Gene: POLDIP3

84271
PDIP3|PDIP46|SKAR
DNA polymerase delta interacting protein 3
protein-coding
22q13.2
Ensembl:ENSG00000100227 MIM:611520 Vega:OTTHUMG00000150887 UniprotKB:Q9BY77
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.638e-1 (AD)  7.817e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DPF20.927
RAF10.915
CALR0.915
P4HB0.905
USP390.903
SURF40.898
CCNK0.897
ADIPOR10.897
AAR20.893
TM9SF10.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.763
OR4F29-0.727
OR6C74-0.206
HMHB1-0.196
CETP-0.192
SPRR2B-0.182
TMEM89-0.168
MYLK2-0.163
KLRB1-0.162
FMO1-0.154

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of POLDIP3 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of POLDIP3 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of POLDIP3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of POLDIP3 gene27153756
D001280AtrazineAtrazine results in increased expression of POLDIP3 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of POLDIP3 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of POLDIP3 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of POLDIP3 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of POLDIP3 protein28903499
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of POLDIP3 protein24527689
C031180chrysenechrysene results in increased expression of POLDIP3 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of POLDIP3 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of POLDIP3 mRNA19549813
D003907DexamethasonePOLDIP3 gene polymorphism results in increased susceptibility to Dexamethasone20400291
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of POLDIP3 mRNA21266533
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of POLDIP3 mRNA"27840820
D007854LeadLead affects the splicing of POLDIP3 mRNA28903495
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of POLDIP3 gene21212295
D008727MethotrexateMethotrexate results in increased expression of POLDIP3 mRNA24449571
D010936Plant ExtractsPlant Extracts results in decreased expression of POLDIP3 mRNA24677778
D010936Plant ExtractsPlant Extracts results in increased expression of POLDIP3 mRNA23557933
C059514resveratrolresveratrol results in decreased expression of POLDIP3 protein25505154
D012643SeleniumSelenium results in increased expression of POLDIP3 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POLDIP3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of POLDIP3 gene21212295
C012589trichostatin Atrichostatin A affects the expression of POLDIP3 mRNA28542535
D014635Valproic AcidValproic Acid affects the expression of POLDIP3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of POLDIP3 mRNA22083351|2317975
D014635Valproic AcidValproic Acid affects the expression of POLDIP3 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI18423201  22928037  
GO ID GO Term Qualifier Evidence PubMed
GO:0006405RNA export from nucleus-TAS-  
GO:0006406mRNA export from nucleus-TAS-  
GO:0016973poly(A)+ mRNA export from nucleus-IDA22928037  
GO:0031124mRNA 3'-end processing-TAS-  
GO:0045727positive regulation of translation-IMP18423201  
GO ID GO Term Qualifier Evidence PubMed
GO:0000346transcription export complexcolocalizes_withIDA20844015  22928037  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-TAS18423201  
GO:0005829cytosol-TAS-  
GO:0016607nuclear speck-IDA18423201  
GO:0035145exon-exon junction complexcolocalizes_withIDA18423201  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109688Cleavage of Growing Transcript in the Termination Region TAS
R-HSA-159236Transport of Mature mRNA derived from an Intron-Containing TranscriptTAS
R-HSA-72187mRNA 3'-end processingTAS
R-HSA-72202Transport of Mature Transcript to CytoplasmTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73856RNA Polymerase II Transcription TerminationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28149327In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. (2017)Chatterton ZEpigenetics Chromatin