Gene: PPP1R1B

84152
DARPP-32|DARPP32
protein phosphatase 1 regulatory inhibitor subunit 1B
protein-coding
17q12
Ensembl:ENSG00000131771 MIM:604399 Vega:OTTHUMG00000133210 UniprotKB:Q9UD71
NG_030330.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.213e-1 (AD)  7.964e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNTA10.893
CNTFR0.868
PBXIP10.868
TTYH10.865
ALDH20.863
CABLES10.862
ZFYVE210.858
HTRA10.858
WFS10.857
IL17D0.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.641
OR4F29-0.628
FER1L6-0.329
GALR1-0.32
GAS2L3-0.31
CD244-0.296
COL15A1-0.294
SCARA5-0.29
GADL1-0.282
ADCY7-0.282

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]"11880652
C0871412-(1-(4-piperonyl)piperazinyl)benzothiazole2-(1-(4-piperonyl)piperazinyl)benzothiazole results in decreased phosphorylation of PPP1R1B protein11880652
C0871412-(1-(4-piperonyl)piperazinyl)benzothiazole2-(1-(4-piperonyl)piperazinyl)benzothiazole results in increased phosphorylation of PPP1R1B protein11880652
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1B mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1B mRNA"25510870
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]17209049
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]17209049
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1B mRNA"25510870
C4062332-ethyl-5-methoxy-N,N-dimethyltryptamine"2-ethyl-5-methoxy-N,N-dimethyltryptamine results in decreased phosphorylation of PPP1R1B protein"11880652
C4062332-ethyl-5-methoxy-N,N-dimethyltryptamine"2-ethyl-5-methoxy-N,N-dimethyltryptamine results in increased phosphorylation of PPP1R1B protein"11880652
C0727902-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
C0727902-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased phosphorylation of PPP1R1B protein"17953657
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of PPP1R1B mRNA25716159
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of PPP1R1B mRNA"26186136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP1R1B mRNA"27188386
C0830094-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride4-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride results in decreased phosphorylation of PPP1R1B protein11880652
C0159524-iodo-2,5-dimethoxyphenylisopropylamine"4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of PPP1R1B protein"11880652
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP1R1B mRNA"27188386
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of PPP1R1B protein]17680995
D000082AcetaminophenAcetaminophen affects the expression of PPP1R1B mRNA17562736
D000324Adrenocorticotropic HormoneCocaine promotes the reaction [PPP1R1B protein results in increased abundance of Adrenocorticotropic Hormone]10516482
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PPP1R1B mRNA23630614
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of PPP1R1B mRNA"22863853
C075631anpirtolineanpirtoline results in decreased phosphorylation of PPP1R1B protein11880652
C547126AZM551248AZM551248 results in decreased expression of PPP1R1B mRNA22323515
C005177benserazide, levodopa drug combination"[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of PPP1R1B protein"17596448
C005177benserazide, levodopa drug combination"PPP1R1B affects the susceptibility to benserazide, levodopa drug combination"17596448
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPP1R1B mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPP1R1B mRNA21839799
D004958EstradiolEstradiol results in increased expression of PPP1R1B mRNA23019147
D004958EstradiolEstradiol results in increased expression of PPP1R1B mRNA20068009
C006780bisphenol Abisphenol A results in increased expression of PPP1R1B mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of PPP1R1B mRNA23019147
C006780bisphenol Abisphenol A affects the expression of PPP1R1B mRNA25181051
D002087ButyratesPPP1R1B protein alternative form results in decreased susceptibility to Butyrates16061638
D002087ButyratesPPP1R1B protein results in decreased susceptibility to Butyrates16061638
D002166CamptothecinPPP1R1B protein alternative form results in decreased susceptibility to Camptothecin16061638
D002166CamptothecinPPP1R1B protein results in decreased susceptibility to Camptothecin16061638
D002518CeramidesPPP1R1B protein alternative form results in decreased susceptibility to Ceramides16061638
D002518CeramidesPPP1R1B protein results in decreased susceptibility to Ceramides16061638
D010133p-ChloroamphetaminePPP1R1B protein affects the reaction [p-Chloroamphetamine results in increased expression of FOS mRNA]11880652
D003010Clorgyline[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]23499958
D003010Clorgyline[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]23499958
D003024ClozapineClozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
D003024ClozapineClozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
D003024ClozapineClozapine results in increased phosphorylation of PPP1R1B protein12871586
C018021cobaltous chloridecobaltous chloride results in decreased expression of PPP1R1B mRNA24386269
C018021cobaltous chloridecobaltous chloride inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]12064480
D003042CocaineCDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]15665076
D003042Cocaine[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]23499958
D003042Cocaine[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]23499958
D003042CocaineCNR1 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]17596442
D003042CocaineCocaine promotes the reaction [PPP1R1B protein results in increased abundance of Adrenocorticotropic Hormone]10516482
D003042CocaineCocaine promotes the reaction [PPP1R1B protein results in increased abundance of Corticosterone]10516482
D003042CocaineCocaine results in increased expression of PPP1R1B protein16710312
D003042CocaineCocaine results in increased phosphorylation of PPP1R1B protein15665076|1759644
D003042Cocaine"N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of PPP1R1B protein]"16710312
D003042CocainePPP1R1B affects the susceptibility to Cocaine20682746
D003042CocainePPP1R1B gene mutant form inhibits the reaction [Cocaine results in increased expression of FOSB protein]10103106
D003042CocainePPP1R1B gene mutant form results in increased susceptibility to Cocaine10103106
D003042CocainePPP1R1B mutant form results in increased susceptibility to Cocaine11268215
D003042Cocaineresveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]23499958
D003042Cocaine6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of PPP1R1B protein]17680995
D003042CocaineCocaine affects the phosphorylation of PPP1R1B protein15287884|1768099
D003042CocaineCocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of PPP1R1B protein]11268215
D003042Cocaineroscovitine affects the reaction [Cocaine affects the phosphorylation of PPP1R1B protein]11268215
D005576ColforsinColforsin results in increased phosphorylation of PPP1R1B protein12077213
D005576ColforsinPDE1B protein affects the reaction [Colforsin results in increased phosphorylation of PPP1R1B protein]12077213
D003345CorticosteroneCocaine promotes the reaction [PPP1R1B protein results in increased abundance of Corticosterone]10516482
D003471CuprizoneCuprizone affects the expression of PPP1R1B mRNA26577399
D003471CuprizoneCuprizone results in decreased expression of PPP1R1B mRNA27523638
D0187506-Cyano-7-nitroquinoxaline-2,3-dione"6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]"12064480
C037304cyhalothrincyhalothrin results in decreased expression of PPP1R1B protein28495607
C107676deguelindeguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]17209049
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of PPP1R1B mRNA28962523
D002945CisplatinPPP1R1B protein results in increased susceptibility to Cisplatin17470401
D019422Dietary SucroseDietary Sucrose results in increased expression of PPP1R1B mRNA26033743
C434247diphenylditelluridediphenylditelluride affects the phosphorylation of PPP1R1B protein21863293
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]12064480
D007980Levodopa"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased phosphorylation of PPP1R1B protein"20808799
D007980LevodopaLevodopa results in increased phosphorylation of PPP1R1B protein17704844|2050421
D007980Levodopa[Oxidopamine co-treated with Levodopa] affects the phosphorylation of PPP1R1B protein17188499
D004298Dopamine[[NTS protein results in increased secretion of Dopamine] which results in increased activity of DRD1 protein] which results in increased phosphorylation of PPP1R1B protein12064480
D004298DopaminePPP1R1B protein affects the reaction [[NTS protein results in increased secretion of Dopamine] which results in increased phosphorylation of GRIA1 protein]12064480
D004317DoxorubicinPPP1R1B protein results in decreased export of Doxorubicin17470401
D004317DoxorubicinPPP1R1B protein results in increased susceptibility to Doxorubicin17470401
C118739entinostatentinostat results in increased expression of PPP1R1B mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP1R1B mRNA"27188386
D000431EthanolEthanol results in increased expression of PPP1R1B mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PPP1R1B mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of PPP1R1B mRNA28189721
C045989eticloprideeticlopride results in increased phosphorylation of PPP1R1B protein12871586
D005472FluorouracilPPP1R1B protein results in increased susceptibility to Fluorouracil17470401
D005473FluoxetineFluoxetine affects the phosphorylation of PPP1R1B protein11880651
D005473FluoxetineFluoxetine results in increased expression of PPP1R1B mRNA11880651
D005473FluoxetineFluoxetine results in increased expression of PPP1R1B protein11880651
D005473FluoxetinePPP1R1B protein promotes the reaction [Fluoxetine affects the phosphorylation of GRIA1 protein]11880651
D005473FluoxetinePPP1R1B protein results in increased susceptibility to Fluoxetine11880651
C039281furanfuran results in increased expression of PPP1R1B mRNA24183702
C039281furanfuran results in decreased methylation of PPP1R1B gene27387713
C039281furanfuran results in increased expression of PPP1R1B mRNA27387713
D019833GenisteinGenistein results in increased expression of PPP1R1B mRNA23019147
D005839GentamicinsGentamicins results in decreased expression of PPP1R1B mRNA22061828
D006220HaloperidolHaloperidol results in increased phosphorylation of PPP1R1B protein12871586
D056572Histone Deacetylase InhibitorsHistone Deacetylase Inhibitors results in increased expression of PPP1R1B mRNA24204683
D056572Histone Deacetylase InhibitorsHistone Deacetylase Inhibitors results in increased expression of PPP1R1B protein24204683
D017313FenretinideFenretinide results in increased expression of PPP1R1B mRNA28973697
D012701Serotonin"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]"11880652
D012701Serotonin2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
D012701Serotonin2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
D012701SerotoninClozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
D012701SerotoninClozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
D012701SerotoninHTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]11880652
D012701SerotoninHTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]11880652
D012701SerotoninHTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]11880652
D012701SerotoninKetanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
D012701SerotoninQuinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
D012701SerotoninQuinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
D012701SerotoninRo 4-6790 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
D012701SerotoninRo 4-6790 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
D012701SerotoninSerotonin results in decreased phosphorylation of PPP1R1B protein11880652
D012701SerotoninSerotonin results in increased phosphorylation of PPP1R1B protein11880652
D012701SerotoninSK&F 82958 promotes the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
D012701SerotoninSK&F 82958 promotes the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
C016517indole-3-carbinolindole-3-carbinol affects the expression of PPP1R1B mRNA21396975
D007501IronIron deficiency results in increased expression of PPP1R1B mRNA16629162
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PPP1R1B mRNA26752646
D007649KetamineKetamine results in increased expression of PPP1R1B mRNA20080153
D007650KetanserinKetanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
D008345ManganeseManganese results in increased phosphorylation of PPP1R1B protein22427945
C025340manganese chloridemanganese chloride results in decreased phosphorylation of PPP1R1B protein23385959
D008694MethamphetamineMethamphetamine results in increased phosphorylation of PPP1R1B protein22564758
D008694Methamphetaminenaloxonazine inhibits the reaction [Methamphetamine results in increased phosphorylation of PPP1R1B protein]22564758
D008694MethamphetamineMethamphetamine results in increased expression of PPP1R1B mRNA28341135
D008727MethotrexateMethotrexate affects the expression of PPP1R1B mRNA18502557
D0087355-Methoxytryptamine5-Methoxytryptamine results in decreased phosphorylation of PPP1R1B protein11880652
D0087355-Methoxytryptamine5-Methoxytryptamine results in increased phosphorylation of PPP1R1B protein11880652
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased phosphorylation of PPP1R1B protein"20808799
D052998MicrocystinsMicrocystins results in increased expression of PPP1R1B protein22430071
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]21600884
D009020MorphineOPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]21600884
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]21600884
D009020MorphineMorphine affects the expression of PPP1R1B protein modified form15287884
D009020MorphineMorphine results in increased phosphorylation of PPP1R1B protein21600884
C034643naloxonazinenaloxonazine inhibits the reaction [Methamphetamine results in increased phosphorylation of PPP1R1B protein]22564758
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PPP1R1B mRNA"25554681
D009532NickelNickel results in decreased expression of PPP1R1B mRNA24768652|2558310
C478058N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine"N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of PPP1R1B protein]"16710312
D016627Oxidopamine"[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of PPP1R1B protein"17596448
D016627Oxidopamine[Oxidopamine co-treated with Levodopa] affects the phosphorylation of PPP1R1B protein17188499
D010293Pargyline[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]23499958
D010293Pargyline[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]23499958
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R1B mRNA"25510870
C006253pirinixic acidpirinixic acid results in decreased expression of PPP1R1B mRNA17426115
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of PPP1R1B mRNA27989595
D011374ProgesteroneProgesterone results in decreased expression of PPP1R1B mRNA16966611|2223828
D011441PropylthiouracilPropylthiouracil results in decreased expression of PPP1R1B mRNA24780913
D019257QuinpiroleQuinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
D019257QuinpiroleQuinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
D020891RacloprideRaclopride results in increased phosphorylation of PPP1R1B protein12064480
D020891RacloprideNTS protein promotes the reaction [Raclopride results in increased phosphorylation of PPP1R1B protein]12064480
D020891Raclopride[SCH 23390 co-treated with Raclopride] inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]12064480
C059514resveratrol[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]23499958
C059514resveratrolresveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]23499958
C114163Ro 4-6790Ro 4-6790 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
C114163Ro 4-6790Ro 4-6790 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
C104586roscovitineroscovitine inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]17209049
C104586roscovitineroscovitine inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]17209049
C104586roscovitineroscovitine affects the reaction [Cocaine affects the phosphorylation of PPP1R1B protein]11268215
C534628SCH 23390[SCH 23390 co-treated with Raclopride] inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]12064480
C534628SCH 23390SCH 23390 inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]12064480
D020123SirolimusSirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]17209049
D020123SirolimusSirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]17209049
C067113SK&F 81297PDE1B protein affects the reaction [SK&F 81297 results in increased phosphorylation of PPP1R1B protein]12077213
C067113SK&F 81297SK&F 81297 results in increased phosphorylation of PPP1R1B protein12077213
C067113SK&F 81297Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of PPP1R1B protein]11268215
C067113SK&F 81297SK&F 81297 results in increased phosphorylation of PPP1R1B protein11268215
C071262SK&F 82958SK&F 82958 promotes the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]11880652
C071262SK&F 82958SK&F 82958 promotes the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]11880652
C114947SR 142948SR 142948 inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]12064480
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPP1R1B mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPP1R1B mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPP1R1B mRNA18465118
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of PPP1R1B mRNA28973375
D013779TetrodotoxinTetrodotoxin inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]12064480
C009495titanium dioxidetitanium dioxide results in decreased expression of PPP1R1B mRNA19464567
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PPP1R1B mRNA20133372
D014212TretinoinTretinoin results in increased expression of PPP1R1B mRNA16026464
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PPP1R1B mRNA25549359
C012589trichostatin Atrichostatin A inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]24204683
C012589trichostatin Atrichostatin A results in increased expression of PPP1R1B mRNA24204683
C012589trichostatin Atrichostatin A results in increased expression of PPP1R1B protein24204683
D014635Valproic AcidValproic Acid affects the expression of PPP1R1B mRNA17292431
D014635Valproic AcidValproic Acid inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]24204683
D014635Valproic AcidValproic Acid results in increased expression of PPP1R1B mRNA24204683
D014635Valproic AcidValproic Acid results in increased expression of PPP1R1B protein24204683
D014640VancomycinVancomycin results in increased expression of PPP1R1B mRNA18930951
D014750VincristinePPP1R1B protein results in increased susceptibility to Vincristine17470401
C009687wortmanninwortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]17209049
C088658zoledronic acidzoledronic acid results in decreased expression of PPP1R1B mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004860protein kinase inhibitor activity-TAS10604473  
GO:0004862cAMP-dependent protein kinase inhibitor activity-TAS-  
GO:0004864protein phosphatase inhibitor activity-IDA10807923  
GO:0004864protein phosphatase inhibitor activity-TAS10604473  
GO:0005515protein binding-IPI25416956  
GO:0019888protein phosphatase regulator activity-TAS-  
GO:0031748D1 dopamine receptor binding-IEA-  
GO:0031749D2 dopamine receptor binding-IEA-  
GO:0031750D3 dopamine receptor binding-IEA-  
GO:0031751D4 dopamine receptor binding-IEA-  
GO:0031752D5 dopamine receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001975response to amphetamine-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007165signal transduction-TAS10604473  
GO:0007621negative regulation of female receptivity-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0008542visual learning-IEA-  
GO:0032515negative regulation of phosphoprotein phosphatase activity-IDA10807923  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0043278response to morphine-IEA-  
GO:0043987histone H3-S10 phosphorylation-IEA-  
GO:0048148behavioral response to cocaine-IEA-  
GO:0071901negative regulation of protein serine/threonine kinase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-111885Opioid SignallingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-180024DARPP-32 eventsTAS
R-HSA-180024DARPP-32 eventsIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17171661Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (2007 Apr 5)Beuten JAm J Med Genet B Neuropsychiatr Genet