Gene: LRRC8C

84230
AD158|FAD158
leucine rich repeat containing 8 VRAC subunit C
protein-coding
1p22.2
Ensembl:ENSG00000171488 MIM:612889 Vega:OTTHUMG00000010305 UniprotKB:Q8TDW0
NC_000001.11
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.466e-1 (AD)  4.649e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2390794chr1:89660007 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs6428561chr1:89637060 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CREB10.753
RPS6KA30.751
NR3C10.75
NAB10.749
ITSN20.744
DYRK20.72
RASSF30.713
TBC1D40.712
ZBTB380.709
NCOA30.709

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.421
OR4F29-0.418
TLCD1-0.347
S100A1-0.345
ABHD1-0.328
HOGA1-0.324
PLIN5-0.323
NPFFR1-0.314
ACOT6-0.313
NTSR2-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LRRC8C mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC8C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC8C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC8C mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of LRRC8C mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC8C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC8C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC8C mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LRRC8C gene27153756
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of LRRC8C mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRRC8C mRNA21569818
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of LRRC8C mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of LRRC8C mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of LRRC8C mRNA29275510
D002104CadmiumCadmium results in increased expression of LRRC8C mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of LRRC8C promoter22457795
D002737ChloropreneChloroprene results in decreased expression of LRRC8C mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of LRRC8C mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of LRRC8C mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LRRC8C mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LRRC8C mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LRRC8C mRNA27392435
D002945CisplatinCisplatin results in increased expression of LRRC8C mRNA27594783
C118739entinostatentinostat results in decreased expression of LRRC8C mRNA26272509
C118739entinostatentinostat results in increased expression of LRRC8C mRNA27188386
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC8C mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LRRC8C mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LRRC8C mRNA28329830
D005557FormaldehydeFormaldehyde results in decreased expression of LRRC8C mRNA23649840
D017313FenretinideFenretinide results in increased expression of LRRC8C mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of LRRC8C mRNA26191083
D007545IsoproterenolIsoproterenol results in increased expression of LRRC8C mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LRRC8C mRNA27392435
C544151jinfukangjinfukang results in decreased expression of LRRC8C mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LRRC8C mRNA21641980
D008694MethamphetamineMethamphetamine results in increased expression of LRRC8C mRNA19564919
D008731MethoxychlorMethoxychlor results in increased methylation of LRRC8C gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LRRC8C mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LRRC8C mRNA23649840
D009151Mustard GasMustard Gas results in increased phosphorylation of LRRC8C protein19845377
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LRRC8C mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LRRC8C mRNA"25554681
D009532NickelNickel results in increased expression of LRRC8C mRNA24768652|2558310
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of LRRC8C mRNA18593933
D010634PhenobarbitalPhenobarbital results in increased expression of LRRC8C mRNA19084549
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC8C mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LRRC8C mRNA26272509
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of LRRC8C mRNA20660070
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LRRC8C mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRRC8C mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LRRC8C promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRRC8C mRNA21889950|2597527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRRC8C mRNA22298810
D019284ThapsigarginThapsigargin results in decreased expression of LRRC8C mRNA22378314
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC8C mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of LRRC8C mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of LRRC8C mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of LRRC8C mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of LRRC8C mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of LRRC8C mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of LRRC8C gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LRRC8C mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LRRC8C gene25560391
D014750VincristineVincristine results in decreased expression of LRRC8C mRNA23649840
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of LRRC8C mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005225volume-sensitive anion channel activity-IBA21873635  
GO:0005225volume-sensitive anion channel activity-IMP26824658  
GO:0005225volume-sensitive anion channel activity-TAS-  
GO:0005515protein binding-IPI24790029  
GO ID GO Term Qualifier Evidence PubMed
GO:0006884cell volume homeostasis-IEA-  
GO:0015698inorganic anion transport-IEA-  
GO:0045444fat cell differentiation-IEA-  
GO:0055085transmembrane transport-TAS-  
GO:0098656anion transmembrane transport-IBA21873635  
GO:0098656anion transmembrane transport-IMP24790029  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA24790029  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-IDA24790029  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IMP26824658  
GO:0016020membrane-HDA19946888  
GO:0034702ion channel complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-5223345Miscellaneous transport and binding eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal