Gene: BCAR3

8412
AND-34|NSP2|SH2D3B
BCAR3, NSP family adaptor protein
protein-coding
1p22.1
Ensembl:ENSG00000137936 MIM:604704 Vega:OTTHUMG00000010301 UniprotKB:O75815
NC_000001.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.858e-1 (AD)  6.967e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL17RB0.873
MERTK0.869
PPP1R3D0.864
PARD30.858
ZNF5160.855
RFX20.847
PAX60.846
SOX90.842
MID10.842
STK17B0.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRHBP-0.412
DUSP27-0.404
PPEF1-0.403
GPD1-0.393
MCHR1-0.378
CNTN6-0.378
QRFPR-0.369
OR4F5-0.367
COL19A1-0.361
AARD-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of BCAR3 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of BCAR3 mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BCAR3 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BCAR3 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of BCAR3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCAR3 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of BCAR3 mRNA"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of BCAR3 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCAR3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of BCAR3 mRNA25596134
D000082AcetaminophenAcetaminophen results in increased expression of BCAR3 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of BCAR3 mRNA17562736
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of BCAR3 mRNA25596134
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of BCAR3 mRNA]21233418
C016601afimoxifeneBCAR3 protein results in decreased susceptibility to afimoxifene18351453
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of BCAR3 mRNA"18687144
D001241AspirinAspirin results in increased expression of BCAR3 mRNA15928584
C547126AZM551248AZM551248 results in decreased expression of BCAR3 mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of BCAR3 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BCAR3 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of BCAR3 mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of BCAR3 mRNA29275510
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of BCAR3 mRNA]19228888
C584509C646 compoundC646 compound results in increased expression of BCAR3 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BCAR3 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BCAR3 mRNA19010381
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of BCAR3 mRNA25596134
C100187chloropicrinchloropicrin results in decreased expression of BCAR3 mRNA26352163|2847649
D002737ChloropreneChloroprene results in increased expression of BCAR3 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCAR3 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of BCAR3 mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of BCAR3 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of BCAR3 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of BCAR3 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BCAR3 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of BCAR3 mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of BCAR3 mRNA22077320
D016572CyclosporineCyclosporine results in increased expression of BCAR3 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of BCAR3 mRNA21198554
D002945CisplatinCisplatin affects the reaction [Piroxicam results in decreased expression of BCAR3 mRNA]21858171
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of BCAR3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of BCAR3 mRNA19561079
D002945CisplatinCisplatin results in increased expression of BCAR3 mRNA25596134
D002945CisplatinCisplatin results in decreased expression of BCAR3 mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of BCAR3 mRNA26924002
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of BCAR3 mRNA20064776
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of BCAR3 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of BCAR3 mRNA21233418
D011345FenofibrateFenofibrate results in decreased expression of BCAR3 mRNA25596134
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of BCAR3 mRNA28329830
D005472FluorouracilBCAR3 protein affects the susceptibility to Fluorouracil15352031
D005472FluorouracilFluorouracil results in decreased expression of BCAR3 protein15352031
D005485FlutamideFlutamide results in increased expression of BCAR3 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCAR3 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of BCAR3 mRNA20655997|2341626
C070081fulvestrantBCAR3 affects the susceptibility to fulvestrant24169358
D019833GenisteinGenistein results in decreased expression of BCAR3 mRNA22228119
D006418HemeHeme metabolite results in increased expression of BCAR3 mRNA19191707
C492448ICG 001ICG 001 results in increased expression of BCAR3 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of BCAR3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BCAR3 mRNA24796395
C410337K 7174K 7174 results in increased expression of BCAR3 mRNA24086573
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of BCAR3 mRNA25890327
D008687MetforminMetformin affects the expression of BCAR3 mRNA25596134
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCAR3 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BCAR3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of BCAR3 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of BCAR3 mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of BCAR3 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of BCAR3 mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of BCAR3 mRNA22546817
C028007nickel monoxidenickel monoxide results in decreased expression of BCAR3 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of BCAR3 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of BCAR3 mRNA25596134
D010126OzoneOzone results in increased expression of BCAR3 mRNA17095637
D010634PhenobarbitalPhenobarbital affects the expression of BCAR3 mRNA19159669
D010795Phthalic AcidsPhthalic Acids results in decreased expression of BCAR3 mRNA21061450
D010894PiroxicamCisplatin affects the reaction [Piroxicam results in decreased expression of BCAR3 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of BCAR3 mRNA21858171
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of BCAR3 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in decreased expression of BCAR3 mRNA24780913
D011794QuercetinQuercetin results in increased expression of BCAR3 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of BCAR3 mRNA19167446
C089730rosiglitazonerosiglitazone results in decreased expression of BCAR3 mRNA25596134
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of BCAR3 mRNA"21148743
D012715Sesame OilSesame Oil results in increased expression of BCAR3 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of BCAR3 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of BCAR3 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of BCAR3 mRNA19073995
D012834SilverSilver results in decreased expression of BCAR3 mRNA27131904
D053260SootSoot results in increased expression of BCAR3 mRNA26551751
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of BCAR3 mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in decreased expression of BCAR3 mRNA19228888
D013629TamoxifenBCAR3 protein affects the susceptibility to Tamoxifen19075277
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCAR3 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCAR3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BCAR3 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCAR3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BCAR3 mRNA21215274
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of BCAR3 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of BCAR3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of BCAR3 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCAR3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of BCAR3 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BCAR3 mRNA"26179874
D014520UrethaneUrethane results in increased expression of BCAR3 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of BCAR3 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of BCAR3 mRNA24383497|2493525
D014640VancomycinVancomycin results in increased expression of BCAR3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of BCAR3 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of BCAR3 mRNA20044591
C088658zoledronic acidzoledronic acid results in decreased expression of BCAR3 mRNA25596134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-IEA-  
GO:0005515protein binding-IPI16273093  24728074  25416956  25814554  
GO ID GO Term Qualifier Evidence PubMed
GO:0002089lens morphogenesis in camera-type eye-IEA-  
GO:0007165signal transduction-TAS9582273  
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0009967positive regulation of signal transduction-IEA-  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IEA-  
GO:0042493response to drug-TAS9582273  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17711772Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma. (2007 Jun)Zhigang HJ Otolaryngol