Gene: GINS4

84296
SLD5
GINS complex subunit 4
protein-coding
8p11.21
Ensembl:ENSG00000147536 MIM:610611 Vega:OTTHUMG00000164079 UniprotKB:Q9BRT9
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.071e-1 (AD)  7.490e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7819949chr8:41530402 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CECR20.744
PHLDB10.698
TMTC20.685
GANC0.681
C22orf230.681
ZBED30.68
TESK20.679
SEMA6A0.678
COL4A50.674
RFFL0.674

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCERG1L-0.323
PRTN3-0.306
CHRNA2-0.292
KCNG1-0.291
KLK5-0.289
PNOC-0.287
NANOS3-0.286
HCN4-0.286
NPAS1-0.285
KCNK3-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GINS4 mRNA"19167446
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of GINS4 mRNA"20713471
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GINS4 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GINS4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GINS4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GINS4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GINS4 mRNA21632981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GINS4 mRNA23630614
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GINS4 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GINS4 mRNA21632981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GINS4 mRNA"20018196|2623829
C006780bisphenol Abisphenol A results in decreased expression of GINS4 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of GINS4 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GINS4 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GINS4 promoter22457795
D002509CephaloridineCephaloridine results in increased expression of GINS4 mRNA18500788
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GINS4 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of GINS4 mRNA26272509
D019327Copper SulfateCopper Sulfate results in decreased expression of GINS4 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GINS4 mRNA"19167446
D016572CyclosporineCyclosporine results in decreased expression of GINS4 mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of GINS4 mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GINS4 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GINS4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of GINS4 mRNA27392435|2759478
C024565ethylene dichlorideethylene dichloride results in decreased expression of GINS4 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GINS4 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of GINS4 mRNA23649840
C039281furanfuran results in increased expression of GINS4 mRNA25539665
C016517indole-3-carbinolindole-3-carbinol affects the expression of GINS4 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GINS4 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GINS4 mRNA27392435
C544151jinfukangjinfukang results in increased expression of GINS4 mRNA27392435
C410337K 7174K 7174 results in decreased expression of GINS4 mRNA24086573
D008748MethylcholanthreneMethylcholanthrene results in increased expression of GINS4 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GINS4 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GINS4 mRNA23649840
D010100OxygenOxygen deficiency results in decreased expression of GINS4 mRNA26516004
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of GINS4 mRNA]19555225
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of GINS4 mRNA22484513
C006253pirinixic acidpirinixic acid results in increased expression of GINS4 mRNA20813756|2381119
D011794QuercetinQuercetin results in increased expression of GINS4 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of GINS4 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GINS4 mRNA21570461|2468072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GINS4 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of GINS4 mRNA23411599
D014520UrethaneUrethane results in decreased expression of GINS4 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  22540012  24299456  25416956  
GO:00431383'-5' DNA helicase activityCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000727double-strand break repair via break-induced replication-IBA21873635  
GO:0001833inner cell mass cell proliferation-IEA-  
GO:0006271DNA strand elongation involved in DNA replication-TAS-  
GO:0032508DNA duplex unwinding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000811GINS complex-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0031298replication fork protection complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-176974Unwinding of DNATAS
R-HSA-176974Unwinding of DNAIEA
R-HSA-69190DNA strand elongationTAS
R-HSA-69190DNA strand elongationIEA
R-HSA-69239Synthesis of DNATAS
R-HSA-69239Synthesis of DNAIEA
R-HSA-69242S PhaseTAS
R-HSA-69242S PhaseIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69306DNA ReplicationTAS
R-HSA-69306DNA ReplicationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal