Gene: UTP23

84294
C8orf53
UTP23, small subunit processome component
protein-coding
8q24.11
Ensembl:ENSG00000147679 Vega:OTTHUMG00000164958 UniprotKB:Q9BRU9
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.310e-1 (AD)  1.151e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS4B0.867
SEC23IP0.853
LYRM20.848
WDR440.842
DHX360.841
GTF2H30.836
NSUN30.836
KIAA15860.835
LTN10.835
VEZT0.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.477
OR4F29-0.426
MMP23B-0.324
CELSR1-0.312
C7orf61-0.306
MTRNR2L6-0.296
CLDN9-0.29
RAX2-0.288
SERPINH1-0.285
HSPA1A-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in increased expression of UTP23 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UTP23 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UTP23 mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of UTP23 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of UTP23 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of UTP23 mRNA19549813
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of UTP23 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of UTP23 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of UTP23 mRNA28302478
D005485FlutamideFlutamide results in increased expression of UTP23 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of UTP23 mRNA20655997
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UTP23 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of UTP23 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of UTP23 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of UTP23 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of UTP23 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UTP23 mRNA"25554681
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of UTP23 mRNA19095052
D011374ProgesteroneProgesterone results in increased expression of UTP23 mRNA23012394
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of UTP23 mRNA21427059
D012969Sodium FluorideSodium Fluoride results in decreased expression of UTP23 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UTP23 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UTP23 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of UTP23 protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of UTP23 mRNA28065790
D014635Valproic AcidValproic Acid results in decreased expression of UTP23 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of UTP23 gene25560391
C025643vinclozolinvinclozolin results in increased expression of UTP23 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003730mRNA 3'-UTR binding-IDA16213212  
GO:0005515protein binding-IPI25416956  
GO:0048027mRNA 5'-UTR binding-IDA16213212  
GO:0070181small ribosomal subunit rRNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000480endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IBA21873635  
GO:0032040small-subunit processome-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22367214Characterization of gene-environment interactions for colorectal cancer susceptibility loci. (2012 Apr 15)Hutter CMCancer Res