Gene: ANTXR1

84168
ATR|GAPO|TEM8
ANTXR cell adhesion molecule 1
protein-coding
2p13.3
Ensembl:ENSG00000169604 MIM:606410 Vega:OTTHUMG00000129575 UniprotKB:Q9H6X2
NG_012649.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.264e-2 (AD)  2.152e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11900784chr2:69045364 (GRCh38.p7)A>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDLIM50.885
GOLIM40.868
CYBRD10.852
RAB310.85
ADD30.85
SUCLG20.847
HSDL20.843
MSRB30.842
PARD3B0.832
KAT2B0.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.519
B3GNT4-0.485
NRG1-0.478
ROPN1L-0.471
OSBPL10-0.468
RHO-0.466
KCNB2-0.463
PNPLA5-0.462
SMPX-0.46
TTC39A-0.453

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05945MDX-1303Small Molecule915947-57-8InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of ANTXR1 mRNA"24680724
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of ANTXR1 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ANTXR1 mRNA21298039
D001151ArsenicArsenic affects the methylation of ANTXR1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of ANTXR1 mRNA22521957
D001280AtrazineAtrazine results in decreased expression of ANTXR1 mRNA22378314
D001379AzathioprineAzathioprine results in increased expression of ANTXR1 mRNA19192274
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANTXR1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ANTXR1 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANTXR1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ANTXR1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANTXR1 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ANTXR1 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of ANTXR1 mRNA20823114
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ANTXR1 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ANTXR1 mRNA17404688
D004958EstradiolEstradiol results in increased expression of ANTXR1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of ANTXR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ANTXR1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of ANTXR1 mRNA26079696
D002104CadmiumCadmium results in decreased expression of ANTXR1 mRNA24067728
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ANTXR1 mRNA17484886
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of ANTXR1 mRNA26272509
C023676chloroquine diphosphatechloroquine diphosphate results in increased expression of ANTXR1 mRNA19192274
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANTXR1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of ANTXR1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of ANTXR1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ANTXR1 mRNA25562108
D000069439DasatinibDasatinib results in increased expression of ANTXR1 mRNA20579391
D003907DexamethasoneDexamethasone results in decreased expression of ANTXR1 mRNA25047013
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of ANTXR1 mRNA20823114
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of ANTXR1 mRNA28962523
D004041Dietary FatsDietary Fats results in increased expression of ANTXR1 mRNA18042831
D002117CalcitriolCalcitriol results in decreased expression of ANTXR1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of ANTXR1 mRNA21592394
C118739entinostatentinostat results in increased expression of ANTXR1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ANTXR1 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of ANTXR1 intron16300676
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANTXR1 mRNA20938992
D004397FonofosFonofos results in increased methylation of ANTXR1 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of ANTXR1 mRNA23649840
C039281furanfuran results in increased expression of ANTXR1 mRNA25539665|2738771
C056507gemcitabinegemcitabine affects the expression of ANTXR1 mRNA17039268
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of ANTXR1 mRNA19192274
D017313FenretinideFenretinide results in decreased expression of ANTXR1 mRNA28973697
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of ANTXR1 mRNA20823114
C042720mercuric bromidemercuric bromide results in increased expression of ANTXR1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of ANTXR1 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANTXR1 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of ANTXR1 mRNA19192274
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ANTXR1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
D008775MethylprednisoloneMethylprednisolone results in increased expression of ANTXR1 mRNA19192274
C500085muraglitazarmuraglitazar results in increased expression of ANTXR1 mRNA21515302
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ANTXR1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ANTXR1 mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ANTXR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ANTXR1 mRNA"25554681
D009532NickelNickel results in decreased expression of ANTXR1 mRNA12540486
C029938nickel sulfatenickel sulfate results in increased expression of ANTXR1 mRNA22714537
D010100OxygenOxygen deficiency results in increased expression of ANTXR1 mRNA26516004
D000073878Palm OilPalm Oil results in increased expression of ANTXR1 mRNA18042831
D010278ParathionParathion results in increased methylation of ANTXR1 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of ANTXR1 mRNA22178795
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ANTXR1 mRNA26272509
D011239PrednisolonePrednisolone results in increased expression of ANTXR1 mRNA19192274
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ANTXR1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ANTXR1 mRNA17404688
C005556propionaldehydepropionaldehyde results in increased expression of ANTXR1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of ANTXR1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ANTXR1 mRNA25895662
C012568terbufosterbufos results in increased methylation of ANTXR1 promoter22847954
C501413tesaglitazartesaglitazar results in increased expression of ANTXR1 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of ANTXR1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of ANTXR1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANTXR1 mRNA20106945|2163298
C009495titanium dioxidetitanium dioxide results in decreased expression of ANTXR1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ANTXR1 mRNA28065790
D014212TretinoinTretinoin results in increased expression of ANTXR1 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANTXR1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ANTXR1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ANTXR1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ANTXR1 mRNA28973697
D014520UrethaneUrethane results in decreased expression of ANTXR1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ANTXR1 mRNA24935251|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ANTXR1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IDA16762926  
GO:0005515protein binding-IPI14507921  16564009  16762926  
GO:0005518collagen binding-IDA16762926  
GO:0046872metal ion binding-IEA-  
GO:0051015actin filament binding-IDA16762926  
GO ID GO Term Qualifier Evidence PubMed
GO:0001568blood vessel development-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-IEA-  
GO:0022414reproductive process-IEA-  
GO:0031532actin cytoskeleton reorganization-IDA16762926  
GO:0034446substrate adhesion-dependent cell spreading-IDA16762926  
GO:1901202negative regulation of extracellular matrix assembly-IEA-  
GO:1901998toxin transport-IBA21873635  
GO:1905050positive regulation of metallopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IDA21129411  
GO:0009986cell surface-HDA19581412  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA21129411  
GO:0010008endosome membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031258lamellipodium membrane-IDA16762926  
GO:0031527filopodium membrane-IDA16762926  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-5210891Uptake and function of anthrax toxinsTAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-5663205Infectious diseaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal