Gene: SGIP1

84251
-
SH3 domain GRB2 like endophilin interacting protein 1
protein-coding
1p31.3
Ensembl:ENSG00000118473 MIM:611540 Vega:OTTHUMG00000009161 UniprotKB:Q9BQI5
NC_000001.11
PubMed
0   ANCO-SNPs
AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.933e-1 (AD)  8.776e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19406367chr1:66999929SGIP17.000e-44Smoking27651444
cg02994349chr1:66999753SGIP12.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITFG10.95
DMXL20.95
KLHL420.95
BRWD10.949
OPA10.946
CHM0.945
OXCT10.945
MTMR90.944
SLC25A460.944
UBE3A0.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.502
CSAG1-0.5
OR4F29-0.449
RAB13-0.422
ROM1-0.419
HEY2-0.408
CDA-0.407
COPZ2-0.402
RNF135-0.398
MYL3-0.394

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of SGIP1 mRNA29067470
C015001arsenitearsenite results in increased methylation of SGIP1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of SGIP1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of SGIP1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SGIP1 promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SGIP1 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SGIP1 mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of SGIP1 mRNA29097150
C013418bromfenacoumbromfenacoum results in decreased expression of SGIP1 protein28903499
D003300CopperCopper results in decreased expression of SGIP1 mRNA24403277
D003471CuprizoneCuprizone results in decreased expression of SGIP1 mRNA26577399
D003561CytarabineCytarabine results in increased expression of SGIP1 mRNA21198554
C118739entinostatentinostat results in decreased expression of SGIP1 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SGIP1 mRNA29097150
D017313FenretinideFenretinide results in increased expression of SGIP1 mRNA28973697
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SGIP1 mRNA"24972896
D015735MifepristoneMifepristone results in increased expression of SGIP1 mRNA17584828
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SGIP1 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of SGIP1 mRNA26516004
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SGIP1 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SGIP1 mRNA20660070
D053260SootSoot results in decreased expression of SGIP1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SGIP1 mRNA22298810
D014212TretinoinTretinoin results in increased expression of SGIP1 mRNA23724009
D014635Valproic AcidValproic Acid results in increased expression of SGIP1 mRNA24383497|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SGIP1 gene25560391
C025643vinclozolinvinclozolin affects the expression of SGIP1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15919751  26822536  
GO:0005543phospholipid binding-IBA21873635  
GO:0005543phospholipid binding-ISS-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-ISS-  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0015631tubulin binding-IBA21873635  
GO:0017124SH3 domain binding-IPI20946875  
GO ID GO Term Qualifier Evidence PubMed
GO:0002021response to dietary excess-ISS-  
GO:0048260positive regulation of receptor-mediated endocytosis-ISS-  
GO:0048268clathrin coat assembly-IBA21873635  
GO:0061024membrane organization-TAS-  
GO:0072583clathrin-dependent endocytosis-IBA21873635  
GO:0072583clathrin-dependent endocytosis-IEA-  
GO:0097009energy homeostasis-ISS-  
GO:0097320plasma membrane tubulation-IBA21873635  
GO:0097320plasma membrane tubulation-IEA-  
GO:2000253positive regulation of feeding behavior-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA20946875  
GO:0005905clathrin-coated pit-IBA21873635  
GO:0005905clathrin-coated pit-IDA20946875  
GO:0030122AP-2 adaptor complex-IBA21873635  
GO:0030122AP-2 adaptor complex-ISS-  
GO:0030136clathrin-coated vesicle-IBA21873635  
GO:0030136clathrin-coated vesicle-ISS-  
GO:0030139endocytic vesicle-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20421487Genome-wide association identifies candidate genes that influence the human electroencephalogram. (2010 May 11)Hodgkinson CAProc Natl Acad Sci U S A
21317682Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power. (2011 Oct)Derringer JPsychiatr Genet
28030933Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage. (2016 Dec 23)Chwedorowicz RAnn Agric Environ Med