Gene: TXNDC2

84203
SPTRX|SPTRX1
thioredoxin domain containing 2
protein-coding
18p11.22
Ensembl:ENSG00000168454 MIM:617790 Vega:OTTHUMG00000131602 UniprotKB:Q86VQ3
NC_000018.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.274e-1 (AD)  6.466e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11664080chr18:9888030 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEFB1120.569
USP17L100.538
TCP11X20.43
LOXL40.387
TP53TG30.376
ZIC10.363
IFNA170.345
CSH20.337
OR2M70.334
CXCL100.331

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPH3AL-0.195
CLEC3B-0.188
SLC6A13-0.184
C19orf73-0.183
DHRS7C-0.181
BHLHA9-0.178
LIMS2-0.175
MUSTN1-0.172
TYW1B-0.171
BTNL9-0.171

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TXNDC2 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TXNDC2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TXNDC2 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of TXNDC2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TXNDC2 gene28505145
D002104CadmiumCadmium results in decreased expression of TXNDC2 mRNA24376830
D016572CyclosporineCyclosporine results in increased methylation of TXNDC2 promoter27989131
D004041Dietary FatsDietary Fats results in decreased expression of TXNDC2 mRNA25016146
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of TXNDC2 mRNA22401849
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of TXNDC2 mRNA27206323
D014635Valproic AcidValproic Acid affects the expression of TXNDC2 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TXNDC2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004791thioredoxin-disulfide reductase activity-IDA11399755  
GO:0004791thioredoxin-disulfide reductase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006662glycerol ether metabolic process-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-NAS11399755  
GO:0030154cell differentiation-IEA-  
GO:0045454cell redox homeostasis-NAS11399755  
GO:0055114oxidation-reduction process-IEA-  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA11399755  
GO:0005737cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal