Gene: STX7

8417
-
syntaxin 7
protein-coding
6q23.2
Ensembl:ENSG00000079950 MIM:603217 Vega:OTTHUMG00000015577 UniprotKB:O15400
NG_050740.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.154e-1 (AD)  4.288e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2842891chr6:132496758 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RUFY30.95
CDC42SE20.946
APPL10.944
CEP1700.943
PJA20.942
CRBN0.942
BTF3L40.94
CCSER20.936
CSE1L0.936
CNOT70.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.611
OR4F29-0.59
CSAG1-0.336
MTRNR2L10-0.333
KCNK5-0.317
MTRNR2L6-0.309
MTRNR2L8-0.29
MTRNR2L9-0.289
AQP5-0.282
PLA2G5-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of STX7 mRNA"19167446
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of STX7 mRNA]12710931
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of STX7 mRNA"19417177|2040685
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of STX7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STX7 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of STX7 mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STX7 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STX7 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STX7 mRNA22300585
C006780bisphenol Abisphenol A results in increased expression of STX7 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of STX7 mRNA15336504
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of STX7 mRNA23650126
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of STX7 mRNA16197558
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of STX7 mRNA"19167446
C000944dicrotophosdicrotophos results in decreased expression of STX7 mRNA28302478
D004237DiuronDiuron results in decreased expression of STX7 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STX7 mRNA22079256
D018120FinasterideFinasteride results in increased expression of STX7 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of STX7 mRNA24136188
D006220HaloperidolHaloperidol results in decreased expression of STX7 mRNA15860345
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of STX7 mRNA"18077114
C016517indole-3-carbinolindole-3-carbinol affects the expression of STX7 mRNA21396975
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of STX7 mRNA15182950
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of STX7 mRNA24297863
C410337K 7174K 7174 results in increased expression of STX7 mRNA24086573
C008261lead acetatelead acetate results in increased expression of STX7 mRNA21891863
C018091maduramicinmaduramicin results in decreased expression of STX7 mRNA29128925
D0156551-Methyl-4-phenylpyridinium2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of STX7 mRNA]12710931
C051752nefazodonenefazodone results in decreased expression of STX7 mRNA24136188
D009532NickelNickel results in decreased expression of STX7 mRNA23195993
C025589ochratoxin Aochratoxin A results in decreased expression of STX7 mRNA22124623
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of STX7 protein26879310
D010936Plant ExtractsPlant Extracts results in increased expression of STX7 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STX7 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of STX7 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of STX7 mRNA24780913
C017947sodium arsenitesodium arsenite results in decreased expression of STX7 mRNA28595984
D013467SulindacSulindac results in decreased expression of STX7 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STX7 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STX7 mRNA21570461
C012589trichostatin Atrichostatin A affects the expression of STX7 mRNA28542535
D014520UrethaneUrethane results in increased expression of STX7 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of STX7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of STX7 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of STX7 mRNA19101580|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of STX7 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0000149SNARE binding-IDA24550300  
GO:0005484SNAP receptor activity-IBA21873635  
GO:0005515protein binding-IPI11382755  21516116  25416956  
GO:0019869chloride channel inhibitor activity-IDA18570918  
GO:0019905syntaxin binding-IPI10564279  
GO ID GO Term Qualifier Evidence PubMed
GO:0001916positive regulation of T cell mediated cytotoxicity-IMP21438968  
GO:0006886intracellular protein transport-IBA21873635  
GO:0006906vesicle fusion-IBA21873635  
GO:0048278vesicle docking-IBA21873635  
GO:0051640organelle localization-IDA21438968  
GO:0070925organelle assembly-IDA21438968  
GO:1902685positive regulation of receptor localization to synapse-IMP21438968  
GO:1903076regulation of protein localization to plasma membrane-IDA18570918  
GO ID GO Term Qualifier Evidence PubMed
GO:0001772immunological synapse-IDA21438968  
GO:0005764lysosome-IDA18980942  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005768endosome-IDA10564279  
GO:0005769early endosome-IDA10564279  18980942  
GO:0005770late endosome-IDA18980942  21438968  
GO:0005886plasma membrane-IDA18980942  20170677  
GO:0008021synaptic vesicle-IBA21873635  
GO:0012505endomembrane system-IBA21873635  
GO:0016021integral component of membrane-IBA21873635  
GO:0030139endocytic vesicle-IDA10564279  
GO:0031201SNARE complex-IBA21873635  
GO:0031901early endosome membrane-IEA-  
GO:0031982vesicle-IDA18570918  20170677  
GO:0042582azurophil granule-IDA20170677  
GO:0048471perinuclear region of cytoplasm-IDA18570918  
GO:0055037recycling endosome-IDA18570918  
GO:0070062extracellular exosome-HDA20458337  
GO:0070820tertiary granule-IDA20170677  
KEGG ID KEGG Term
hsa04130SNARE interactions in vesicular transport
hsa04145Phagosome
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal