Gene: LTBP4

8425
ARCL1C|LTBP-4|LTBP4L|LTBP4S
latent transforming growth factor beta binding protein 4
protein-coding
19q13.2
Ensembl:ENSG00000090006 MIM:604710 Vega:OTTHUMG00000182635 UniprotKB:Q8N2S1
NG_021201.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.690e-1 (AD)  6.840e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITGA30.818
JAG20.813
ZNF3350.777
PCNT0.772
SYT70.77
VIPR10.769
RPS6KA40.767
CACNA1H0.767
RAP1GAP0.764
CELF30.764

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.482
OR4F29-0.448
LRAT-0.354
EVC2-0.34
WDR38-0.333
NXT2-0.332
HORMAD2-0.323
PHEX-0.303
SH2D4A-0.294
ACOT6-0.291

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LTBP4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LTBP4 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LTBP4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LTBP4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of LTBP4 mRNA17562736
D020106AcrylamideAcrylamide affects the expression of LTBP4 mRNA28959563
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of LTBP4 mRNA28522335
C547126AZM551248AZM551248 results in decreased expression of LTBP4 mRNA22323515
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA]15477007
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LTBP4 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of LTBP4 mRNA15289156
C006780bisphenol Abisphenol A results in decreased expression of LTBP4 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LTBP4 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LTBP4 gene20938992
C014347decitabinedecitabine affects the expression of LTBP4 mRNA23300844
C014347decitabinedecitabine results in increased expression of LTBP4 mRNA27915011
D003907DexamethasoneDexamethasone results in increased expression of LTBP4 mRNA22733784
D002945CisplatinCisplatin affects the expression of LTBP4 mRNA23300844
D004041Dietary FatsDietary Fats results in increased expression of LTBP4 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LTBP4 mRNA17854601
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of LTBP4 gene23968726
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of LTBP4 mRNA]17854601
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of LTBP4 mRNA15289156
D004237DiuronDiuron results in decreased expression of LTBP4 mRNA25152437
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LTBP4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LTBP4 mRNA17557909
C024565ethylene dichlorideethylene dichloride results in decreased expression of LTBP4 mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LTBP4 gene20938992
D019833GenisteinGenistein results in decreased expression of LTBP4 mRNA15289156
D017313FenretinideFenretinide results in decreased expression of LTBP4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LTBP4 mRNA20044591
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA]15477007
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA15477007
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LTBP4 mRNA"24972896
D008694MethamphetamineMethamphetamine results in increased expression of LTBP4 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LTBP4 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LTBP4 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LTBP4 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LTBP4 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LTBP4 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of LTBP4 mRNA24768652|2558310
D009532NickelNickel results in decreased expression of LTBP4 mRNA12540486
D000073878Palm OilPalm Oil results in increased expression of LTBP4 mRNA18042831
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of LTBP4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of LTBP4 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LTBP4 mRNA"27188386
D010672PhenytoinPhenytoin results in increased expression of LTBP4 mRNA20345932
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of LTBP4 gene23968726
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LTBP4 mRNA19710929
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA]15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA]15477007
D012643SeleniumSelenium results in increased expression of LTBP4 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LTBP4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LTBP4 mRNA17942748
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of LTBP4 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LTBP4 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LTBP4 mRNA21215274
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA]15477007
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA15477007
C009495titanium dioxidetitanium dioxide results in decreased expression of LTBP4 mRNA23557971
D014050TolueneToluene results in decreased expression of LTBP4 mRNA28245982
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of LTBP4 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of LTBP4 mRNA19140230
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LTBP4 gene25560391
C025643vinclozolinvinclozolin affects the expression of LTBP4 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of LTBP4 mRNA23034163
D014800VitalliumVitallium analog results in increased expression of LTBP4 mRNA23825117
D014810Vitamin EVitamin E results in increased expression of LTBP4 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005024transforming growth factor beta-activated receptor activity-NAS9660815  
GO:0005178integrin binding-NAS9660815  
GO:0005509calcium ion binding-NAS9660815  
GO:0005515protein binding-IPI12429738  21078624  
GO:0005539glycosaminoglycan binding-NAS9660815  
GO:0050431transforming growth factor beta binding-IDA9660815  
GO:0050431transforming growth factor beta binding-IPI10930463  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-TAS9660815  
GO:0006457protein folding-TAS9660815  
GO:0007179transforming growth factor beta receptor signaling pathway-IEA-  
GO:0007275multicellular organism development-TAS9660815  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-TAS9660815  
GO:0030162regulation of proteolysis-IDA9660815  
GO:0030252growth hormone secretion-TAS9660815  
GO:0045595regulation of cell differentiation-TAS9660815  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA20551380  
GO:0031012extracellular matrix-IDA9660815  16157329  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1566948Elastic fibre formationTAS
R-HSA-2129379Molecules associated with elastic fibresTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20106877Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD. (2010 Mar-Apr)Wempe FDis Model Mech
24498427Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2. (2014)Ryan DMPLoS One