Gene: NLRC5

84166
CLR16.1|NOD27|NOD4
NLR family CARD domain containing 5
protein-coding
16q13
Ensembl:ENSG00000140853 MIM:613537 Vega:OTTHUMG00000133470 UniprotKB:Q86WI3
NG_030337.3
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.197e-2 (AD)  4.661e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11639875chr16:57079952 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16411857chr16:57023191NLRC54.540e-9Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM50.927
TRIM210.896
SP1100.896
PARP90.895
GBP10.894
DTX3L0.893
IL18BP0.893
PARP140.893
SP140L0.89
HELZ20.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.448
MYADML2-0.443
SLC7A4-0.429
ABCC12-0.427
TMEM179-0.426
NEUROD6-0.425
CPLX3-0.422
EXTL1-0.416
MARCH4-0.416
ADRA1D-0.415

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NLRC5 mRNA"28903501
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased expression of AKT1 mRNA]27338800
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased phosphorylation of AKT1 protein]27338800
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased secretion of VEGFA protein]27338800
D000082AcetaminophenAcetaminophen results in decreased expression of NLRC5 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NLRC5 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NLRC5 mRNA24449571
D001151ArsenicArsenic affects the methylation of NLRC5 gene25304211
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of NLRC5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NLRC5 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NLRC5 mRNA23735875
C006780bisphenol Abisphenol A affects the expression of NLRC5 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NLRC5 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NLRC5 mRNA26806094
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NLRC5 protein26806094
D019327Copper SulfateCopper Sulfate results in decreased expression of NLRC5 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of NLRC5 mRNA20106945
D016572CyclosporineCyclosporine results in increased methylation of NLRC5 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NLRC5 mRNA24317228
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of NLRC5 mRNA]26806094
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of NLRC5 protein]26806094
D003907DexamethasoneNLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]26806094
D003907DexamethasoneNLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]26806094
D003907DexamethasoneNLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]26806094
D003907DexamethasoneNLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]]26806094
D003907DexamethasoneNLRC5 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]]26806094
D003907DexamethasoneNLRC5 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of RELA protein]]26806094
D016264Dextran SulfateDextran Sulfate results in increased expression of NLRC5 mRNA23894361
D002945CisplatinCisplatin results in decreased expression of NLRC5 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of NLRC5 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of NLRC5 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of NLRC5 mRNA21592394
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NLRC5 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of NLRC5 mRNA]26806094
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of NLRC5 protein]26806094
D0150561-Methyl-3-isobutylxanthineNLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]26806094
D0150561-Methyl-3-isobutylxanthineNLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]26806094
D0150561-Methyl-3-isobutylxanthineNLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]26806094
D0150561-Methyl-3-isobutylxanthineNLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]]26806094
D0150561-Methyl-3-isobutylxanthineNLRC5 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]]26806094
D0150561-Methyl-3-isobutylxanthineNLRC5 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of RELA protein]]26806094
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NLRC5 mRNA23086925
D008727MethotrexateMethotrexate results in decreased expression of NLRC5 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of NLRC5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NLRC5 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NLRC5 mRNA"25620056
D019829NevirapineNevirapine results in increased expression of NLRC526626330
D009532NickelNickel results in increased expression of NLRC5 mRNA24768652|2558310
D010100OxygenOxygen deficiency results in decreased expression of NLRC5 mRNA26516004
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NLRC5 mRNA22714537
D019438RitonavirRitonavir results in decreased expression of NLRC526626330
D012834SilverSilver results in decreased expression of NLRC5 mRNA27131904
C017947sodium arsenitesodium arsenite affects the expression of NLRC5 mRNA29319823
D018038Sodium SeleniteSodium Selenite results in increased expression of NLRC5 mRNA18175754
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of NLRC5 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of NLRC5 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of NLRC5 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NLRC5 mRNA20106945
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NLRC5 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NLRC5 mRNA28065790
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NLRC5 mRNA29024780
D014520UrethaneUrethane results in decreased expression of NLRC5 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20639463  
GO:0005515protein binding-IPI20434986  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0023052signaling-IBA21873635  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA20434986  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0043549regulation of kinase activity-IDA20434986  
GO:0045087innate immune response-IMP20434986  
GO:0045345positive regulation of MHC class I biosynthetic process-IBA21873635  
GO:0045345positive regulation of MHC class I biosynthetic process-IDA20639463  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA20639463  
GO:0051607defense response to virus-IEP20061403  
GO:0060335positive regulation of interferon-gamma-mediated signaling pathway-IDA20061403  
GO:0060335positive regulation of interferon-gamma-mediated signaling pathway-IMP20639463  
GO:0060339negative regulation of type I interferon-mediated signaling pathway-IBA21873635  
GO:0060339negative regulation of type I interferon-mediated signaling pathway-IDA20434986  
GO:0060340positive regulation of type I interferon-mediated signaling pathway-IDA20061403  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20639463  
GO:0005737cytoplasmCOLOCALIZES_WITHIBA21873635  
GO:0005737cytoplasm-IDA20061403  20434986  
GO:0005813centrosome-IDA-  
GO:0005829cytosol-IDA20639463  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28915241The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases. (2017 Sep)Ahsan MPLoS Genet