Gene: CAMKK1

84254
CAMKKA
calcium/calmodulin dependent protein kinase kinase 1
protein-coding
17p13.2
Ensembl:ENSG00000004660 MIM:611411 Vega:OTTHUMG00000090725 UniprotKB:Q8N5S9
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.675e-1 (AD)  3.645e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20871826chr17:3790402CAMKK15.000e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NGEF0.966
PHYHIP0.962
KIAA1211L0.958
ACTL6B0.956
SLC12A50.956
DNM10.955
ABLIM20.954
ENC10.954
KIAA05130.954
SYT70.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.533
HEY2-0.519
REST-0.517
CNN2-0.516
TFPI2-0.51
YES1-0.509
MYL3-0.507
WWTR1-0.503
MBNL3-0.493
FZD10-0.484

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of CAMKK1 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CAMKK1 mRNA24449571
C006780bisphenol Abisphenol A results in increased expression of CAMKK1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of CAMKK1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of CAMKK1 mRNA12075121
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of CAMKK120938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CAMKK1 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CAMKK1 mRNA20938992
D003024ClozapineClozapine results in decreased expression of CAMKK1 protein19289156
D003471CuprizoneCuprizone results in decreased expression of CAMKK1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased methylation of CAMKK1 promoter27989131
D003891DesipramineDesipramine results in decreased expression of CAMKK1 mRNA15555640
D002945CisplatinCisplatin results in decreased expression of CAMKK1 mRNA27392435
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of CAMKK120938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CAMKK1 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CAMKK1 mRNA20938992
D006220HaloperidolHaloperidol results in decreased expression of CAMKK1 protein19289156
C544151jinfukangjinfukang results in increased expression of CAMKK1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of CAMKK1 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CAMKK1 mRNA24796395
D007649KetamineKetamine results in increased expression of CAMKK1 mRNA20080153
D007657Ketone BodiesKetone Bodies results in increased expression of CAMKK1 mRNA16807920
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of CAMKK120938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CAMKK1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CAMKK1 mRNA20938992
C013598methoxyacetic acidmethoxyacetic acid affects the expression of CAMKK1 mRNA20864626
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CAMKK1 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CAMKK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CAMKK1 mRNA"25554681
D009281NaphthalenesNaphthalenes results in decreased expression of CAMKK1 protein17337753
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CAMKK1 mRNA23146750
C010313pseudocumenepseudocumene results in decreased expression of CAMKK1 protein17337753
D020891RacloprideRaclopride results in decreased expression of CAMKK1 protein19289156
D018967RisperidoneRisperidone results in decreased expression of CAMKK1 protein19289156
D012402RotenoneRotenone results in decreased expression of CAMKK1 mRNA23186747
D012969Sodium FluorideSodium Fluoride results in decreased expression of CAMKK1 mRNA21340527
D012999SomanSoman results in decreased expression of CAMKK1 mRNA19281266
D053260SootSoot results in decreased expression of CAMKK1 mRNA26551751
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CAMKK1 mRNA25172293
C022884undecaneundecane results in decreased expression of CAMKK1 protein17337753
D014635Valproic AcidValproic Acid results in increased methylation of CAMKK1 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of CAMKK1 mRNA23034163
D014750VincristineCAMKK1 gene SNP results in increased susceptibility to Vincristine21245421

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004683calmodulin-dependent protein kinase activity-IBA21873635  
GO:0004683calmodulin-dependent protein kinase activity-TAS-  
GO:0005515protein binding-IPI18242179  
GO:0005516calmodulin binding-IBA21873635  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0035556intracellular signal transduction-IBA21873635  
GO:0045860positive regulation of protein kinase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-442717CREB phosphorylation through the activation of CaMKKTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23737288Polymorphism rs7214723 in CAMKK1 and lung cancer risk in Chinese population. (2013 Oct)Zhang YHTumour Biol
20106900International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. (2010 Apr)Truong TCarcinogenesis