Gene: MIEN1

84299
C17orf37|C35|ORB3|RDX12|XTP4
migration and invasion enhancer 1
protein-coding
17q12
Ensembl:ENSG00000141741 MIM:611802 Vega:OTTHUMG00000133252 UniprotKB:Q9BRT3
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.767e-1 (AD)  7.284e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIGD2A0.937
WDR83OS0.932
HCFC1R10.926
BANF10.924
RABAC10.923
LAMTOR40.921
TMEM1470.92
CTDNEP10.92
AIP0.918
UBL50.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.829
OR4F29-0.813
PZP-0.272
FER1L6-0.26
GADL1-0.246
TBX4-0.243
HMCN1-0.236
KRT73-0.234
C2orf83-0.228
DNASE1L3-0.227

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in increased expression of MIEN1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MIEN1 mRNA27153756
D001280AtrazineAtrazine results in increased expression of MIEN1 mRNA22982499
C006780bisphenol Abisphenol A results in increased expression of MIEN1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MIEN1 mRNA28628672
D016572CyclosporineCyclosporine results in decreased expression of MIEN1 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MIEN1 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MIEN1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of MIEN1 mRNA27392435
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MIEN1 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MIEN1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MIEN1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MIEN1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of MIEN1 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MIEN1 mRNA23103053
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MIEN1 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MIEN1 mRNA"25620056
D012715Sesame OilSesame Oil results in increased expression of MIEN1 mRNA29191790
D014635Valproic AcidValproic Acid affects the expression of MIEN1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MIEN1 mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0010269response to selenium ion-IBA21873635  
GO:0030335positive regulation of cell migration-IDA21628459  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043066negative regulation of apoptotic process-IDA21068479  
GO:0051491positive regulation of filopodium assembly-IBA21873635  
GO:0051491positive regulation of filopodium assembly-IDA21628459  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA21628459  
GO:0031235intrinsic component of the cytoplasmic side of the plasma membrane-IDA21628459  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25996585MIEN1 promotes oral cancer progression and implicates poor overall survival. (2015)Rajendiran SCancer Biol Ther