Gene info: ID 84132

Gene: USP42

GENE ID: 84132

Synonyms: -

Description: ubiquitin specific peptidase 42

Gene type: protein-coding

Location: 7p22.1

dbXrefs: Ensembl:ENSG00000106346 Vega:OTTHUMG00000151888 UniprotKB:Q9H9J4

RefSeq: NC_000007.14

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.034e-1 (AD) 3.418e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs12667392	chr7:6112051 (GRCh38.p7)	A>C	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDK13	0.915
PROSER1	0.904
KDM5B	0.901
PIP5K1A	0.899
QSOX2	0.899
BRD1	0.896
DCP1A	0.893
NUP153	0.89
SART3	0.89
RPRD2	0.89

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.515
OR4F29	-0.463
KLRC2	-0.364
TRDN	-0.291
KLRC3	-0.288
MYL3	-0.267
SH2D1A	-0.265
CTNNA3	-0.264
MTRNR2L10	-0.253
OR4F16	-0.253

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of USP42 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of USP42 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of USP42 mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of USP42 mRNA	28959563
C044887	beta-methylcholine	beta-methylcholine affects the expression of USP42 mRNA	21179406
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of USP42 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of USP42 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of USP42 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of USP42 mRNA	25181051
D019327	Copper Sulfate	Copper Sulfate results in increased expression of USP42 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of USP42 mRNA	20106945\|2556210
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of USP42 mRNA	28628672
D002945	Cisplatin	Cisplatin results in decreased expression of USP42 mRNA	27594783
D004221	Disulfiram	Disulfiram results in decreased expression of USP42 mRNA	20530235
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of USP42 mRNA	17942748
D005557	Formaldehyde	Formaldehyde results in decreased expression of USP42 mRNA	20655997
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of USP42 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of USP42 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of USP42 mRNA	28628672
C008261	lead acetate	lead acetate results in increased expression of USP42 mRNA	20542052
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of USP42 mRNA	26011545
D009930	Organic Chemicals	Organic Chemicals results in decreased expression of USP42 mRNA	20526952
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of USP42 mRNA	23892564
C006253	pirinixic acid	pirinixic acid results in decreased expression of USP42 mRNA	21318169
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in decreased expression of USP42 mRNA]	21318169
C017947	sodium arsenite	sodium arsenite results in decreased expression of USP42 mRNA	21297353
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of USP42 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of USP42 mRNA	25270620
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of USP42 mRNA	25613284
D013893	Thiram	Thiram results in decreased expression of USP42 mRNA	20530235
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of USP42 mRNA	28065790
C483909	torcetrapib	torcetrapib results in increased expression of USP42 mRNA	23228038
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of USP42 mRNA	26272509
D014520	Urethane	Urethane results in increased expression of USP42 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of USP42 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of USP42 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in increased methylation of USP42 gene	29154799
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of USP42 mRNA"	20526952

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004843	thiol-dependent ubiquitin-specific protease activity	-	IDA	14715245
GO:0005515	protein binding	-	IPI	22085928
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006284	base-excision repair	-	IBA	21873635
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	-
GO:0007283	spermatogenesis	-	IEA	-
GO:0016579	protein deubiquitination	-	IDA	14715245
GO:0016579	protein deubiquitination	-	ISS	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0030154	cell differentiation	-	IEA	-
GO:0042981	regulation of apoptotic process	-	IBA	21873635
GO:0045892	negative regulation of transcription, DNA-templated	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal