Gene: EEA1

8411
MST105|MSTP105|ZFYVE2
early endosome antigen 1
protein-coding
12q22
Ensembl:ENSG00000102189 MIM:605070 Vega:OTTHUMG00000170110 UniprotKB:Q15075
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.992e-1 (AD)  1.441e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM91A10.896
RRM2B0.883
TMF10.882
DMXL10.882
SUZ120.881
KIAA11430.871
MIB10.87
SNX130.869
SIKE10.869
C5orf240.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.534
OR4F29-0.501
MMP23B-0.282
ADAMTSL5-0.272
CSAG1-0.261
PTGDR2-0.26
HIGD1B-0.253
EYA2-0.245
JSRP1-0.245
S100A7-0.243

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02942Inositol 1,3-BisphosphateSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of EEA1 mRNA28329830
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EEA1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEA1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of EEA1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of EEA1 mRNA17562736
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of EEA1 mRNA]18700144
D020106AcrylamideAcrylamide results in increased expression of EEA1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EEA1 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of EEA1 mRNA"23195993
D001151ArsenicArsenic affects the methylation of EEA1 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of EEA1 mRNA"18687144
C547126AZM551248AZM551248 results in increased expression of EEA1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EEA1 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EEA1 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of EEA1 mRNA21932408|2606340
C006780bisphenol Abisphenol A results in decreased expression of EEA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EEA1 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EEA1 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EEA1 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EEA1 mRNA18804290
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EEA1 mRNA18654764
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EEA1 mRNA18654764
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EEA1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of EEA1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of EEA1 mRNA21852083
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of EEA1 mRNA24534155
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EEA1 mRNA22079256
D000431EthanolEthanol results in decreased expression of EEA1 protein20133374
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of EEA1 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of EEA1 mRNA28329830
C001277geldanamycingeldanamycin results in increased expression of EEA1 mRNA26705709
D006046GoldGold results in decreased expression of EEA1 mRNA25523186
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EEA1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of EEA1 mRNA27392435
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EEA1 mRNA18654764
D008628MercuryMercury results in increased expression of EEA1 mRNA16823088
D008748MethylcholanthreneMethylcholanthrene results in increased expression of EEA1 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EEA1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EEA1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EEA1 mRNA"26251327
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EEA1 mRNA26924002
D009532NickelNickel results in decreased expression of EEA1 mRNA23195993
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of EEA1 mRNA23948077
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of EEA1 mRNA27153767
D010634PhenobarbitalPhenobarbital results in increased expression of EEA1 mRNA19270015
D010936Plant ExtractsPlant Extracts results in increased expression of EEA1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EEA1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EEA1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of EEA1 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of EEA1 mRNA19690047
C009277sodium arsenatesodium arsenate results in increased expression of EEA1 mRNA21795629
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of EEA1 mRNA25172293
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased localization of [SLC6A3 protein co-treated with EEA1 protein]22683840
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EEA1 mRNA25613284
D013792ThalidomideThalidomide results in increased expression of EEA1 mRNA28892372
D013849ThimerosalThimerosal results in decreased expression of EEA1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EEA1 mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of EEA1 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of EEA1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of EEA1 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEA1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of EEA1 mRNA26272509|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EEA1 gene25560391
C111237vorinostatvorinostat results in decreased expression of EEA1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0005515protein binding-IPI9697774  10491193  10506127  11870209  14613930  16314522  
16902405  24029230  29568061  
GO:0005516calmodulin binding-NAS11741531  
GO:00055451-phosphatidylinositol binding-IDA11256955  
GO:0008270zinc ion binding-TAS11741531  
GO:0030742GTP-dependent protein binding-IDA10491193  
GO:0042803protein homodimerization activity-IDA11741531  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-IMP21081650  
GO:0006906vesicle fusion-IMP9697774  
GO:0016189synaptic vesicle to endosome fusion-TAS11741531  
GO:0039694viral RNA genome replication-IMP19376974  
GO:0045022early endosome to late endosome transport-NAS7768953  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS7768953  
GO:0005769early endosome-IDA11741531  12536145  15229288  15792797  15880641  16542649  18388320  18767904  19535332  22719997  25327288  
GO:0005829cytosol-IDA7768953  
GO:0005969serine-pyruvate aminotransferase complex-IEA-  
GO:0016020membrane-TAS7768953  
GO:0019897extrinsic component of plasma membrane-IDA7768953  
GO:0031901early endosome membrane-IEA-  
GO:0044308axonal spine-IEA-  
GO:0055037recycling endosome-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04145Phagosome
Reactome ID Reactome Term Evidence
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet