Gene: TCHP

84260
TpMs
trichoplein keratin filament binding
protein-coding
12q24.11
Ensembl:ENSG00000139437 MIM:612654 Vega:OTTHUMG00000169281 UniprotKB:Q9BT92
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.300e-1 (AD)  8.566e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs74416240chr12:109904793 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EZH10.898
MAU20.893
POGZ0.893
RBM190.887
RBM50.887
ARGLU10.881
STX160.88
ELMOD30.877
METTL30.875
VPS520.874

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.603
OR4F29-0.578
SDR42E1-0.335
AGTR1-0.333
C9orf135-0.326
GSC-0.318
SIM1-0.312
IL22-0.31
IRX3-0.309
LHX5-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TCHP mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TCHP mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TCHP mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TCHP mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TCHP mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TCHP mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TCHP mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TCHP mRNA19770486
D001280AtrazineAtrazine results in decreased expression of TCHP mRNA22378314
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TCHP mRNA]22228805
C006780bisphenol Abisphenol A affects the expression of TCHP mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TCHP mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of TCHP mRNA19549813
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TCHP mRNA29097150
D005485FlutamideFlutamide results in decreased expression of TCHP mRNA21126777
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TCHP mRNA26846883
D007213IndomethacinIndomethacin results in decreased expression of TCHP mRNA28201806
C544151jinfukangjinfukang results in increased expression of TCHP mRNA27392435
C045463leflunomideleflunomide results in decreased expression of TCHP mRNA28988120
D008727MethotrexateMethotrexate results in decreased expression of TCHP mRNA24449571
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TCHP mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TCHP mRNA19710929
C045362prochlorazprochloraz results in increased expression of TCHP mRNA21470553
C009495titanium dioxidetitanium dioxide results in increased expression of TCHP mRNA23131501
D014635Valproic AcidValproic Acid affects the expression of TCHP mRNA25979313
C029297vinylidene chloridevinylidene chloride results in increased expression of TCHP mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15731013  16189514  25270598  25416956  26638075  27173435  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IDA18931701  
GO:0030030cell projection organization-IEA-  
GO:0030308negative regulation of cell growth-IDA18931701  
GO:1902018negative regulation of cilium assembly-IMP25270598  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA18931701  
GO:0005739mitochondrion-IDA18931701  
GO:0005813centrosome-IDA21399614  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA18931701  
GO:0030057desmosome-IEA-  
GO:0045095keratin filament-IDA15731013  
GO:0045179apical cortex-IDA15731013  
GO:0097539ciliary transition fiber-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal