Gene: NTPCR

84284
C1orf57|HCR-NTPase
nucleoside-triphosphatase, cancer-related
protein-coding
1q42.2
Ensembl:ENSG00000135778 Vega:OTTHUMG00000037822 UniprotKB:Q9BSD7
NC_000001.11
SNP Mapped
2   ANCO-SNPs
AD
0   
2.423e-1 (AD)  4.709e-1 (ND)   (Frontal_Cortex)
2.651e-1 (AD)  1.953e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7523847chr1:232964658 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4141442chr1:232963129 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRPS10.875
RTN40.871
PHAX0.865
ATP6V1D0.863
ASH2L0.863
SLC25A40.863
PAIP20.863
MAGEH10.863
PLEKHB20.862
GRSF10.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.573
OR4F29-0.564
MTRNR2L6-0.429
MTRNR2L10-0.403
CSAG1-0.393
MTRNR2L2-0.379
KCNJ15-0.371
MTRNR2L9-0.368
MTRNR2L8-0.367
C8orf74-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of NTPCR mRNA21420995|2906747
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of NTPCR mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NTPCR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NTPCR gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NTPCR mRNA21632981|2715375
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NTPCR mRNA24449571
D001280AtrazineAtrazine results in increased expression of NTPCR mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NTPCR mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NTPCR mRNA20106945|2163298
D004958EstradiolEstradiol promotes the reaction [NTPCR protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A results in increased expression of NTPCR mRNA25181051
D002065BuspironeBuspirone results in increased expression of NTPCR mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NTPCR mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NTPCR protein24527689
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of NTPCR mRNA25596134
C059262cidofovircidofovir results in increased expression of NTPCR mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of NTPCR mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of NTPCR mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of NTPCR mRNA19549813
D016572CyclosporineCyclosporine affects the expression of NTPCR mRNA25596134
D016572CyclosporineCyclosporine results in decreased expression of NTPCR mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of NTPCR mRNA25596134
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NTPCR mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NTPCR mRNA27392435
D002945CisplatinCisplatin results in increased expression of NTPCR mRNA25596134|2739243
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NTPCR protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NTPCR mRNA23649840
D011345FenofibrateFenofibrate affects the expression of NTPCR mRNA25596134
D005485FlutamideFlutamide results in decreased expression of NTPCR mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of NTPCR mRNA23649840
D007069IfosfamideIfosfamide results in increased expression of NTPCR mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NTPCR mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NTPCR mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NTPCR mRNA23086925
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NTPCR mRNA"24972896
D008687MetforminMetformin results in decreased expression of NTPCR mRNA25596134
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NTPCR mRNA23649840
C025256nonylphenolnonylphenol results in decreased expression of NTPCR mRNA22982499
D010100OxygenOxygen deficiency results in increased expression of NTPCR mRNA25596134
C059514resveratrolresveratrol results in increased expression of NTPCR protein25505154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NTPCR mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NTPCR mRNA25613284
D014520UrethaneUrethane results in decreased expression of NTPCR mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of NTPCR mRNA23179753|2915479
C088658zoledronic acidzoledronic acid results in increased expression of NTPCR mRNA25596134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0005524ATP binding-IEA-  
GO:0017111nucleoside-triphosphatase activity-IEA-  
GO:0098519nucleotide phosphatase activity, acting on free nucleotides-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016311dephosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00730Thiamine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal