Gene info: ID 8431

Gene: NR0B2

GENE ID: 8431

Synonyms: SHP|SHP1

Description: nuclear receptor subfamily 0 group B member 2

Gene type: protein-coding

Location: 1p36.11

dbXrefs: Ensembl:ENSG00000131910 MIM:604630 Vega:OTTHUMG00000004231 UniprotKB:Q15466

RefSeq: NG_012143.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.506e-1 (AD) 7.535e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CRYBA4	0.597
CALCA	0.522
TMPRSS9	0.518
TMEM95	0.517
LRRC15	0.511
FBXO47	0.481
MMP19	0.475
HSPA1L	0.469
SLC30A2	0.467
PLA2G4E	0.465

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FAAH2	-0.248
CC2D2B	-0.247
SLC22A9	-0.242
RGS18	-0.225
CPXM1	-0.215
MEI4	-0.208
KLRK1	-0.206
LACTBL1	-0.205
TLR10	-0.204
HOXC13	-0.203

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of NR0B2 mRNA"	19162173
C466800	1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane	"1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane results in decreased expression of NR0B2 mRNA"	15254889
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in decreased expression of NR0B2 mRNA"	24819614
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of NR0B2 mRNA"	25768209
C014211	2,3,7,8-tetrachlorodibenzofuran	"AHR protein promotes the reaction [2,3,7,8-tetrachlorodibenzofuran results in decreased expression of NR0B2 mRNA]"	25768209
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased activity of NR0B2 protein"	27589886
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of NR0B2 mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]	25712622
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of NR0B2 mRNA"	20816883
C556168	3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid	3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid binds to NR0B2 protein	21548569
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NR0B2 mRNA"	20959002
C000598200	4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid	"4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of NR0B2 mRNA"	22918042
C000598200	4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid	"NR1H4 gene mutant form inhibits the reaction [4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of NR0B2 mRNA]"	22918042
C000598200	4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid	"4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of NR0B2 mRNA"	22918042
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of NR0B2 mRNA"	18648102
C583074	4,4'-hexafluorisopropylidene diphenol	"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NR0B2 protein modified form]"	28751236
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of NR0B2 mRNA"	21346803
C488107	6-(3'-(1-adamantyl)-4'-hydroxyphenyl)-5-chloronaphthalenecarboxylic acid	6-(3'-(1-adamantyl)-4'-hydroxyphenyl)-5-chloronaphthalenecarboxylic acid binds to NR0B2 protein	22136251
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]"	19593819
C412852	7-hydroxytheonellasterol	7-hydroxytheonellasterol inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]	22291955
D000082	Acetaminophen	Acetaminophen affects the expression of NR0B2 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of NR0B2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of NR0B2 mRNA	21632981
C031143	AICA ribonucleotide	AICA ribonucleotide results in decreased expression of NR0B2 mRNA	24428821
C526957	alisol B 23-acetate	alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]	25655198
C526957	alisol B 23-acetate	"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]]"	25655198
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of NR0B2 mRNA	28522335
D000639	Amitriptyline	Amitriptyline results in increased expression of NR0B2 mRNA	15342952\|1717555
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NR0B2 mRNA	16483693
D000924	Anticholesteremic Agents	Anticholesteremic Agents results in decreased expression of NR0B2 mRNA	28275691
D000965	Antimony	Antimony results in decreased expression of NR0B2 mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of NR0B2 mRNA	17547211
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased expression of NR0B2 mRNA	25278499
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NR0B2 mRNA	21632981\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NR0B2 mRNA	20127859
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NR0B2 mRNA"	26238291
C095105	bexarotene	bexarotene results in increased expression of NR0B2 mRNA	17630414\|2329279
D001629	Bezafibrate	Bezafibrate results in increased expression of NR0B2 mRNA	19124612
D001629	Bezafibrate	PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR0B2 mRNA]	19124612
D001647	Bile Acids and Salts	Bile Acids and Salts analog results in increased expression of NR0B2 mRNA	15145977
D001647	Bile Acids and Salts	NR0B2 protein affects the abundance of Bile Acids and Salts	16213224
D001647	Bile Acids and Salts	Bile Acids and Salts results in increased activity of NR0B2 protein	20699090
D001647	Bile Acids and Salts	[[Bile Acids and Salts results in increased activity of NR0B2 protein] co-treated with [Bile Acids and Salts results in decreased activity of HNF4A protein]] results in decreased expression of CYP7A1 mRNA	20699090
C006780	bisphenol A	[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NR0B2 protein modified form]	28751236
C006780	bisphenol A	bisphenol A affects the methylation of NR0B2 promoter	27334623
C006780	bisphenol A	bisphenol A affects the expression of NR0B2 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of NR0B2 mRNA	17553608
C011686	boldine	boldine results in increased expression of NR0B2 mRNA	25771127
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of NR0B2 mRNA	23410634
C055494	caffeic acid phenethyl ester	[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of NR0B2 mRNA	28223344
C055494	caffeic acid phenethyl ester	GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of NR0B2 mRNA]	28223344
D002118	Calcium	Calcium affects the expression of NR0B2 mRNA	15913539
D000074262	Canola Oil	Canola Oil affects the expression of NR0B2 mRNA	16177195
D002220	Carbamazepine	Carbamazepine affects the expression of NR0B2 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of NR0B2 mRNA	27339419
C099555	CD 437	CD 437 analog binds to NR0B2 protein	22136251
C099555	CD 437	CD 437 binds to NR0B2 protein	22136251
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA	15629111
D002635	Chenodeoxycholic Acid	7-hydroxytheonellasterol inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]	22291955
D002635	Chenodeoxycholic Acid	[Chenodeoxycholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA	17963371
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA	16037943\|1626982
D002635	Chenodeoxycholic Acid	epigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]	22178739
D002635	Chenodeoxycholic Acid	NR1H4 affects the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]	19072826
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA	16946559\|2418913
D002635	Chenodeoxycholic Acid	NR1H4 protein promotes the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]	16946559
D002635	Chenodeoxycholic Acid	[Chenodeoxycholic Acid binds to NR1H4 protein] which results in increased expression of NR0B2 mRNA	19562681
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA	15980055\|1635730
C084597	chlorcyclizine	chlorcyclizine results in increased expression of NR0B2 mRNA	15342952
D002738	Chloroquine	Chloroquine results in decreased expression of NR0B2 mRNA	24189133
D002746	Chlorpromazine	Chlorpromazine results in increased expression of NR0B2 mRNA	17175557
D002777	Cholestanols	Cholestanols analog results in increased expression of NR0B2 mRNA	15145977
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of NR0B2 mRNA"	28549616
D002791	Cholesterol, Dietary	"[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of NR0B2 mRNA"	14684380
D019826	Cholic Acid	Cholic Acid results in increased expression of NR0B2 mRNA	25055961
D019826	Cholic Acid	[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA	22540009
D019826	Cholic Acid	Cholic Acid results in increased expression of NR0B2 mRNA	12072388\|1569493
D019826	Cholic Acid	IL1B protein inhibits the reaction [Cholic Acid results in increased expression of NR0B2 mRNA]	12072388
D019826	Cholic Acid	"[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of NR0B2 mRNA"	14684380
D019826	Cholic Acid	Cholic Acid results in increased expression of NR0B2 mRNA	14684380
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of NR0B2 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of NR0B2 mRNA	27344345
D002794	Choline	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]	25712622
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA	25712622
D002794	Choline	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]	25712622
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of NR0B2 mRNA	19593819
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA	25712622
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]]	19593819
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]]	19593819
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]]	19593819
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]	19593819
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]	19593819
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]]	19593819
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]]	19593819
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]]	19593819
D002794	Choline	NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of CYP4A14 mRNA]	19593819
D002794	Choline	NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with pirinixic acid] results in increased expression of CYP4A14 mRNA]	19593819
D002794	Choline	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]	25712622
D002857	Chromium	Chromium results in decreased expression of NR0B2 mRNA	17547211
D002939	Ciprofloxacin	Ciprofloxacin results in increased expression of NR0B2 mRNA	24657338
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of NR0B2 mRNA	28973556
D002994	Clofibrate	Clofibrate results in increased expression of NR0B2 mRNA	29175453
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA]	17585979
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NR0B2 mRNA	17602206
D002997	Clomipramine	Clomipramine results in increased expression of NR0B2 mRNA	17175557
D003024	Clozapine	Clozapine results in increased expression of NR0B2 mRNA	15342952\|1717555
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of NR0B2 mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of NR0B2 mRNA	19549813
C030123	coumarin	coumarin results in increased expression of NR0B2 mRNA	18480146
D003471	Cuprizone	Cuprizone affects the expression of NR0B2 mRNA	26577399
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of NR0B2 mRNA	27344345
D016572	Cyclosporine	Cyclosporine results in decreased expression of NR0B2 mRNA	20106945\|2556210
D017373	Cyproterone Acetate	[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B2 protein modified form]	28751236
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]	19593819
D003671	DEET	[fipronil co-treated with DEET] results in increased expression of NR0B2 mRNA	27091632
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of NR0B2 mRNA	22540009\|2505596
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of NR0B2 mRNA	25582706
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of NR0B2 mRNA	27743861
D003907	Dexamethasone	[Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 mRNA	29222744
D003907	Dexamethasone	[Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 protein	29222744
D003907	Dexamethasone	Dexamethasone results in decreased expression of NR0B2 mRNA	20832446\|2922274
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of NR0B2 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of NR0B2 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of NR0B2 mRNA	28962523
D004008	Diclofenac	Diclofenac affects the expression of NR0B2 mRNA	24752500
C000944	dicrotophos	dicrotophos results in increased expression of NR0B2 mRNA	28302478
D004041	Dietary Fats	[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of NR0B2 mRNA	28223344
D004041	Dietary Fats	Dietary Fats results in increased expression of NR0B2 mRNA	18457598\|2254000
D004041	Dietary Fats	GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of NR0B2 mRNA]	28223344
D004041	Dietary Fats	NR1H4 protein affects the reaction [Dietary Fats results in increased expression of NR0B2 mRNA]	22540009
D004041	Dietary Fats	Oligosaccharides inhibits the reaction [Dietary Fats results in increased expression of NR0B2 mRNA]	28549616
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of NR0B2 mRNA	25975992
C014476	diethyl maleate	diethyl maleate results in decreased expression of NR0B2 mRNA	21161181
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NR0B2 mRNA	17602206
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of NR0B2 mRNA	19638242
C118756	dihydroxy-vitamin D3	dihydroxy-vitamin D3 promotes the reaction [[VDR protein binds to RXRA protein] which binds to NR0B2 protein modified form]	20947021
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of NR0B2 mRNA	17072980
C019357	dioscin	dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]	27317372
C019357	dioscin	dioscin results in increased expression of NR0B2 mRNA	27317372
D004206	Disopyramide	Disopyramide results in decreased expression of NR0B2 mRNA	15342952
C547512	eldecalcitol	eldecalcitol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NR0B2 protein modified form]	20947021
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of NR0B2 mRNA	25187966
C062669	epicatechin gallate	epicatechin gallate results in increased expression of NR0B2 mRNA	22178739
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]	22178739
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]	22178739
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of NR0B2 mRNA	22178739
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of NR0B2 mRNA	22178739
C045651	epigallocatechin gallate	NR1H4 protein affects the reaction [epigallocatechin gallate results in increased expression of NR0B2 mRNA]	22178739
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of NR0B2 mRNA	23146761
D000431	Ethanol	Ethanol promotes the reaction [NR1H4 gene mutant form results in decreased expression of NR0B2 mRNA]	25460735
D004997	Ethinyl Estradiol	ESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of NR0B2 mRNA]	29112739
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of NR0B2 mRNA]	12072388
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of NR0B2 mRNA	29112739
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR0B2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of NR0B2 mRNA	23300682
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of NR0B2 mRNA	23146761
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of NR0B2 mRNA	16487557\|1710823
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of NR0B2 gene	16495775
D011345	Fenofibrate	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]"	19593819
D011345	Fenofibrate	Dactinomycin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]	19593819
D011345	Fenofibrate	Fenofibrate results in increased expression of NR0B2 mRNA	19593819
D011345	Fenofibrate	Fenofibrate results in increased expression of NR0B2 protein	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	pyrazolanthrone inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]	19593819
D011345	Fenofibrate	Fenofibrate results in increased expression of NR0B2 mRNA	19593819
D011345	Fenofibrate	[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of NR0B2 mRNA	19593819
D011345	Fenofibrate	NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of CYP4A14 mRNA]	19593819
D011345	Fenofibrate	Fenofibrate results in increased expression of NR0B2 mRNA	19593819
C082360	fipronil	[fipronil co-treated with DEET] results in increased expression of NR0B2 mRNA	27091632
D005395	Fish Oils	Fish Oils affects the reaction [NR1H4 protein affects the expression of NR0B2 mRNA]	29142166
D005411	Flame Retardants	ESR1 gene mutant form inhibits the reaction [Flame Retardants results in increased expression of NR0B2 mRNA]	29112739
D005411	Flame Retardants	Flame Retardants results in increased expression of NR0B2 mRNA	29112739
D005424	Flecainide	Flecainide results in increased expression of NR0B2 mRNA	17175557
D005473	Fluoxetine	Fluoxetine results in increased expression of NR0B2 mRNA	15342952\|1717555
D005485	Flutamide	Flutamide results in decreased expression of NR0B2 mRNA	24136188
D015378	Imipenem	[Vancomycin co-treated with Imipenem] results in increased expression of NR0B2 mRNA	24657338
C057580	gallocatechol	gallocatechol results in increased expression of NR0B2 mRNA	22178739
C049864	ginsenoside Re	ginsenoside Re results in increased expression of NR0B2 mRNA	21971952
C026474	ginsenoside Rg2	ginsenoside Rg2 results in increased activity of NR0B2 protein	22062806
C026474	ginsenoside Rg2	[ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein	22062806
C026474	ginsenoside Rg2	ginsenoside Rg2 results in increased expression of NR0B2 mRNA	22062806
C026474	ginsenoside Rg2	[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose	22062806
D005947	Glucose	[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose	22062806
D005978	Glutathione	Glutathione deficiency results in increased expression of NR0B2 mRNA	15345336
D006002	Glycodeoxycholic Acid	Glycodeoxycholic Acid affects the expression of NR0B2 mRNA	24994853
D019695	Glycyrrhizic Acid	Glycyrrhizic Acid results in increased expression of NR0B2 mRNA	22982774
C516216	GSK 8470	GSK 8470 promotes the reaction [NR5A2 protein results in increased expression of NR0B2 mRNA]	17154495
C516216	GSK 8470	GSK 8470 results in increased expression of NR0B2 mRNA	17154495
C018562	guggulu extract	guggulu extract results in increased expression of NR0B2 mRNA	12525500
C412815	GW 4064	epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]	22178739
C412815	GW 4064	[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA	22540009
C412815	GW 4064	GW 4064 results in increased expression of NR0B2 mRNA	16269825\|2217873
C412815	GW 4064	ATP7B protein affects the reaction [GW 4064 results in increased expression of NR0B2 mRNA]	26241054
C412815	GW 4064	[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA	21480330\|2254000
C412815	GW 4064	GW 4064 inhibits the reaction [ATP7B gene mutant form results in decreased expression of NR0B2 mRNA]	26241054
C412815	GW 4064	GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of NR0B2 mRNA]	28223344
C412815	GW 4064	GW 4064 promotes the reaction [NR1H4 protein binds to NR0B2 gene]	20091679
C412815	GW 4064	GW 4064 results in increased expression of NR0B2 mRNA	19072826\|2291804
C412815	GW 4064	NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]	22918042
C412815	GW 4064	NR1H4 mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]	19072826
C412815	GW 4064	GW 4064 results in increased expression of NR0B2 mRNA	19963001
C412815	GW 4064	GW 4064 results in increased expression of NR0B2 mRNA	14623915\|1564443
D006220	Haloperidol	Haloperidol results in increased expression of NR0B2 mRNA	17175557
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of NR0B2 mRNA	23410634
D007052	Ibuprofen	[Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 mRNA	29222744
D007052	Ibuprofen	[Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 protein	29222744
D000068877	Imatinib Mesylate	Imatinib Mesylate results in increased expression of NR0B2 mRNA	22414727
D000068877	Imatinib Mesylate	"pregna-4,17-diene-3,16-dione inhibits the reaction [Imatinib Mesylate results in increased expression of NR0B2 mRNA]"	22414727
D007099	Imipramine	Imipramine results in increased expression of NR0B2 mRNA	15342952
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of NR0B2 mRNA	26752646
C410337	K 7174	K 7174 results in increased expression of NR0B2 mRNA	24086573
D007654	Ketoconazole	Ketoconazole results in increased expression of NR0B2 mRNA	15342952\|1717555
C017461	lead nitrate	lead nitrate results in decreased expression of NR0B2 mRNA	16049268
C017461	lead nitrate	lead nitrate results in decreased expression of NR0B2 mRNA	15475176
D001556	Lindane	Lindane results in increased expression of NR0B2 mRNA	17785943
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of NR0B2 mRNA	15312234\|1600256
D008095	Lithocholic Acid	[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA	17963371
D008095	Lithocholic Acid	[Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA	17963371
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of NR0B2 mRNA	19562681\|2254000
D008095	Lithocholic Acid	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of NR0B2 mRNA	20359477
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of NR0B2 mRNA	20359477
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of NR0B2 mRNA	22982774\|2558270
D008095	Lithocholic Acid	[Lithocholic Acid binds to VDR protein] which results in increased expression of NR0B2 mRNA	19562681
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of NR0B2 mRNA	20888898
D017336	Loratadine	Loratadine results in increased expression of NR0B2 mRNA	15342952
D008687	Metformin	Metformin results in decreased expression of NR0B2 mRNA	24428821
D008715	Methionine	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]	25712622
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA	25712622
D008715	Methionine	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]	25712622
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of NR0B2 mRNA	19593819
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA	25712622
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]]	19593819
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]]	19593819
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]]	19593819
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]	19593819
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]	19593819
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]]	19593819
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]]	19593819
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]]	19593819
D008715	Methionine	NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of CYP4A14 mRNA]	19593819
D008715	Methionine	NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with pirinixic acid] results in increased expression of CYP4A14 mRNA]	19593819
D008715	Methionine	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]	25712622
D008730	Methoxsalen	Methoxsalen results in decreased expression of NR0B2 mRNA	28552422
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of NR0B2 mRNA	19118567
C030957	methylmercury II	methylmercury II results in decreased expression of NR0B2 mRNA	17905399
D015741	Metribolone	[Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B2 protein modified form]	28751236
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of NR0B2 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of NR0B2 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of NR0B2 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of NR0B2 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA	17175557
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA	19181614\|2565519
D015058	1-Naphthylisothiocyanate	alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]	25655198
D015058	1-Naphthylisothiocyanate	NFE2L2 promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]	19181614
D015058	1-Naphthylisothiocyanate	"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]]"	25655198
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA	27317372
D015058	1-Naphthylisothiocyanate	dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]	27317372
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of NR0B2 mRNA	19812364
C022838	nickel chloride	nickel chloride results in decreased expression of NR0B2 mRNA	17547211
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of NR0B2 mRNA	19716841
C464660	obeticholic acid	obeticholic acid promotes the reaction [PRMT2 protein binds to NR0B2 promoter]	15911693
C464660	obeticholic acid	obeticholic acid results in increased expression of NR0B2 mRNA	15911693\|2793961
C464660	obeticholic acid	obeticholic acid results in increased expression of NR0B2 mRNA	26655953
C464660	obeticholic acid	obeticholic acid results in increased expression of NR0B2 protein	26655953
C464660	obeticholic acid	NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]]	15860571
C464660	obeticholic acid	NR0B2 protein affects the reaction [obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein]	15860571
C464660	obeticholic acid	obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA]	27255380
C464660	obeticholic acid	obeticholic acid results in increased expression of NR0B2 mRNA	15644430\|1598005
C464660	obeticholic acid	obeticholic acid results in increased expression of NR0B2 protein	15860571
D009844	Oligosaccharides	Oligosaccharides inhibits the reaction [Dietary Fats results in increased expression of NR0B2 mRNA]	28549616
C506614	PD 0325901	PD 0325901 results in decreased expression of NR0B2 mRNA	24819614
D010419	Pentamidine	Pentamidine results in increased expression of NR0B2 mRNA	15342952
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of NR0B2 mRNA	21723365
D010480	Perhexiline	Perhexiline results in increased expression of NR0B2 mRNA	15342952\|1717555
D010634	Phenobarbital	Phenobarbital results in decreased expression of NR0B2 mRNA	19270015
D019800	Phenol	Phenol results in decreased expression of NR0B2 mRNA	17547211
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NR0B2 mRNA	19710929
C006253	pirinixic acid	NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with pirinixic acid] results in increased expression of CYP4A14 mRNA]	19593819
C006253	pirinixic acid	pirinixic acid results in increased expression of NR0B2 mRNA	17426115\|1844570
C006253	pirinixic acid	RXRA protein inhibits the reaction [pirinixic acid results in increased expression of NR0B2 mRNA]	19176532
D010936	Plant Extracts	Plant Extracts results in decreased expression of NR0B2 mRNA	23557933
C531249	Poly(amidoamine)	Poly(amidoamine) analog results in increased expression of NR0B2 mRNA	24813635
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of NR0B2 mRNA	17547211
D017035	Pravastatin	Pravastatin results in decreased expression of NR0B2 mRNA	27225895
D017035	Pravastatin	Pravastatin results in decreased expression of NR0B2 mRNA	27225895
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione inhibits the reaction [Imatinib Mesylate results in increased expression of NR0B2 mRNA]"	22414727
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]]"	25655198
C071461	pregnenolone 16-acetonitrile	pregnenolone 16-acetonitrile results in increased expression of NR0B2 mRNA	21311750
D011285	Pregnenolone Carbonitrile	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of NR0B2 mRNA	20359477
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of NR0B2 mRNA	20359477
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of NR0B2 mRNA	22982774
D011718	Pyrazinamide	obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA]	27255380
D011718	Pyrazinamide	Pyrazinamide results in decreased expression of NR0B2 mRNA	27255380
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]	19593819
D011794	Quercetin	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]	25712622
D011794	Quercetin	Quercetin results in decreased expression of NR0B2 mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]	25712622
C031389	resorcinol	resorcinol results in increased expression of NR0B2 mRNA	22623647
C059514	resveratrol	PRKAA1 mutant form inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA]	26044878
C059514	resveratrol	PRKAA2 mutant form inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA]	26044878
C059514	resveratrol	resveratrol results in increased expression of NR0B2 mRNA	26044878
C059514	resveratrol	SIRT1 mutant form inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA]	26044878
C059514	resveratrol	sirtinol inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA]	26044878
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of NR0B2 mRNA	25905778
C059514	resveratrol	resveratrol results in increased expression of NR0B2 mRNA	25905778
D012293	Rifampin	Rifampin results in increased expression of NR0B2 mRNA	15670600
C009237	senecionine	senecionine results in decreased expression of NR0B2 mRNA	24641316
D020280	Sertraline	Sertraline results in increased expression of NR0B2 mRNA	15342952
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of NR0B2 mRNA	25895662
D012834	Silver	Silver results in decreased expression of NR0B2 mRNA	26014281
C439060	sirtinol	sirtinol inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA]	26044878
C017947	sodium arsenite	sodium arsenite results in increased expression of NR0B2 mRNA	25610880
C016104	sodium bichromate	sodium bichromate results in increased expression of NR0B2 mRNA	25993096
D013015	Sotalol	Sotalol results in decreased expression of NR0B2 mRNA	15342952\|1717555
D013015	Sotalol	Sotalol results in increased expression of NR0B2 mRNA	17175557
C075117	squalestatin 1	squalestatin 1 results in decreased expression of NR0B2 mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in decreased expression of NR0B2 mRNA	27225895
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of NR0B2 mRNA	25905778
D018170	Sumatriptan	Sumatriptan results in decreased expression of NR0B2 mRNA	15342952
D013629	Tamoxifen	Tamoxifen inhibits the reaction [ESR1 protein binds to NR0B2 protein]	23665804
D013629	Tamoxifen	Tamoxifen results in increased expression of NR0B2 mRNA	15342952\|1717555
D013629	Tamoxifen	Tamoxifen affects the expression of NR0B2 mRNA	20937368
D013629	Tamoxifen	Tamoxifen results in increased expression of NR0B2 mRNA	17555576
D013656	Taurocholic Acid	Taurocholic Acid results in increased expression of NR0B2 mRNA	18706437
D013739	Testosterone	NR0B2 protein affects the metabolism of Testosterone	17289919
D013749	Tetrachlorodibenzodioxin	NR0B2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]	11368516
D013749	Tetrachlorodibenzodioxin	NR0B2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]	11368516
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NR0B2 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NR0B2 mRNA	24058054
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR0B2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NR0B2 mRNA	16054898\|2095900
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of NR0B2 mRNA	20558275
D013853	Thioacetamide	Thioacetamide results in decreased expression of NR0B2 mRNA	23411599
D013881	Thioridazine	Thioridazine results in increased expression of NR0B2 mRNA	17175557
D001371	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of NR0B2 mRNA"	15342952\|1717555
D014212	Tretinoin	Tretinoin results in increased expression of NR0B2 mRNA	18230668
D014212	Tretinoin	Tretinoin results in increased expression of NR0B2 mRNA	21274875
D014212	Tretinoin	NR0B2 protein affects the metabolism of Tretinoin	17289919
D014212	Tretinoin	Tretinoin results in increased expression of NR0B2 mRNA	21274875
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of NR0B2 mRNA	25055964
C005445	triphenyl phosphate	"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NR0B2 mRNA]"	29112739
C005445	triphenyl phosphate	"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NR0B2 mRNA"	29112739
C016805	tris(1,3-dichloro-2-propyl)phosphate	"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NR0B2 mRNA]"	29112739
C016805	tris(1,3-dichloro-2-propyl)phosphate	"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NR0B2 mRNA"	29112739
D014317	Tritolyl Phosphates	"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NR0B2 mRNA]"	29112739
D014317	Tritolyl Phosphates	"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NR0B2 mRNA"	29112739
C113580	U 0126	U 0126 results in decreased expression of NR0B2 mRNA	24819614
C112106	UAB 30	UAB 30 analog results in increased expression of NR0B2 mRNA	23292798
D014520	Urethane	Urethane results in increased expression of NR0B2 mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of NR0B2 mRNA	18706437\|2505596
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of NR0B2 mRNA	25582706
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of NR0B2 mRNA	16764892\|2127487
D014635	Valproic Acid	Valproic Acid results in increased expression of NR0B2 mRNA	17175557
D014635	Valproic Acid	Valproic Acid affects the expression of NR0B2 mRNA	17292431
D014640	Vancomycin	[Vancomycin co-treated with Imipenem] results in increased expression of NR0B2 mRNA	24657338
D024483	Vitamin K 3	Vitamin K 3 affects the expression of NR0B2 mRNA	23410634
C540004	WAY-362450	NR1H4 gene mutant form inhibits the reaction [WAY-362450 results in increased expression of NR0B2 mRNA]	22918042
C540004	WAY-362450	WAY-362450 results in increased expression of NR0B2 mRNA	22918042
D015031	Zimeldine	Zimeldine results in increased expression of NR0B2 mRNA	17175557
D019345	Zinc Acetate	[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]	26241054
D019345	Zinc Acetate	[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of NR0B2 mRNA	26241054

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0003677	DNA binding	-	IEA	-
GO:0003707	steroid hormone receptor activity	-	IEA	-
GO:0003714	transcription corepressor activity	-	IBA	21873635
GO:0003714	transcription corepressor activity	-	IDA	14752053
GO:0005515	protein binding	-	IPI	14752053 15317749 16709599 17895379 20375098 22504882 22575647
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0019904	protein domain specific binding	-	IPI	17686645
GO:0042803	protein homodimerization activity	-	IPI	16709599
GO:0042975	peroxisome proliferator activated receptor binding	-	IEA	-
GO:0044877	protein-containing complex binding	-	IEA	-
GO:0046965	retinoid X receptor binding	-	IEA	-
GO:0046966	thyroid hormone receptor binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0007219	Notch signaling pathway	-	IEA	-
GO:0008203	cholesterol metabolic process	-	TAS	11030331
GO:0009749	response to glucose	-	IEA	-
GO:0010628	positive regulation of gene expression	-	IMP	19085950
GO:0010629	negative regulation of gene expression	-	IMP	19085950
GO:0031100	animal organ regeneration	-	IEA	-
GO:0032024	positive regulation of insulin secretion	-	IEA	-
GO:0043401	steroid hormone mediated signaling pathway	-	IEA	-
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IBA	21873635
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IDA	14752053

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	14752053 16709599
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	14752053
GO:0032991	protein-containing complex	-	IEA	-

KEGG ID	KEGG Term
hsa04976	Bile secretion

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-383280	Nuclear Receptor transcription pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25701738	Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice. (2015 May)	Tsuchiya H	Gastroenterology