Gene: C7orf50

84310
YCR016W
chromosome 7 open reading frame 50
protein-coding
7p22.3
Ensembl:ENSG00000146540 Vega:OTTHUMG00000151477 UniprotKB:Q9BRJ6
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
2.968e-1 (AD)  5.714e-1 (ND)   (Frontal_Cortex)
6.880e-1 (AD)  2.179e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3817576chr7:983555 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01504489chr7:1131626C7orf50Gene body7.344e-5Alcohol use disorders26763658
cg14939096chr7:1145852C7orf50Gene body6.706e-4Alcohol use disorders26763658
cg07104557chr7:1036653C7orf505.600e-12Maternal smoking in pregnancy27040690
cg07104557chr7:1036653C7orf506.400e-12Maternal smoking in pregnancy27040690
cg07104557chr7:1036653C7orf503.140e-15Maternal smoking in pregnancy27040690
cg15693483chr7:1102177C7orf501.400e-8Smoking27651444
cg07104557chr7:1036653C7orf506.900e-8Smoking27651444
cg21248060chr7:1039957C7orf502.290e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GUK10.898
DGCR6L0.892
TIMM130.88
C19orf700.879
NDUFA130.878
NDUFB70.877
AURKAIP10.875
BAD0.864
THAP70.863
MZT2B0.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.739
OR4F29-0.713
ACER2-0.296
DNAH11-0.29
CCDC36-0.284
MTRNR2L6-0.256
SFTPA1-0.251
MS4A6A-0.251
MS4A14-0.251
KCNJ15-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of C7ORF50 gene27153756
D001151ArsenicArsenic affects the expression of C7ORF50 mRNA18414638
D001280AtrazineAtrazine results in increased expression of C7ORF50 mRNA25929836
D001554BenzeneBenzene results in increased expression of C7ORF50 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of C7ORF50 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in increased expression of C7ORF50 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of C7ORF50 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of C7ORF50 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of C7ORF50 mRNA26472689
C018021cobaltous chloridecobaltous chloride results in decreased expression of C7ORF50 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of C7ORF50 mRNA19549813
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of C7ORF50 protein23301498
C492448ICG 001ICG 001 results in increased expression of C7ORF50 mRNA26191083
C544151jinfukangjinfukang results in increased expression of C7ORF50 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of C7ORF50 mRNA23086925
C410337K 7174K 7174 results in decreased expression of C7ORF50 mRNA24086573
D011794QuercetinQuercetin results in decreased expression of C7ORF50 mRNA21632981
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of C7ORF50 gene26756918
D014635Valproic AcidValproic Acid affects the expression of C7ORF50 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of C7ORF50 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of C7ORF50 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal