorouracilFluorouracil results in increased activity of CASP8 protein10568827
D005473FluoxetineFluoxetine results in increased activity of CASP8 protein28482088
D005485FlutamideFlutamide results in decreased expression of CASP8 mRNA21126777
D000068298Fluticasone[Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP8 protein15536434
C065180fluvastatinfluvastatin results in increased activity of CASP8 protein24964743
C065180fluvastatinMevalonic Acid inhibits the reaction [fluvastatin results in increased activity of CASP8 protein]24964743
D005492Folic AcidFolic Acid affects the expression of CASP8 mRNA16361273
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CASP8 gene20938992
D005557FormaldehydeFormaldehyde results in increased activity of CASP8 protein20448356
D005557FormaldehydeFormaldehyde results in increased expression of CASP8 mRNA20448356
C007768formononetinAcetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]23867903
C007768formononetinEpirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]23867903
C007768formononetinEpirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA]23867903
C007768formononetinformononetin results in increased activity of CASP8 protein23867903
C007768formononetinformononetin results in increased expression of CASP8 mRNA23867903
C058728fosbretabulinfosbretabulin analog results in increased cleavage of CASP8 protein25529822
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of CASP8 mRNA20846436
C039281furanfuran results in increased expression of CASP8 mRNA27387713
D005665FurosemideFurosemide affects the expression of CASP8 mRNA17497460
C002469fusarenon-Xfusarenon-X results in increased expression of CASP8 mRNA24983900
C000600490G226 compoundG226 compound results in increased activity of CASP8 protein25066322
D005688Galactosaminebaicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]20850421
D005688Galactosamine[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein21146893
D005688Galactosamine[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein20558151
D005688Galactosamine[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form20558151
D005688Galactosaminegentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein]20558151
D005688Galactosaminegentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form]20558151
D005688Galactosamine"[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased activity of CASP8 protein"24830863
D005688Galactosamine[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form20850421
D005688Galactosamine"Rotenone inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased activity of CASP8 protein]"24830863
D005688GalactosamineSilymarin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]20850421
D005688GalactosamineUrsodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein]21146893
D005707Gallic AcidGallic Acid results in increased expression of CASP8 protein22245431
D005708GalliumGallium results in increased activity of CASP8 protein21194614
C052659gambogic acid[gambogic acid co-treated with Bortezomib] results in increased activity of CASP8 protein24291039
C052659gambogic acid[Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein24373880
C000591222gardenin Bgardenin B results in increased cleavage of and results in increased activity of CASP8 protein27423764
C505531GCS-100GCS-100 results in increased cleavage of and results in increased activity of CASP8 protein16166312
C106014geduningedunin results in increased activity of CASP8 protein21381696
C056507gemcitabine[Calcitriol co-treated with gemcitabine] results in increased expression of CASP8 protein20699664
C056507gemcitabine[gemcitabine co-treated with TNFRSF10B] affects the activity of CASP8 protein18089714
C056507gemcitabinegemcitabine results in increased activity of and results in increased cleavage of CASP8 protein26894857
C056507gemcitabinegemcitabine results in increased activity of CASP8 protein12479703|1715960
C056507gemcitabinegemcitabine results in increased cleavage of CASP8 protein14750167
C056507gemcitabineSFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]26894857
C056507gemcitabine[TNFSF10 co-treated with gemcitabine] results in increased activity of CASP8 protein17671697
C056507gemcitabineYAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]26894857
D019833Genistein[Genistein co-treated with TNFSF10 protein] results in increased activity of CASP8 protein19497411
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]23452621
D019833GenisteinGenistein promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP8 protein]18546268
D005839GentamicinsGentamicins results in increased activity of CASP8 protein17132701
D005839Gentamicinstetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP8 protein]17132701
D005839Gentamicinstetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]]17132701
D005839GentamicinsTNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]17132701
C012997gentiopicrosidegentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein]20558151
C012997gentiopicrosidegentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form]20558151
C007836geraniolgeraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]21907755
C007836geraniolgeraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA]21907755
C007845gingerolAcetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]25034532
C007845gingerolgingerol results in increased cleavage of CASP8 protein28249781
C007845gingerol[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein25034532
C007845gingerolgingerol affects the activity of CASP8 protein17454143
C097367ginsenoside Rg3"ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP8 protein]"26427350
C030691gluconic acid[gluconic acid co-treated with Zinc Sulfate] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA]27017951
D005947GlucoseGlucose results in increased activity of CASP8 protein18973755
D005947GlucoseAcetylcysteine inhibits the reaction [Glucose results in increased activity of CASP8]18791325
D005947GlucoseGlucose results in increased activity of CASP818791325
D005978Glutathione"Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP8 protein]"24515801
D005978GlutathioneGlutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein]24515801
D005978GlutathioneGlutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein]24376112
C071834glycidamideCASP8 gene polymorphism affects the susceptibility to glycidamide27062911
D005999Glycochenodeoxycholic AcidGlycochenodeoxycholic Acid results in increased cleavage of CASP8 protein25125499
D005999Glycochenodeoxycholic AcidGlycochenodeoxycholic Acid results in increased activity of CASP8 protein12873810|1576724
D019695Glycyrrhizic AcidGlycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP8 protein]22051199
D006046GoldGold results in increased expression of CASP8 mRNA22178767
C103280goniothalamingoniothalamin results in increased cleavage of CASP8 protein21810437
C058858grifolingrifolin results in increased activity of CASP8 protein15949805
C401311GW 7845benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [GW 7845 results in increased activity of and results in increased cleavage of CASP8 protein]17400580
C401311GW 7845GW 7845 results in increased activity of and results in increased cleavage of CASP8 protein17400580
C001329helenalinhelenalin inhibits the reaction [CD 437 results in increased activity of CASP8 protein]16024638
D006571Heterocyclic CompoundsAcetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein]19014919
D006571Heterocyclic Compounds[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein19014919
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in increased activity of CASP8 protein"21500194
C089796hexabromocyclododecanehexabromocyclododecane results in increased activity of CASP8 protein24780359
D006581HexachlorobenzeneHexachlorobenzene results in increased activity of CASP8 protein21787832|2370840
C501367hispanoloneacetyl-isoleucyl-glutamyl-threonyl-aspartyl-aldehyde inhibits the reaction [hispanolone analog results in increased activity of CASP8 protein]25930665
C501367hispanoloneacetyl-isoleucyl-glutamyl-threonyl-aspartyl-aldehyde inhibits the reaction [TNFSF10 protein promotes the reaction [hispanolone analog results in increased activity of CASP8 protein]]25930665
C501367hispanolonehispanolone analog results in increased activity of CASP8 protein25930665
C501367hispanoloneTNFRSF10A protein affects the reaction [TNFSF10 protein promotes the reaction [hispanolone analog results in increased activity of CASP8 protein]]25930665
C501367hispanoloneTNFRSF10B protein affects the reaction [TNFSF10 protein promotes the reaction [hispanolone analog results in increased activity of CASP8 protein]]25930665
C501367hispanoloneTNFSF10 protein promotes the reaction [hispanolone analog results in increased activity of CASP8 protein]25930665
C005499honokiolhonokiol results in increased activity of CASP8 protein15802533
D017313Fenretinide[Fenretinide co-treated with TNFSF10 protein] results in increased activity of CASP8 protein17273769
D006812Humic SubstancesHumic Substances results in decreased expression of CASP8 mRNA23042718
D006812Humic SubstancesHumic Substances results in increased cleavage of CASP8 protein18683188
D006820Hyaluronic Acid[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein20237495
D006835Hydrazones[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to Hydrazones22056764
D006835HydrazonesHydrazones results in increased cleavage of and results in increased activity of CASP8 protein22056764
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CASP8 protein21179406
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of CASP8 protein21431366
D006861Hydrogen PeroxideMelatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]21431366
D006861Hydrogen Peroxide"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]"15799720
D006861Hydrogen PeroxideCholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]20946910
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of CASP8 protein]20946910
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of CASP8 protein15799720|1615729
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CASP8 protein20946910|2752527
D006861Hydrogen PeroxideLuteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]27525270
D006861Hydrogen Peroxide[mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]15799720
D006861Hydrogen PeroxideQuercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]16647178
D006861Hydrogen PeroxideQuercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]27525270
C012353hydroperoxyisophosphamideBAX promotes the reaction [hydroperoxyisophosphamide results in increased activity of CASP8 protein]11723234
C012353hydroperoxyisophosphamideBCL2 inhibits the reaction [hydroperoxyisophosphamide results in increased activity of CASP8 protein]11723234
C012353hydroperoxyisophosphamidehydroperoxyisophosphamide results in increased activity of CASP8 protein11723234
C031927hydroquinonehydroquinone results in increased activity of CASP8 protein23776099
C031927hydroquinoneMPO protein affects the reaction [hydroquinone results in increased cleavage of CASP8 protein]15777082
C051414hydroxygenkwaninApigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP8 protein]24144774
C051414hydroxygenkwaninhydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP8 protein]24144774
C051414hydroxygenkwaninhydroxygenkwanin results in increased activity of CASP8 protein24144774
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased activity of CASP8 protein23776099
C559745hyperforin dicyclohexylammoniumhyperforin dicyclohexylammonium results in increased activity of CASP8 protein21376709
C467077ilimaquinoneilimaquinone results in increased cleavage of CASP8 protein24930757
D000068877Imatinib Mesylate[Imatinib Mesylate co-treated with alvocidib] results in increased activity of CASP8 protein12231544
D000068877Imatinib Mesylate[tetraarsenic tetrasulfide co-treated with Imatinib Mesylate] results in increased expression of CASP8 mRNA19208803
D007099ImipramineImipramine inhibits the reaction [lead acetate results in increased activity of CASP8 protein]22033380
C428264indioside DCASP8 protein affects the susceptibility to indioside D18376857
C428264indioside Dindioside D results in increased activity of CASP8 protein18376857
C428264indioside Dindioside D results in increased cleavage of CASP8 protein18376857
C474021indirubin-3'-monoxime[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CASP8 mRNA18958680
D007213Indomethacin[Indomethacin results in increased activity of CASP8 protein] which results in increased susceptibility to Doxorubicin15812552
D007213IndomethacinIndomethacin results in increased cleavage of and results in increased activity of CASP8 protein15812552
D007213IndomethacinIndomethacin results in increased expression of and results in increased activity of CASP8 protein15265368
D007213IndomethacinIndomethacin results in decreased activity of CASP8 protein19615346
D007213IndomethacinIndomethacin results in increased activity of CASP8 protein18375387
D007213IndomethacinLansoprazole inhibits the reaction [Indomethacin results in increased activity of CASP8 protein]18375387
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]15477007
D015759Ionomycinbathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]]15477007
D015759Ionomycin[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP8 protein12165276
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA25613284
C033148iprodione[iprodione co-treated with acetamiprid] results in decreased expression of CASP8 mRNA29091792
C033148iprodione[iprodione co-treated with pyrachlostrobin co-treated with acetamiprid co-treated with iprodione] results in increased expression of CASP8 mRNA29091792
C033148iprodione[iprodione co-treated with pyrachlostrobin co-treated with acetamiprid] results in increased expression of CASP8 mRNA29091792
C033148iprodione[iprodione co-treated with pyrachlostrobin] results in decreased expression of CASP8 mRNA29091792
C033148iprodione[iprodione co-treated with pyrimethanil co-treated with acetamiprid] results in increased expression of CASP8 mRNA29091792
C033148iprodione[iprodione co-treated with pyrimethanil] results in decreased expression of CASP8 mRNA29091792
C051890irinotecanirinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP8 protein]18182997
C051890irinotecanirinotecan results in increased activity of CASP8 protein16432164
C051890irinotecanirinotecan results in increased cleavage of and results in increased activity of CASP8 protein18182997
C051890irinotecanUrsodeoxycholic Acid promotes the reaction [irinotecan results in increased activity of CASP8 protein]16432164
D007529IsoflavonesIsoflavones results in increased expression of CASP8 mRNA25035168
D007530IsofluraneIsoflurane results in increased activity of CASP8 protein23922164
D007530Isofluraneresveratrol inhibits the reaction [Isoflurane results in increased activity of CASP8 protein]23922164
C425644isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketoneisoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [arsenic trioxide promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]]16434995
C425644isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketoneisoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Fluorouracil results in increased activity of CASP8 protein]14607657
C425644isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketoneisoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein11464216
C040920isoliquiritigeninisoliquiritigenin results in increased activity of CASP8 protein16158945
D007545IsoproterenolIsoproterenol results in increased expression of CASP8 mRNA25794854|2699654
D007545IsoproterenolThymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]26996544
D007545IsoproterenolVanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]25794854
C545474JAI-51JAI-51 results in increased activity of CASP8 protein24134853
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CASP8 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound analog promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]26415225
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]26415225
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CASP8 mRNA26830473
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CASP8 protein26830473
C561695(+)-JQ1 compound[TNFSF10 protein co-treated with (+)-JQ1 compound] results in increased cleavage of CASP8 protein26415225
C005134juglonejuglone results in increased activity of CASP8 protein20138029
C046438kahweol acetateCFLAR protein inhibits the reaction [[TNFSF10 protein co-treated with kahweol acetate] results in increased activity of CASP8 protein]20403343
C046438kahweol acetate[TNFSF10 protein co-treated with kahweol acetate] results in increased activity of CASP8 protein20403343
C047382kamebakaurinkamebakaurin promotes the reaction [TNF protein results in increased activity of CASP8 protein]11877450
D007649KetamineKetamine results in increased expression of CASP8 mRNA28716577
C011890kojic acid[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA18544905
C000620717kuntai capsulekuntai capsule results in increased expression of CASP8 protein27597876
C067713lactacystinlactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]]20671745
D064747LansoprazoleLansoprazole inhibits the reaction [Indomethacin results in increased activity of CASP8 protein]18375387
C477361LAQ824[LAQ824 co-treated with fludarabine] results in increased activity of CASP8 protein18852132
C008261lead acetate"1,3-dimethylthiourea inhibits the reaction [lead acetate results in increased activity of CASP8 protein]"22033380
C008261lead acetateClotrimazole inhibits the reaction [lead acetate results in increased activity of CASP8 protein]22033380
C008261lead acetateImipramine inhibits the reaction [lead acetate results in increased activity of CASP8 protein]22033380
C008261lead acetatelead acetate results in increased activity of CASP8 protein22033380
C008261lead acetate[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]22033380
C008261lead acetateS-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP8 protein]22033380
C018584linaloollinalool results in increased expression of CASP8 mRNA26703569
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in increased expression of CASP8 protein"20155912
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased activity of CASP8 protein"24830863
C482199lipopolysaccharide, E coli O55-B5"Rotenone inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased activity of CASP8 protein]"24830863
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CASP8 protein21844306
D008070Lipopolysaccharidesbaicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]20850421
D008070LipopolysaccharidesE804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of CASP8 mRNA]23107598
D008070Lipopolysaccharides[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein21146893
D008070Lipopolysaccharides[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein20558151
D008070Lipopolysaccharides[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form20558151
D008070Lipopolysaccharidesgentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein]20558151
D008070Lipopolysaccharidesgentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form]20558151
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form20850421
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [E804 bisindole results in increased expression of CASP8 mRNA]23107598
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of CASP8 protein23170834
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CASP8 mRNA23107598
D008070Lipopolysaccharidesnotoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP8 protein]23170834
D008070LipopolysaccharidesSilymarin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]20850421
D008070LipopolysaccharidesUrsodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein]21146893
C054164lipstatinlipstatin analog results in increased cleavage of and results in increased activity of CASP8 protein20577697
D008094LithiumLithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]15475000
D008094LithiumLithium inhibits the reaction [Etoposide results in increased activity of CASP8 protein]15475000
D008095Lithocholic Acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP8 protein]19054763
D008095Lithocholic Acid[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein19054763
D008095Lithocholic Acid[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein19054763
D008095Lithocholic Acid[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein19054763
D008095Lithocholic Acid[[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein19054763
D008095Lithocholic AcidLithocholic Acid results in increased cleavage of and results in increased activity of CASP8 protein19054763
C115354lonafarnib[lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP8 protein16118318
C016371lonidamine[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein21889928
C016371lonidamineBCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein]21889928
D017336LoratadineLoratadine results in increased cleavage of CASP8 protein20570632
D019808LosartanLosartan results in decreased activity of CASP8 protein23875703
D008148LovastatinLovastatin results in increased activity of CASP8 protein15705602
D008148LovastatinLovastatin results in increased activity of CASP8 protein15180944
D047311Luteolin[Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein24525192
D047311LuteolinLuteolin promotes the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]15334063
D047311LuteolinLuteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]16140950
D047311LuteolinLuteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]27525270
C015329lycopenelycopene results in decreased expression of CASP8 mRNA16886892
C015329lycopenelycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
C015329lycopene[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
C048341mafosfamideBAX promotes the reaction [mafosfamide results in increased activity of CASP8 protein]11723234
C048341mafosfamideBCL2 inhibits the reaction [mafosfamide results in increased activity of CASP8 protein]11723234
C048341mafosfamidemafosfamide results in increased activity of CASP8 protein11723234
D008277Magnesium OxideMagnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA]27920530
D008294MalathionMalathion results in increased activity of CASP8 protein12505448
C013099mancozebmancozeb results in increased activity of CASP8 protein22289270|2282450
D008344ManebManeb results in increased activity of CASP8 protein22824503
C025340manganese chloridebafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]28378122
C025340manganese chlorideCA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]28378122
C025340manganese chloridemanganese chloride results in increased cleavage of CASP8 protein21704098|2837812
C025340manganese chloridepepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]28378122
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[resveratrol co-treated with panobinostat] results in increased cleavage of CASP8 protein]22923501
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[resveratrol co-treated with vorinostat] results in increased cleavage of CASP8 protein]22923501
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[XCT790 results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP8 protein]19464277
C021053mangostinmangostin results in increased activity of CASP8 protein24480042
D009637Masoprocol[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein17645780
D009637MasoprocolMasoprocol results in increased expression of CASP8 protein17645780
D009637MasoprocolMasoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein]10203695
D009637MasoprocolMasoprocol inhibits the reaction [[TNF protein co-treated with Cycloheximide] results in increased activity of CASP8 protein]15950244
D008550MelatoninMelatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]21431366
D008550MelatoninMelatonin results in increased activity of CASP8 protein19012662
D008550MelatoninMelatonin inhibits the reaction [bisphenol A results in increased activity of CASP8 protein]25454643
D008555MelittenMelitten results in increased expression of CASP8 protein modified form22027265
C042720mercuric bromidemercuric bromide results in increased expression of CASP8 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of CASP8 mRNA20353558
D008627Mercuric Chloride[Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased activity of CASP8 protein16421179
D008627Mercuric ChlorideMercuric Chloride results in increased activity of CASP8 protein16421179
D008687MetforminMetformin results in decreased activity of CASP8 protein15531508
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CASP8 gene20938992
D008727MethotrexateMethotrexate results in increased expression of and results in increased cleavage of CASP8 protein22010212
D008727MethotrexateMethotrexate results in increased expression of CASP8 mRNA17400583|1763774
D008727MethotrexateMethotrexate results in increased expression of CASP8 protein17637740|2533030
D008727Methotrexate[Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Antineoplastic Agents22010212
D008727Methotrexate[Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Cyclophosphamide metabolite22010212
D008727Methotrexate[Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Dexamethasone22010212
D008727Methotrexate[Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Doxorubicin22010212
D008727MethotrexateSOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP8 mRNA]25330300
D008727MethotrexateSOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP8 protein]25330300
D008727MethotrexateTP53 protein promotes the reaction [Methotrexate results in increased expression of CASP8 mRNA]17637740
D008727MethotrexateTP53 protein promotes the reaction [Methotrexate results in increased expression of CASP8 protein]17637740|2201021
D008727MethotrexateMethotrexate results in increased expression of CASP8 protein modified form23406595
D008731MethoxychlorMethoxychlor results in increased activity of CASP8 protein20568958
D008730MethoxsalenMethoxsalen results in decreased expression of CASP8 protein22796345
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased expression of CASP8 protein"25246272
C587228methyl 3-hydroxyimino-11-oxoolean-12-en-28-oatemethyl 3-hydroxyimino-11-oxoolean-12-en-28-oate results in increased activity of CASP8 protein24291674
C555027methyl 5-chloro-4,5-didehydrojasmonate"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [methyl 5-chloro-4,5-didehydrojasmonate results in increased activity of CASP8 protein]"20696234
C555027methyl 5-chloro-4,5-didehydrojasmonate"methyl 5-chloro-4,5-didehydrojasmonate results in increased activity of and results in increased cleavage of CASP8 protein"20696234
C072239methyl jasmonate[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [methyl jasmonate metabolite results in increased susceptibility to TNFSF10 protein]22079975
C072239methyl jasmonatemethyl jasmonate metabolite promotes the reaction [TNFSF10 protein results in decreased expression of CASP8 protein]22079975
C072239methyl jasmonatemethyl jasmonate metabolite promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]22079975
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CASP8 mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CASP8 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of CASP8 protein"22983118|2725538
D008769Methylnitronitrosoguanidinelycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein16030430
D008769Methylnitronitrosoguanidine[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
D008769MethylnitronitrosoguanidineS-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
D008770Methylnitrosourea[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP8 protein22465879
D008770Methylnitrosourea[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP8 mRNA20732338
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of CASP8 mRNA28688903
C400939methylonemethylone results in increased activity of CASP8 protein27255387
C008493methylselenic acid"[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of CASP8 protein"18444175
C008493methylselenic acid[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP8 protein18790785
C008493methylselenic acid[[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein18790785
C008493methylselenic acidmethylselenic acid results in increased cleavage of CASP8 protein18790785
C008493methylselenic acid[methylselenic acid results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein18790785
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [fluvastatin results in increased activity of CASP8 protein]24964743
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]]17070682
D015735MifepristoneMifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]]12645856
D008911MinocyclineMinocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]12930891
D008911MinocyclineMinocycline results in decreased expression of and results in decreased activity of CASP8 protein14998631
D008911MinocyclineMinocycline results in decreased expression of CASP8 mRNA14998631
D016685MitomycinMitomycin results in increased activity of CASP8 protein10960761|1709445
D016685MitomycinMitomycin results in increased cleavage of and results in increased activity of CASP8 protein12181741
D016685MitomycinMitomycin results in increased cleavage of CASP8 protein16019139|1702165
D016685MitomycinBCL2 protein inhibits the reaction [Mitomycin results in increased cleavage of and results in increased activity of CASP8 protein]12181741
C429015mitoquinol[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
C429015mitoquinol[mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]15799720
C429014mitoquinone[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]15799720
C429014mitoquinone[mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]15799720
D008942MitoxantroneMitoxantrone results in increased activity of CASP8 protein12948851
D008982MolybdenumMolybdenum analog results in increased activity of CASP8 protein26391003
D009020MorphineARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]19239323
D009020MorphineMorphine results in decreased expression of CASP8 protein alternative form19239323
D009020MorphineMorphine results in increased activity of CASP8 protein19070643
D009020MorphineMorphine results in increased activity of CASP8 protein11590188
D009151Mustard Gasbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Mustard Gas results in increased activity of CASP8 protein]20226831
D009151Mustard GasCALM1 protein promotes the reaction [Mustard Gas results in increased cleavage of and results in increased activity of CASP8 protein]16935404
D009151Mustard GasFADD protein affects the reaction [Mustard Gas results in increased cleavage of CASP8 protein]12482751
D009151Mustard GasMustard Gas results in increased activity of CASP8 protein16738803|2022683
D009151Mustard GasMustard Gas results in increased cleavage of and results in increased activity of CASP8 protein12482751|1693540
D009151Mustard GasMustard Gas results in increased expression of CASP8 mRNA18955075
C058815N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamideN-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide affects the localization of and results in increased cleavage of and results in increased activity of CASP8 protein15520213
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of CASP8 protein12414664
C064769N-acetylsphingosineN-acetylsphingosine promotes the reaction [TNF protein results in increased activity of CASP8 protein]10792026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CASP8 mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CASP8 protein"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CASP8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CASP8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CASP8 mRNA"26146619
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased activity of CASP8 protein"19827037
D009285NaphthoquinonesNaphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]19497415
C498045NCX 4040NCX 4040 results in increased expression of CASP8 mRNA20188076
C002443neem oilneem oil results in increased cleavage of and results in increased activity of CASP8 protein22915764
D019888NelfinavirNelfinavir results in increased activity of CASP8 protein20105315
C013613neohesperidin dihydrochalconeneohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP8 protein]24530446
C011947neoxanthinneoxanthin results in increased activity of CASP8 protein17186379
D009532Nickelbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Nickel results in increased cleavage of CASP8 protein]24840272
D009532Nickel[Nickel co-treated with austenitic steel analog] results in increased expression of CASP8 mRNA23638002
D009532NickelNickel results in decreased expression of CASP8 protein28330870
D009532NickelNickel results in increased cleavage of CASP8 protein24840272
D009532NickelNickel results in increased expression of CASP8 mRNA21054559
D009532NickelNickel analog results in increased expression of CASP8 mRNA27257140
C022838nickel chloridenickel chloride affects the expression of CASP8 mRNA22546817
D009538NicotineNicotine affects the expression of CASP8 mRNA20426880
D009544Niflumic Acidbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ciglitazone promotes the reaction [Niflumic Acid results in increased activity of CASP8 protein]]21067863
D009544Niflumic Acidbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Niflumic Acid promotes the reaction [ciglitazone results in increased activity of CASP8 protein]]21067863
D009544Niflumic Acidciglitazone promotes the reaction [Niflumic Acid results in increased activity of CASP8 protein]21067863
D009544Niflumic AcidDDIT3 mutant form inhibits the reaction [ciglitazone promotes the reaction [Niflumic Acid results in increased activity of CASP8 protein]]21067863
D009544Niflumic AcidDDIT3 mutant form inhibits the reaction [Niflumic Acid promotes the reaction [ciglitazone results in increased activity of CASP8 protein]]21067863
D009544Niflumic AcidNiflumic Acid promotes the reaction [ciglitazone results in increased activity of CASP8 protein]21067863
D009544Niflumic AcidNiflumic Acid results in increased activity of CASP8 protein21067863
C042198nimbolidenimbolide results in increased expression of CASP8 protein20429769
C012655nimesulidebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [nimesulide results in increased cleavage of and results in increased activity of CASP8 protein]19360361
C012655nimesulidenimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP8 protein]21745461
C012655nimesulidenimesulide results in increased activity of and results in increased cleavage of CASP8 protein19360361
D015376NimustineNimustine results in increased cleavage of CASP8 protein26418950
D009569Nitric OxideNitric Oxide results in increased activity of CASP8 protein15126337
D009569Nitric Oxide[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP8 protein22878015
D009569Nitric OxideNitric Oxide results in decreased cleavage of and results in decreased activity of CASP8 protein10358093
D009569Nitric Oxide"[1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one co-treated with Dithiothreitol] inhibits the reaction [[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein results in increased activity of CASP8 protein]]"10792026
D009569Nitric Oxide"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein results in increased activity of CASP8 protein]]"10792026
D009569Nitric Oxide[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein results in increased activity of CASP8 protein]10792026
D009589Nitrogen OxidesNitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP8 protein]16041517
D009599NitroprussideNitroprusside inhibits the reaction [Deferoxamine results in increased activity of CASP8 protein]16374551
D009599Nitroprusside[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP8 protein22878015
D009599Nitroprussidecilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP8 protein]18311796
D009599NitroprussideNitroprusside results in increased activity of CASP8 protein18311796
D026423S-Nitroso-N-Acetylpenicillamine"[1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one co-treated with Dithiothreitol] inhibits the reaction [[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein results in increased activity of CASP8 protein]]"10792026
D026423S-Nitroso-N-Acetylpenicillamine"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein results in increased activity of CASP8 protein]]"10792026
D026423S-Nitroso-N-Acetylpenicillamine[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein results in increased activity of CASP8 protein]10792026
D026422S-NitrosoglutathioneS-Nitrosoglutathione results in increased activity of CASP8 protein20153346
C542681N,N-dimethylphytosphingosine"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [N,N-dimethylphytosphingosine results in increased activity of CASP8 protein]"19481559
C542681N,N-dimethylphytosphingosine"benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [N,N-dimethylphytosphingosine results in increased cleavage of and results in increased activity of CASP8 protein]"19481559
C542681N,N-dimethylphytosphingosine"N,N-dimethylphytosphingosine results in increased cleavage of and results in increased activity of CASP8 protein"19481559
C542681N,N-dimethylphytosphingosine"Quercetin inhibits the reaction [N,N-dimethylphytosphingosine results in increased activity of CASP8 protein]"19481559
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of CASP8 protein15816005
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of CASP8 protein"17979179
D015739NocodazoleCaspase Inhibitors inhibits the reaction [Nocodazole analog results in increased expression of CASP8 protein modified form]28412508
D015739NocodazoleNocodazole analog results in increased cleavage of CASP8 protein28412508
C063998nodularinnodularin results in increased expression of CASP8 mRNA27061667
C063998nodularinsauchinone inhibits the reaction [nodularin results in increased expression of CASP8 mRNA]27061667
C063998nodularinnodularin results in increased activity of CASP8 protein25192816
C069741norcantharidinnorcantharidin results in increased activity of CASP8 protein20040369|2126619
D009638NorepinephrineNorepinephrine affects the activity of CASP8 protein25437044
C072936notoginsenoside R1notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP8 protein]23170834
C404397NSC 680410NSC 680410 results in increased cleavage of and results in increased activity of CASP8 protein14647418
C404397NSC 680410NSC 680410 results in increased cleavage of CASP8 protein16481037
C520337NSC 74859NSC 74859 results in decreased expression of CASP8 protein24525192
C520337NSC 74859Paclitaxel promotes the reaction [NSC 74859 results in decreased expression of CASP8 protein]24525192
C482205nutlin 3nutlin 3 results in increased cleavage of and results in increased activity of CASP8 protein16014563
C000594859nymphayolnymphayol inhibits the reaction [Ethanol results in increased activity of CASP8 protein]25289771
D009761NystatinNystatin inhibits the reaction [resveratrol affects the localization of CASP8 protein]12902349
C107010O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of CASP8 protein]"12540782
C067207obacunoneobacunone results in decreased expression of CASP8 protein21333732
C067207obacunoneobacunone results in increased cleavage of CASP8 protein25592883
C411188obacunone glucosideobacunone glucoside results in increased cleavage of CASP8 protein25592883
C464660obeticholic acidobeticholic acid results in increased expression of CASP8 mRNA27939613
C025589ochratoxin Aochratoxin A results in decreased expression of CASP8 mRNA17316727|2475539
C025589ochratoxin Aochratoxin A results in increased activity of CASP8 protein27193732
D015242OfloxacinOfloxacin results in increased expression of CASP8 mRNA24582689
D015242OfloxacinTNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]24582689
D019319Okadaic Acidacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Okadaic Acid results in increased cleavage of and results in increased activity of CASP8 protein]19084044
D019319Okadaic Acidbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Okadaic Acid results in increased cleavage of and results in increased activity of CASP8 protein]19084044
D019319Okadaic AcidOkadaic Acid results in increased cleavage of and results in increased activity of CASP8 protein19084044
C531550olaparibbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein]26544897
C531550olaparib[Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein26544897
C021065oleandrinoleandrin results in increased activity of CASP8 protein24172227
D009828Oleanolic AcidOleanolic Acid results in increased activity of CASP8 protein20005942
C484027oligofectamineoligofectamine results in increased expression of CASP8 mRNA14668052
D009853OmeprazoleOmeprazole analog results in increased cleavage of CASP8 protein18336733
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of CASP8 mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of CASP8 mRNA"22937105
D009942Organometallic CompoundsOrganometallic Compounds results in increased activity of CASP818760261
D009942Organometallic CompoundsOrganometallic Compounds results in increased activity of CASP8 protein21194614|2639100
D009942Organometallic CompoundsOrganometallic Compounds results in decreased activity of CASP8 protein18571097
C055122orlistatorlistat analog results in increased cleavage of and results in increased activity of CASP8 protein20577697
C055122orlistatorlistat results in increased cleavage of and results in increased activity of CASP8 protein18796435
C030110oxaliplatin[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of and results in increased activity of CASP8 protein19728331
C030110oxaliplatinpifithrin inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]19728331
C030110oxaliplatinTP53 mutant form inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]19728331
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of CASP8 mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]23452621
D017239Paclitaxel[Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP8 protein16168113
D017239Paclitaxel[Doxorubicin co-treated with Paclitaxel] results in increased activity of CASP8 protein16168113
D017239Paclitaxel[esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein16051289
D017239Paclitaxel[Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein24525192
D017239PaclitaxelPaclitaxel promotes the reaction [NSC 74859 results in decreased expression of CASP8 protein]24525192
D017239PaclitaxelPaclitaxel results in increased activity of CASP8 protein11716366
D017239PaclitaxelPaclitaxel results in increased cleavage of CASP8 protein18071906|1809827
D017239PaclitaxelPaclitaxel results in increased expression of CASP8 mRNA18058816
D017239PaclitaxelPaclitaxel results in increased expression of CASP8 protein15907983
D017239Paclitaxel[resveratrol co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein14749477
D017239Paclitaxel[Tretinoin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein18098270
D017239Paclitaxel[TYMP mutant form co-treated with Paclitaxel] results in increased cleavage of CASP8 protein15492279
D017239PaclitaxelPaclitaxel results in increased expression of CASP8 mRNA26091902
C000588809paederosidic acidMAPK8 protein affects the reaction [paederosidic acid results in increased cleavage of CASP8 protein]28185768
C000588809paederosidic acidpaederosidic acid results in increased cleavage of CASP8 protein28185768
D000073878Palm OilPalm Oil results in decreased expression of CASP8 mRNA18042831
D000073878Palm OilPalm Oil results in increased expression of CASP8 mRNA18042831
C482884panduratin Apanduratin A results in increased cleavage of CASP8 protein16497706
C496932panobinostatCASP8 protein affects the susceptibility to [resveratrol co-treated with panobinostat]22923501
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of CASP8 mRNA21791302
C496932panobinostatmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[resveratrol co-treated with panobinostat] results in increased cleavage of CASP8 protein]22923501
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C496932panobinostat[panobinostat co-treated with vorinostat] results in increased cleavage of CASP8 protein22923501
C496932panobinostatpanobinostat results in increased expression of CASP8 mRNA26272509
C496932panobinostat[resveratrol co-treated with panobinostat] results in increased cleavage of CASP8 protein22923501
D010261Paraoxonbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]12831782
D010261Paraoxonbenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]12831782
D010261Paraoxonbenzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]12831782
D010261ParaoxonParaoxon results in increased cleavage of and results in increased activity of CASP8 protein12831782
D010269ParaquatParaquat results in increased expression of CASP8 mRNA27288846
D010269Paraquat6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of CASP8 protein modified form]28414160
D010269ParaquatParaquat promotes the reaction [TNFRSF10B protein binds to CASP8 protein]28414160
D010269ParaquatParaquat results in decreased expression of CASP8 mRNA26468117
D010269ParaquatParaquat results in increased cleavage of CASP8 protein28414160
D010269ParaquatParaquat results in increased expression of CASP8 mRNA20883675
D010269ParaquatParaquat results in increased expression of CASP8 mRNA alternative form17064354
D010269ParaquatParaquat results in increased activity of CASP8 protein17561093|2491263
D010269ParaquatSodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP8 protein]17561093
D017374ParoxetineParoxetine results in increased activity of CASP8 protein28482088
C022097partheninparthenin analog results in increased activity of CASP8 protein25196075
C002669parthenolide[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein20154269
C002669parthenolide[[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen20154269
D052638Particulate MatterParticulate Matter results in increased expression of CASP8 protein21371539
C000610380p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased cleavage of CASP8 protein"26035713
C074968pentaacetyl geniposidepentaacetyl geniposide results in increased activity of CASP8 protein15975050
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased activity of CASP8 protein18453545
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CASP8 mRNA23948077
D010416PentachlorophenolPentachlorophenol results in increased expression of CASP8 mRNA19442831
C572410pentedronepentedrone results in increased activity of CASP8 protein27255387
D010424PentobarbitalPentobarbital results in decreased expression of CASP8 mRNA16978161
D010431PentoxifyllinePentoxifylline promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]20804743
C031375pepstatinpepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]28378122
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of CASP8 protein19878704
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased activity of CASP8 protein19646514
C105905perifosine[perifosine co-treated with Butyrates] results in increased activity of CASP8 protein15781658
C105905perifosine[perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein15781658
C105905perifosine[perifosine co-treated with vorinostat] results in increased activity of CASP8 protein15781658
D015232DinoprostoneDinoprostone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CASP8 mRNA]18463360
D015232DinoprostoneDinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]25432964
C526145Phellinus linteus extract[Doxorubicin co-treated with Phellinus linteus extract] results in increased cleavage of and results in increased activity of CASP8 protein16868541
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased activity of CASP8 protein16054126
D010634Phenobarbital[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of CASP8 mRNA27048571
D019800PhenolPhenol results in increased activity of CASP8 protein23776099
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CASP8 mRNA26272509
C005435phenylmethylpyrazolonephenylmethylpyrazolone results in decreased expression of CASP8 protein17967739
D010713Phosphatidylcholines[rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP8 protein21695227
C107448phthalocyanine Pc 4phthalocyanine Pc 4 results in increased cleavage of and results in increased activity of CASP8 protein16007152
C522973PI103BCL2 protein inhibits the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]20856197
C522973PI103PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]20856197
C522973PI103TP53 protein promotes the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]20856197
C121565pifithrinpifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]19732952
C121565pifithrinpifithrin inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]19728331
C121565pifithrinpifithrin inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP8 protein]16777994
C121565pifithrinpifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]16687611
D020110PinacidilPinacidil results in decreased expression of CASP8 mRNA17612592
C006253pirinixic acidNCF1 protein affects the reaction [pirinixic acid results in decreased expression of CASP8 protein]17483499
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CASP8 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CASP8 protein17483499
C006253pirinixic acidpirinixic acid results in increased expression of CASP8 mRNA18301758|2381119
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of CASP8 protein]17483499
D010936Plant Extracts[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to Plant Extracts20229524
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]23452621
D010936Plant ExtractsPlant Extracts inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]20971099
D010936Plant ExtractsPlant Extracts results in decreased expression of CASP8 mRNA21920417
D010936Plant ExtractsPlant Extracts results in decreased expression of CASP8 protein24021570
D010936Plant ExtractsPlant Extracts results in increased activity of CASP8 protein18070620|2060080
D010936Plant ExtractsPlant Extracts results in increased cleavage of and results in increased activity of CASP8 protein17619071
D010936Plant ExtractsPlant Extracts results in increased cleavage of CASP8 protein20229524|2544919
D010936Plant ExtractsPlant Extracts results in increased expression of and results in increased activity of CASP8 protein24677778
D010936Plant ExtractsPlant Extracts results in increased expression of CASP8 protein24534064
D010936Plant ExtractsPlant Extracts results in increased activity of CASP8 protein24991116
C014758plumbaginAcetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein]20576514
C014758plumbaginplumbagin results in increased activity of CASP8 protein20576514
D011070Poly I-CPoly I-C results in increased activity of CASP8 protein19563882
D011070Poly I-Carsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP8 protein]21418039
D011070Poly I-CPoly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein]21418039
D011070Poly I-CPoly I-C results in increased activity of CASP8 protein21418039
D059808Polyphenols[Polyphenols co-treated with Bleomycin] results in increased expression of CASP8 mRNA26800624
D059808PolyphenolsPolyphenols results in decreased expression of CASP8 protein24021570
D059808PolyphenolsPolyphenols results in increased activity of CASP8 protein24021570
C472086polyphenon Epolyphenon E results in increased cleavage of CASP8 protein23285096
D011166PorphyrinsPorphyrins results in increased expression of CASP8 mRNA26468117
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CASP8 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CASP8 mRNA22079256
D011224PrazosinPrazosin results in increased activity of CASP8 protein26449523
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione results in increased activity of CASP8 protein"17475222
D011353ProdigiosinProdigiosin results in increased cleavage of CASP8 protein15746575
D011374ProgesteroneProgesterone inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]23482746
D011374ProgesteroneProgesterone results in increased expression of CASP8 mRNA21549006
D011374Progesterone[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP8 protein22465879
D011374Progesterone[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP8 mRNA20732338
D011374ProgesteroneProgesterone results in increased expression of CASP8 mRNA21770760
D015742PropofolPropofol results in increased expression of CASP8 mRNA26103940
D011429PropolisPropolis results in increased activity of CASP8 protein26367700
D015237DinoprostDinoprost inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CASP8 mRNA]18463360
C028025protoporphyrin IXprotoporphyrin IX results in decreased activity of CASP8 protein16051694
C498383psymberinCASP8 protein results in increased susceptibility to psymberin20920557
C107773pterostilbenepterostilbene results in increased cleavage of and results in increased activity of CASP8 protein20681671
C033607puerarinarsenic trioxide promotes the reaction [puerarin results in increased expression of CASP8 protein]20416161
C033607puerarinpuerarin results in increased expression of CASP8 protein20416161
C115642punicalaginpunicalagin results in increased expression of CASP8 protein28709945
C572726pycnidionepycnidione results in increased activity of and results in increased cleavage of CASP8 protein22450442
C513428pyrachlostrobin[iprodione co-treated with pyrachlostrobin co-treated with acetamiprid co-treated with iprodione] results in increased expression of CASP8 mRNA29091792
C513428pyrachlostrobin[iprodione co-treated with pyrachlostrobin co-treated with acetamiprid] results in increased expression of CASP8 mRNA29091792
C513428pyrachlostrobin[iprodione co-treated with pyrachlostrobin] results in decreased expression of CASP8 mRNA29091792
C432165pyrazolanthrone"pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP8 protein]"23212307
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP8 protein]21138480
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein]17145888
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP8 protein]15501958
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP8 protein]21165570
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein]15767555
C432165pyrazolanthronepyrazolanthrone promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein]16972261
C432165pyrazolanthronepyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP8 protein]16061660
D011736PyridoxinePyridoxine results in increased expression of CASP8 mRNA28716455
D011739PyrimethaminePyrimethamine results in increased activity of CASP8 protein18593930
C108337pyrimethanil[iprodione co-treated with pyrimethanil co-treated with acetamiprid] results in increased expression of CASP8 mRNA29091792
C108337pyrimethanil[iprodione co-treated with pyrimethanil] results in decreased expression of CASP8 mRNA29091792
C108337pyrimethanilpyrimethanil results in decreased expression of CASP8 mRNA29091792
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in increased activity of CASP8 protein23320119
C010423pyrithione zincpyrithione zinc results in increased activity of CASP8 protein20151177
C010423pyrithione zincpyrithione zinc results in increased expression of CASP8 mRNA21424779
D011748PyrogallolPyrogallol results in increased activity of CASP8 protein19000662
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]15477007
C020972pyrrolidine dithiocarbamic acidbathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]]15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]15477007
D011794Quercetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased cleavage of CASP8 protein]21165570
D011794Quercetin[arsenic trioxide co-treated with Quercetin] results in increased cleavage of and results in increased activity of CASP8 protein18359480
D011794QuercetinBCL2 protein inhibits the reaction [[arsenic trioxide co-treated with Quercetin] results in increased cleavage of and results in increased activity of CASP8 protein]18359480
D011794Quercetinpyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP8 protein]21165570
D011794QuercetinQuercetin affects the localization of CASP8 protein17876056
D011794Quercetin"Quercetin inhibits the reaction [N,N-dimethylphytosphingosine results in increased activity of CASP8 protein]"19481559
D011794QuercetinQuercetin promotes the reaction [TNFSF10 protein affects the localization of CASP8 protein]17876056
D011794QuercetinQuercetin promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]18377872
D011794QuercetinQuercetin promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]17548900|2009629
D011794QuercetinQuercetin results in increased activity of CASP8 protein16158945|2080312
D011794QuercetinQuercetin results in increased cleavage of CASP8 protein18455702|2009629
D011794QuercetinQuercetin results in increased expression of CASP8 protein25339540
D011794QuercetinTNFSF10 protein promotes the reaction [Quercetin results in increased cleavage of CASP8 protein]24612139
D011794Quercetin"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CASP8 protein]"21294050
D011794QuercetinQuercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]]15914627
D011794QuercetinQuercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of and results in increased activity of CASP8 protein]24316378
D011794QuercetinQuercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of CASP8 mRNA]24316378
D011794QuercetinQuercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]16647178
D011794QuercetinQuercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]27525270
C523166quercetin 3-O-beta-(2''-galloyl)-rhamnopyranosidequercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]23711929
C523166quercetin 3-O-beta-(2''-galloyl)-rhamnopyranosidequercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]25845326
C523166quercetin 3-O-beta-(2''-galloyl)-rhamnopyranosidequercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]25845326
C012526quercitrinquercitrin results in increased expression of CASP8 mRNA25193878
C468548quinoline-val-asp(OMe)-CH2-OPHquinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP8 protein]27732882
D017382Reactive Oxygen Species[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein19054763
D017382Reactive Oxygen Species[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein19054763
D017382Reactive Oxygen Species[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein19054763
D017382Reactive Oxygen Species[[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein19054763
D017382Reactive Oxygen Speciesmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[XCT790 results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP8 protein]19464277
D017382Reactive Oxygen Species[XCT790 results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP8 protein19464277
D012110ReserpineIAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein]19463876
D012110ReserpineReserpine results in increased activity of CASP8 protein19463876
D012116Resins, Plant"Resins, Plant results in increased activity of CASP8 protein"27268964
C059514resveratrol"[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of CASP8 protein"18444175
C059514resveratrolbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [[resveratrol results in increased activity of CASP8 protein] which results in increased activity of CASP3 protein]19423619
C059514resveratrolbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [[resveratrol results in increased activity of CASP8 protein] which results in increased activity of CASP9 protein]19423619
C059514resveratrol[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [resveratrol results in increased localization of BAK1 protein]12902349
C059514resveratrol[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [resveratrol results in increased localization of BAX protein]12902349
C059514resveratrol[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to resveratrol19561642
C059514resveratrolbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[resveratrol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein]18222423
C059514resveratrolCapsaicin promotes the reaction [resveratrol results in decreased expression of CASP8 protein]19846903
C059514resveratrolCASP8 protein affects the susceptibility to resveratrol22923501
C059514resveratrolCASP8 protein affects the susceptibility to [resveratrol co-treated with panobinostat]22923501
C059514resveratrolCASP8 protein affects the susceptibility to [resveratrol co-treated with vorinostat]22923501
C059514resveratrolmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[resveratrol co-treated with panobinostat] results in increased cleavage of CASP8 protein]22923501
C059514resveratrolmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[resveratrol co-treated with vorinostat] results in increased cleavage of CASP8 protein]22923501
C059514resveratrolNystatin inhibits the reaction [resveratrol affects the localization of CASP8 protein]12902349
C059514resveratrolresveratrol affects the localization of CASP8 protein12902349
C059514resveratrol[resveratrol co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein14749477
C059514resveratrol[resveratrol co-treated with panobinostat] results in increased cleavage of CASP8 protein22923501
C059514resveratrol[resveratrol co-treated with SB 203580] results in increased activity of CASP8 protein22644961
C059514resveratrol[resveratrol co-treated with TNFSF10 protein] results in increased activity of CASP8 protein15763656
C059514resveratrol[resveratrol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein18222423
C059514resveratrol[resveratrol co-treated with vorinostat] results in increased cleavage of CASP8 protein22923501
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]23452621
C059514resveratrolresveratrol promotes the reaction [Capsaicin results in decreased expression of CASP8 protein]19846903
C059514resveratrolresveratrol promotes the reaction [FAS protein binds to CASP8 protein]12902349
C059514resveratrolresveratrol promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]20097879
C059514resveratrolresveratrol promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]17823925
C059514resveratrolresveratrol results in decreased activity of CASP8 protein12925042
C059514resveratrolresveratrol results in decreased expression of CASP8 protein18089832|1984690
C059514resveratrolresveratrol results in increased activity of CASP8 protein18276737|1942361
C059514resveratrol[resveratrol results in increased activity of CASP8 protein] which results in increased activity of CASP3 protein19423619
C059514resveratrol[resveratrol results in increased activity of CASP8 protein] which results in increased activity of CASP9 protein19423619
C059514resveratrol[resveratrol results in increased activity of CASP8 protein] which results in increased cleavage of BID protein18276737|1942361
C059514resveratrolresveratrol results in increased cleavage of and results in increased activity of CASP8 protein12902349|1661705
C059514resveratrolresveratrol results in increased cleavage of CASP8 protein18347188|2292350
C059514resveratrolresveratrol results in increased localization of and results in increased activity of CASP8 protein19561642
C059514resveratrolresveratrol inhibits the reaction [Isoflurane results in increased activity of CASP8 protein]23922164
C059514resveratrolresveratrol results in increased cleavage of CASP8 protein17872969
C059514resveratrolresveratrol results in increased expression of CASP8 mRNA22610192
C059514resveratrolresveratrol results in decreased expression of CASP8 protein modified form24040416
C059514resveratrolresveratrol results in increased activity of CASP8 protein24534837|2466925
C059514resveratrolAcetylcysteine inhibits the reaction [resveratrol results in increased cleavage of CASP8 protein]26849945
C059514resveratrolresveratrol results in increased cleavage of CASP8 protein26849945
D015474IsotretinoinIsotretinoin results in increased cleavage of CASP8 protein16135400
D012254RibavirinRibavirin promotes the reaction [FAS protein results in increased activity of CASP8 protein]12760867
D012293RifampinMifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]]12645856
D012293RifampinRifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]11958592|1264585
D019782RiluzoleRiluzole results in increased activity of CASP8 protein19528481
D000068296Risedronate SodiumRisedronate Sodium results in increased activity of CASP8 protein19505369
C064758Ro 31-8220Ro 31-8220 results in increased activity of CASP8 protein18054255
C064758Ro 31-8220TNF protein promotes the reaction [Ro 31-8220 results in increased activity of CASP8 protein]18054255
D012402Rotenone"Rotenone inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased activity of CASP8 protein]"24830863
D012402RotenoneRotenone results in increased expression of CASP8 mRNA23186747
D012402RotenoneRotenone results in increased expression of CASP8 protein25502462
D012402RotenoneUrsodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP8 protein]25502462
C046245rubimaillinBCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]19716835
C046245rubimaillinbenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]19716835
C046245rubimaillinrubimaillin results in increased activity of CASP8 protein19716835
C079905rubitecan[rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP8 protein21695227
C079905rubitecanrubitecan results in increased expression of CASP8 protein21695227
D012431Rutin[Rutin binds to Zinc] which results in increased expression of CASP8 mRNA26091902
D012431RutinRutin results in increased expression of CASP8 mRNA26091902
C039961S-(1,2-dichlorovinyl)cysteine"S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP8 protein"29129777
C049705S-1,2-dichlorovinyl-N-acetylcysteine"S-1,2-dichlorovinyl-N-acetylcysteine affects the expression of CASP8 mRNA"16844155
D012451SafroleSafrole results in increased expression of CASP8 mRNA21591240
C413684salicylaldehyde isonicotinoyl hydrazonesalicylaldehyde isonicotinoyl hydrazone analog results in increased activity of CASP8 protein22521999
C010327salinomycinsalinomycin results in decreased expression of CASP8 mRNA19682730
C065299S-allylcysteine[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]22033380
C065299S-allylcysteineS-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP8 protein]22033380
C065299S-allylcysteine[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
C065299S-allylcysteineS-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
D000068299Salmeterol Xinafoate[Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP8 protein15536434
C018381salvinAcetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein]28918123
C018381salvinsalvin results in increased cleavage of CASP8 protein28918123
C005705sanguinarine[sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein24345465
C005705sanguinarine[sanguinarine co-treated with arsenic trioxide] results in increased activity of CASP8 protein24345465
C005705sanguinarine[sanguinarine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein24345465
C005705sanguinarinesanguinarine results in increased activity of CASP8 protein19346183|2366033
C410958sauchinonesauchinone inhibits the reaction [nodularin results in increased expression of CASP8 mRNA]27061667
C093642SB 203580[resveratrol co-treated with SB 203580] results in increased activity of CASP8 protein22644961
C093642SB 203580SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]27032576
C115461SC 560SC 560 promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]25432964
C499748SCIO-469SCIO-469 promotes the reaction [Bortezomib results in increased cleavage of CASP8 protein]16617327
D012643Selenium[Doxorubicin co-treated with Selenium] promotes the reaction [FADD protein binds to CASP8 protein]17970047
D012643Selenium[Doxorubicin co-treated with Selenium] promotes the reaction [FAS protein binds to CASP8 protein]17970047
D012643SeleniumSelenium analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA]27920530
D012643SeleniumSelenium results in decreased expression of CASP8 mRNA19244175
D012643SeleniumSelenium results in increased activity of CASP8 protein12432279
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form25321483
C025583sesamolsesamol results in increased activity of CASP8 protein27270451
D012717SesquiterpenesSesquiterpenes results in increased activity of CASP8 protein18070620
C440975silybinbenzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP8 protein]16777994
C440975silybinpifithrin inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP8 protein]16777994
C440975silybinsilybin results in increased cleavage of and results in increased activity of CASP8 protein16777994
D012838SilymarinSilymarin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]20850421
D019821SimvastatinSimvastatin results in increased activity of CASP8 protein15705602
D019821SimvastatinSimvastatin results in increased cleavage of and results in increased activity of CASP8 protein21910007
D019821SimvastatinSimvastatin results in increased cleavage of CASP8 protein12962723|2046444
D019821SimvastatinAcetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP8 protein]20883752
D019821SimvastatinSimvastatin results in increased activity of CASP8 protein20883752
C574383sinularinAcetylcysteine inhibits the reaction [sinularin results in increased cleavage of CASP8 protein]28548367
C574383sinularinsinularin results in increased cleavage of CASP8 protein28548367
D020123Sirolimus[7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP8 protein15767555
D020123Sirolimuspyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein]15767555
D020123SirolimusSirolimus promotes the reaction [Cisplatin results in increased cleavage of CASP8 protein]18058806
D020123SirolimusSirolimus results in increased cleavage of CASP8 protein25307878
D020123Sirolimus[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein17121904
D020123SirolimusSirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]]28342888
C534922SNX 2112SNX 2112 results in increased activity of CASP8 protein23777986
C009277sodium arsenatesodium arsenate results in decreased expression of CASP8 mRNA24349563
C017947sodium arsenitesodium arsenite results in decreased methylation of CASP8 gene25199682
C017947sodium arsenitesodium arsenite results in increased cleavage of CASP8 protein24100277
C017947sodium arsenite[Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased activity of CASP8 protein16421179
C017947sodium arsenitesodium arsenite results in decreased expression of CASP8 mRNA14691202
C017947sodium arsenitesodium arsenite results in increased activity of CASP8 protein16421179|2000668
C017947sodium arsenite[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein]20946910
C017947sodium arsenite[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased expression of CASP8 protein]20946910
C017947sodium arsenitesodium arsenite results in increased activity of CASP8 protein20946910
C017947sodium arsenitesodium arsenite results in increased expression of CASP8 protein20946910
C016104sodium bichromatesodium bichromate results in increased activity of CASP8 protein18544562
C016104sodium bichromateCAT protein inhibits the reaction [sodium bichromate results in increased degradation of CASP8 protein]20298709
C016104sodium bichromatesodium bichromate results in decreased expression of CASP8 protein21047991
C016104sodium bichromatesodium bichromate results in increased degradation of CASP8 protein20298709
C016104sodium bichromateTRP53 mutant form inhibits the reaction [sodium bichromate results in increased degradation of CASP8 protein]20298709
D012965Sodium ChlorideSodium Chloride results in increased expression of CASP8 mRNA23634900
D012965Sodium Chloridelycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
D012965Sodium Chloride[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein16030430
D012965Sodium Chloride[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
D012965Sodium ChlorideS-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]16030430
D012969Sodium FluorideSodium Fluoride results in increased cleavage of and results in increased activity of CASP8 protein21708216
D012969Sodium FluorideSodium Fluoride results in increased expression of CASP8 mRNA19852076
D012980Sodium SalicylateSodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP8 protein]17561093
D012980Sodium SalicylateSodium Salicylate results in increased activity of CASP8 protein17561093
D018038Sodium SeleniteSodium Selenite results in increased expression of CASP8 mRNA19363675
D018038Sodium SeleniteSodium Selenite results in decreased activity of CASP8 protein18209489
D053260SootSoot results in decreased expression of CASP8 mRNA26551751
C471405sorafenibATG5 protein inhibits the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]18787411
C471405sorafenibBoc-D-FMK inhibits the reaction [sorafenib results in increased cleavage of and results in increased activity of CASP8 protein]16007148
C471405sorafenibEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]18787411
C471405sorafenibEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to FADD protein binds to CASP8 protein]]18787411
C471405sorafenibEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]18787411
C471405sorafenibFADD protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]18787411
C471405sorafenibsorafenib affects the localization of CASP8 protein modified form17909059
C471405sorafenib[sorafenib co-treated with TNFSF10 protein] promotes the reaction [CASP8 protein modified form results in increased cleavage of BID protein]17909059
C471405sorafenib[sorafenib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein17909059
C471405sorafenib[sorafenib co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein20071162
C471405sorafenib[sorafenib co-treated with Vitamin K 1] results in increased cleavage of CASP8 protein20301194
C471405sorafenib[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to FAS protein binds to FADD protein]18787411
C471405sorafenib[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to CASP8 protein binds to ATG5 protein binds to HSPA5 protein]18787411
C471405sorafenib[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein18787411
C471405sorafenibsorafenib results in increased cleavage of and results in increased activity of CASP8 protein16007148|1610971
C471405sorafenibsorafenib results in increased cleavage of CASP8 protein18200035
D013012SorbitolSorbitol results in increased activity of CASP8 protein20609311
D013012SorbitolSpironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]20609311
D013012SorbitolTestosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]20609311
D013096SpermineSpermine inhibits the reaction [Dexamethasone results in increased activity of CASP8 protein]11399061
D013148SpironolactoneSpironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]20609311
C485419spiruchostatin Aspiruchostatin A results in increased activity of CASP8 protein25078973
C529984spiruchostatin Bspiruchostatin B results in increased activity of CASP8 protein25078973
D019311Staurosporinebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Staurosporine results in increased cleavage of CASP8 protein]24658017
D019311StaurosporineStaurosporine results in increased activity of CASP8 protein19352495
D019311StaurosporineStaurosporine results in increased cleavage of and results in increased activity of CASP8 protein16007152
D019311StaurosporineStaurosporine results in increased cleavage of CASP8 protein24658017
D013311StreptozocinCurcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]25541178
D013311StreptozocinCurcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]23267840
D013311StreptozocinINS1 protein inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]23267840
D013311StreptozocinStreptozocin results in increased cleavage of CASP8 protein25541178
D013311StreptozocinStreptozocin results in increased expression of CASP8 mRNA23267840
D020058StyreneStyrene results in increased activity of CASP8 protein17420221
C061636suillinsuillin results in increased cleavage of and results in increased activity of CASP8 protein19616521
C016766sulforafansulforafan results in increased expression of and results in increased activity of CASP8 protein26833863
D013458Sulfur DioxideSulfur Dioxide results in increased expression of and results in increased activity of CASP8 protein19621461
D013458Sulfur DioxideSulfur Dioxide results in increased expression of CASP8 mRNA19621461
D013467Sulindac[Sulindac co-treated with TNFSF10 protein] results in increased activity of CASP8 protein21171083
C025462sulindac sulfideBAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]12203115
C025462sulindac sulfidePTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]12414664
C025462sulindac sulfidesulindac sulfide results in increased activity of CASP8 protein11559570|1241466
C025462sulindac sulfidesulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein12203115
C025462sulindac sulfideTNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]12203115
C025462sulindac sulfidesulindac sulfide results in increased activity of CASP8 protein16886631
C025463sulindac sulfonesulindac sulfone results in increased activity of CASP8 protein11559570
D013605T-2 ToxinT-2 Toxin results in increased expression of CASP8 mRNA26141394
C112689TAC 101TAC 101 results in increased activity of CASP8 protein17436592
D016559TacrolimusTacrolimus inhibits the reaction [FAS protein results in increased activity of CASP8 protein]15548389
D013629TamoxifenTamoxifen results in increased expression of CASP8 mRNA26908177
D013629Tamoxifen[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP8 protein18790785
D013629Tamoxifen[[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein18790785
D013629Tamoxifen[[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen20154269
D013629Tamoxifen[Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of CASP8 protein modified form17767197
D013629TamoxifenTamoxifen results in increased expression of CASP8 protein17767197
C112765tanespimycin[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein17121904
C112765tanespimycintanespimycin results in increased cleavage of CASP8 protein17121904
C021751tanshinonetanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]26203587
D013656Taurocholic AcidTaurocholic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein]12388182
C041348tcdA protein, Clostridium difficile"alanylglutamine inhibits the reaction [tcdA protein, Clostridium difficile results in increased activity of CASP8 protein]"16368960
C041348tcdA protein, Clostridium difficile"tcdA protein, Clostridium difficile results in increased activity of CASP8 protein"16368960
D013662Tea[Tea co-treated with Bleomycin] results in increased expression of CASP8 mRNA26800624
D013691TelluriumTellurium results in decreased activity of CASP8 protein18571097
C047246temozolomide[eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein21514314
C047246temozolomidetemozolomide results in increased cleavage of CASP8 protein26418950
D016593TerfenadineTerfenadine results in increased activity of CASP8 protein16569656
D016593TerfenadineTerfenadine results in increased cleavage of CASP8 protein20570632
D016593TerfenadineTerfenadine results in increased activity of CASP8 protein15288570
D013739TestosteroneSpironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]20609311
D013739TestosteroneTestosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]20609311
D013739TestosteroneTestosterone results in increased cleavage of CASP8 protein24658017
D013739TestosteroneFADD protein promotes the reaction [Testosterone results in increased expression of CASP8]16845445
D013739TestosteroneTestosterone results in increased expression of CASP8 mRNA16845445
D013739TestosteroneTestosterone results in increased expression of CASP8 protein16845445
C534735tetraarsenic tetrasulfide[tetraarsenic tetrasulfide co-treated with Imatinib Mesylate] results in increased expression of CASP8 mRNA19208803
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of and results in increased cleavage of CASP8 protein27484784
C000591600tetrachlorobenzoquinoneAcetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of CASP8 protein]27484784
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone promotes the reaction [TNFRSF10B protein binds to FADD protein binds to CASP8 protein]27484784
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased cleavage of CASP8 protein27484784
C000591600tetrachlorobenzoquinoneTNFRSF10B protein promotes the reaction [tetrachlorobenzoquinone results in increased cleavage of CASP8 protein]27484784
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CASP8 mRNA24349563
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CASP8 mRNA16039398
D013749TetrachlorodibenzodioxinNFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CASP8 protein]21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CASP8 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CASP8 mRNA22666406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of CASP8 protein21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased cleavage of and affects the activity of CASP8 protein15664267
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CASP8 mRNA12167310|1531085
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CASP8 protein15972635
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CASP8 mRNA19520675
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]15477007
D013755Tetradecanoylphorbol Acetatebathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]]15477007
D013755Tetradecanoylphorbol Acetate[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CASP8 mRNA18958680
D013755Tetradecanoylphorbol Acetate[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP8 protein12165276
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA25613284
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased activity of CASP8 protein]17997382
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased activity of CASP8 protein17997382
C017953tetramethylpyrazinetetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP8 protein]17132701
C017953tetramethylpyrazinetetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]]17132701
C009438tetrandrinetetrandrine results in increased cleavage of and results in increased activity of CASP8 protein26822499
C009438tetrandrinetetrandrine results in increased cleavage of CASP8 protein25266202
C020809tetrathiomolybdate[Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein22276220
C020809tetrathiomolybdate[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein22276220
C531352tetrazolium violettetrazolium violet results in increased activity of CASP8 protein18547555
D013792ThalidomideThalidomide analog results in increased cleavage of CASP8 protein15858615
D013792ThalidomideThalidomide results in decreased expression of CASP8 mRNA26217789
C042172thallium nitrateEGF protein inhibits the reaction [thallium nitrate analog results in increased activity of CASP8 protein]27412756
C042172thallium nitratethallium nitrate analog results in increased activity of CASP8 protein19371624|2741275
D019284ThapsigarginThapsigargin results in increased activity of CASP8 protein16018998
D013827ThiabendazoleThiabendazole results in increased activity of CASP8 protein26748015
D013844ThiazolesAcetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein]19014919
D013844Thiazoles[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein19014919
C022616thiazolyl bluethiazolyl blue results in increased activity of CASP8 protein22401948
D013853ThioacetamideThioacetamide results in increased expression of CASP8 mRNA16456712
D013853Thioacetamidechloroquine diphosphate inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]29133031
D013853Thioacetamidechloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]]29133031
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA23830814
D013853ThioacetamideDoxorubicin inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]29133031
D013853ThioacetamideDoxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in decreased expression of CASP8 mRNA]]29133031
D013853ThioacetamideThioacetamide results in decreased expression of CASP8 mRNA29133031
D008063Thioctic AcidThioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]27544635
D008063Thioctic Acid[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA23830814
D013866ThioguanineCASP8 protein results in increased susceptibility to Thioguanine22010212
D013866ThioguanineThioguanine results in increased expression of CASP8 protein22010212
C441201thiosalicylic acid[Diethylnitrosamine co-treated with thiosalicylic acid] results in increased activity of CASP8 protein19427195
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in decreased activity of CASP8 protein20931265
C100040thiosulfinic acidsthiosulfinic acids results in increased activity of CASP8 protein19446247
D013943ThymolThymol results in increased activity of CASP8 protein21640085
D013943ThymolThymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]26996544
C003466thymoquinonethymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein]29085585
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]16051694
C032628tin protoporphyrin IXtin protoporphyrin IX results in decreased activity of CASP8 protein16051694
D014028Tobacco Smoke Pollution2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tobacco Smoke Pollution results in increased phosphorylation of and results in increased activity of MAPK1 protein] promotes the reaction [FAS protein binds to CASP8 protein]]20118622
D014028Tobacco Smoke Pollution2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tobacco Smoke Pollution results in increased phosphorylation of and results in increased activity of MAPK3 protein] promotes the reaction [FAS protein binds to CASP8 protein]]20118622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [Tobacco Smoke Pollution results in increased activity of CASP8 protein]20118622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution promotes the reaction [FAS protein binds to CASP8 protein]20118622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased activity of CASP8 protein20118622
D014028Tobacco Smoke Pollution[Tobacco Smoke Pollution results in increased phosphorylation of and results in increased activity of MAPK1 protein] promotes the reaction [FAS protein binds to CASP8 protein]20118622
D014028Tobacco Smoke Pollution[Tobacco Smoke Pollution results in increased phosphorylation of and results in increased activity of MAPK3 protein] promotes the reaction [FAS protein binds to CASP8 protein]20118622
D019772Topotecan[Amlodipine co-treated with Topotecan] results in increased activity of CASP8 protein16516327
D019772Topotecanchrysin inhibits the reaction [Topotecan results in increased activity of CASP8 protein]20457140
D019772TopotecanTopotecan results in increased activity of CASP8 protein20457140
D014118Toxins, Biological"Toxins, Biological affects the expression of CASP8 mRNA"19682533
D014212TretinoinTGFB1 protein inhibits the reaction [Tretinoin results in increased cleavage of and results in increased activity of CASP8 protein]16242776
D014212Tretinoin[Tretinoin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein18098270
D014212TretinoinTretinoin results in increased cleavage of and results in increased activity of CASP8 protein16242776
D014212TretinoinTretinoin results in increased cleavage of CASP8 protein16135400
D014222Triamcinolone AcetonideTriamcinolone Acetonide results in increased activity of CASP8 protein15987869
C011559tributyltintributyltin results in decreased expression of CASP8 protein28707438
C011559tributyltintributyltin results in increased expression of CASP8 protein23743147
C012589trichostatin A[Bortezomib co-treated with trichostatin A] results in increased cleavage of and results in increased activity of CASP8 protein16904634
C012589trichostatin A[[decitabine co-treated with trichostatin A] affects the methylation of CASP8 promoter] which affects the expression of CASP8 mRNA18819746|1881974
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C012589trichostatin A[perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein15781658
C012589trichostatin A[trichostatin A co-treated with Bortezomib] results in increased cleavage of CASP8 protein21345073
C012589trichostatin Atrichostatin A results in increased expression of CASP8 mRNA24935251|2627250
C046498tricyclodecane-9-yl-xanthogenatetricyclodecane-9-yl-xanthogenate inhibits the reaction [TNF protein results in increased activity of CASP8 protein]10792026
C020946triethylene glycol dimethacrylatetriethylene glycol dimethacrylate results in increased activity of CASP8 protein24307521
D014271TrifluridineTrifluridine results in increased cleavage of CASP8 protein19816940
C050414tripterinetripterine results in decreased expression of CASP8 mRNA27374097
C050414tripterinetripterine results in increased cleavage of CASP8 protein21466843
C001899triptolidetriptolide results in increased expression of and results in increased activity of CASP8 protein26990902
C057693troglitazonetroglitazone results in decreased expression of CASP8 mRNA19631733
C057693troglitazonetroglitazone results in increased activity of CASP8 protein14508522
C057693troglitazonetroglitazone results in increased expression of CASP812680223
C057693troglitazonetroglitazone results in increased expression of CASP8 mRNA19631733
C057693troglitazonetroglitazone results in increased expression of CASP8 protein modified form16820965
C057693troglitazonetroglitazone results in increased expression of CASP8 mRNA28973697
C080163trovafloxacin[trovafloxacin co-treated with TNF protein] results in increased activity of CASP8 protein24097668
D014361Trypsin InhibitorsTrypsin Inhibitors results in increased activity of CASP8 protein19481592
C113580U 0126U 0126 promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein]16972261
C113580U 0126U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein]27032576
C113580U 0126U 0126 results in increased cleavage of CASP8 protein20301194
C005460uranyl acetateuranyl acetate results in increased activity of CASP8 protein19096828
D014580Ursodeoxycholic AcidFADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]21362627
D014580Ursodeoxycholic Acid[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of and results in increased activity of CASP8 protein19728331
D014580Ursodeoxycholic Acidpifithrin inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]19728331
D014580Ursodeoxycholic AcidRIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]21362627
D014580Ursodeoxycholic AcidTNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]21362627
D014580Ursodeoxycholic AcidTP53 mutant form inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]19728331
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid promotes the reaction [irinotecan results in increased activity of CASP8 protein]16432164
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased activity of CASP8 protein21362627
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein]21146893
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP8 protein]25502462
C005466ursolic acidursolic acid results in increased activity of CASP8 protein20005942
D014635Valproic AcidCASP8 mRNA affects the reaction [[Valproic Acid co-treated with decitabine] results in increased susceptibility to TNFSF10 protein]21771726
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CASP8 mRNA25979313
D014635Valproic Acid[Valproic Acid co-treated with arsenic trioxide] results in increased expression of CASP8 mRNA25815518
D014635Valproic Acid[Valproic Acid co-treated with arsenic trioxide] results in increased expression of CASP8 protein25815518
D014635Valproic Acid[Valproic Acid co-treated with Cladribine] results in increased cleavage of CASP8 protein19006566
D014635Valproic Acid[Valproic Acid co-treated with fludarabine] results in increased cleavage of CASP8 protein19006566
D014635Valproic AcidValproic Acid promotes the reaction [decitabine results in increased expression of CASP8 mRNA]21771726
D014635Valproic AcidValproic Acid promotes the reaction [decitabine results in increased expression of CASP8 protein]21771726
D014635Valproic AcidValproic Acid results in increased cleavage of and results in increased activity of CASP8 protein22814014
D014635Valproic AcidValproic Acid results in increased cleavage of CASP8 protein19006566
D014635Valproic AcidValproic Acid results in increased expression of CASP8 mRNA21771726|2317975
D014635Valproic AcidValproic Acid results in increased expression of CASP8 protein21771726
D014635Valproic AcidValproic Acid affects the expression of CASP8 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of CASP8 mRNA24896083
D014638VanadatesVanadates inhibits the reaction [Deferoxamine results in increased activity of CASP8 protein]16374551
D017968Vanadium CompoundsVanadium Compounds results in increased activity of CASP8 protein26391003
D014641Vanillic AcidVanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]25794854
C551177vemurafenibAZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP8 protein]]27222248
C551177vemurafenib[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP8 protein]27222248
C551177vemurafenibRAF1 protein affects the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP8 protein]]27222248
D014700Verapamil[Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein24373880
D014750VincristineCASP8 protein results in increased susceptibility to Vincristine22010212
D014750VincristineVincristine results in increased expression of and results in increased cleavage of CASP8 protein22010212
D014750VincristineVincristine results in increased expression of CASP8 mRNA16001973
D014757Viper VenomsViper Venoms results in increased cleavage of CASP8 protein25417048
D012256RiboflavinRiboflavin analog results in increased activity of CASP8 protein20688149
D010837Vitamin K 1[sorafenib co-treated with Vitamin K 1] results in increased cleavage of CASP8 protein20301194
C111237vorinostatATG5 protein inhibits the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]18787411
C111237vorinostatbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] affects the localization of CASP8 protein]19643600
C111237vorinostatbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] results in increased activity of CASP8 protein]19643600
C111237vorinostat[Bortezomib co-treated with vorinostat] results in increased activity of CASP8 protein18005386|1864136
C111237vorinostat[Bortezomib co-treated with vorinostat] results in increased cleavage of and results in increased activity of CASP8 protein12893773
C111237vorinostatBortezomib promotes the reaction [vorinostat results in increased activity of CASP8 protein]15173093
C111237vorinostatCASP8 protein affects the susceptibility to [resveratrol co-treated with vorinostat]22923501
C111237vorinostatEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]18787411
C111237vorinostatEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to FADD protein binds to CASP8 protein]]18787411
C111237vorinostatEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]18787411
C111237vorinostatFADD protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]18787411
C111237vorinostatmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[resveratrol co-treated with vorinostat] results in increased cleavage of CASP8 protein]22923501
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA"27188386
C111237vorinostat[panobinostat co-treated with vorinostat] results in increased cleavage of CASP8 protein22923501
C111237vorinostat[perifosine co-treated with vorinostat] results in increased activity of CASP8 protein15781658
C111237vorinostat[resveratrol co-treated with vorinostat] results in increased cleavage of CASP8 protein22923501
C111237vorinostat[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to FAS protein binds to FADD protein]18787411
C111237vorinostat[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to CASP8 protein binds to ATG5 protein binds to HSPA5 protein]18787411
C111237vorinostat[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein18787411
C111237vorinostatTNFSF10 protein promotes the reaction [vorinostat results in increased cleavage of and results in increased activity of CASP8 protein]17410615
C111237vorinostat[vorinostat co-treated with Bortezomib] results in increased cleavage of CASP8 protein17351739
C111237vorinostat[vorinostat co-treated with TNFSF10 protein] affects the localization of CASP8 protein19643600
C111237vorinostat[vorinostat co-treated with TNFSF10 protein] results in increased activity of CASP8 protein19509267|1964360
C111237vorinostat[vorinostat co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein19643600
C111237vorinostatvorinostat results in increased activity of CASP8 protein15173093|1802528
C111237vorinostatvorinostat results in increased cleavage of and results in increased activity of CASP8 protein17410615
C111237vorinostatvorinostat results in increased cleavage of CASP8 protein15897598|1735173
C111237vorinostatvorinostat results in increased expression of CASP8 mRNA26272509
C111237vorinostat[carfilzomib co-treated with vorinostat] results in increased activity of CASP8 protein20233973
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of CASP8 mRNA"23063069
C085514wogoninwogonin inhibits the reaction [IL1B protein results in increased cleavage of CASP8 protein]28688942
C085514wogoninwogonin results in decreased cleavage of CASP8 protein28688942
C085514wogoninwogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein]26756871
C009687wortmanninABT-737 promotes the reaction [wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]20104024
C009687wortmanninwortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]20104024
C009687wortmannin"wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP8 protein]"24726520
C104426WP 631WP 631 results in increased activity of CASP8 protein24287111
C104536xanthohumolxanthohumol results in increased activity of CASP8 protein26297991
C104536xanthohumolxanthohumol results in increased cleavage of and results in increased activity of CASP8 protein15995977
C488234XCT790manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[XCT790 results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP8 protein]19464277
C488234XCT790[XCT790 results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP8 protein19464277
C108830Y 27632Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP8 protein]28743511
D015215ZidovudineAcrolein promotes the reaction [Zidovudine results in increased cleavage of CASP8 protein]27238871
D015215ZidovudineZidovudine promotes the reaction [Acrolein results in increased cleavage of CASP8 protein]27238871
D015215ZidovudineZidovudine results in increased cleavage of CASP8 protein27238871
D015032Zinc[Rutin binds to Zinc] which results in increased expression of CASP8 mRNA26091902
D015034Zinc OxideZinc Oxide affects the expression of CASP8 protein28648595
D015034Zinc Oxidebenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]27544635
D015034Zinc OxideThioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]27544635
D015034Zinc OxideZinc Oxide analog results in increased activity of CASP8 protein27544635
D015034Zinc OxideAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein]24614525
D015034Zinc OxideZinc Oxide analog results in increased cleavage of CASP8 protein24614525
C017803zinc protoporphyrinzinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]16051694
D019287Zinc Sulfate[gluconic acid co-treated with Zinc Sulfate] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA]27017951
D019287Zinc SulfateZinc Sulfate inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA]27017951
D019287Zinc Sulfate3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein]28803810
D019287Zinc SulfateZinc Sulfate results in increased cleavage of CASP8 protein28803810
D015039ZiramZiram results in increased activity of CASP8 protein22159898
C000588918ziyuglycoside IIziyuglycoside II results in increased activity of CASP8 protein24680927
C000588918ziyuglycoside IIziyuglycoside II results in increased cleavage of and results in increased activity of CASP8 protein24680927
C088658zoledronic acidzoledronic acid results in increased expression of CASP8 mRNA19036117|2097792
C088658zoledronic acid[zoledronic acid co-treated with Doxorubicin] results in increased activity of CASP8 protein19789217

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004197cysteine-type endopeptidase activity-IDA16920334  19240112  
GO:0004197cysteine-type endopeptidase activity-TAS-  
GO:0005123death receptor binding-IEA-  
GO:0005164tumor necrosis factor receptor binding-IEA-  
GO:0005515protein binding-IPI9208847  9334338  9343261  9560245  10235259  10442631  
11717445  12198154  12884866  12887920  12888622  14612908  
15069192  15509781  16498403  16936772  17047155  17159907  
17170703  17245429  17479112  18086677  18245485  18328427  
18485876  19060883  19176810  19427028  19524512  19524513  
20103630  20956295  21183955  21458669  21525013  21625644  
21713032  21785459  21803845  21988832  22173242  22267217  
22274400  23955153  24025841  24438025  25043603  25911380  
26942442  
GO:0008233peptidase activity-IDA19740745  
GO:0008233peptidase activity-IMP17047155  
GO:0008234cysteine-type peptidase activity-TAS8681376  
GO:0031625ubiquitin protein ligase binding-IPI15069192  
GO:0035877death effector domain binding-IBA21873635  
GO:0035877death effector domain binding-IPI11717445  
GO:0042802identical protein binding-IPI11717445  16169070  17170703  
GO:0044877protein-containing complex binding-IEA-  
GO:0097110scaffold protein binding-IPI21785459  
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process-IBA21873635  
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process-IMP21737330  
GO:0097199cysteine-type endopeptidase activity involved in apoptotic signaling pathway-IBA21873635  
GO:0097199cysteine-type endopeptidase activity involved in apoptotic signaling pathway-IMP11717445  
GO:0097200cysteine-type endopeptidase activity involved in execution phase of apoptosis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA12888622  
GO:0006915apoptotic process-IBA21873635  
GO:0006915apoptotic process-IGI17599062  
GO:0006915apoptotic process-IMP22891283  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IBA21873635  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-TAS-  
GO:0007166cell surface receptor signaling pathway-TAS-  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-IBA21873635  
GO:0009409response to cold-IEA-  
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0030101natural killer cell activation-TAS18309324  
GO:0030225macrophage differentiation-IBA21873635  
GO:0030225macrophage differentiation-TAS18309324  
GO:0032025response to cobalt ion-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0034138toll-like receptor 3 signaling pathway-TAS-  
GO:0034612response to tumor necrosis factor-IMP10521396  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0036462TRAIL-activated apoptotic signaling pathway-IDA21785459  
GO:0039650suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process-TAS-  
GO:0042110T cell activation-TAS18309324  
GO:0042113B cell activation-TAS18309324  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IMP12884866  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IMP17047155  
GO:0045471response to ethanol-IEA-  
GO:0045651positive regulation of macrophage differentiation-IMP17047155  
GO:0045862positive regulation of proteolysis-IDA18387192  
GO:0051603proteolysis involved in cellular protein catabolic process-IMP10521396  
GO:0060544regulation of necroptotic process-TAS-  
GO:0060715syncytiotrophoblast cell differentiation involved in labyrinthine layer development-TAS18309324  
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway-TAS-  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:0071550death-inducing signaling complex assembly-TAS-  
GO:0097190apoptotic signaling pathway-IMP11101870  
GO:0097190apoptotic signaling pathway-TAS-  
GO:0097191extrinsic apoptotic signaling pathway-IDA21785459  
GO:0097194execution phase of apoptosis-IBA21873635  
GO:0097194execution phase of apoptosis-IMP21737330  
GO:0097194execution phase of apoptosis-TAS-  
GO:0097202activation of cysteine-type endopeptidase activity-IDA18387192  
GO:0097296activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-TAS-  
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-TAS-  
GO:1901216positive regulation of neuron death-IEA-  
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors-TAS-  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-TAS10891503  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005829cytosol-IDA17167422  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-TAS10891503  
GO:0031264death-inducing signaling complex-IDA11101870  21803845  
GO:0031265CD95 death-inducing signaling complex-IDA11717445  
GO:0043005neuron projection-IEA-  
GO:0044297cell body-IEA-  
GO:0045121membrane raft-IEA-  
GO:0097342ripoptosome-IDA21737330  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
hsa04210Apoptosis
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05200Pathways in cancer
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-109606Intrinsic Pathway for ApoptosisTAS
R-HSA-111465Apoptotic cleavage of cellular proteinsTAS
R-HSA-140534Ligand-dependent caspase activationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168638NOD1/2 Signaling PathwayTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-2562578TRIF-mediated programmed cell deathTAS
R-HSA-264870Caspase-mediated cleavage of cytoskeletal proteinsTAS
R-HSA-3371378Regulation by c-FLIPTAS
R-HSA-5213460RIPK1-mediated regulated necrosisTAS
R-HSA-5218859Regulated NecrosisTAS
R-HSA-5218900CASP8 activity is inhibitedTAS
R-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathwayTAS
R-HSA-5357786TNFR1-induced proapoptotic signalingTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5357905Regulation of TNFR1 signalingTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5660668CLEC7A/inflammasome pathwayTAS
R-HSA-5675482Regulation of necroptotic cell deathTAS
R-HSA-69416Dimerization of procaspase-8TAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-75108Activation, myristolyation of BID and translocation to mitochondriaTAS
R-HSA-75153Apoptotic execution phaseTAS
R-HSA-75157FasL/ CD95L signalingTAS
R-HSA-75158TRAIL signalingTAS
R-HSA-75893TNF signalingTAS
R-HSA-9013957TLR3-mediated TICAM1-dependent programmed cell deathTAS
R-HSA-933543NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10TAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26834999Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrence. (2015)Krishnan NF1000Res
19258216CpG island methylation of TMS1/ASC and CASP8 genes in cervical cancer. (2009)Kordi Tamandani DMEur J Med Res
19276244A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer. (2009 Apr 1)Wang MClin Cancer Res
28314692Identification of an atypical etiological head and neck squamous carcinoma subtype featuring the CpG island methylator phenotype. (2017 Mar)Brennan KEBioMedicine
18566573Promoter methylation of cancer-related genes in gastric carcinoma. (2008 Jun)Poplawski TExp Oncol
25631445Comprehensive genomic characterization of head and neck squamous cell carcinomas. (2015 Jan 29)-Nature
22357491[Polymorphisms in Fas pathway genes and risk of coal worker pneumoconiosis]. (2011 Oct)Wang SSZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
17940865CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk. (2008 Jul)Han SBreast Cancer Res Treat
28542283Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China. (2017)Zhao XKPLoS One
18483392Functional variants in cell death pathway genes and risk of pancreatic cancer. (2008 May 15)Yang MClin Cancer Res
29617660Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. (2018 Apr 3)Campbell JDCell Rep
23358896Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics. (2013)Colacino JAPLoS One
23544014Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. (2013)Nickels SPLoS Genet
22345985A six-nucleotide deletion polymorphism in the casp8 promoter is associated with reduced risk of esophageal and gastric cancers in Kashmir valley. (2011 Sep)Malik MAIndian J Hum Genet
21791674Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. (2011 Aug 17)Campa DJ Natl Cancer Inst