Gene: ARID5B

84159
DESRT|MRF-2|MRF2
AT-rich interaction domain 5B
protein-coding
10q21.2
Ensembl:ENSG00000150347 MIM:608538 Vega:OTTHUMG00000018298 UniprotKB:Q14865
NG_030027.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.788e-1 (AD)  5.074e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16401465chr10:63809170ARID5B3.900e-14Smoking27651444
cg25953130chr10:63753550ARID5B4.500e-12Smoking27651444
cg07520810chr10:63809149ARID5B1.600e-10Smoking27651444
cg00928816chr10:63809098ARID5B8.500e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FNIP20.882
OTUD40.878
RANBP20.864
CBLL10.862
RPS6KB10.861
PDS5A0.86
PAPOLG0.858
GAPVD10.858
DCP1A0.858
DERL10.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.475
OR4F29-0.436
HES5-0.345
RERGL-0.342
REM1-0.316
C16orf74-0.309
KLRC2-0.304
COX4I2-0.303
BTBD17-0.299
PTGDR2-0.296

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ARID5B mRNA"22698814
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ARID5B mRNA"20453058
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of ARID5B mRNA"23829299
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C0118647-hydroxymethotrexateARID5B gene SNP affects the abundance of 7-hydroxymethotrexate24712521
D000393Air PollutantsAir Pollutants analog results in decreased expression of ARID5B mRNA21757418
C006632arsenic trioxidearsenic trioxide results in decreased expression of ARID5B mRNA27829220
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ARID5B mRNA"18687144
D001280AtrazineAtrazine results in increased expression of ARID5B mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARID5B mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ARID5B mRNA"26238291
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of ARID5B mRNA]24758408
D004958EstradiolEstradiol affects the expression of ARID5B mRNA22574217
D004958EstradiolEstradiol results in decreased expression of ARID5B mRNA24758408
C044887beta-methylcholinebeta-methylcholine affects the expression of ARID5B mRNA21179406
C004541biochanin Abiochanin A results in increased expression of ARID5B mRNA12111696
C006780bisphenol Abisphenol A results in increased expression of ARID5B mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of ARID5B mRNA26063408
C006780bisphenol Abisphenol A affects the expression of ARID5B mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ARID5B mRNA22079614
C584509C646 compoundC646 compound affects the expression of ARID5B mRNA26191083
D002737ChloropreneChloroprene results in increased expression of ARID5B mRNA23125180
D019327Copper SulfateCopper Sulfate results in increased expression of ARID5B mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ARID5B mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of ARID5B mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ARID5B mRNA17361019|2126653
D002945CisplatinARID5B protein affects the susceptibility to Cisplatin16217747
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ARID5B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ARID5B mRNA27392435
D004008DiclofenacDiclofenac results in decreased expression of ARID5B mRNA26934552
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARID5B mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ARID5B mRNA23649840
D005472FluorouracilARID5B protein affects the susceptibility to Fluorouracil16217747
D005557FormaldehydeFormaldehyde results in increased expression of ARID5B mRNA23649840
C106014geduningedunin results in decreased expression of ARID5B mRNA17010675
D007213IndomethacinIndomethacin results in decreased expression of ARID5B mRNA16984733
D007545IsoproterenolIsoproterenol results in increased expression of ARID5B mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ARID5B mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ARID5B mRNA27392435
C045463leflunomideleflunomide results in increased expression of ARID5B mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ARID5B mRNA"18930950
C042720mercuric bromidemercuric bromide results in increased expression of ARID5B mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
D008727MethotrexateARID5B gene SNP affects the abundance of Methotrexate24712521
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ARID5B mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ARID5B mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ARID5B mRNA"26251327
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ARID5B mRNA26272509
C410127PCB 180PCB 180 results in decreased expression of ARID5B mRNA23829299
C046012pentanalpentanal results in decreased expression of ARID5B mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of ARID5B mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of ARID5B mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ARID5B mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARID5B mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ARID5B mRNA20813756|2381119
D010938Plant OilsPlant Oils results in increased expression of ARID5B mRNA23370395
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ARID5B mRNA23608068
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of ARID5B mRNA14699072
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ARID5B mRNA25895662
D012834SilverSilver results in increased expression of ARID5B mRNA26014281
C009277sodium arsenatesodium arsenate results in decreased expression of ARID5B mRNA21795629
C017947sodium arsenite[sodium arsenite co-treated with sodium arsenite deficiency] results in decreased methylation of ARID5B promoter28336213
C017947sodium arsenitesodium arsenite results in increased expression of ARID5B mRNA16014739
D012999SomanSoman results in increased expression of ARID5B mRNA19281266
D013629TamoxifenTamoxifen affects the expression of ARID5B mRNA14699072
D013629TamoxifenTamoxifen affects the expression of ARID5B mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARID5B mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARID5B mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ARID5B mRNA28065790
C024746tobacco tartobacco tar results in decreased expression of ARID5B mRNA19559774
D014212TretinoinTretinoin results in increased expression of ARID5B mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ARID5B gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ARID5B mRNA24935251|2627250
C050414tripterinetripterine results in decreased expression of ARID5B mRNA17010675
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ARID5B mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ARID5B mRNA"18930950
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID5B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ARID5B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ARID5B mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ARID5B mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ARID5B gene25560391
C111237vorinostatvorinostat results in increased expression of ARID5B mRNA26272509|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA8649988  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA8649988  
GO:0003677DNA binding-IDA10329386  
GO:0003713transcription coactivator activity-IDA21532585  
GO:0005515protein binding-IPI21532585  23752268  26496610  
GO:0032452histone demethylase activity-TAS-  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IDA21532585  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA8649988  
GO:0001822kidney development-IEA-  
GO:0001889liver development-TAS21532585  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0008584male gonad development-IEA-  
GO:0008585female gonad development-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0010761fibroblast migration-IEA-  
GO:0016577histone demethylation-IEA-  
GO:0030325adrenal gland development-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0045444fat cell differentiation-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-TAS15640446  
GO:0048008platelet-derived growth factor receptor signaling pathway-IEA-  
GO:0048468cell development-IEA-  
GO:0048644muscle organ morphogenesis-IEA-  
GO:0048705skeletal system morphogenesis-IEA-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA21532585  
GO:0060021roof of mouth development-IEA-  
GO:0060325face morphogenesis-IEA-  
GO:0060612adipose tissue development-ISS-  
GO:0060613fat pad development-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214842HDMs demethylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26045716Genetic susceptibility in childhood acute leukaemias: a systematic review. (2015)Brisson GDEcancermedicalscience
23577190PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)Suzuki TPLoS One
25806972ARID5B, IKZF1 and non-genetic factors in the etiology of childhood acute lymphoblastic leukemia: the ESCALE study. (2015)Rudant JPLoS One