Gene: USP42

84132
-
ubiquitin specific peptidase 42
protein-coding
7p22.1
Ensembl:ENSG00000106346 Vega:OTTHUMG00000151888 UniprotKB:Q9H9J4
NC_000007.14
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.034e-1 (AD)  3.418e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12667392chr7:6112051 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDK130.915
PROSER10.904
KDM5B0.901
PIP5K1A0.899
QSOX20.899
BRD10.896
DCP1A0.893
NUP1530.89
SART30.89
RPRD20.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.515
OR4F29-0.463
KLRC2-0.364
TRDN-0.291
KLRC3-0.288
MYL3-0.267
SH2D1A-0.265
CTNNA3-0.264
MTRNR2L10-0.253
OR4F16-0.253

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of USP42 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of USP42 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of USP42 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of USP42 mRNA28959563
C044887beta-methylcholinebeta-methylcholine affects the expression of USP42 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of USP42 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of USP42 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of USP42 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of USP42 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of USP42 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of USP42 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of USP42 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of USP42 mRNA27594783
D004221DisulfiramDisulfiram results in decreased expression of USP42 mRNA20530235
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of USP42 mRNA17942748
D005557FormaldehydeFormaldehyde results in decreased expression of USP42 mRNA20655997
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of USP42 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of USP42 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of USP42 mRNA28628672
C008261lead acetatelead acetate results in increased expression of USP42 mRNA20542052
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of USP42 mRNA26011545
D009930Organic ChemicalsOrganic Chemicals results in decreased expression of USP42 mRNA20526952
D010416PentachlorophenolPentachlorophenol results in increased expression of USP42 mRNA23892564
C006253pirinixic acidpirinixic acid results in decreased expression of USP42 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of USP42 mRNA]21318169
C017947sodium arsenitesodium arsenite results in decreased expression of USP42 mRNA21297353
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of USP42 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of USP42 mRNA25270620
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of USP42 mRNA25613284
D013893ThiramThiram results in decreased expression of USP42 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of USP42 mRNA28065790
C483909torcetrapibtorcetrapib results in increased expression of USP42 mRNA23228038
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of USP42 mRNA26272509
D014520UrethaneUrethane results in increased expression of USP42 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP42 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of USP42 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of USP42 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of USP42 gene29154799
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of USP42 mRNA"20526952

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004843thiol-dependent ubiquitin-specific protease activity-IDA14715245  
GO:0005515protein binding-IPI22085928  
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006284base-excision repair-IBA21873635  
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0016579protein deubiquitination-IDA14715245  
GO:0016579protein deubiquitination-ISS-  
GO:0016579protein deubiquitination-TAS-  
GO:0030154cell differentiation-IEA-  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal